Status Report

NASA Spaceline Current Awareness List #893 3 April 2020 (Space Life Science Research Results)

By SpaceRef Editor
April 3, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Inglesby DC, Antonucci MU, Spampinato MV, Collins HR, Meyer TA, Schlosser RJ, Shimada K, Roberts DR.

Spaceflight-associated changes in the opacification of the paranasal sinuses and mastoid air cells in astronauts.

JAMA Otolaryngol Head Neck Surg. 2020 Mar 26. [Epub ahead of print]

PI: D.R. Roberts

Note: ISS and Space Shuttle results. See #2 below for a Comment on this article.

Journal Impact Factor: 3.502

Funding: “This study was funded by grant NNX13AJ92G from NASA. Dr Inglesby received support through the South Carolina NASA Established Program to Stimulate Competitive Research.”



Stenger MB, Macias BR.

Sinus space in outer space.

JAMA Otolaryngol Head Neck Surg. 2020 Mar 26. [Epub ahead of print]

Note: The authors comment on #1 above.

Journal Impact Factor: 3.502

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.



O’Rourke A, Zoumplis A, Wilburn P, Lee MD, Lee Z, Vecina M, Mercader K.

Following the Astrobiology Roadmap: Origins, habitability and future exploration.

Curr Issues Mol Biol. 2020;38:1-32. Epub 2020 Jan 23.

PI: A. O’Rourke, NASA Postdoctoral Program Fellowship

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.511

Funding: The PI reports funding under NASA grant 80NSSC17K0035.




Other papers of interest:



Clément G, Bukley A, Loureiro N, Lindblad L, Sousa D, Zandvilet A.

Horizontal and vertical distance perception in altered gravity.

Sci Rep. 2020 Mar 25;10(1):5471.

Note: Parabolic flight results. This article may be obtained online without charge.



Hauslage J, Görög M, Krause L, Schüler O, Schäferm M, Witten A, Kesseler L, Böhmer M, Hemmersbach R.

ARABIDOMICS—A new experimental platform for molecular analyses of plants in drop towers, on parabolic flights, and sounding rockets.

Rev Sci Instrum. 2020 Mar;91(3):034504.

Note: MAPHEUS 5 sounding rocket results. This article may be obtained online without charge.



Wakabayashi K, Soga K, Hoson T, Kotake T, Yamazaki T, Ishioka N, Shimazu T, Kamada M.

Microgravity affects the level of matrix polysaccharide 1,3:1,4-β-glucans in cell walls of rice shoots by increasing the expression level of a gene involved in their breakdown.

Astrobiology. 2020 Mar 24. [Epub ahead of print]

Note: ISS results.                                                 



Grigoryev AI, Ostrovsky MA, Potapov AN.

Contribution of researchers of the Russian Academy of Sciences to the origin and development of space physiology.

Hum Physiol. 2020 Jan;46(1):1-7.



Takhtobina YV, Shchelykalina SP, Smirnov YI, Smirnov AV, Koloteva MI, Vassilieva GY, Nikolaev D.

Monitoring of body fluid redistribution using segmental bioimpedance during rotation on a short radius centrifuge.

Physiol Meas. 2020 Mar 27. [Epub ahead of print]

Note: A short radius centrifuge was used.



Bauer J.

Microgravity and cell adherence.

Int J Mol Sci. 2020 Mar 23;21(6):E2214.

Note: This Editorial introduces a special issue on “Microgravity and Cell Adherence,” which contains nine articles. Seven have appeared in past SPACELINE Current Awareness Lists and two appear in this list (see #7 and #8 below). This article and the entire collection are available without charge at



Bauer TJ, Gombocz E, Wehland M, Bauer J, Infanger M, Grimm D.

Insight in adhesion protein sialylation and microgravity dependent cell adhesion—An omics network approach.

Int J Mol Sci. 2020 Mar 4;21(5):E1749.

Note: From the Conclusion: “The omics network approach described in this paper shows how to gain advantage from combining the results of three different experiments with each other and with the knowledge described in the literature, while focusing on those parts of the data which are related to the topic of cell adhesion.” The cells had been cultured either in a random positioning machine or onboard the ISS. This article may be obtained online without charge.



Ivanova K, Hemmersbach R.

Guanylyl cyclase-cGMP signaling pathway in melanocytes: Differential effects of altered gravity in non-metastatic and metastatic cells.

Int J Mol Sci. 2020 Feb 8;21(3):E1139. Review.

Note: Studies reviewed include results from spaceflight, clinostat, and centrifuge experiments. This article may be obtained online without charge.



Hammel JH, Bellas E.

Endothelial cell crosstalk improves browning but hinders white adipocyte maturation in 3D engineered adipose tissue.

Integr Biol (Camb). 2020 Mar 26. [Epub ahead of print]



Petrocelli JJ, McKenzie AI, Mahmassani ZS, Reidy PT, Stoddard GJ, Poss AM, Holland WL, Summers SA, Drummond MJ.

Ceramide biomarkers predictive of cardiovascular disease risk increase in healthy older adults after bed rest.

J Gerontol A Biol Sci Med Sci. 2020 Mar 26. [Epub ahead of print]

Note: Bed rest study.



Sajdel-Sulkowska EM.

Disruption of the microbiota-gut-brain (MGB) axis and mental health of astronauts during long-term space travel.

In: Manto M, Gruol D, Schmahmann J, Koibuchi N, Sillitoe R, eds. Handbook of the Cerebellum and Cerebellar Disorders. 2nd ed. Cham: Springer, 2019.



Dai X, Ye S, Chen X, Jiang T, Huang H, Li W, Yu H, Bao J, Chen H.

Rodent retinal microcirculation and visual electrophysiology following simulated microgravity.

Exp Eye Res. 2020 Mar 25:108023. [Epub ahead of print]

Note: Hindlimb unloading study.



Ji L, Yeo D, Kang C.

Muscle disuse atrophy caused by discord of intracellular signaling.

Antioxid Redox Signal. 2020 Mar 25. [Epub ahead of print]



Zhao D, Liu R, Li G, Chen M, Shang P, Yang H, Jiang JX, Xu H.

Connexin 43 channels in osteocytes regulate bone responses to mechanical unloading.

Front Physiol. 2020 Mar 21;11:299.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Bryant J, White L, Coen N, Shields L, McClean B, Meade AD, Lyng FM, Howe O.

MicroRNA analysis of ATM-deficient cells indicate PTEN and CCDN1 as potential biomarkers of radiation response.

Radiat Res. 2020 Mar 27. [Epub ahead of print]



Loeliger BW, Hanu C, Panyutin IV, Maass-Moreno R, Wakim P, Pritchard WF, Neumann RD, Panyutin IG.

Effect of ionizing radiation on transcriptome during neural differentiation of human embryonic stem cells.

Radiat Res. 2020 Mar 27. [Epub ahead of print]



Sun M, Moquet J, Barnard S, Lloyd D, Ainsbury E.

A simplified calyculin A-induced premature chromosome condensation (PCC) protocol for the biodosimetric analysis of high-dose exposure to gamma radiation.

Radiat Res. 2020 Mar 27. [Epub ahead of print]



Yogo K, Murayama C, Fujisawa Y, Maeyama T, Hirayama R, Ogawa Y, Matsumoto KI, Nakanishi I, Yasuda H, Ishiyama H, Hayakawa K.

Potential mechanisms for protective effect of D-methionine on plasmid DNA damage induced by therapeutic carbon ions.

Radiat Res. 2020 Mar 27. [Epub ahead of print]



Parkhurst A, Jeevendrampillai D.

Towards an anthropology of gravity: Emotion and embodiment in microgravity environments.

Emot Space Soc. 2020 May;35:100680. Epub 2020 Mar 27.

Note: From the Abstract: “Drawing on astronaut testimony, experiences of microgravity environments, laboratory experiments and art practice this paper argues that gravity, or rather its absence, offers a unique vantage point through which to consider the human relationship to emotion, cognition, and the curation of social relations via experiences of the body in different gravitational environments.”



Kimura T, Tsuchida-Mayama T, Imai H, Okajima K, Ito K, Sakai T.

Arabidopsis ROOT PHOTOTROPISM2 is a light-dependent dynamic modulator of phototropin1.

Plant Cell. 2020 Mar 25. [Epub ahead of print]



Legris M, Boccaccini A.

Stem phototropism towards blue and ultraviolet light.

Physiol Plant. 2020 Mar 24. [Epub ahead of print]



Nelson GJ, Vijapur SH, Hall TD, Brown BR, Peña-Duarte A, Cabrera CR.

Electrochemistry for space life support.

Electrochem Soc Interface. 2020 Mar 27;29(1):47-52.



Bequette B, Norton A, Jones E, Stirling L.

Physical and cognitive load effects due to a powered lower-body exoskeleton.

Hum Factors. 2020 Mar 23. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Miyake S.

[Mental workload assessment of health care staff by NASA-TLX].

J UOEH. 2020;42(1):63-75. Japanese.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.