NASA Spaceline Current Awareness List #883 24 January 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Lindsey T, Lee JJ.
Automated cardiovascular pathology assessment using semantic segmentation and ensemble learning.
J Digit Imaging. 2020 Jan 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 2.572
Funding: No funding cited. The authors are affiliated with NASA Ames Research Center.
2
Roberts DR, Asemani D, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, George MS, Brown TR.
Reply [to Comments on “Prolonged Microgravity Affects Human Brain Structure and Function”].
AJNR Am J Neuroradiol. 2020 Jan 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: D.R. Roberts
Note: The authors reply to #8 in the ‘Other papers of interest’ section.
Journal Impact Factor: 3.256
Funding: From the original paper: “This study was funded by a grant from the National Aeronautics and Space Administration (NNX13AJ92G). Dr Nieter’s time on this project was funded, in part, by the National Institutes of Health National Center for Advancing Translational Science (grant No. UL1-TR001450) and the National Institute of General Medical Sciences (grant No. U54-GM104941). Dr Inglesby’s time on this project was funded by a Minorities in STEM Student Scholarship from the South Carolina Space Grant Consortium (grant No. NNX15AL49H).”
3
Jones DA, Gaewsky JP, Somers JT, Gayzik FS, Weaver AA, Stitzel JD.
Head injury metric response in finite element ATDs and a human body model in multidirectional loading regimes.
Traffic Inj Prev. 2020 Jan 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: J.T. Somers
Journal Impact Factor: 1.465
Funding: “This study was supported by NASA Human Health and Performance Contract (HHPC) through KBRwyle (NNJ15HK11B). This study also used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by the NSF grant OCI-1053575. Specifically, it used the Bridges system, which is supported by the NSF award ACI-1445606, at the Pittsburgh Supercomputing Center (PSC).”
4
Ma W, Lutsko JF, Rimer JD, Vekilov PG.
Antagonistic cooperativity between crystal growth modifiers.
Nature. 2020 Jan 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: P.G. Vekilov
Journal Impact Factor: 43.070
Funding: “This work was supported by the National Science Foundation (award number DMR-1710354), the National Institutes of Health (award number 1R21AI126215-01), NASA (award numbers NNX14AD68G and NNX14AE79G), the European Space Agency (ESA) and the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Programme (contract number ESA17 AO-2004-070) and The Welch Foundation (grant E-1794).”
5
Nuernberger B, Tapella R, Berndt SH, Kim SY, Samochina S, Tory M, Keefe DF.
Under water to outer space: Augmented reality for astronauts and beyond.
IEEE Comput Graph Appl. 2020 Jan-Feb;40(1):82-9.
https://www.ncbi.nlm.nih.gov/
Note: The study was conducted in the Aquarius, an undersea research facility used as an analog to the International Space Station.
Journal Impact Factor: 1.725
Funding: “This work was supported by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”
______________________________
Other papers of interest:
1
Thiel CS, Christoffel S, Tauber S, Vahlensieck C, Zélicourt D, Layer LE, Lauber B, Polzer J, Ullrich O.
Rapid cellular perception of gravitational forces in human Jurkat T cells and transduction into gene expression regulation.
Int J Mol Sci. 2020 Jan 14;21(2):E514.
https://www.ncbi.nlm.nih.gov/
Note: Sounding rocket results; a 3D clinostat and centrifugation were used for ground studies. This article may be obtained online without charge.
2
Limper U, Moestl S, Tank J, Prisk GK, Heusser K, Hoffmann F, Goßmann A, Migeotte PF, Gauger P, Beck LEJ, Schlegel HW, Levine BD, Jordan J.
A 20-year evolution of cardiac performance in microgravity in a male astronaut.
Clin Auton Res. 2020 Jan 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Flight results are from STS-55 (German Spacelab D2) and parabolic flights.
3
Wang J, Liu Y, Zhao G, Gao J, Liu J, Wu X, Xu C, Li Y.
Integrated proteomic and metabolomic analysis to study the effects of spaceflight on Candida albicans.
BMC Genomics. 2020 Jan 17;21(1):57.
https://www.ncbi.nlm.nih.gov/
Note: SJ-10 Chinese satellite results. This article may be obtained online without charge.
4
Harrison JF, Adjerid K, Kassi A, Klok CJ, VandenBrooks JM, Duell ME, Campbell JB, Talal S, Abdo CD, Fezzaa K, Pendar H, Socha JJ.
Physiological responses to gravity in an insect.
Proc Natl Acad Sci U S A. 2020 Jan 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Grasshoppers were held in head-up, head-down, and prone positions.
5
Liu H, Li Y, Wang J, Gao J, Wang R, Li Y.
[Urinary excretion of moxifloxacin in tail-suspension simulated weightlessness rats after oral administration].
Space Med Med Eng. 2019;2019(6):478-83. Chinese.
http://caod.oriprobe.com/
Note: Hindlimb unloading study.
6
Lou R, Liu J, Rui Z, Zhang H.
[Development of body mass measuring device under weightless condition based on spring oscillator principle].
Space Med Med Eng. 2019;2019(6):503-7. Chinese.
http://caod.oriprobe.com/
Note: An air flotation method was used to simulate weightlessness.
7
Gomarasca M, Banfi G, Lombardi G.
Myokines: The endocrine coupling of skeletal muscle and bone.
Adv Clin Chem. 2020;94:155-218. Review.
https://www.ncbi.nlm.nih.gov/
8
Bevelacqua JJ, Welsh J, Mortazavi SMJ.
Comments on “Prolonged microgravity affects human brain structure and function.”
AJNR Am J Neuroradiol. 2020 Jan 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on: Roberts DR, Asemani D, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, George MS, Brown TR. Prolonged microgravity affects human brain structure and function. AJNR Am J Neuroradiol. 2019 Nov;40(11):1878-1885. https://www.ncbi.nlm.nih.gov/
9
Gordon T, Tyreman N, Harris LR, Victor FR.
Medial gastrocnemius muscles fatigue but do not atrophy in paralyzed cat hindlimb after long-term spinal cord hemisection and unilateral deafferentation.
Exp Neurol. 2020 Jan 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimbs were paralyzed via spinal cord hemisection.
10
Okushima D, Poole DC, Barstow TJ, Kondo N, Chin LMK, Koga S.
Effect of differential muscle activation patterns on muscle deoxygenation and microvascular hemoglobin regulation.
Exp Physiol. 2020 Jan 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
11
Powers S, Ozdemir M, Hyatt H.
Redox control of proteolysis during inactivity-induced skeletal muscle atrophy.
Antioxid Redox Signal. 2020 Jan 15. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: The review is based on human and animal studies using bed rest, limb immobilization, and prolonged mechanical ventilation.
12
Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P.
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.
Nat Commun. 2020 Jan 13;11(1):189.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading was accomplished via immobilization and denervation. This article may be obtained online without charge.
13
Chatziravdeli V, Katsaras GN, Lambrou GI.
Gene expression in osteoblasts and osteoclasts under microgravity conditions: A systematic review.
Curr Genomics. 2019 Apr;20(3):184-98. Review.
https://www.ncbi.nlm.nih.gov/
Note: The authors reviewed studies conducted in Space Shuttle missions, ISS, and sounding rockets. Ground studies included head-down tilt bed rest and hindlimb unloading as well as cell studies using the Rotary Cell Culture System, clinostats, rotating wall vessels, random positioning machines, and large gradient high magnetic field. This article may be obtained online without charge.
14
Lacombe J, Al Rifai O, Loter L, Moran T, Turcotte AF, Grenier-Larouche T, Tchernof A, Biertho L, Carpentier AC, Prud’homme D, Rabasa-Lhoret R, Karsenty G, Gagnon C, Jiang W, Ferron M.
Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function.
Am J Physiol Endocrinol Metab. 2020 Jan 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Frantzidis CA, Nday CM, Chriskos P, Gkivogkli PT, Bamidis PD, Kourtidou-Papadeli C.
Advanced network neuroscience approaches in sleep neurobiology on extreme environments.
Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4046-67.
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt bed rest study.
16
Shi H, Guo L, Xu D, Feng J, Liu D, Zhang H, Zhang X.
[Diseases and injuries in spaceflight].
Space Med Med Eng. 2019;2019(6):551-7. Chinese.
http://caod.oriprobe.com/
17
Pollack AH, Pratt W.
Association of health record visualizations with physicians’ cognitive load when prioritizing hospitalized patients.
JAMA Netw Open. 2020 Jan 3;3(1):e1919301.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
