NASA Spaceline Current Awareness List #878 13 December 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Hand AR, Dagdeviren D, Larson NA, Haxhi C, Mednieks MI.
Effects of spaceflight on the mouse submandibular gland.
Arch Oral Biol. 2019 Nov 18;110:104621.
https://www.ncbi.nlm.nih.gov/
PI: M.I. Mednieks
Note: Space Shuttle STS 131 and STS 135 results.
Journal Impact Factor: 1.663
Funding: “This work was supported by the National Aeronautics and Space Administration (grant number NNX09AP13G [MIM]), the Connecticut Space Grant College Consortium (grant number P-536 [ARH]), and the National Institutes of Health (Shared Instrumentation grant number 1S10RR024742 [ARH]).”
2
Herranz R, Vandenbrink JP, Villacampa A, Manzano A, Poehlman WL, Feltus FA, Kiss JZ, Medina FJ.
RNAseq analysis of the response of Arabidopsis thaliana to fractional gravity under blue-light stimulation during spaceflight.
Front Plant Sci. 2019 Nov 26;10:1529.
https://www.frontiersin.org/
PI: J.Z. Kiss
Note: ISS results. The article is part of the Research Topic: Higher Plants, Algae and Cyanobacteria in Space Environments (https://www.frontiersin.org/
Journal Impact Factor: 3.677
Funding: “This work was supported by the Spanish “Plan Estatal de Investigación Científica y Técnica e Innovación” of the Ministry of Economy, Industry and Competitiveness (Grant numbers AYA2012–33982 and ESP2015–64323-R to FJM, cofounded by ERDF), by pre-doctoral fellowships to (AM) and (AV) from the Spanish National Program for Young Researchers Training (MINECO, Ref. BES-2013-063933, BES-2016-077976) and the Seedling Growth Project to the ISS LSRA2009-0932/1177 of ESA-ELIPS Program. Funding for the RNA-seq was provided by NASA Grants NNX12A065G and 80NSSC17K0546 to JZK.”
3
Kiss JZ, Wolverton C, Wyatt SE, Hasenstein KH, van Loon JJWA.
Comparison of microgravity analogs to spaceflight in studies of plant growth and development.
Front Plant Sci. 2019 Dec 6;10:1577. Review.
https://www.frontiersin.org/
PIs: J.Z. Kiss, C. Wolverton, K.H. Hasenstein
Note: Simulation techniques discussed include clinostats, random positioning machines, magnetic levitation, and centrifuges. Results from ISS studies are cited. The article is part of the Research Topic: Higher Plants, Algae and Cyanobacteria in Space Environments (https://www.frontiersin.org/
Journal Impact Factor: 3.677
Funding: “Financial support provided by grants from the National Aeronautics and Space Administration (NASA) to JK (#80NSSC17K0546 and #NNX12AO65G), CW (#NNX15AG55G), and KH (#80NSSC17K0344).”
4
McKaig J, Caro T, Hyer A, Talburt ED, Verma S, Cui K, Boguraev A-S, Heitm M, Johnson A, Johnson E, Jong A, Shepard B, Stankiewiz J, Tran N, Rask J.
A high-altitude balloon platform for space life sciences education.
Gravit Space Res. 2019 Nov 27;7(1):62-9.
https://content.sciendo.com/
Note: A trial balloon flight is described. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “Funding for this study was provided by NASA Space Biology.”
5
Ganesan V, Spagnuolo M, Agrawal A, Smith S, Gao D, Blenner M.
Advances and opportunities in gene editing and gene regulation technology for Yarrowia lipolytica.
Microb Cell Fact. 2019 Nov 29;18(1):208.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.402
Funding: “This work was supported by NSF CBET-1403099 (MB), CBET-1706134 (MB), National Institute of General Medical Sciences (NIH-R35GM133803), and Creative Inquiry funds from Clemson University. This work was also supported by an Early Career Faculty Grant from NASA’s Space Technology Research Grants Program (MB) (Grant no. NNX15AU46G).”
6
Mader TH, Gibson CR, Miller NR, Brunstetter TJ, Killer HE, Wostyn P, Lee AG.
Letter: Brain physiological response and adaptation during spaceflight.
Neurosurgery. 2019 Dec 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on: Marshall-Goebel K, Damani R, Bershad EM. Brain physiological response and adaptation during spaceflight. Neurosurgery. 2019 Nov 1;85(5):E815-E821. https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 4.605
Funding: No funding cited. T.J. Brunstetter is affiliated with NASA Johnson Space Center.
7
Bershad EM, Marshall-Goebel K, Damani R.
In reply: Brain physiological response and adaptation during spaceflight.
Neurosurgery. 2019 Dec 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: K. Marshall-Goebel
Note: The authors reply to #6 above: Mader TH, Gibson CR, Miller NR, Brunstetter TJ, Killer HE, Wostyn P, Lee AG. Neurosurgery. 2019 Dec 3. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 4.605
Funding: From the original article: “This work was supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A.”
8
Schuemann J, McNamara AL, Ramos J, Perl J, Held K, Zhu H, Incerti S, Paganetti H, Faddegon B.
TOPAS-nBio: A Monte Carlo simulation toolkit for cell-scale radiation effects.
THREE. 2019 Dec 6.
https://three.jsc.nasa.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: “This work was supported by the National Institutes of Health (NIH)/National Cancer Institute (NCI), grant no. R01 CA187003.” THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.
9
Bartone PT, Roland RR, Bartone JV, Krueger GP, Sciarretta AA, Johnsen BH.
Human adaptability for deep space missions: An exploratory study.
J Hum Perform Extreme Environ. 2019 Mar;15(1):5. Epub 2019 Dec 4.
https://docs.lib.purdue.edu/
Note: From the abstract: “The present qualitative study conducts in-depth interviews with astronauts and other subject matter experts in order to shed light on human adaptability in extreme environments.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by NASA, no. NNJ16HP03I.”
10
Yamazaki EM, Goel N.
Robust stability of trait-like vulnerability or resilience to common types of sleep deprivation in a large sample of adults.
Sleep. 2019 Nov 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: N. Goel
Journal Impact Factor: 4.571
Funding: “This work was primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361) to N.G. Other support provided by National Aeronautics and Space Administration (NASA) NNX14AN49G (to N.G.) and Clinical and Translational Research Center grant UL1TR000003.”
11
Sadot E, Blancaflor EB.
The actomyosin system in plant cell division: Lessons learned from microscopy and pharmacology.
In: Sahi VP, Baluška F, eds. The Cytoskeleton: Diverse Roles in a Plant’s Life. Cham: Springer, 2019. p. 85-100.
https://link.springer.com/
PI: E.B. Blancaflor
Journal Impact Factor: Not applicable to this publication
Funding: “Research on the plant cytoskeleton in the authors’ laboratories is supported by the National Aeronautics and Space Administration (NASA grant numbers 80NSSC18K1462 and 80NSSC19K0129) to EBB and BSF Binational Science Foundation (grant number 2013084) to ES.”
12
Zeidler C, Zabel P, Vrakking V, Dorn M, Bamsey M, Schubert D, Ceriello A, Fortezza R, De Simone D, Stanghellini C, Kempkes F, Meinen Er, Mencarelli A, Swinkels G-J, Paul A-L, Ferl RJ.
The Plant Health Monitoring System of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase.
Front Plant Sci. 2019 Nov 22;10:1457.
https://www.ncbi.nlm.nih.gov/
PIs: R.J. Ferl, A-L. Paul
Note: The article is part of the Research Topic: Higher Plants, Algae and Cyanobacteria in Space Environments (https://www.frontiersin.org/
Journal Impact Factor: 3.677
Funding: “The EDEN ISS project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 636501. The participation of the Dutch team was co-financed by the Top Sector Horticulture & Starting Materials. The participation of the UF team was funded by NASA grant 80NSSC17K0199 and the Florida Space Grant Consortium grant FSGC NNX15_016 FSGC08 170829.”
______________________________
Other papers of interest:
1
Izzo LG, Romano LE, De Pascale S, Mele G, Gargiulo L, Aronne G.
Chemotropic vs hydrotropic stimuli for root growth orientation in microgravity.
Front Plant Sci. 2019 Nov 22;10:1547.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. The article is part of the Research Topic: Higher Plants, Algae and Cyanobacteria in Space Environments (https://www.frontiersin.org/
2
Bowden Davies KA, Pickles S, Sprung VS, Kemp GJ, Alam U, Moore DR, Tahrani AA, Cuthbertson DJ.
Reduced physical activity in young and older adults: Metabolic and musculoskeletal implications.
Ther Adv Endocrinol Metab. 2019 Nov 19;10:2042018819888824. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
3
Ott E, Fuchs FM, Moeller R, Hemmersbach R, Kawaguchi Y, Yamagishi A, Weckwerth W, Milojevic T.
Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach.
Sci Rep. 2019 Dec 5;9(1):18462.
https://www.ncbi.nlm.nih.gov/
Note: A 2-D clinostat was used. This article may be obtained online without charge.
4
Llanos PJ, Andrijauskaite K.
Investigation of murine T-cells and cancer cells under thermal stressors and 2D slow rotating system effects as a testbed for suborbital flights.
Gravit Space Res. 2019 Sep 17;7(1):45-61.
https://content.sciendo.com/
Note: Centrifugation and rotation were used. This article may be obtained online without charge.
5
Wang L, Chen W, Guo H, Qian A.
Response of membrane tension to gravity in an approximate cell model.
Theor Biol Med Model. 2019 Dec 5;16(1):19.
https://www.ncbi.nlm.nih.gov/
Note: From the introduction: “…this paper applies a theoretical modelling method to study the response of membrane tension under the action of gravity. In the model, the vesicles are simplified as water sacs, where the membrane of the vesicle is assumed to be a thin closed shell and the vesicle cavity is represented by water. The equilibrium differential equations of the deformed vesicle model are constructed and solved by using the analysis method of the elasticity mechanics and semi-inverse method.” This article may be obtained online without charge.
6
Furst B.
The effect of gravity and upright posture on circulation.
In: The Heart and Circulation: An Integrative Model. Cham: Springer, 2020. p. 319-41.
https://link.springer.com/
7
Stahn AC, Gunga HC, Kohlberg E, Gallinat J, Dinges DF, Kühn S.
Brain changes in response to long Antarctic expeditions.
N Engl J Med. 2019 Dec 5;381(23):2273-5.
https://www.ncbi.nlm.nih.gov/
8
Wojcik P, Kini A, Al Othman B, Galdamez LA, Lee AG.
Spaceflight associated neuro-ocular syndrome.
Curr Opin Neurol. 2019 Nov 27. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
9
Dolopikou CF, Kourtzidis IA, Tsiftsis AN, Margaritelis NV, Theodorou AA, Paschalis V, Frantzidis CA, Nikolaidis MG, Kourtidou-Papadeli C, Kyparos A.
Systemic redox biomarkers suggest non-redox mediated processes in the prevention of bed rest-induced muscle atrophy after exercise training: The Cologne RSL Study.
Acta Astronautica. 2019 Dec 5. [Article in Press]
http://www.sciencedirect.com/
Note: The Cologne RSL is a 60-day head-down tilt bed rest study.
10
Wonders J.
Flywheel training in musculoskeletal rehabilitation: A clinical commentary.
Int J Sports Phys Ther. 2019 Dec;14(6):994-1000.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
11
Cheong VS, Campos Marin A, Lacroix D, Dall’Ara E.
A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions.
Biomech Model Mechanobiol. 2019 Nov 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: A novel mechanistic model to predict bone adaptation based on physiological loading is presented. This article may be obtained online without charge.
12
Howe JG, Hill RS, Stroncek JD, Shaul JL, Favell D, Cheng RR, Engelke K, Genant HK, Lee DC, Keaveny TM, Bouxsein ML, Huber B.
Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: A long-term prospective cohort study.
Osteoporos Int. 2019 Dec 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
13
O’Sullivan LM, Allison H, Parle EE, Schiavi J, McNamara LM.
Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss.
Osteoporos Int. 2019 Nov 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
14
Sørensen TG, Brent MB, Thomsen JS, Brüel A.
Disuse-induced loss of bone mineral density and bone strength is attenuated by post-lactational bone gain in NMRI mice.
Bone. 2019 Nov 30;131:115183.
https://www.ncbi.nlm.nih.gov/
Note: Botulinum toxin was injected to induce hindlimb disuse.
15
Ghandhi SA, Shuryak I, Morton SR, Amundson SA, Brenner DJ.
New approaches for quantitative reconstruction of radiation dose in human blood cells.
Sci Rep. 2019 Dec 5;9(1):18441.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
16
Pfuhl T, Friedrich T, Scholz M.
Prediction of cell survival after exposure to mixed radiation fields with the local effect model.
Radiat Res. 2019 Dec 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Aichner S, Haile A, Hoffmann V, Olliges E, Tschöp MH, Meissner K.
The role of tactile stimulation for expectation, perceived treatment assignment and the placebo effect in an experimental nausea paradigm.
Front Neurosci. 2019 Nov 13;13:1212.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
18
Peterson SA, Wolkow AP, Lockley SW, O’Brien CS, Qadri S, Sullivan JP, Czeisler CA, Rajaratnam SMW, Barger LK.
Associations between shift work characteristics, shift work schedules, sleep and burnout in North American police officers: A cross-sectional study.
BMJ Open. 2019 Dec 1;9(11):e030302.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
19
Chauhan V, Galwankar S, Deepak KK, Mohan A, Guleria R, Bhoi S, Aggarwal P.
The 2019 WACEM and Academic College of Emergency Experts India position paper on developing the academic department of space medicine in India – The time has come!
J Emerg Trauma Shock. 2019 Oct-Dec;12(4):229-31.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
20
Cao P, Kim SJ, Xing A, Schenck CA, Liu L, Jiang N, Wang J, Last RL, Brandizzi F.
Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis.
Elife. 2019 Dec 6;8:e50747.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
21
Liu J, Geisler M.
Cooperation between auxin and actin during the process of plant polar growth.
In: Sahi VP, Baluška F, eds. The Cytoskeleton: Diverse Roles in a Plant’s Life. Cham: Springer, 2019. p. 101-23.
https://link.springer.com/
22
Pu Y, Ruberti C, Angelos ER, Brandizzi F.
AtIRE1C, an unconventional isoform of the UPR master regulator AtIRE1, is functionally associated with AtIRE1B in Arabidopsis gametogenesis.
Plant Direct. 2019 Nov;3(11):e00187.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
23
Retzer K, Akhmanova M, Konstantinova N, Malínská K, Leitner J, Petrášek J, Luschnig C.
Brassinosteroid signaling delimits root gravitropism via sorting of the Arabidopsis PIN2 auxin transporter.
Nat Commun. 2019 Dec 4;10(1):5516.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
24
Yamazaki K, Ohmori Y, Fujiwara T.
A positive tropism of rice roots toward a nutrient source.
Plant Cell Physiol. 2019 Dec 6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
