Status Report

NASA Spaceline Current Awareness List #904 19 June 2020 (Space Life Science Research Results)

By SpaceRef Editor
June 19, 2020
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Lee SMC, Ribeiro LC, Martin DS, Zwart SR, Feiveson AH, Laurie SS, Macias BR, Crucian BE, Krieger S, Weber D, Grune T, Platts SH, Smith SM, Stenger MB.

Arterial structure and function during and after long-duration spaceflight.

J Appl Physiol (1985). 2020 Jun 11. [Epub ahead of print]

PI: S.M.C. Lee

Note: ISS results.

Journal Impact Factor: 3.140

Funding: “This research was supported by NASA’s Human Research Program.”



Monje O, Richards JT, Carver JA, Dimapilis DI, Levine HG, Dufour NF, Onate BG.

Hardware validation of the Advanced Plant Habitat on ISS: Canopy photosynthesis in reduced gravity.

Front Plant Sci. 2020 Jun 18;11:673.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.106

Funding: “This work was funded by NASA’s Space Life and Physical Sciences Research and Applications Division and by NASA’s ISS Program Office.”



Bas G, Loisate S, Hudon SF, Woods K, Hayden EJ, Pu X, Beard R, Oxford JT, Uzer G.

Low intensity vibrations augment mesenchymal stem cell proliferation and differentiation capacity during in vitro expansion.

Sci Rep. 2020 Jun 10;10(1):9369.

Note: Vibration at room temperature was used. This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “This study was supported by NASA ISGC NNX15AI04H, NSF 1929188, NIH R01AG059923, 5P2CHD086843-03, P20GM109095 and P20GM103408. We also acknowledge support from The Biomolecular Research Center at Boise State with funding from the National Science Foundation, Grants #0619793 and #0923535; the MJ Murdock Charitable Trust; Lori and Duane Steuckle, and the Idaho State Board of Education.”



Zea L, McLean RJC, Rook TA, Angle G, Carter DL, Delegard A, Denvir A, Gerlach R, Gorti S, McIlwaine D, Nur M, Peyton BM, Stewart PS, Sturman P, Velez Justiniano YA.

Potential biofilm control strategies for extended spaceflight missions.

Biofilm. 2020 Dec;2:100026. Epub 2020 May 20.

PIs: L. Zea, R.J.C. McLean

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “LZ and RJCM also gratefully acknowledge research support from NASA (80NSSC17K0036 (LZ) and (NNX17AC79G) (RJCM)).”



Moccetti F, Belcik T, Latifi Y, Xie A, Ozawa K, Brown E, Davidson BP, Packwood W, Ammi A, Huke S, Lindner JR.

Flow augmentation in the myocardium by ultrasound cavitation of microbubbles: Role of shear-mediated purinergic signaling.

J Am Soc Echocardiogr. 2020 Jun 9. [Epub ahead of print]

PI: J.R. Lindner

Journal Impact Factor: 6.111

Funding: “Dr. Lindner is supported by grants R01-HL078610, R01-HL130046, and P51-OD011092 from the National Institutes of Health Bethesda, Maryland. Dr. Lindner is also supported by a grant (14-14NSBRI1-0025) from the NASA National Space Biomedical Research Institute. Dr. Moccetti is supported by a grant from the Swiss National Science Foundation and Novartis Foundation for Biomedical Research. Mr. Brown is supported by grant 18PRE33960532 from the American Heart Association. Dr. Ozawa is supported by the JSPS Overseas Research Fellowship Foundation and a Manpei Suzuki Diabetes grant.”



Huang S, Aleksashin NA, Loveland AB, Klepacki D, Reier K, Kefi A, Szal T, Remme J, Jaeger L, Vázquez-Laslop N, Korostelev AA, Mankin AS.

Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly.

Nat Commun. 2020 Jun 9;11(1):2900.

Note: This article may be obtained online without charge.

Journal Impact Factor: 11.878

Funding: “This work was supported by the grants R35 GM127134 (to A.S.M.) and R35 GM127094 (to A.A.K) from the National Institutes of Health, by Estonian Research Council grant PUT669 (to J.R.) and by the grant 80NSSC17K0031 from the National Aeronautics and Space Administration (to L.J).”



ElAbd H, Bromberg Y, Hoarfrost A, Lenz T, Franke A, Wendorff M.

Amino acid encoding for deep learning applications.

BMC Bioinformatics. 2020 Jun 9;21(1):235.

Note: This article may be obtained online without charge.

Journal impact Factor: 2.511

Funding: “This study was funded by the German Research Foundation (DFG) Research Training Group 1743 Genes, Environment and Inflammation and the applicants HE and MW received infrastructure support from the DFG Excellence Cluster 2167 Precision Medicine in Inflammation (PMI). Funding also provided by NASA Astrobiology Institute grant 80NSSC18M0093 to YB, and a NASA Astrobiology Postdoctoral Fellowship to AH.”



Basu D, Haswell ES.

The mechanosensitive ion channel MSL10 potentiates responses to cell swelling in Arabidopsis seedlings.

Curr Biol. 2020 Jun 4. [Epub ahead of print]

PI: E.S. Haswell

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.193

Funding: “This work was supported by the NSF Science and Technology Center Grant 1548571, NASA NNX13AM55G to E.S.H., and NSF MCB 1253103 to E.S.H.”



Olthoff CT.

An approach to mixed-fidelity system simulation of extravehicular activities.

Acta Astronaut. 2020 Oct;175:484-92. Epub 2020 Jun 10.

Note: From the Introduction: “This paper describes the continued work on V-SUIT, specifically its integration into another simulation system under development at JSC that is being used for spacesuit testing, software design and crew training within the Exploration Extravehicular Mobility Unit (xEMU) project.”

Journal Impact Factor: 2.482

Funding: “This research was supported by an appointment to the NASA Postdoctoral Program at the NASA Johnson Space Center, administered by Universities Space Research Association under contract with NASA.”




Other papers of interest:



Kidder LS, Zea L, Countryman SM, Stodieck LS, Hammer BE.

A novel protocol permitting the use of frozen cell cultures on low Earth orbit.

Gravit Space Res. 2020 May;8(1):8. Epub 2020 Jun 13. 

Note: ISS results. This article may be obtained online without charge.



Chakraborty N, Waning DL, Gautam A, Hoke A, Sowe B, Youssef D, Butler S, Savaglio M, Childress PJ, Kumar R, Moyler C, Dimitrov G, Kacena MA, Hammamieh R.

Gene-metabolite network linked to inhibited bioenergetics in association with spaceflight-induced loss of male mouse quadriceps muscle.

J Bone Miner Res. 2020 Jun 8. [Epub ahead of print]

Note: ISS results.



Yagi-Utsumi M, Yanaka S, Song CH, Satoh T, Yamazaki C, Kasahara H, Shimazu T, Murata K, Kato K.

Characterization of amyloid β fibril formation under microgravity conditions.

npj Microgravity. 2020 Jun 12;6(1):17.

Note: ISS results. This article may be obtained online without charge.



Cao Z, Liu H, Zhao B, Pang Q, Zhang X.

Extreme environmental stress-induced biological responses in the planarian.

Biomed Res Int. 2020 Jun 11;2020:7164230. Review.

Note: From the abstract: “In this review, we will summarize the response of planarians to some typical environmental stress and hope to shed light on basic mechanisms of how organisms interact with extreme environmental stress and survive it, such as altered gravity, temperature, and oxygen, and this information will help researchers improve the design in future studies.” This article may be obtained online without charge.



Gawel SH, Davis GJ, Luo M, Deutz NEP, Wolfe RR, Pereira SL.

Serum biomarkers that predict lean mass loss over bed rest in older adults: An exploratory study.

Clin Chim Acta. 2020 Oct;509:72-8. Epub 2020 Jun 4.

Note: Bed rest study. This article may be obtained online without charge.



Kathrins M.

Out of this world: Fertility investigations and the space program.

Fertil Steril. 2020 Jun 9. [Epub ahead of print]

Note: This is a commentary on the article: Cockett AT, Elbadawi A, Zemjanis R, Adey WR. The effects of immobilization on spermatogenesis in subhuman primates. Fertil Steril 1970;21:610-4. This article may be obtained online without charge.



Sandal PH, Kim D, Fiebig L, Winnard A, Caplan N, Green DA, Weber T.

Effectiveness of nutritional countermeasures in microgravity and its ground-based analogues to ameliorate musculoskeletal and cardiopulmonary deconditioning – A systematic review.

PLoS One. 2020 Jun 9;15(6):e0234412.

Note: From the Introduction: “…the aim of this systematic review was to evaluate the evidence relating to the effectiveness of any nutritional countermeasures, as a standalone intervention, to ameliorate musculoskeletal and cardiopulmonary deconditioning in gravitationally unloaded humans, either inflight or in long term ground-based analogues.” This article may be obtained online without charge.



Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.

A discrete neuronal circuit induces a hibernation-like state in rodents.

Nature. 2020 Jun 11. [Epub ahead of print]



Reidt U, Helwig A, Müller G, Lenic J, Grosser J, Fetter V, Kornienko A, Kharin S, Novikova N, Hummel T.

Detection of microorganisms with an electronic nose for application under microgravity conditions.

Gravit Space Res. 2020 May;8(1):1. Epub 2020 Jun 18.

Note: This article may be obtained online without charge.



Al-Khazraji BK.

Pulling back on the push-pull effect: Use of lower body negative pressure to protect against drops in cerebral perfusion during airflight maneuvers.

J Physiol. 2020 Jun 13. [Epub ahead of print]



Jordan J, Hellweg CE, Mulder E, Stern C.

[From human terrestrial models to new preventive measures for ocular changes in astronauts: Results of the German Aerospace Center studies].

Ophthalmologe. 2020 Jun 9. [Epub ahead of print] German. Review.

Note: Bed rest studies are reviewed.



Lin JQ, Huang YY, Bian MY, Wan QH, Fang SG.

A unique energy-saving strategy during hibernation revealed by multi-omics analysis in the Chinese alligator.

iScience. 2020 May 27;23(6):101202.

Note: This article may be obtained online without charge.



Rappaport MB, Szocik K, Corbally C.

Neuroplasticity as a foundation for human enhancements in space.

Acta Astronaut. 2020 Oct;175:438-46. Epub 2020 Jun 10.



Ato S, Kido K, Sase K, Fujita S.

Response of resistance exercise-induced muscle protein synthesis and skeletal muscle hypertrophy are not enhanced after disuse muscle atrophy in rat.

Front Physiol. 2020 May 21;11:469.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Jacko D, Bersiner K, Schulz O, Przyklenk A, Spahiu F, Höhfeld J, Bloch W, Gehlert S.

Coordinated CRYAB phosphorylation and desmin expression indicate adaptation and de-adaptation to resistance exercise-induced loading in human skeletal muscle.

Am J Physiol Cell Physiol. 2020 Jun 10. [Epub ahead of print]

Note: Periods of exercise bouts were followed by detraining.



Jurczyk MU, Dziekan K, Wszołek K, Chmaj-Wierzchowska K.

Skeletal system evaluation using RTG absorptiometry in women with bone mineral density disorders.

Prz Menopauzalny. 2020 Mar;19(1):11-7.

Note: This article may be obtained online without charge.



Truesdell SL, George EL, Van Vranken CC, Saunders MM.

A lab-on-a-chip platform for stimulating osteocyte mechanotransduction and analyzing functional outcomes of bone remodeling.

J Vis Exp. 2020 May 21(159):e61076.



Pannkuk EL, Laiakis EC, Ake P, Strawn SJ, Wang YW, Fornace AJ Jr.

Effects of genetic variation on urinary small molecule signatures of mice after exposure to ionizing radiation: A study of p53 deficiency.

Metabolites. 2020 Jun 8;10(6):E234.

Note: This article may be obtained online without charge.



Frett T, Green DA, Arz M, Noppe A, Petrat G, Kramer A, Kuemmel J, Tegtbur U, Jordan J.

Motion sickness symptoms during jumping exercise on a short-arm centrifuge.

PLoS One. 2020 Jun 12;15(6):e0234361.

Note: A short-arm centrifuge was used. This article may be obtained online without charge.



Martin T, Bonargent T, Besnard S, Quarck G, Mauvieux B, Pigeon E, Denise P, Davenne D.

Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats.

Sci Rep. 2020 Jun 8;10(1):9216.

Note: This article may be obtained online without charge.



Sweeten BLW, Adkins AM, Wellman LL, Sanford LD.

Group II metabotropic glutamate receptor activation in the basolateral amygdala mediates individual differences in stress-induced changes in rapid eye movement sleep.

Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 10. [Epub ahead of print]



Corlett T, Stavnichuk M, Komarova SV.

Population analysis of space travelers.

Life Sci Space Res. 2020 Jun 16. [Article in Press]

Note: From the abstract: “Our primary objective was to examine space-travelers’ sociodemographic characteristics and spaceflight activities, and their changes with time from the first spaceflight. Our secondary objective was to evaluate the publication practices to assess data availability for health-related meta-analytic studies.”



Liu D, Xie B, Liu H, Yao Z, Liu H.

Effect of solid waste fermentation substrate on wheat (Triticum aestivum L.) growth in closed artificial ecosystem.

Life Sci Space Res. 2020 Jun 18. [Article in Press]



Deng X, Gong G.

Comparison of mixing and displacement ventilation under limited space air stability conditions in a space capsule.

Microgravity Sci Technol. 2020 Jun 13. [Article in Press]  

Note: The Shenzhou VI orbital module was used as the model in this study.

SpaceRef staff editor.