Status Report

NASA Spaceline Current Awareness List #885 7 February 2020 (Space Life Science Research Results)

By SpaceRef Editor
February 7, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Gilbert R, Torres ML, Clemens R, Hateley S, Hosamani R, Wade W, Bhattacharya S.

Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model.

npj Microgravity. 2020 Feb 4;6(1):4.

PIs: S. Govind, R. Bodmer

Note: ISS results; a rotating wall vessel was used for ground studies. This article may be obtained online without charge.

Journal Impact Factor: 3.111

Funding: “We would like to thank . . . NASA’s Space Life and Physical Sciences Research Program (SLPSRA) for the following grants to S.B.: NNX13AN38G and NNX15AB42G.”



Regan MD, Flynn-Evans EE, Griko YV, Kilduff T, Rittenberger JC, Ruskin KJ, Buck CL.

Shallow metabolic depression and human spaceflight: A feasible first step.

J Appl Physiol (1985). 2020 Jan 30. [Epub ahead of print]

Note: From the Acknowledgements: “Initial ideas presented in this paper were generated at a NASA-hosted workshop held at NASA Ames Research Center, Moffett Field, CA in March 2018.” The NASA Space Torpor Workshop program book can be found at:

Journal Impact Factor: 3.140

Funding: “Research and writing efforts were supported by a NSERC Postdoctoral Fellowship awarded to M.D.R., the NASA Human Research Program (E.E.F.), the NIH R21 NS101983 (T.S.K.), and the NSF‐IOS #1656063 & #1558056 (C.L.B.).”



Britten RA, Duncan VD, Fesshaye A, Rudobeck E, Nelson GA, Vlkolinsky R.

Altered cognitive flexibility and synaptic plasticity in the rat prefrontal cortex after exposure to low (≤15 cGy) doses of 28Si radiation.

Radiat Res. 2020 Feb 3. [Epub ahead of print]

PIs: R.A. Britten; C. Limoli/R.A. Britten/NSCOR

Journal Impact Factor: 2.530

Funding: “This work was funded by NASA grant nos. NNX15AI22G and NNX14AE73G.”



Hupfeld KE, Lee JK, Gadd NE, Kofman IS, De Dios YE, Bloomberg JJ, Mulavara AP, Seidler RD.

Neural correlates of vestibular processing during a spaceflight analog with elevated carbon dioxide (CO2): A pilot study.

Front Syst Neurosci. 2020 Jan 10;13:80.

PI: R.D. Seidler

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 3.928

Funding: “This work was supported by grants to RS, AM, and JB from the National Aeronautics and Space Administration (NASA; 80NSSC17K0021), the National Space Biomedical Research Institute (NSBRI; NCC 9-58 and SA02802), and the National Institutes of Health and National Center for Advancing Translational Sciences (1UL1RR029876-01). Additionally, during completion of this work KH was supported by a National Science Foundation Graduate Research Fellowship under Grant Nos. DGE-1315138 and DGE-1842473, as well as training grant NIH T32-NS082128.”



Stirling L, Kelty-Stephen D, Fineman R, Jones MLH, Park BKD, Reed MP, Parham J, Choi HJ.

Static, dynamic, and cognitive fit of exosystems for the human operator.

Hum Factors. 2020 Jan 31. [Epub ahead of print]

Journal Impact Factor: 2.649

Funding: “This work was partially supported by NASA Grant NNX15AR20G (LS), NSF Award 1905524 (LS), NASA Space Technology Research Fellowships NNX16AM71H (RF), and the U.S. Army Combat Capabilities Development Command Soldier Center research project 18-114 (JP, HC).”



de Bang L, Paez-Garcia A, Cannon AE, Chin S, Kolape J, Liao F, Sparks JA, Jiang Q, Blancaflor EB.

Brassinosteroids inhibit autotropic root straightening by modifying filamentous-actin organization and dynamics.

Front Plant Sci. 2020 Feb 4;11:5.

PI: E.B. Blancaflor

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.677

Funding: “This work was supported by the National Aeronautics and Space Administration grants 80NSSC18K1462 and 80NSSC19K0129 to EB, and the Noble Research Institute LLC. LB was supported by a fellowship from Biomass for the 21st century (”



Other papers of interest:



Meirhaeghe N, Bayet V, Paubel P-V, Mélan C.

Selective facilitation of egocentric mental transformations under short-term microgravity.

Acta Astronaut. 2020 Jan 31. [Article in Press]

Note: Parabolic flight results.



Scott JPR, Weber T, Green DA.

Editorial: Optimization of exercise countermeasures for human space flight  Lessons from terrestrial physiology and operational implementation. 

Front Physiol. 2020 Jan 10;10:1567.

Note: The editorial introduces the Frontiers in Physiology Research Topic: Optimization of Exercise Countermeasures for Human Space Flight – Lessons from Terrestrial Physiology and Operational Implementation. The 15 review articles in this topic have appeared in earlier issues of SPACELINE Current Awareness Lists. A complete list of articles is available at:—lessons-from-terrestrial-physiolog#articles. The articles may be obtained online without charge.



Sokolovskaya A, Korneeva E, Zaichenko D, Virus ED, Kolesov DV, Moskovtsev AA, Kubatiev A.

Changes in the surface expression of intercellular adhesion molecule 3, the induction of apoptosis, and the inhibition of cell-cycle progression of human multidrug-resistant Jurkat/A4 cells exposed to a random positioning machine.

Int J Mol Sci. 2020 Jan 28;21(3):855.

Note: A random positioning machine was used.



Netea MG, Domínguez-Andrés J, Eleveld M, Op den Camp HJM, van der Meer JWM, Gow NAR, de Jonge MI.

Immune recognition of putative alien microbial structures: Host-pathogen interactions in the age of space travel.

PLoS Pathog. 2020 Jan;16(1):e1008153. Review.

Note: This article may be obtained online without charge.



McKenzie AI, Reidy PT, Nelson DS, Mulvey JL, Yonemura NM, Petrocelli JJ, Mahmassani ZS, Tippetts TS, Summers SA, Funai K, Drummond MJ.

Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice.

Am J Physiol Regul Integr Comp Physiol. 2020 Jan 29. [Epub ahead of print]

Note: Hindlimb unloading study.



Galea GL, Delisser PJ, Meakin L, Price JS, Windahl SH.

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Bone. 2020 Apr;133:115255. Epub 2020 Jan 25.

Note: Tibial mechanical loading was used. This article may be obtained online without charge.



Rolvien T, Milovanovic P, Schmidt FN, von Kroge S, Wölfel EM, Krause M, Wulff B, Püschel K, Ritchie RO, Amling M, Busse B.

Long-term immobilization in elderly females causes a specific pattern of cortical bone and osteocyte deterioration different from postmenopausal osteoporosis.

J Bone Miner Res. 2020 Jan 30. [Epub ahead of print]



Anuja K, Kar M, Chowdhury AR, Shankar G, Padhi S, Roy S, Akhter Y, Rath AK, Banerjee B.

Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer.

Int J Radiat Biol. 2020 Jan 27. [Epub ahead of print]



Czub J, Braziewicz J, Wasilewski A, Wysocka-Rabin A, Wołowiec P, Wójcik A.

Monte Carlo dosimetry using Fluka code and experimental dosimetry with Gafchromic EBT2, XR-RV3 of self-built experimental setup for radiobiological studies with low-energy X-rays.

Int J Radiat Biol. 2020 Jan 27. [Epub ahead of print]



Murray D, Mirzayans R.

Non-linearities in the cellular response to ionizing radiation and the role of p53 therein.

Int J Radiat Biol. 2020 Jan 27. [Epub ahead of print]



Oskouee S, Feghhi SAH, Soleimani N.

Antibiotic susceptibility variations of Methicillin-resistant Staphylococcus aureus after gamma irradiation.

Int J Radiat Biol. 2020 Jan 27. [Epub ahead of print]



Laurens J, Angelaki DE.

Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion.

Proc Natl Acad Sci U S A. 2020 Jan 27. [Epub ahead of print]



Shirah BH, Al Talhi YM.

Saudi Arabia and aerospace medicine in the era of the national vision of 2030.

Int J Health Sci (Qassim). 2020 Jan-Feb;14(1):1-2.

Note: This article may be obtained online without charge.



Shindo M, Makigawa S, Matsumoto K, Iwata T, Wasano N, Kano A, Morita MT, Fujii Y.

Essential structural features of (2Z,4E)-5-phenylpenta-2,4-dienoic acid for inhibition of root gravitropism.

Phytochemistry. 2020 Apr 1;172:112287. Epub 2020 Feb 1.



Temte JL, Beasley JW, Holden RJ, Karsh BT, Potter B, Smith P, O’Halloran P.

Relationship between number of health problems addressed during a primary care patient visit and clinician workload.

Appl Ergon. 2020 Apr;84:103035. Epub 2020 Jan 13.

Note: The NASA Task Load Index was used.



Please Note: The Winter 2020 issue of Physiology News magazine, a publication of The Physiological Society, is devoted to human physiology during spaceflight. The issue, “Space physiology: To Mars and beyond,” and individual articles are available online without charge at: Articles are listed below:



Berg RA.

Editorial: Space is in the air.

Physiol News. 2020 Winter;(117):5. 



Berg RA, Turan J.

Physiologist among the stars: A conversation with Jim Pawelczyk.

Physiol News. 2020 Winter;(117):10-1.



Keller E, Scott R.

Physiological discoveries abound within NASA samples.

Physiol News. 2020 Winter;(117):12-3.

Note: The authors discuss the NASA Ames Research Center’s Institutional Scientific Collection of spaceflight biological specimens and NASA’s Biospecimen Sharing Program, which makes samples available to all researchers.



Watkins A.

Sex in space: Our final reproductive frontier.

Physiol News. 2020 Winter;(117):14.



Vitaterna MH, Jiang P.

The NASA Twins studies.

Physiol News. 2020 Winter;(117):16-7.



Vernice NA, Bailey SM, Mason CE.

Telomeres and genomic instability during long-duration spaceflight.

Physiol News. 2020 Winter;(117):17-8.



Lawley JS, Levine BD.

Don’t lose sight under pressure: Cranial consequences of a life without gravity.

Physiol News. 2020 Winter;(117):22-5.



Limoli C.

Space brain: The adverse impact of deep space radiation exposure on the brain.

Physiol News. 2020 Winter;(117):26-9.



Mekjavic I.

May the (Gz) force be with you: Gravity and human space exploration.

Physiol News. 2020 Winter;(117):30-4.



Whittaker I.

The invisible space killers: The dangers of space radiation from both inside and outside the solar system.

Physiol News. 2020 Winter;(117):36-9.



Norsk P.

Getting to the heart of it: The cardiovascular consequences of spaceflight.

Physiol News. 2020 Winter;(117):40-3.


SpaceRef staff editor.