Status Report

NASA Spaceline Current Awareness List #906 10 July 2020 (Space Life Science Research Results)

By SpaceRef Editor

July 10, 2020

Filed under ISS, Spaceline, Spaceline Current Awareness, US

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

Bijlani S, Singh NK, Mason CE, Wang CCC, Venkateswaran K.

Draft genome sequences of Tremellomycetes strains isolated from the International Space Station.

Microbiol Resour Announc. 2020 Jun 25;9(26):e00504-20.

https://pubmed.ncbi.nlm.nih.gov/32586865

PI: K. Venkateswaran

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 0.88

Funding: “This research was funded by 2012 Space Biology NNH12ZTT001N grant number 19-12829-26 under task order NNN13D111T awarded to K.V., which was also subcontracted to C.C.C.W. and funded the postdoctoral fellowship for S.B.”

Law J, Gilmore S, Kelly S.

Postflight rash and skin sensitivity following a year-long spaceflight mission.

Aerosp Med Hum Perform. 2020 Jul 1;91(7):604-7.

https://pubmed.ncbi.nlm.nih.gov/32591038

Note: ISS results.

Journal Impact Factor: 0.889

Funding: No funding cited. S. Kelly is affiliated with NASA Johnson Space Center.

Becket E, Johnson KO, Burke CJ, Clark JJ, Cohen MJS, Coil DA, Eggleston CA, Farmer TL, Farr TR, Hernandez SM, Jaureguy JP, Jospin G, Khan A, Lee MD, McKee LN, O’Brien EM, Read BA, Saisho R, Seuylemezian A, Serrato-Arroyo SS, Steinecke D, Vaishampayan P.

Draft genome gequences of Bacillus glennii V44-8, Bacillus saganii V47-23a, Bacillus sp. strain V59.32b, Bacillus sp. strain MER_TA_151, and Paenibacillus sp. strain MER_111, isolated from cleanrooms where the Viking and Mars Exploration Rover spacecraft were assembled.

Microbiol Resour Announc. 2020 Jun 25;9(26):e00345-20.

https://pubmed.ncbi.nlm.nih.gov/32586854

Note: This article may be obtained online without charge.

Journal Impact Factor: 0.88

Funding: “The research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration….We received financial support from JPL’s Center for Academic Partnership (CAP) funding. Computational resources for the course were made available by the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number ACI-1548526, via JetStream through allocation TGMCB200008 (15).”

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA.

Mitochondrial substrate utilization regulates cardiomyocyte cell cycle progression.

Nat Metab. 2020 Feb;2(2):167-78.

https://pubmed.ncbi.nlm.nih.gov/32617517

PI: H.A. Sadek

Note: This article may be obtained online without charge on 1 Aug 2020.

Journal Impact Factor: Not available for this journal

Funding: “H.A.S. is supported by grants from the NIH (1R01HL115275 and 5R01H2131778), National Aeronautics and Space Administration (NNX-15AE06G), American Heart Association (16EIA27740034), Cancer Prevention and Research Institute of Texas (RP160520), Hamon Center for Regenerative Science and Medicine and Fondation Leducq. N.T.L. is supported by a Haberecht Wildhare-Idea Research Grant. A.D.S. is supported by grant from the NIH (R37-HL034557), C.R.M. is supported by grant from the NIH (P41-EB015908) and G.S. is supported by the grant from the AHA (18POST34050049). M.K. is supported by the grants from NIH (3P20GM103447 and 5P30AG050911). I.M.M. is supported by Alfonso Martin Escudero Foundation Fellowship. N.U.N.N. is supported by AHA Postdoctoral Fellowship 19POST34450039. J.A.H. is supported by grants from the NIH (HL-120732, HL-128215 and HL-126012).”

Villa MM, Bloom RJ, Silverman JD, Durand HK, Jiang S, Wu A, Dallow EP, Huang S, You L, David LA.

Interindividual variation in dietary carbohydrate metabolism by gut bacteria revealed with droplet microfluidic culture.

mSystems. 2020 Jun 30;5(3):e00864-20.

https://pubmed.ncbi.nlm.nih.gov/32606031

PI: L.A. David

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.280

Funding: “L.A.D. acknowledges support from the Global Probiotics Council, a Searle Scholars Award, an Alfred P. Sloan Research Fellowship, the Beckman Young Investigator program, the Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, the UNC CGIBD (NIDDK P30DK034987), and NIH 1R01DK116187-01. This work used a high-performance computing facility partially supported by grant 2016-IDG-1013 (“HARDAC+: Reproducible HPC for Next-generation Genomics”) from the North Carolina Biotechnology Center. M.M.V. holds a Postdoctoral Enrichment Program Award from the Burroughs Wellcome Fund. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under grant no. DGE-1644868 to R.J.B.”

Steller JG, Blue RS, Burns R, Bayuse TM, Antonsen EL, Jain V, Blackwell MM, Jennings RT.

Gynecologic risk mitigation considerations for long-duration spaceflight.

Aerosp Med Hum Perform. 2020 Jul 1;91(7):543-64.

https://pubmed.ncbi.nlm.nih.gov/32591031

Journal Impact Factor: 0.889

Funding: No funding cited. E.L. Antonsen is affiliated with NASA Johnson Space Center.

Lenne RL, Mann T, Burns RJ, Vickers Z, Redden JP.

Variety salience and enjoyment of repetitiously consumed foods: A field experiment.

Int J Behav Med. 2020 Jun 29. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32601978

PI: Z. Vickers

Journal Impact Factor: 2.139

Funding: “This research was supported by the National Aeronautics and Space Administration, Award #NNX12AE56G to ZV, JPR, and TM.”

Semple C, Riveros D, Nagy JA, Rutkove SB, Mortreux M.

Corrigendum: Partial weight-bearing in female rats: Proof of concept in a Martian-gravity analog.

Front Physiol. 2020 Jul 3;11:672.

https://www.frontiersin.org/article/10.3389/fphys.2020.00672

PI: S.B. Rutkove

Note: The correction is: “In the original article, there was a mistake in Table 1 as published. The value displayed for heart rate on day 0 for the PWB40 group was incorrect. The incorrect value was 349 ± 59, it has been replaced by the correct value 397 ± 28.” The original article has been updated and can be found at https://pubmed.ncbi.nlm.nih.gov/32308630. The original article appeared in SPACELINE Current Awareness List #894, 10 April 2020. This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: From the original article: “This work was funded by a grant from the National Aeronautics and Space Administration (NASA: NNX16AL36G).”

Britten RA, Fesshaye AS, Duncan VD, Wellman LL, Sanford LD.

Sleep fragmentation exacerbates executive function impairments induced by low doses of Si ions.

Radiat Res. 2020 Jun 30. [Epub ahead of print]

https://meridian.allenpress.com/radiation-research/article/doi/10.1667/RADE-20-00080.1/439619/Sleep-Fragmentation-Exacerbates-Executive-Function

PI: R.A. Britten

Journal Impact Factor: 2.719

Funding: “Funding for this work was provided by NASA grant nos. NNX14AE73G and NNX16AC40G.”

Nia AM, Khanipov K, Barnette BL, Ullrich RL, Golovko G, Emmett MR.

Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of ⁵⁶Fe, ¹⁶O, and ²⁸Si irradiation on the induction of murine hepatocellular carcinoma.

BMC Genomics. 2020 Jul 1;21(1):453.

https://pubmed.ncbi.nlm.nih.gov/32611366

PI: M.R. Emmett

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.594

Funding: “This work was supported by the Ground-Based Studies in Space Radiobiology through the National Aeronautics and Space Administration NASA (NNX15AD65G)….The Radiation Effects Research Foundation (RERF), Hiroshima, and Nagasaki, Japan, is a public interest foundation funded by the Japanese Ministry of Health, Labor and Welfare (MHLW) and the US Department of Energy (DOE). The research was also funded in part through DOE award DEHS0000031 to the National Academy of Sciences….Additionally, this research was partially supported by NASA/Texas Space Grant Consortium Fellowship (BLB), and Shirley Patricia Parker & Katherina Siebert Award for Excellence in Oncologic Scholarship (AMN & BLB).”

Rithidech KN, Mortazavi SMJ, Brooks AL.

Letter to Editor Re: Fang et al entitled “Assessment of genomic instability in medical workers exposed to chronic low-dose X-Rays in Northern China.”

Dose Response. 2020 Apr-Jun;18(2):1559325820922101.

https://pubmed.ncbi.nlm.nih.gov/32577116

PI: K.N. Rithidech

Note: The authors comment on the article: Fang L, Li J, Li W, Mao X, Ma Y, Hou D, Zhu W, Jia X, Qiao J. Assessment of genomic instability in medical workers exposed to chronic low-dose X-rays in Northern China. Dose Response. 2019 Nov 28;17(4):1559325819891378. https://pubmed.ncbi.nlm.nih.gov/31819742. This article may be obtained online without charge.

Journal Impact Factor: 2.438

Funding: “This research was supported by NASA grant #80NSSC19K0435 and Pathology Department, SBU.”

_______________________________________________________

Other papers of interest:

Kamyshev NG, Besedina NG, Bragina JV, Danilenkova LV, Fedotov SA, Goncharova AA, Kamysheva EA, Burlakova AA, Larina ON.

Behavioral changes in Drosophila males after travel to International Space Station.

Acta Astronaut. 2020 Jun 30. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S009457652030415X

Note: ISS results.

Ueda J.

Comprehensive report on the Auxin Transport space experiment: The analysis of gravity response and attitude control mechanisms of plants under microgravity conditions in space on the International Space Station.

Biol Sci Space. 2020;34:12-33.

https://www.jstage.jst.go.jp/article/bss/34/0/34_12/_article/-char/en

Note: ISS results. This article may be obtained online without charge.

Stahn AC, Riemer M, Wolbers T, Werner A, Brauns K, Besnard S, Denise P, Kühn S, Gunga HC.

Spatial updating depends on gravity.

Front Neural Circuits. 2020 Jun 5;14:20.

https://pubmed.ncbi.nlm.nih.gov/32581724

Note: Parabolic flight results. This article may be obtained online without charge.

Kermorgant M, Nasr N, Czosnyka M, Arvanitis DN, Hélissen O, Senard J-M, Pavy-Le Traon A.

Impacts of microgravity analogs to spaceflight on cerebral autoregulation.

Front Physiol. 2020 Jul 3;11:778.

https://www.frontiersin.org/article/10.3389/fphys.2020.00778

Note: Spaceflight, head-down tilt bed rest, and dry immersion studies are discussed. This article may be obtained online without charge.

Sanjana F, DeConne TM.

Lower body negative pressure: A novel remedy for preserving the cerebrovasculature from gravitational stress.

J Physiol. 2020 Jun 30. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32602948

Greene MR, Jacobs SE.

Decompression sickness treatment using a pressure suit after loss of spacecraft atmosphere.

Aerosp Med Hum Perform. 2020 Jul 1;91(7):571-7.

https://pubmed.ncbi.nlm.nih.gov/32591033

Dufurrena Q, Ullah KI, Taub E, Leszczuk C, Ahmad S.

Feasibility and clinical implications of remotely guided ultrasound examinations.

Aerosp Med Hum Perform. 2020 Jul 1;91(7):592-6.

https://pubmed.ncbi.nlm.nih.gov/32591036

Egawa T, Kido K, Yokokawa T, Fujibayashi M, Goto K, Hayashi T.

Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice.

Acta Astronaut. 2020 Nov;176:332-40. Epub 2020 Jul 2.

http://www.sciencedirect.com/science/article/pii/S0094576520304197

Note: Hindlimb unloading study.

Kawashima M, Miyakawa M, Sugiyama M, Miyoshi M, Arakawa T.

Unloading during skeletal muscle regeneration retards iNOS-expressing macrophage recruitment and perturbs satellite cell accumulation.

Histochem Cell Biol. 2020 Jul 3. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32617655

Note: Hindlimb unloading study.

Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O’Gorman DJ, Bertile F.

Effectiveness of resistive vibration exercise and whey protein supplementation plus alkaline salt on the skeletal muscle proteome following 21 days of bedrest in healthy males.

J Proteome Res. 2020 Jul 1. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32609523

Note: Bed rest study.

Lawrence MM, Van Pelt DW, Confides AL, Hettinger ZR, Hunt ER, Reid JJ, Laurin JL, Peelor FF 3rd, Butterfield TA, Miller BF, Dupont-Versteegden EE.

Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading.

Geroscience. 2020 Jun 25. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32588343

Note: Hindlimb unloading study.

Mañas-García L, Guitart M, Duran X, Barreiro E.

Satellite cells and markers of muscle regeneration during unloading and reloading: Effects of treatment with resveratrol and curcumin.

Nutrients. 2020 Jun 23;12(6):E1870.

https://pubmed.ncbi.nlm.nih.gov/32585875

Note: Hindlimb unloading study. This article may be obtained online without charge.

Marmolejo-Martínez-Artesero S, Romeo-Guitart D, Mañas-García L, Barreiro E, Casas C.

NeuroHeal reduces muscle atrophy and modulates associated autophagy.

Cells. 2020 Jun 28;9(7):E1575.

https://pubmed.ncbi.nlm.nih.gov/32605216

Note: Hindlimb immobilization was accomplished via splinting or denervation. This article may be obtained online without charge.

Ohira T, Kawano F, Ozaki Y, Fukuda S, Goto K, Ohira Y.

Roles of satellite cells and/or myonuclei in the regulation of morphological properties of anti-gravitational skeletal muscle in response to mechanical stress.

Biol Sci Space. 2020;34:1-11. Review.

https://www.jstage.jst.go.jp/article/bss/34/0/34_1/_article/-char/en

Note: Hindlimb unloading studies are reviewed. This article may be obtained online without charge.

Hong AR, Kim K, Lee JY, Yang JY, Kim JH, Shin CS, Kim SW.

Transformation of mature osteoblasts into bone lining cells and RNA sequencing-based transcriptome profiling of mouse bone during mechanical unloading.

Endocrinol Metab (Seoul). 2020 Jun;35(2):456-69.

https://pubmed.ncbi.nlm.nih.gov/32615730

Note: Unloading was accomplished via botulinum toxin injection. This article may be obtained online without charge.

Smith JK.

Microgravity, bone homeostasis, and insulin-like growth factor-1.

Appl Sci. 2020 Jun 27;10(13):4433. Review.

https://www.mdpi.com/2076-3417/10/13/4433

Note: From the abstract: “This article reviews the basics of bone formation and resorption and details how exposure to microgravity or simulated microgravity affects the structure and function of osteoblasts, osteocytes, osteoclasts, and their mesenchymal and hematologic stem cell precursors.” The article belongs to the Special Issue “Advances in Space Biology: Cell Behavior in Microgravity,” available at https://www.mdpi.com/journal/applsci/special_issues/Space_Biology. This article may be obtained online without charge.

Ferrè ER, Haggard P.

Vestibular cognition: State-of-the-art and future directions.

Cogn Neuropsychol. 2020 Mar 19. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32192411

Harris LR.

Does the vestibular system exert specific or general influences on cognitive processes?

Cogn Neuropsychol. 2020 Jun 30. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32605434

Note: This is an editorial commentary on the preceding article.

Gallagher M, Torok A, Klaas J, Ferrè ER.

Gravity prior in human behaviour: A perceptual or semantic phenomenon?

Exp Brain Res. 2020 Jun 21. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32567030

Note: This article may be obtained online without charge.

Freiberg AS, Zhou S.

Celestial versus terrestrial travel – An analysis of spaceflight fatalities and comparison to other modes of transportation.

Am J Med. 2020 Jun 24. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/32592663

Note: From the abstract: “We break down the fatality rates of human spaceflight and compare them to those of several terrestrial transportation modes. We created a database of human space travel, containing the vehicles, launches, and the total time and distance travelled.”

Moustogiannis A, Philippou A, Zevolis E, Taso O, Chatzigeorgiou A, Koutsilieris M.

Characterization of optimal strain, frequency and duration of mechanical loading on skeletal myotubes’ biological responses.

In Vivo. 2020 Jul-Aug;34(4):1779-88.

https://pubmed.ncbi.nlm.nih.gov/32606147

Note: This article may be obtained online without charge.

Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN.

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.

Nat Commun. 2020 Jul 1;11(1):3282.

https://pubmed.ncbi.nlm.nih.gov/32612176

Note: This article may be obtained online without charge.

Cooper JM, Wheatley CL, McCarty MM, Motzkus CJ, Lopes CL, Erickson GG, Baucom BRW, Horrey WJ, Strayer DL.

Age-related differences in the cognitive, visual, and temporal demands of in-vehicle information systems.

Front Psychol. 2020 Jun 3;11:1154.

https://pubmed.ncbi.nlm.nih.gov/32581959

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

Varas-Diaz G, Kannan L, Bhatt T.

Effect of mental fatigue on postural sway in healthy older adults and stroke populations.

Brain Sci. 2020 Jun 19;10(6):E388.