Status Report

NASA Spaceline Current Awareness List #879 20 December 2019 (Space Life Science Research Results)

By SpaceRef Editor
December 20, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Please Note: The next SPACELINE Current Awareness List will be distributed on January 3, 2020.


Papers deriving from NASA support:



Beheshti A, Chakravarty K, Fogle H, Fazelinia H, Silveira WAD, Boyko V, Polo SL, Saravia-Butler AM, Hardiman G, Taylor D, Galazka JM, Costes SV.

Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver.

Sci Rep. 2019 Dec 16;9(1):19195. 

Note: Space Shuttle results. From the Materials and Methods section: “The omics data for the mouse liver samples were obtained from NASA’s GeneLab public omics repository ( from previous experiments performed by previous investigators from three spaceflight missions, Rodent Research-1 (RR-1) (with samples from both NASA and CASIS), and Rodent Research-3 (RR-3) and STS-135.” This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “Research funding was provided by the GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Space Life and Physical Sciences Research and Applications (SLPSRA).”



Boothby TC.

Mechanisms and evolution of resistance to environmental extremes in animals.

Evodevo. 2019 Nov 18;10:30. Review.

PI: T.C. Boothby

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.120

Funding: “The author TCB was supported by NASA Grant NNX15AB44G.”



Fujii Y, Shimada K, Takita A, Thornton W.

Evaluation of the Dr. William Thornton’s Skylab BMMD.

Microgravity Sci Technol. 2019 Dec 18. [Article in Press]

Note: From the abstract: “The characteristics of a pre-flight model of the Skylab BMMD (Body Mass Measurement Device), which was made around 1970 by the team led by Dr. William Thornton, are accurately evaluated using an optical interferometer on ground.”

Journal Impact Factor: 1.973

Funding: No funding cited. W. Thornton was a physician astronaut and principal investigator for Skylab experiments on mass measurement, anthropometric measurements, hemodynamics, and fluid shifts.



Morgenthaler AB, Kinney WR, Ebmeier CC, Walsh CM, Snyder DJ, Cooper VS, Old WM, Copley SD.

Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome.

Elife. 2019 Dec 9;8:e53535.

Note: This article may be obtained online without charge.

Journal Impact Factor: 7.551

Funding: “National Aeronautics and Space Administration (NASA) Astrobiology Institute NNA15BB04A, Shelley D. Copley and Vaughn S. Cooper; Department of Defense (DOD)/Defense Advanced Research Projects Agency (DARPA) 13-34-RTA-FP-007, William M. Old.”



Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM.

Altered m6A modification of specific cellular transcripts affects Flaviviridae infection.

Mol Cell. 2019 Nov 25. [Epub ahead of print]

PI: C.E. Mason

Journal Impact Factor: 14.548

Funding: “This work was supported by funds from Burroughs Wellcome Fund (S.M.H.) and National Institutes of Health: R01AI125416, R21AI129851 (S.M.H. and C.E.M.), 5P30AI064518 (S.M.H.), R01MH117406 (C.E.M.), and R03HL135475 (C.L.H). Other funding sources include: American Heart Association (N.S.G. Pre-doctoral Fellowship, 17PRE33670017), National Science and Engineering Research Council of Canada (A.B.R.M. PGS-D funding), Bert L. and N. Kuggie Vallee Foundation, WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G), and startup funds from the UNC Lineberger Comprehensive Cancer Center (H.M.L. and M.D.M).”



Qin YX, Hu M.

In vivo models of muscle stimulation and mechanical loading in bone mechanobiology.

In: Niebur GL, eds. Mechanobiology: From Molecular Sensing to Disease. [S.l.]: Elsevier, 2020. p. 117-36.

PI: Y.X. Qin

Journal Impact Factor: Not applicable to this publication

Funding: “This research was supported by the National Institutes of Health (R01 AR52379, AR61821, and AR49286) and the National Space Biomedical Research Institute through a NASA Cooperative Agreement NCC 9-58.”



Hinkle JJ, Olschowka JA, Love TM, Williams JP, O’Banion MK.

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice.

Sci Rep. 2019 Dec 11;9(1):18899.

PI: M.K. O’Banion

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “Financial support from the National Institutes of Health, grant U19 AI091036, and NASA grants NNX13AC33G and NNX16AE07G are gratefully acknowledged.”



Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patel MS, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza ML, Barcellos-Hoff MH.

Aggressive mammary cancers lacking lymphocytic infiltration arise in irradiated mice and can be prevented by dietary intervention.

Cancer Immunol Res. 2019 Dec 12. [Epub ahead of print]

PIs: M.H. Barcellos-Hoff/S. Demaria/J.H. May/NSCOR

Journal Impact Factor: 8.619

Funding: “This research was supported by NASA Specialized Center for Research in Radiation Health Effects, NNX09AM52G at New York University School of Medicine and NIH R01CA190980 and R01CA19098005S1 awards at UCSF to M.H. Barcellos-Hoff, and K08 CA172722 to C. Omene.”



Lee G, Moore TM, Basner M, Nasrini J, Roalf DR, Ruparel K, Port AM, Dinges DF, Gur RC.

Age, sex, and repeated measures effects on NASA’s “Cognition” test battery in STEM educated adults.

Aerosp Med Hum Perform. 2020 Jan 1;91(1):18-25.

PI: M. Basner

Journal Impact Factor: 0.889

Funding: “This research was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58; by NASA through grants NNX14AM81G, NNX14AH27G, and NNX14AH98G; by NIMH through grants MH089983, MH019112, MH096891, and MH042228; through the Office of Naval Research through grant ONR N00014-11-1-0361; by NIH through grant R01NR004281-14; and by the Dowshen Neuroscience Fund.”



Fischer D, McHill AW, Sano A, Picard RW, Barger LK, Czeisler CA, Klerman EB, Phillips AJK.

Irregular sleep and event schedules are associated with poorer self-reported well-being in US college students.

Sleep. 2019 Dec 14. [Epub ahead of print]

PIs: E.B. Klerman, D. Schreckenghost

Journal Impact Factor: 4.571

Funding: “NIH (F32DK107146, T32HL007901, KL2TR002370, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392, R00HL119618, R01DK099512, R01DK105072, R01HL118601, R01OH07567) and NSBRI (HFP02802, HFP04201, HDP0006). D.F. was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – FI 2275/1-1. This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541), and financial contributions from Harvard University and its affiliated academic healthcare centers.”



Wotring VE, Smith LK.

Dose tracker application for collecting medication use data from International Space Station crew.

Aerosp Med Hum Perform. 2020 Jan 1;91(1):41-5.

PI: V.E. Wotring

Journal Impact Factor: 0.889

Funding: “Funding was provided by NASA’s Human Research Program (NNX16AK78G) to V. E. Wotring.”



Wheeler RM, Fitzpatrick AH, Tibbitts TW.

Potatoes as a crop for space life support: Effect of CO2, irradiance, and photoperiod on leaf photosynthesis and stomatal conductance.

Front Plant Sci. 2019 Dec 19;10:1632.

PI: T.W. Tibbitts

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.677

Funding: “Research funded by a grant from NASA, US National Aeronautics and Space Administration.”




Other papers of interest:



Pastushkova LH, Rusanov VB, Orlov OI, Goncharova AG, Chernikova AG, Kashirina DN, Kussmaul AR, Brzhozovskiy AG, Kononikhin AS, Kireev KS, Nosovsky AM, Nikolaev EN, Larina IM. 

The variability of urine proteome and coupled biochemical blood indicators in cosmonauts with different preflight autonomic status.

Acta Astronaut. 2019 Dec 15. [Article in Press]

Note: ISS results.



Trudel G, Shafer J, Laneuville O, Ramsay T.

Characterizing the effect of exposure to microgravity on anemia, more space is worse.

Am J Hematol. 2019 Dec 9. [Epub ahead of print]

Note: Data are from the Longitudinal Study of Astronaut Health (LSAH) and from space missions flown between 1968 and 2017.



León-Espinosa G, DeFelipe J, Muñoz A.

The Golgi apparatus of neocortical glial cells during hibernation in the Syrian hamster.

Front Neuroanat. 2019 Nov 19;13:92.

Note: This article may be obtained online without charge.



Romswinkel A, Infanger M, Dietz C, Strube F, Kraus A.

The role of C-X-C chemokine receptor type 4 (CXCR4) in cell adherence and spheroid formation of human Ewing’s sarcoma cells under simulated microgravity.

Int J Mol Sci. 2019 Dec 2;20(23):E6073.

Note: A Random Positioning Machine was used. This article may be obtained online without charge.



Han X, Lei W, Qu L, Li Y, Hu S, Yin W.

[Research progress of cellular mechanisms in space environment induced cardiovascular deconditioning].

Space Med Med Eng. 2019;2019(5):456-62. Chinese. 

Note: The spaceflight mission is not identified in the English abstract.



Liu J, Hu T, Jia M, Zheng H, Yao J, Yuan M, Wang J, Yuan M.

[Effects of oxidative stress on the microRNAs profiles of EA.Hy926 cells and bioinformatics analysis under simulated microgravity].

Space Med Med Eng. 2019;2019(5):393-400. Chinese.  

Note: A clinostat was used.



Chouchou F, Pichot V, Costes F, Guillot M, Barthélémy JC, Bertoletti L, Roche F.

Autonomic cardiovascular adaptations to acute head-out water immersion, head-down tilt and supine position.

Eur J Appl Physiol. 2019 Dec 7. [Epub ahead of print]

Note: Dry immersion and head-down tilt bed rest were used.



Gong Y, Xu Y, Zhao H, Zhao J, Wang Y, Guo X, Shi L, Si S, Qin Y, Wu B, Luo L.

[Study of simulated weightlessness by tail suspension on changes of ocular hemodynamics and axis in rats].

Space Med Med Eng. 2019;2019(5):401-5. Chinese. 

Note: Hindlimb unloading study.



Mancinelli R, Toniolo L, Di Filippo ES, Doria C, Marrone M, Maroni CR, Verratti V, Bondi D, Maccatrozzo L, Pietrangelo T, Fulle S.

Neuromuscular electrical stimulation induces skeletal muscle fiber remodeling and specific gene expression profile in healthy elderly.

Front Physiol. 2019 Nov 27;10:1459.

Note: This article may be obtained online without charge.



Wei Y, Zhang J, Yan X, Peng X, Xu S, Chang H, Wang H, Gao Y.

Remarkable protective effects of Nrf2-mediated antioxidant enzymes and tissue specificity in different skeletal muscles of Daurian ground squirrels over the torpor-arousal cycle.

Front Physiol. 2019 Nov 22;10:1449.

Note: This article may be obtained online without charge.



Donahue HJ, Friendman MJ, Genetos DC.

Osteocyte mechanobiology in aging and disease.

In: Niebur GL, eds. Mechanobiology: From Molecular Sensing to Disease. [S.l.]: Elsevier, 2020. p. 1-21.



Kesavan C, Bajwa NM, Watt H, Mohan S.

Growth hormone effects on bone loss-induced by mild traumatic brain injury and/or hind limb unloading.

Sci Rep. 2019 Dec 12;9(1):18995.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Storlino G, Colaianni G, Sanesi L, Lippo L, Brunetti G, Errede M, Colucci S, Passeri G, Grano M.

Irisin prevents disuse-induced osteocyte apoptosis.

J Bone Miner Res. 2019 Dec 11. [Epub ahead of print]

Note: Hindlimb unloading study.



Cruz-Garcia L, O’Brien G, Sipos B, Mayes S, Love MI, Turner DJ, Badie C.

Generation of a transcriptional radiation exposure signature in human blood using long-read nanopore sequencing.

Radiat Res. 2019 Dec 12. [Epub ahead of print]



Lucertini M, Lancia S, Sanjust F, Guadagno AG, Lucertini L, Sisto R.

Lack of significant audiometric changes under hypobaric hypoxia at 15,000 ft.

Aerosp Med Hum Perform. 2020 Jan 1;91(1):32-6.



Zhang W, Liu H, Li Z, Liu H.

Synergistic effects of edible plants with light environment on the emotion and sleep of humans in long-duration isolated environment.

Life Sci Space Res. 2019 Dec 16. [Article in Press]



Witthaus MW, Patel SR, Erturk ES, Nakada SY, Rabinowitz R.

Stones, space, and Dr. Abraham T. K. Cockett: A history of urolithiasis and aerospace medicine.

Urology. 2019 Dec 5. [Epub ahead of print]



Goelzer M, Thompson WR, Uzer G.

Cells as functional load sensors and drivers of adaptation.

In: Niebur GL, eds. Mechanobiology: From Molecular Sensing to Disease. [S.l.]: Elsevier, 2020. p. 79-98.



Tang Y, Gao F, Feng H, Ji Y.

[Study on growth characteristics of four lettuce varieties under hypobaria and hyperoxia].

Space Med Med Eng. 2019;2019(5):412-9. Chinese.  



Yoshihara T, Spalding EP.

Switching the direction of stem gravitropism by altering two amino acids in AtLAZY1.

Plant Physiol. 2019 Dec 9. [Epub ahead of print]

Note: This article may be obtained online without charge.



Chen J, Wang Q, Hao Z, Li Z, Sahu SK, Liu H, Xiao L.

Relationship between the gut microbiome and energy/nutrient intake in a confined bioregenerative life support system (BLSS).

Appl Environ Microbiol. 2019 Dec 6. [Epub ahead of print]



Jiang J, Zhang M, Bhandari B, Cao P.

Current processing and packing technology for space foods: A review.

Crit Rev Food Sci Nutr. 2019 Dec 13. [Epub ahead of print] Review.



Giulianotti MA, Low LA.

Pharmaceutical research enabled through microgravity: Perspectives on the use of the International Space Station U.S. National Laboratory.

Pharm Res. 2020 Jan;37(1):1.



Low LA, Giulianotti MA.

Tissue chips in space: Modeling human diseases in microgravity.

Pharm Res. 2020 Jan;37(1):8.



Yang J, Yang P, Yang Z, Wang Z, Lyu Y, Xie L, Yin D, Shang P.

[Biological effects and application of diamagnetic levitation by large gradient high magnetic field].

Space Med Med Eng. 2019;2019(5):377-85. Chinese.

Note: A large gradient high magnetic field (LGHMF) is described for use in weightlessness simulation studies.



Rölfing JD, Nørskov JK, Paltved C, Konge L, Andersen SAW.

Failure affects subjective estimates of cognitive load through a negative carry-over effect in virtual reality simulation of hip fracture surgery.

Adv Simul (Lond). 2019 Nov 21;4:26.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.