Status Report

NASA Spaceline Current Awareness List #907 17 July 2020 (Space Life Science Research Results)

By SpaceRef Editor
July 17, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Lee SMC, Ribeiro LC, Laurie SS, Feiveson AH, Kitov VV, Kofman IS, Macias BR, Rosenberg M, Rukavishnikov IV, Tomilovskaya ES, Bloomberg JJ, Kozlovskaya IB, Reschke MF, Stenger MB. 

Efficacy of gradient compression garments in the hours after long-duration spaceflight.

Front Physiol. 2020 Jul 17;11:784.

PI: M.F. Reschke

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: “This research was funded by NASA’s Human Research Program and the Russian Academy of Sciences (63.1)….This study was one arm of a larger project titled, “Recovery of Functional Performance following Long Duration Space Flight” (co-principal investigators, Drs. Millard Reschke and Inessa Kozlovskaya).”



Qadota H, Moody JC, Lesanpezeshki L, Moncrief T, Kitzler D, Bhat PD, Vanapalli SA, Oberhauser AF, Benian GM.

A region of UNC-89 (obscurin) lying between two protein kinase domains is a highly elastic spring required for proper sarcomere organization.

J Mol Biol. 2020 Jul 6. [Epub ahead of print]

PI: S.A. Vanapalli

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.76

Funding: “This study was supported in-part by a grant from the National Institutes of Health (R01 AR064307) to G.M.B. J.C.M. was supported in-part by the National Science Foundation-Graduate Research Fellowship Program (Grant #DGE 1444932). T.M. was partially supported by a grant from the National Institutes of Health (R01GM118534) to A.F.O. and G.M.B. L.L. and S.A.V. were partially supported by the National Aeronautics and Space Administration (Grant # NNX15AL16G).”



Tarasova OS, Kalenchuk VU, Borovik AS, Golubinskaya VO, Delp MD, Vinogradova OL.

Simulated microgravity induces regionally distinct neurovascular and structural remodeling of skeletal muscle and cutaneous arteries in the rat.

Front Physiol. 2020 Jun 30;11:675.

PI: M.D. Delp

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: “The study was performed according to the Plan for Fundamental research of State Research Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences (N 64.1).” PI reports NASA support.



Sapoval N, Mahmoud M, Jochum MD, Liu Y, Leo Elworth RA, Wang Q, Albin D, Ogilvie H, Lee MD, Villapol S, Hernandez KM, Berry IM, Foox J, Beheshti A, Ternus K, Aagaard KM, Posada D, Mason CE, Sedlazeck F, Treangen TJ. 

Hidden genomic diversity of SARS-CoV-2: Implications for qRT-PCR diagnostics and transmission.

bioRxiv. 2020 Jul 2. [Epub ahead of print]

PI: A. Beheshti

Note: This article is a preprint and has not been peer reviewed. This article may be obtained online without charge. 

Journal Impact Factor: Not applicable to this publication

Funding: “N.S. and Y.L. are supported by the Department of Computer Science, Rice University. Q.W., D.A., T.J.T, and R.A.L.E. are supported by startup funds from Rice University. M.J. is supported under NIH award No. R01HD091731 from the NICHD. F.J.S. acknowledges funding and part of the data was produced by Baylor College of Medicine under NIAID (U19AI144297-01). A.B. is supported by supplemental funds for COVID-19 research from Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (T-0404) and further funding was provided by KBR, Inc. D.P. is supported by the European Research Council (ERC-617457-PHYLOCANCER), Spanish Ministry of Economy and Competitiveness, and Xunta de Galicia.”



Douglas GL, Zwart SR, Smith SM.

Space food for thought: Challenges and considerations for food and nutrition on exploration missions.

J Nutr. 2020 Jul 11. [Epub ahead of print]

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.281

Funding: “This work was funded by NASA, in the form of employment of the authors either directly (GLD, SMS) or through the Human Health and Performance Contract (SRZ).”



Ghanem MA, Maxwell AD, Wang YN, Cunitz BW, Khokhlova VA, Sapozhnikov OA, Bailey MR.

Noninvasive acoustic manipulation of objects in a living body.

Proc Natl Acad Sci U S A. 2020 Jul 6. [Epub ahead of print]

PI: M.R. Bailey

Journal Impact Factor: 7.5804

Funding: “We gratefully acknowledge support for this work from National Institutes of Health Grants P01 DK043881, K01 DK104854, and R01 EB007643 and from the Russian Foundation for Basic Research Grant 20-02-00139. Work on manipulating objects was initiated by support from the National Space Biomedical Research Institute through NASA NCC 9-58.”



Patel R, Zhang L, Desai A, Hoenerhoff MJ, Kennedy LH, Radivoyevitch T, La Tessa C, Gerson SL, Welford SM.

Protons and high-LET radiation induce genetically similar lymphomas with high penetrance in a mouse model of the aging human hematopoietic system.

Int J Radiat Oncol Biol Phys. 2020 Jul 3. [Epub ahead of print]

PI: S.L. Gerson

Journal Impact Factor: 5.859

Funding: “This work was funded by NASA (NNX14AC95G) and the Case Comprehensive Cancer Center (5P30 CA043703).”



Rasheed RM, Thomas EA, Gardner P, Rogers T, Verduzco R, Weislogel MM.

Omni-gravity nanophotonic heating and Leidenfrost-driven water recovery system.

Gravit Space Res. 2020 Jul 14;8(1):31.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work is the result of a collaborative effort supported in part by a NASA Small Business Innovative Research Phase I grant titled “Nanophotonic Capillary Distiller” (80NSSC18P1957), COR John McQuillen, and a NASA Space Technology Research Fellowship grant titled “Leidenfrost Driven Waste-Water Separator” (80NSSC17K0175), September 15, 2017: COR Jennifer Pruitt.”




Other papers of interest:



Oka M, Kamada M, Inoue R, Miyamoto K, Uheda E, Yamazaki C, Shimazu T, Sano H, Kasahara H, Suzuki T, Higashibata A, Ueda J.

Altered localisation of ZmPIN1a proteins in plasma membranes responsible for enhanced-polar auxin transport in etiolated maize seedlings under microgravity conditions in space.

Funct Plant Biol. 2020 Jul 8. [Epub ahead of print]

Note: ISS results.



Larina IM, Pastushkova LK, Kononikhin AS, Nikolaev EN, Orlov OI.

Piloted space flight and post-genomic technologies.

REACH. 2020 Jul 11. [Article in Press] Review.  

Note: From the abstract: “Purpose of the review was to systemize the available proteomic data on the effects of spaceflight factors on the human organism obtained after real space flights and in ground simulation experiments.” The particular missions are not identified in the available abstract.



Shi H, Du S, Xu D, Yang Y, Liu J, Liu D, Wu B.

[Analysis of fluid loading protocols research for spaceflight].

Space Med Med Eng. 2020;2020(3):258-65. Chinese.

Note: Spaceflight results; the particular missions are not identified in the available abstract. From the abstract: “In this paper, the changes of body fluid and plasma volume of astronauts after space flight missions, the fluid loading protocols before returning to earth and research progress for US/Russia were reviewed, and the similarities and differences between US and Russian protocols were compared.”



Constant T, Giroud S, Viblanc VA, Tissier ML, Bergeron P, Dobson FS, Habold C.

Integrating mortality risk and the adaptiveness of hibernation.

Front Physiol. 2020 Jul 10;11:706. Review.

Note: This article may be obtained online without charge.



Gonzalez JT, Dirks ML, Holwerda AM, Kouw IWK, van Loon LJC.

Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.

Eur J Appl Physiol. 2020 Jul 10. [Epub ahead of print]

Note: Bed rest study. This article may be obtained online without charge.



Mittelstaedt JM.

Individual predictors of the susceptibility for motion-related sickness: A systematic review.

J Vestib Res. 2020 Jun 27. [Epub ahead of print] Review.



Landry KS, Morey JM, Bharat B, Haney NM, Panesar SS.

Biofilms—Impacts on human health and its relevance to space travel.

Microorganisms. 2020 Jul 3;8(7):E998. Review.

Note: This article may be obtained online without charge.



Rusanov VB, Pastushkova LK, Larina IM, Chernikova AG, Goncharova AG, Nosovsky AM, Kashirina DN, Brzhozovsky AG, Navasiolava N, Kononikhin AS, Kussmaul AR, Custaud M-A, Nikolaev EN. 

The effect of five-day dry immersion on the nervous and metabolic mechanisms of the circulatory system.

Front Physiol. 2020 Jul 10;11:692.

Note: Dry immersion study. This article may be obtained online without charge.



Bodine SC.

Adolph lecture: Skeletal muscle atrophy: Multiple pathways leading to a common outcome.

J Appl Physiol (1985). 2020 Jul 9. [Epub ahead of print] Review.



Mochalova EP, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.

Differences in the role of HDACs 4 and 5 in the modulation of processes regulating MAFbx and MuRF1 expression during muscle unloading.

Int J Mol Sci. 2020 Jul 7;21(13):E4815.

Note: Hindlimb unloading study. This article may be obtained online without charge.



O’Conor DK, Dalal S, Ramachandran V, Shivers B, Shender BS, Jones JA.

Crew-friendly countermeasures against musculoskeletal injuries in aviation and spaceflight.

Front Physiol. 2020 Jul 10;11:837. Review.

Note: This article may be obtained online without charge.



Welch C, Greig CA, Masud T, Pinkney T, Jackson TA.

Protocol for understanding acute sarcopenia: A cohort study to characterise changes in muscle quantity and physical function in older adults following hospitalisation.

BMC Geriatr. 2020 Jul 10;20(1):239.

Note: This article may be obtained online without charge.



Weyrauch LA, McMillin SL, Witczak CA.

Insulin resistance does not impair mechanical overload-stimulated glucose uptake, but does alter the metabolic fate of glucose in mouse muscle.

Int J Mol Sci. 2020 Jul 1;21(13):E4715.

Note: This article may be obtained online without charge.



Ashrafi M, Gubaua JE, Pereira JT, Gahlichi F, Doblaré M.

A mechano-chemo-biological model for bone remodeling with a new mechano-chemo-transduction approach.

Biomech Model Mechanobiol. 2020 Jul 4. [Epub ahead of print]



Cardoso AL, Frederico ÉH, Guimarães CA, Guedes-Aguiar EO, Moreira-Marconi E, Paineiras-Domingos LL, Sá-Caputo DC, Bernardo-Filho M, Asad NR.

Long-term effects of mechanical vibration stimulus on the bone formation of Wistar rats: An assessment method based on X-rays images.

Acad Radiol. 2020 Jul 2. [Epub ahead of print]



Miyamura G, Wakabayashi H, Nagao N, Kato S, Nakagawa T, Naito Y, Sudo A.

Prevention of bone loss and improvement of pain-related behavior in hind limb-unloaded mice by administration of teriparatide and bisphosphonate.

Mod Rheumatol. 2020 Jul 10. [Epub ahead of print]

Note: Hindlimb unloading study.



Tousen Y, Ichimaru R, Kondo T, Inada M, Miyaura C, Ishimi Y.

The combination of soy isoflavones and resveratrol preserve bone mineral density in hindlimb-unloaded mice.

Nutrients. 2020 Jul 9;12(7):E2043.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM.

CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH.

J Bone Miner Res. 2020 Jul 7. [Epub ahead of print]



Cao W, McCallum NC, Ni QZ, Li W, Boyce H, Mao H, Zhou X, Sun H, Thompson MP, Battistella C, Wasielewski MR, Dhinojwala A, Shawkey MD, Burkart MD, Wang Z, Gianneschi NC.

Selenomelanin: An abiotic selenium analogue of pheomelanin.

J Am Chem Soc. 2020 Jul 8. [Epub ahead of print]

Note: Selenomelanin shows promise as a lightweight radioprotective biomaterial.



Khaksarighiri S, Guo J, Wimmer-Schweingruber R, Narici L, Lohf H.

Calculation of dose distribution in a realistic brain structure and the indication of space radiation influence on human brains.

Life Sci Space Res. 2020 Jul 15. [Article in Press]



von Salm-Hoogstraeten S, Müsseler J.

Human cognition in interaction with robots: Taking the robot’s perspective into account.

Hum Factors. 2020 Jul 10. [Epub ahead of print]

Note: This article may be obtained online without charge.



Ge X, Chen Y, Zhou Q, Liu Z.

[Research progress of complexity evaluation method in space station on-orbit maintenance tasks].

Space Med Med Eng. 2020;2020(3):274-82. Chinese.



Chaudhari GN, Kadam SR, Yadav SA.

Plants in the space environment.

Ag Lett. 2020 Jun;1(2):37-9.

Note: This article may be obtained online without charge.



Cheng Z, Zhang Q, Wei Y.

[Mass flow of combined AnMBR-MBR process in wastewater treatment of simulated ground-based controlled ecological life support system].

Space Med Med Eng. 2020;2020(3):233-9. Chinese. 



Aronne G, Romano LE, Izzo LG.

Subsequent inclusion/exclusion criteria to select the best species for an experiment performed on the ISS in a refurbished hardware.

Life Sci Space Res. 2020 Nov;27:19-26. Epub 2020 Jul 11.



Li W, Liu Z, Xie X, Chang Y.

[Comparison of suitability of five scales in measuring subjective mental workload during flight activities].

Space Med Med Eng. 2020;2020(3):221-7. Chinese. 

Note: The NASA Task Load Index was used.


SpaceRef staff editor.