Status Report

NASA Spaceline Current Awareness List #901 29 May 2020 (Space Life Science Research Results)

By SpaceRef Editor
May 29, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Jayarathne S, Ramalingam L, Edwards H, Vanapalli SA, Moustaid-Moussa N.

Tart cherry increases lifespan in Caenorhabditis elegans by altering metabolic signaling pathways.

Nutrients. 2020 May 20;12(5):E1482.

PI: S.A. Vanapalli

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.171

Funding: “This project was in part supported by USDA NIFA AFRI Exploratory award # 2014-07216 (N.M.-M., S.A.V.), and USDA NIFA AFRI award # 2018-07980 (N.M.-M.). N.M.-M. is in part supported by NIH (NCCIH and NIA) award # R15 AT 8879-01A1; and S.A.V. is in part supported by NIH AWARD # RO1 AG051995-04 and NASA award # NNX15AL16G.”



Vera DL, Seuylemezian A, Landry KS, Hendrickson R.

Draft genome sequences of six strains isolated from the InSight spacecraft and associated surfaces using Oxford nanopore- and illumina-based sequencing.

Microbiol Resour Announc. 2020 May 21;9(21):e01161-19.

Note: Results are from samples taken prelaunch from the Interior Exploration using Seismic Investigations, Geodesy, and Heat Transport (InSight) spacecraft. This article may be obtained online without charge.

Journal Impact Factor: 0.486

Funding: “This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.”



Sridharan V, Seawright JW, Landes RD, Cao M, Singh P, Davis CM, Mao XW, Singh SP, Zhang X, Nelson GA, Boerma M.

Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats.

Life Sci Space Res. 2020 Aug;26:62-8. Epub 2020 May 22.

PIs: M. Boerma, C.M. Davis, R.D. Heinz; C.M. Davis/VNSCOR; M. Boerma/X.W. Mao/G.A. Nelson/NSBRI Center for Research in Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.066

Funding: “This work was supported by the National Space Biomedical Research Institute through NCC 9-58 under grants RE03701 [M.B.], PF02602 [C.M.D.] and NBPF02802 [C.M.D.], NASA grants NNX15AC71G [C.M.D.], 80NSSC18K1080 [C.M.D.], 80NSSC17K0425 [M.B.], and 80NSSC19K0437 [M.B.], and NIGMS grant P20 GM109005 [M.B.].”



Allen BD, Syage AR, Maroso M, Baddour AAD, Luong V, Minasyan H, Giedzinski E, West BL, Soltesz I, Limoli CL, Baulch JE, Acharya MM.

Mitigation of helium irradiation-induced brain injury by microglia depletion.

J Neuroinflammation. 2020 May 19;17(1):159.

PIs: C.L. Limoli/I. Soltesz/J.E. Baulch/M.A. Acharya/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.700

Funding: “This work was supported by UCI Institute for Clinical and Translational Sciences (ICTS) KL2 training award KL2TR001416 (MMA) and NASA Specialized Center of Research (NSCOR) grant NNX15AI22G (IS, CLL, JEB, MMA).”



Antone B, Gupta A, Bell S, DeChurch L, Contractor N.

Testing influence of network structure on team performance using STERGM-based controls.

In: Cherifi H, Gaito S, Mendes JF, Moro E, Rocha LM, eds. Complex Networks and Their Applications VIII. Studies in Computational Intelligence. Volume 2. Proceedings of the Eighth International Conference on Complex Networks and Their Applications: COMPLEX NETWORKS 2019. Cham: Springer International Publishing, 2020. p. 1018-30.

PIs: N. Contractor, L. DeChurch

Journal Impact Factor: Not applicable to this publication

Funding: “This material is based upon work supported by NASA under award numbers NNX15AM32G, NNX15AM26G, and 80NSSC18K0221.”



McLaughlin AC, Byrne VE.

A fundamental cognitive taxonomy for cognition aids.

Hum Factors. 2020 May 21. [Epub ahead of print]

PI: A.C. McLaughlin

Journal Impact Factor: 2.649

Funding: “This material is based on the work supported by the National Aeronautics and Space Administration (NASA) under Grant No. NNX16AP91G issued through the Human Research Program.”



Barrow BE, Pantalos GM, Roussel TJ.

Design and evaluation of a multifunctional surgical device for space-based applications.

Acta Astronaut. 2020 May 25. [Article in Press]

Journal Impact Factor: 2.482

Funding: “The authors would like to thank the NASA Flight Opportunities Program (Grant NNX16AC59G); and the University of Louisville National Science Foundation (NSF) Innovation Corps (I-Corps) Site Program (Grant 6N14150841) for their support of this research.”



Brown ZD, Bishawi M, Roan JN, Lee F, Nevo A, Watson M, Bowles DE.

The use of an inexpensive processing aid device (the mouse PAD) to facilitate rodent tissue banking.

Biotechniques. 2020 May 18. [Epub ahead of print]

PI: D.E. Bowles

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.659

Funding: “This research is supported by NASA research grant NNX16AK20G.”



Shymanovich T, Kiss JZ.

Growth and development of ecotypes of Arabidopsis thaliana: Preliminary experiments to prepare for a Moon lander mission.

Gravit Space Res. 2020 May 20;8(1):1.

PI: J.Z. Kiss

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “Financial support was provided by NASA grant 80NSSC17K0546.”



McLamore ES, Huffaker R, Shupler M, Ward K, Datta SPA, Katherine Banks M, Casaburi G, Babilonia J, Foster JS.

Digital Proxy of a Bio-Reactor (DIYBOT) combines sensor data and data analytics to improve greywater treatment and wastewater management systems.

Sci Rep. 2020 May 15;10(1):8015.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “This project was supported by Agriculture and Food Research Initiative Competitive Grant no. 2018-67016-27578 awarded as a Center of Excellence from the USDA National Institute of Food and Agriculture. The authors also acknowledge support from the UF IFAS Equipment Grant (ESM and JF), the Department of Agricultural & Biological Engineering (ESM), the UF Innovation Grant (ESM), and the NASA Florida Space Grant Consortium (JF) for student support.”




Other papers of interest:



Kamada M, Oka M, Miyamoto K, Uheda E, Yamazaki C, Shimazu T, Sano H, Kasahara H, Suzuki T, Higashibata A, Ueda J.

Microarray profile of gene expression in etiolated Pisum sativum seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport.”

Life Sci Space Res. 2020 Aug;26:55-61. Epub 2020 May 21.

Note: ISS results.



Karahara I, Suto T, Yamaguchi T, Yashiro U, Tamaoki D, Okamoto E, Yano S, Tanigaki F, Shimazu T, Kasahara H, Kasahara H, Yamada M, Hoson T, Soga K, Kamisaka S.

Vegetative and reproductive growth of Arabidopsis under microgravity conditions in space.

J Plant Res. 2020 May 18. [Epub ahead of print]

Note: ISS results.



Borovik AS, Orlova EA, Tomilovskaya ES, Tarasova OS, Vinogradova OL.

Phase coupling between baroreflex oscillations of blood pressure and heart rate changes in 21-day dry immersion.

Front Physiol. 2020 May 21;11:455.

Note: Dry immersion was used. This article may be obtained online without charge.



Corbier C, Chouchou F, Roche F, Barthélémy JC, Pichot V.

Causal analyses to study autonomic regulation during acute head-out water immersion, head-down tilt and supine position.

Exp Physiol. 2020 May 21. [Epub ahead of print]

Note: Water immersion, head-down tilt, and supine position were used.



Green SR, Storey KB.

Regulation of the α-ketoglutarate dehydrogenase complex during hibernation in a small mammal, the Richardson’s ground squirrel (Urocitellus richardsonii).

Biochim Biophys Acta Proteins Proteom. 2020 May 20;1868(9):140448.



Hadj-Moussa H, Wijenayake S, Storey KB.

Multi-tissue profile of NFκB pathway regulation during mammalian hibernation.

Comp Biochem Physiol B Biochem Mol Biol. 2020 May 20. [Epub ahead of print]



Rühle F, Stark H.

Emergent collective dynamics of bottom-heavy squirmers under gravity.

Eur Phys J E Soft Matter. 2020 May 25;43(5):26.

Note: Hydrodynamic simulation was used. This article may be obtained online without charge.



Anil-Inevi M, Sarigil O, Kizilkaya M, Mese G, Tekin HC, Ozcivici E.

Stem cell culture under simulated microgravity.

Adv Exp Med Biol. 2020 May 19. [Epub ahead of print]

Note: Techniques discussed include the clinostat, random positioning machine, Rotating Wall Vessel, and magnetic levitation-based systems.



Limper U, Tank J, Ahnert T, Maegele M, Grottke O, Hein M, Jordan J.

The thrombotic risk of spaceflight: Has a serious problem been overlooked for more than half of a century?

Eur Heart J. 2020 May 18. [Epub ahead of print]

Note: The authors call for further study of venous thrombosis risk during spaceflight.



Wostyn P.

Re: Stenger et al.: Focus on the optic nerve head in spaceflight-associated neuro-ocular syndrome (Ophthalmology. 2019;126:1604-6).

Ophthalmology. 2020 Jun;127(6):e40-e41.

Note: The authors comments on: Stenger MB, Laurie SS, Sadda SR, Sadun AA, Macias BR, Huang AS. Focus on the optic nerve head in spaceflight-associated neuro-ocular syndrome. Ophthalmology. 2019 Dec;126(12):1604-6., which appeared in SPACELINE Current Awareness List #876, 29 Nov 2019. This article may be obtained online without charge.



Frankish BP, Najdovska P, Xu H, Wette SG, Murphy RM.

Effects of voluntary wheel running on mitochondrial content and dynamics in rat skeletal muscle.

J Muscle Res Cell Motil. 2020 May 21. [Epub ahead of print]

Note: A running wheel was used.



Kargl CK, Sullivan BP, Gavin TP.

Massage during muscle unloading increases protein turnover in the massaged and non-massaged, contralateral limb, but does not attenuate muscle atrophy.

Acta Physiol (Oxf). 2020 May 15. [Epub ahead of print]

Note: Hindlimb unloading study. This article may be obtained online without charge.



Wakabayashi H, Miyamura G, Nagao N, Kato S, Naito Y, Sudo A.

Functional block of interleukin-6 reduces a bone pain marker but not bone loss in hindlimb-unloaded mice.

Int J Mol Sci. 2020 May 15;21(10):E3521.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Naito M, Kodaira S, Ogawara R, Tobita K, Someya Y, Kusumoto T, Kusano H, Kitamura H, Koike M, Uchihori Y, Yamanaka M, Mikoshiba R, Endo T, Kiyono N, Hagiwara Y, Kodama H, Matsuo S, Takami Y, Sato T, Orimo S. 

Investigation of shielding material properties for effective space radiation protection.

Life Sci Space Res. 2020 Aug;26:69-76. Epub 2020 May 23.

Note: This article may be obtained online without charge.



Jäger FI, Platho-Elwischger K, Wiest G.

Assessment of static graviceptive perception in the roll-plane using the subjective visual vertical paradigm.

J Vis Exp. 2020 Apr 28(158):e60418.



Suri K, Clark TK.

Human vestibular perceptual thresholds for pitch tilt are slightly worse than for roll tilt across a range of frequencies.

Exp Brain Res. 2020 May 22. [Epub ahead of print]

Note: A tilt-translation sled was used.



Zabel P, Zeidler C, Vrakking V, Dorn M, Schubert D.

Biomass production of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase.

Front Plant Sci. 2020 May 26;11:656.

Note: This article may be obtained online without charge.



Zhang J, Müller BSF, Tyre KN, Hersh HL, Bai F, Hu Y, Resende MFR, Rathinasabapathi B, Settles AM.

Competitive growth assay of mutagenized Chlamydomonas reinhardtii compatible with the International Space Station Veggie plant growth chamber.

Front Plant Sci. 2020 May 25;11:631.

Note: This article may be obtained online without charge.



Zhang N, Li J, Luo J, Yu Q, Ai W, Zhang L, Tang Y.

Wheat cultivation and nutrient control for the 180-day CELSS integrated experiment.

Life Sci Space Res. 2020 Aug;26:46-54. Epub 2020 May 22.

SpaceRef staff editor.