Status Report

NASA Spaceline Current Awareness List #874 15 November 2019 (Space Life Science Research Results)

By SpaceRef Editor
November 15, 2019
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PACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Kwok A, Rosas S, Bateman TA, Livingston EW, Smith TL, Moore JE, Zawieja DC, Hampton T, Mao XW, Delp MD, Willey JS.

Altered rodent gait characteristics after 35 days in orbit aboard the International Space Station.

Life Sci Space Res. 2019 Nov 8.  [Article in Press]

PI: J.S. Willey

Note: ISS results.

Journal Impact Factor: 2.066

Funding: “This research was supported by the National Aeronautics and Space Administration (NNX15AB50G to JSW).”



Laranjeiro R, Harinath G, Hewitt JE, Hartman JH, Royal MA, Meyer JN, Vanapalli SA, Driscoll M.

Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration.

Proc Natl Acad Sci U S A. 2019 Nov 4. [Epub ahead of print]

PI: S.A. Vanapalli

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.5804

Funding: “This work was funded in part by National Institute on Aging (NIA) Grant R01AG051995 (to M.D.), National Institute of Environmental Health Sciences (NIEHS) Grant R01ES028218 (to J.N.M.), National Aeronautics and Space Administration (NASA) Grant NNX15AL16G (to J.E.H. and S.A.V.), and postdoctoral fellowships from Life Sciences Research Foundation (Award Laranjeiro-2015, sponsored by Simons Foundation; to R.L.), American Heart Association (Award 18POST33960502; to R.L.), and NIEHS (Award F32ES027306; to J.H.H.).”



Makedonas G, Mehta S, Choukèr A, Simpson RJ, Marshall G, Orange JS, Aunon-Chancellor S, Smith SM, Zwart SR, Stowe RP, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Krieger SS, Lorenzi H, Buchheim JI, Ginsburg GS, Ott CM, Downs M, Pierson D, Baecker N, Sams C, Crucian B.

Specific immunologic countermeasure protocol for deep-space exploration missions.

Front Immunol. 2019 Oct 11;10:2407.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.716

Funding: “AC and J-IB are supported by the German National Space Program (50WB1622). This work is also supported by activities of the European Space Agency (ESA)’s Topical Team Stress and Immunity as funded by the ESA ELIPS 4 and SciSpacE programs.” G. Makedonas, S. Mehta, S. Aunon-Chancellor, S.M. Smith, S.R. Zwart, A. Whitmire, G.L. Douglas, S.S. Krieger, C.M. Ott, M. Downs, D. Pierson, S. Sams, and B. Crucian are affiliated with NASA Johnson Space Center.



Wey B, Heavner ME, Wittmeyer KT, Briese T, Hopper KR, Govind S.

Immune suppressive extracellular vesicle proteins of Leptopilina heterotoma are encoded in the wasp genome.

G3 (Bethesda). 2019 Nov 1. [Epub ahead of print]

PI: S. Govind

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.630

Funding: “This work was supported by grants from NASA (NNX15AB42G), NSF (IOS-1121817), NIH (1F31GM111052-01A1, 5G12MD007603-30, and GM103446).”



Ye X, Jones DA, Gaewsky J, Koya B, McNamara K, Saffarzadeh M, Putnam J, Somers J, Gayzik FS, Stitzel JD, Weaver A.

Lumbar spine response of computational finite element models in multidirectional spaceflight landing conditions.

J Biomech Eng. 2019 Nov 1. [Epub ahead of print]

Journal Impact Factor: 2.576

Funding: “The authors acknowledge David Shumate from the REU program for help with this project and the National Science Foundation (NSF) REU Site Grant (Award No. 1559700) for funding. Simulations were performed on the Wake Forest DEAC Cluster, a centrally managed resource with support provided in part by the university. This study also used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by the NSF grant OCI-1053575. Specifically, it used the Bridges system, which is supported by the NSF award ACI-1445606, at the Pittsburgh Supercomputing Center (PSC) [42]. This study was supported by NASA Human Health and Performance Contract (HHPC) award number NNJ15HK118 through KBR, with additional support from NIH/NIA (K25AG058804).”



Borak TB, Heilbronn L, Krumland N, Weil MM.

Design and dosimetry of a facility to study health effects following exposures to fission neutrons at low dose rates for long durations.

Int J Radiat Biol. 2019 Nov 5. [Epub ahead of print]

PIs: M.M. Weil/T.B. Borak/NSCOR

Journal Impact Factor: 2.266

Funding: “This work was supported with federal funds from the National Aeronautics and Space Administration under grant NNX15AK13G. Additional funds were provided by the Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biosciences, and Office of the Vice-President for Research, Colorado State University.”



Rouchka EC, Flight RM, Fasciotto BH, Estrada R, Eaton JW, Patibandla PK, Waigel SJ, Li D, Kirtley JK, Sethu P, Keynton RS.

Dataset for dose and time-dependent transcriptional response to ionizing radiation exposure.

Data Brief. 2019 Dec;27:104624. Epub 2019 Oct 5.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “Funding was provided by the National Aeronautics and Space Administration (NASA) contract NNX10AJ36G (BHF, ECR, JK, JWE, PKP, PS, RE and RSK); the National Institutes of Health (NIH) grants P20RR016481 (DL, ECR, RMF and SJW), 3P20RR016481-09S1 (ECR, RMF and SJW), and P20GM103436 (ECR and SJW).”



Lee JK, De Dios Y, Kofman I, Mulavara AP, Bloomberg JJ, Seidler RD.

Head down tilt bed rest plus elevated CO2 as a spaceflight analog: Effects on cognitive and sensorimotor performance.

Front Hum Neurosci. 2019 Oct 17;13:355.

PI: R.D. Seidler

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 2.870

Funding: “This work was supported by the NASA grant #80NSSC17K0021, National Space Biomedical Research Institute (NASA NCC 9-58 and NSBRI SA02802) NASA’s Flight Analogs Project, and the National Institutes of Health and National Center for Advancing Translational Sciences, 1UL1RR029876-01.”



Su S-H, Masson PH.

Gravitropism of plant organs undergoing primary growth.

In: Sopory S, ed. Sensory Biology of Plants. Singapore: Springer, 2019. p. 95-136.

PI: P.H. Masson

Journal Impact Factor: Not applicable to this publication

Funding: “This chapter was made possible by grants from the National Aeronautics and Space Administration (#NNX14AT23G and #80NSSC18K1481), the University of Wisconsin-Madison College of Agriculture and Life Sciences HATCH program (#WIS10338), and a Fall Competition Award from the Office of Vice Chancellor for Research and Graduate Education from the University of Wisconsin-Madison, to PHM.”




Other papers of interest:



Pastushkova LK, Goncharova AG, Vasilyeva GY, Tagirova SK, Kashirina DN, Sayk OV, Rittweger J, Larina IM.

Search for blood proteome proteins involved in the regulation of bone remodeling in astronauts.

Hum Physiol. 2019 Sep 1;45(5):536-42.

Note: ISS results. Originally published in published in Fiziologiya Cheloveka, 2019;45(5):91-8.



Tafforin C, Segal NL.

Twins in space: Review and perspectives.

Hum Ethol. 2019 Oct 5;34:123-9. Review.

Note: ISS results. This paper was presented at XXIV Biennial Conference of Human Ethology 2018, in Santiago, Chile.



Griko Y, Palma E, Galicia E, Selch F.

Factors limiting the duration of artificially induced torpor in mice.

Life Sci Space Res. 2019 Nov 11.  [Article in Press]



Moon RE.

Hyperbaric treatment of air or gas embolism: Current recommendations.

Undersea Hyperb Med. 2019 Sep-Dec;46(5):673-83.



Moon RE, Mitchell S.

Hyperbaric treatment for decompression sickness: Current recommendations.

Undersea Hyperb Med. 2019 Sep-Dec;46(5):685-93.



Ogoh S, Sato K, de Abreu S, Denise P, Normand H.

Arterial and venous cerebral blood flow responses to long-term head-down bed rest in male volunteers.

Exp Physiol. 2019 Nov 6. [Epub ahead of print]

Note: Head-down tilt bed rest study.



Kilroe SP, Fulford J, Jackman SR, van Loon LJC, Wall BT.

Temporal muscle-specific disuse atrophy during one week of leg immobilization.

Med Sci Sports Exerc. 2019 Nov 1. [Epub ahead of print]

Note: Knee bracing was used for immobilization.



Qiu J, Zhu J, Zhang R, Liang W, Ma W, Zhang Q, Huang Z, Ding F, Sun H.

miR-125b-5p targeting TRAF6 relieves skeletal muscle atrophy induced by fasting or denervation.

Ann Transl Med. 2019 Sep;7(18):456.

Note: Muscle atrophy was induced via sciatic nerve resection. This article may be obtained online without charge.



Ramkumar PN, Navarro SM, Becker J, Ahmad F, Minkara AA, Haeberle HS, Mont MA, Williams RJ.

The effects of space microgravity on hip and knee cartilage: A new frontier in orthopaedics.

Surg Technol Int. 2019 Nov 10;35:421-5. Review.



Yang J, Li J, Cui X, Li W, Xue Y, Shang P, Zhang H.

Blocking glucocorticoid signaling in osteoblasts and osteocytes prevents mechanical unloading-induced cortical bone loss.

Bone. 2020 Jan;130:115108. Epub 2019 Nov 5.

Note: Hindlimb unloading study.



Yi Q, Liu H, Feng J, Wu Y, Sun W, Ou M, Tang L.

Splicing factor-modulated generation of mechano growth factor regulates physiological processes in osteoblasts under mechanical stimuli.

Cell Adh Migr. 2019 Dec;13(1):322-31.



Ashraf ZM, Ibrahim HA, El-Sawi MR, Habza MN.

Effects of silymarin and mesenchymal stem cells on hematological and some biochemical changes induced by gamma radiation in albino rats.

Int J Radiat Biol. 2019 Nov 6. [Epub ahead of print]



Cataldi S, Borrelli A, Ceccarini MR, Nakashidze I, Codini M, Belov O, Ivanov A, Krasavin E, Ferri I, Conte C, Patria FF, Traina G, Beccari T, Mancini A, Curcio F, Ambesi-Impiombato FS, Albi E. 

Neutral sphingomyelinase modulation in the protective/preventive role of rMnSOD from radiation-induced damage in the brain.

Int J Mol Sci. 2019 Oct 31;20(21):E5431.

Note: This article may be obtained online without charge.



Chen X, Feng H, Du Y, Luo S, Li W, Yu L, Feng Z, Cui T, Zhou L.

Genetic polymorphisms in mutagenesis progeny of Arabidopsis thaliana irradiated by carbon-ion beams and ɣ-rays irradiations.

Int J Radiat Biol. 2019 Nov 6. [Epub ahead of print]



Paulin MG, Hoffman LF.

Models of vestibular semi-circular canal afferent neuron firing activity.

J Neurophysiol. 2019 Nov 6. [Epub ahead of print] Review.



Smith PF.

The growing evidence for the importance of the otoliths in spatial memory.

Front Neural Circuits. 2019 Oct 18;13:66. Review.

Note: This article may be obtained online without charge.



Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer F.

Sex differences in the circadian misalignment effects on energy regulation.

Proc Natl Acad Sci U S A. 2019 Nov 4. [Epub ahead of print]



Awan H, Zeid K, Adve RS, Wallbridge N, Plummer C, Eckford AW.

Communication in plants: Comparison of multiple action potential and mechanosensitive signals with experiments.

IEEE Trans Nanobioscience. 2019 Nov 4. [Epub ahead of print]



Roué J, Chauvet H, Brunel-Michac N, Bizet F, Moulia B, Badel E, Legué V.

Root cap size and shape influence responses to the physical strength of the growth medium in Arabidopsis thaliana primary roots.

J Exp Bot. 2019 Nov 4. [Epub ahead of print]



Carberry C.

Alcohol in Space: Past, Present and Future.

Jefferson, NC: McFarland, 2019.  217 p. 



Qian X, Zhao Y, Alsaid Y, Wang X, Hua M, Galy T, Gopalakrishna H, Yang Y, Cui J, Liu N, Marszewski M, Pilon L, Jiang H, He X.

Artificial phototropism for omnidirectional tracking and harvesting of light.

Nat Nanotechnol. 2019 Nov 4. [Epub ahead of print]



Keunecke JG, Gall C, Birkholz T, Moritz A, Eiche C, Prottengeier J.

Workload and influencing factors in non-emergency medical transfers: A multiple linear regression analysis of a cross-sectional questionnaire study.

BMC Health Serv Res. 2019 Nov 7;19(1):812.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.