Status Report

NASA Spaceline Current Awareness List #890 13 March 2020 (Space Life Science Research Results)

By SpaceRef Editor
March 13, 2020
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Khodadad CLM, Hummerick ME, Spencer LE, Dixit AR, Richards JT, Romeyn MW, Smith TM, Wheeler RM, Massa GD.

Microbiological and nutritional analysis of lettuce crops grown on the International Space Station.

Front Plant Sci. 2020 Mar 6;11:199.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.677

Funding: “Funding for the Veggie hardware technology validation tests was from NASA’s Space Life and Physical Sciences (SLPS) Space Biology Program.”



Hart DA, Zernicke RF.

Optimal human functioning requires exercise across the lifespan: Mobility in a 1g environment is intrinsic to the integrity of multiple biological systems.

Front Physiol. 2020 Feb 27;11:156. Review.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.201

Funding: “Financial support from the Canadian Space Agency and the Alberta Health Services Strategic Clinical Network Program support to DH, and the Canadian Institutes of Health Research, National Institutes of Health, National Aeronautical and Space Administration, and University of Michigan support to RZ are gratefully acknowledged.”



Doll JR, Hoebe K, Thompson RL, Sawtell NM.

Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction.

PLoS Pathog. 2020 Mar;16(3):e1008296.

PI: N.M. Sawtell

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.436

Funding: “This work was supported primarily by NASA NNX13AO47G to NMS and NIH R01 AI093614 to NMS.”



Tomoiaga D, Aguiar-Pulido V, Shrestha S, Feinstein P, Levy SE, Mason CE, Rosenfeld JA.

Single-cell sperm transcriptomes and variants from fathers of children with and without autism spectrum disorder.

npj Genom Med. 2020 Mar 7;5:14.

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.422

Funding: “We would like to thank the Epigenomics Core Facility at Weill Cornell Medicine, as well as the Starr Cancer Consortium (I9-A9-071) and funding sources from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, 1R21AI129851, 1R01MH117406), TRISH (NNX16AO69A:0107, NNX16AO69A:0061), the Bill and Melinda Gates Foundation (OPP1151054), the Leukemia and Lymphoma Society (LLS) grants (LLS 9238–16, Mak, LLS-MCL-982, Chen-Kiang) and the Alfred P. Sloan Foundation (G-2015-13964). Dr. Jeffrey A. Rosenfeld is supported by Cancer Center Support grant (2P30-CA072720-20) and the Systems Biology program at the Cancer Institute of New Jersey. He is also supported by a NARSAD grant.”



Vanderburg C, Beheshti A.

MicroRNAs (miRNAs), the final frontier: The hidden master regulators impacting biological response in all organisms due to spaceflight.

THREE. 2020 Mar 9.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: “Research funding was provided by the GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Space Life and Physical Sciences Research and Applications (SLPSRA).” THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.



Werneth CM, Slaba TC, Blattnig SR, Huff JL, Norman RB.

A methodology for investigating the impact of medical countermeasures on the risk of exposure induced death.

Life Sci Space Res. 2020 Mar 10. [Article in Press]

Journal Impact Factor: 2.066

Funding: “This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of NASA and Human Health and Performance contract NNJ15HK11B.”



Napoli NJ, Demas M, Stephens CL, Kennedy KD, Harrivel AR, Barnes LE, Pope AT.

Activation complexity: A cognitive impairment tool for characterizing neuro-isolation.

Sci Rep. 2020 Mar 3;10(1):3909.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: No funding cited. C.L. Stephens, K.D. Kennedy, A.R. Harrivel, and A.T. Pope are affiliated with NASA Langley Research Center.



Wu S-C, Vera AH.

Capability considerations for enhancing safety on long duration crewed missions: Insights from a technical interchange meeting on autonomous crew operations.

J Space Safety Eng. 2020 Mar 4. [Article in Press]

Note: From the abstract: “In August 2018, the Human Factors and Behavioral Performance Element of NASA’s Human Research Program convened a Technical Interchange Meeting (TIM) on Autonomous Crew Operations at NASA Ames Research Center to address how intelligent technologies can be utilized to augment crew capabilities to support real-time anomaly response. In this paper, we highlight three topic areas discussed at the TIM that have direct implications for future crew anomaly response capabilities: smart structures, cognitive assistants, and manpower.” This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. The authors are affiliated with NASA Ames Research Center.




Other papers of interest:



Bauer TJ, Gombocz E, Wehland M, Bauer J, Infanger M, Grimm D.

Insight in adhesion protein sialylation and microgravity dependent cell adhesion—An omics network approach.

Int J Mol Sci. 2020 Mar 4;21(5):E1749.

Note: Shenzhou-8 results. A Random Positioning Machine was used for ground studies. This article may be obtained online without charge.



Al-Attar R, Storey KB.

Suspended in time: Molecular responses to hibernation also promote longevity.

Exp Gerontol. 2020 Jun;134:110889. Review. Epub 2020 Feb 27.



Mekjavic PJ, Amoaku W, Mlinar T, Mekjavic IB.

The aetiology of Spaceflight-Associated Neuro-ocular Syndrome (SANS) might be explained by a neural mechanism regulating intraocular pressure.

J Physiol. 2020 Mar 2. [Epub ahead of print]

Note: The authors comment on #4 below and relate findings to spaceflight-associated neuro-ocular syndrome.



Ficarrotta KR, Passaglia CL.

Intracranial pressure modulates aqueous humour dynamics of the eye.

J Physiol. 2020 Jan;598(2):403-13.



Bosutti A, Mulder E, Zange J, Bühlmeier J, Ganse B, Degens H.

Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions.

Eur J Appl Physiol. 2020 Mar 4. [Epub ahead of print]

Note: Bed rest study. This article may be obtained online without charge.



Dang K, Yu HJ, Xu SH, Ma TR, Wang HP, Li Y, Li Z, Gao YF.

Remarkable homeostasis of protein sialylation in skeletal muscles of hibernating Daurian ground squirrels (Spermophilus dauricus).

Front Physiol. 2020 Feb 7;11:37.

Note: This article may be obtained online without charge.



Jacunski M, Rafferty GF.

The effects of hypoxia and fatigue on skeletal muscle electromechanical delay.

Exp Physiol. 2020 Mar 5. [Epub ahead of print]



Kobayashi J, Uchida H, Kofuji A, Ito J, Shimizu M, Kim H, Sekiguchi Y, Kushibe S.

Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review.

FASEB Bioadv. 2019 Jun;1(6):364-74. Review.

Note: This article may be obtained online without charge.



Lawrence MM, Van Pelt DW, Confides AL, Hunt ER, Hettinger ZR, Laurin JL, Reid JJ, Peelor FF 3rd, Butterfield TA, Dupont-Versteegden EE, Miller BF.

Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats.

Acta Physiol (Oxf). 2020 Mar 3. [Epub ahead of print]

Note: Hindlimb unloading study.



Ghanem MA, Maxwell AD, Sapozhnikov OA, Khokhlova VA, Bailey MR.

Quantification of acoustic radiation forces on solid objects in fluid.

Phys Rev Appl. 2019 Oct;12(4):044076.

Note: This article may be obtained online without charge.



Nuta O, Rothkamm K, Darroudi F.

The role of telomerase in radiation-induced genomic instability.

Radiat Res. 2020 Mar 9. [Epub ahead of print]



Takahashi N, Misumi M, Niwa Y, Murakami H, Ohishi W, Inaba T, Nagamachi A, Tanaka S, Iii IBT, Suzuki G.

Effects of radiation on blood pressure and body weight in the spontaneously hypertensive rat model. Are radiation effects on blood pressure affected by genetic background?

Radiat Res. 2020 Mar 9. [Epub ahead of print]



Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayir H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS.

Anti-ferroptosis drug enhances total-body irradiation mitigation by drugs that block apoptosis and necroptosis.

Radiat Res. 2020 Mar 5. [Epub ahead of print]



Riad M, Hithe CC.


In: StatPearls. Treasure Island, FL: StatPearls Publishing, 2020.

Note: This article may be obtained online without charge.



O’Bryan L, Beier M, Salas E.

How approaches to animal swarm intelligence can improve the study of collective intelligence in human teams.

J Intell. 2020 Mar 2;8(1):E9. 

Note: This article may be obtained online without charge.



Kumar N, Iyer-Pascuzzi AS.

Shedding the last layer: Mechanisms of root cap cell release.

Plants (Basel). 2020 Mar 1;9(3):E308. Review.

Note: This article may be obtained online without charge.



Renna L, Brandizzi F.

The mysterious life of the plant trans-Golgi network: Advances and tools to understand it better.

J Microsc. 2020 Mar 1. [Epub ahead of print] Review.



Yang Z, Guo G, Yang N, Pun SS, Ho TKL, Ji L, Hu I, Zhang J, Burlingame AL, Li N.

The change of gravity vector induces short-term phosphoproteomic alterations in Arabidopsis.

J Proteomics. 2020 Apr;218:103720. Epub 2020 Feb 28.



Ponathil A, Ozkan F, Welch B, Bertrand J, Chalil Madathil K.

Family health history collected by virtual conversational agents: An empirical study to investigate the efficacy of this approach.

J Genet Couns. 2020 Mar 3. [Epub ahead of print]

Note: The NASA Task Load Index was used.

SpaceRef staff editor.