NASA Spaceline Current Awareness List #902 5 June 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Crucian BE, Makedonas G, Sams CF, Pierson DL, Simpson R, Stowe RP, Smith SM, Zwart SR, Krieger SS, Rooney B, Douglas G, Downs M, Nelman-Gonzalez M, Williams TJ, Mehta S.
Countermeasures-based improvements in stress, immune system dysregulation and latent herpesvirus reactivation onboard the International Space Station – Relevance for deep space missions and terrestrial medicine.
Neurosci Biobehav Rev. 2020 May 25. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
PIs: B.E. Crucian, C.F. Sams, R. Simpson
Note: “This unique article reviews some construction era ISS findings in the areas of immunity and stress, and compares it to newly generated data from the post construction period. Improvements were noted in general immune status, inflammation was reduced, as was the reactivation of several latent herpesviruses. The article ascribes these improvements to several operational countermeasures deployed to ISS post construction, including improved aerobic and resistive exercise, certain nutritional supplements, frequency of resupply and improved behavioral health support. Interestingly, the reactivation of HSV1 has emerged as a ‘new’ concern during ISS missions, indicating that distinct herpesvirus require separate mechanisms for immunological control. The relevant finding is that we can positively influence immunity during spaceflight, which may reduce specific clinical risks. International teams will now work to translate the successful ISS countermeasures to the more constrained deep space vehicles and mission profiles.” — B.E. Crucian. This article may be obtained online without charge.
Journal Impact Factor: 8.002
Funding: “The authors also acknowledge the support provided by the JSC Clinical Laboratory, the JSC Mission Integration Team, and the Kennedy Space Center Baseline Data Collection Facility during this study.”
2
Kruse CPS, Meyers AD, Basu P, Hutchinson S, Luesse DR, Wyatt SE.
Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses.
BMC Plant Biol. 2020 May 27;20(1):237.
https://pubmed.ncbi.nlm.nih.
PI: S.E. Wyatt
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.670
Funding: “…this research was partially funded by NASA (#NNX13AM48G to SEW and DRL) with supplemental funding provided by NASA GeneLab.”
3
Klerman EB, Rahman SA, St Hilaire MA.
What time is it? A tale of three clocks, with implications for personalized medicine.
J Pineal Res. 2020 May;68(4):e12646.
https://pubmed.ncbi.nlm.nih.
PI: M.A. St. Hilaire
Journal Impact Factor: 15.221
Funding: “National Aeronautics and Space Administration, Grant/Award Number 80NSSC20K0576; National Institutes of Health, Grant/Award Number: K24-02114, HL105664, P01-AG009975, ROI-GM-105018, R01-HL128538 and R21-NR018974.”
4
Dayal D, Jesudasen S, Scott R, Stevens B, Hazel R, Nasrini J, Donoviel D, Basner M.
Effects of short-term -12° head-down tilt on cognitive performance.
Acta Astronaut. 2020 May 30. [Article in Press]
http://www.sciencedirect.com/
PI: M. Basner
Journal Impact Factor: 2.482
Funding: “The research was supported by the Center for Space Medicine (CSM) at Baylor College of Medicine (BCM) and the National Space Biomedical Research Institution (NSBRI) through NASA NCC 9-58.”
______________________________
Other papers of interest:
1
Huang P, Russell AL, Lefavor R, Durand NC, James E, Harvey L, Zhang C, Countryman S, Stodieck L, Zubair AC.
Feasibility, potency, and safety of growing human mesenchymal stem cells in space for clinical application.
npj Microgravity. 2020 Jun 1;6(1):16.
https://www.nature.com/
Note: ISS results. This article may be obtained online without charge.
2
Borer B, Jimenez-Martinez J, Stocker R, Or D.
Reduced gravity promotes bacterially mediated anoxic hotspots in unsaturated porous media.
Sci Rep. 2020 May 25;10(1):8614.
https://pubmed.ncbi.nlm.nih.
Note: Parabolic flight results. This article may be obtained online without charge.
3
Guo Y, Niu Z, Liu Y.
[Effects of high +Gx exposure and simulated weightlessness on the expression of parotid secretory protein in parotid gland of rhesus macaque].
Space Med Med Eng. 2020;2020(2):102-6. Chinese.
http://caod.oriprobe.com/
Note: Head-down tilt and centrifugation were used.
4
Hao Z, Feng S, Zhu Y, Yang J, Meng C, Hu D, Liu H, Liu H.
Physiological phenotypes and urinary metabolites associated with the psychological changes of healthy human: A study in “Lunar Palace 365.”
Acta Astronaut. 2020 May 29. [Article in Press]
http://www.sciencedirect.com/
Note: The experiment took place in the Chinese Lunar Palace 365, a bioregenerative life support system.
5
Liu H, Li D, Zhang R, Sun L, Wang D.
Lipid metabolic sensors of MDT-15 and SBP-1 regulated the response to simulated microgravity in the intestine of Caenorhabditis elegans.
Biochem Biophys Res Commun. 2020 May 21. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The method used for microgravity stimulation is not identified in the available abstract.
6
Owen PJ, Belavy DL, Rittweger J.
Using whole-body vibration for countermeasure exercise.
In: Rittweger J, ed. Manual of Vibration Exercise and Vibration Therapy. Cham: Springer International Publishing, 2020. p. 229-44.
https://link.springer.com/
Note: Bed rest studies are reviewed.
7
Xu Y, Li B, Wei Z, Wang H, Lin R, Wang Q, Jin Z, Wang H, Zhang L, Geng X.
[Study on approach prospect of continuous push-pull effect training with centrifuge].
Space Med Med Eng. 2020;2020(2):95-101. Chinese.
http://caod.oriprobe.com/
Note: Centrifugation was used.
8
Xue Y, Xu G, Hu S, Gao Y, He X.
[Application prospect of olfactory emotion effect in long-term manned spaceflight].
Space Med Med Eng. 2020;2020(2):182-8. Chinese.
http://caod.oriprobe.com/
9
Deval C, Calonne J, Coudy-Gandilhon C, Vazeille E, Bechet D, Polge C, Taillandier D, Attaix D, Combaret L.
Mitophagy and mitochondria biogenesis are differentially induced in rat skeletal muscles during immobilization and/or remobilization.
Int J Mol Sci. 2020 May 23;21(10):E369.
https://pubmed.ncbi.nlm.nih.
Note: Casting was used for immobilization. This article may be obtained online without charge.
10
Hanson ED, Betik AC, Timpani CA, Tarle J, Zhang X, Hayes A.
Testosterone suppression does not exacerbate disuse atrophy and impairs muscle recovery that is not rescued by high protein.
J Appl Physiol (1985). 2020 May 28. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The method of immobilization is not identified in the available abstract.
11
Jang YC, Rodriguez K, Lustgarten MS, Muller FL, Bhattacharya A, Pierce A, Choi JJ, Lee NH, Chaudhuri A, Richardson AG, Van Remmen H.
Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems.
Geroscience. 2020 May 26. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
12
Kilroe SP, Fulford J, Jackman S, Holwerda A, Gijsen A, van Loon L, Wall BT.
Dietary protein intake does not modulate daily myofibrillar protein synthesis rates or loss of muscle mass and function during short-term immobilization in young men: A randomized controlled trial.
Am J Clin Nutr. 2020 May 29. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The method of immobilization is not identified in the available abstract.
13
Reidy PT, Edvalson LT, McKenzie AI, Petrocelli JJ, Mahmassani ZS, Drummond MJ.
Neuromuscular electrical stimulation and protein during bed rest increased CD11b+ skeletal muscle macrophages but does not correspond to muscle size or insulin sensitivity.
Appl Physiol Nutr Metab. 2020 May 29. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study.
14
Shimoide T, Kawao N, Morita H, Ishida M, Takafuji Y, Kaji H.
Roles of olfactomedin 1 in muscle and bone alterations induced by gravity change in mice.
Calcif Tissue Int. 2020 May 27. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Centrifugation was used.
15
Farley A, Gnyubkin V, Vanden-Bossche A, Laroche N, Neefs M, Baatout S, Baselet B, Vico L, Mastrandrea C.
Unloading-induced cortical bone loss is exacerbated by low-dose irradiation during a simulated deep space exploration mission.
Calcif Tissue Int. 2020 May 25. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study.
16
Liphardt AM, Mündermann A, Heer M, Achtzehn S, Niehoff A, Mester J.
Locomotion replacement exercise cannot counteract cartilage biomarker response to 5 days of immobilization in healthy adults.
J Orthop Res. 2020 May 26. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study. This article may be obtained online without charge.
17
Morabito C, Guarnieri S, Cucina A, Bizzarri M, Mariggiò MA.
Antioxidant strategy to prevent simulated microgravity-induced effects on bone osteoblasts.
Int J Mol Sci. 2020 May 21;21(10):E3638.
https://pubmed.ncbi.nlm.nih.
Note: A random positioning machine was used. This article may be obtained online without charge.
18
Vassiliev ON, Peterson CB, Grosshans DR, Mohan R.
A simple model for calculating relative biological effectiveness of X-rays and gamma radiation in cell survival.
Br J Radiol. 2020 May 28. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
19
Zaman F, Townsend LW, de Wet WC, Schwadron NA, Spence HE, Wilson JK, Jordan AP, Smith SS, Looper MD.
Absorbed doses from GCR and albedo particles emitted by the lunar surface.
Acta Astronaut. 2020 May 28. [Article in Press]
http://www.sciencedirect.com/
20
Chai Y, Fang Z, Yang FN, Xu S, Deng Y, Raine A, Wang J, Yu M, Basner M, Goel N, Kim JJ, Wolk DA, Detre JA, Dinges DF, Rao H.
Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation.
Sci Rep. 2020 May 29;10(1):8774.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
21
von Ehrenfried M.
NASA and commercial crew development.
In: The Artemis Lunar Program: Returning People to the Moon. Cham: Springer International Publishing, 2020. p. 111-29.
https://link.springer.com/
Note: The author is a former NASA civil servant.
22
Nasser M, Peres N, Knight J, Haines A, Young C, Maranan D, Wright J, Carvil P, Robinson K, Westmore M, Griffin J, Halkes M.
Designing clinical trials for future space missions as a pathway to changing how clinical trials are conducted on Earth.
J Evid Based Med. 2020 May;13(2):153-60.
https://pubmed.ncbi.nlm.nih.
Note: From the abstract: “The project aims to build a framework for conducting clinical trials for long-term interplanetary missions to contribute to innovation in clinical trials on Earth, especially around patient involvement and ownership.” This article may be obtained online without charge.
23
Tang Y, Mao R, Guo S.
Effects of LED spectra on growth, gas exchange, antioxidant activity and nutritional quality of vegetable species.
Life Sci Space Res. 2020 Aug;26:77-84. Epub 2020 May 30.
http://www.sciencedirect.com/
24
Vale P.
Extremely-low frequency magnetic field exposure for simulating geomagnetic pulsations in Alexandrium pacificum and Gymnodinium catenatum cultures.
Life Sci Space Res. 2020 Jun 3. [Article in Press]
http://www.sciencedirect.com/
25
Zhang Y, Li J, Ding P, Cai L, Cui G, Han Y, Dong J, Liang Y.
[Compatibility research of ion exchange resin and pretreatment agent with strong oxidation in environmental control and life support system].
Space Med Med Eng. 2020;2020(2):128-33. Chinese.
http://caod.oriprobe.com/
26
Davila VJ, Meltzer AJ, Fortune E, Morrow MMB, Lowndes BR, Linden AR, Hallbeck MS, Money SR.
Intraprocedural ergonomics of vascular surgeons.
J Vasc Surg. 2020 May 22. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
