NASA Spaceline Current Awareness List #873 8 November r2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Burkhart K, Allaire B, Anderson DE, Lee D, Keaveny TM, Bouxsein ML.
Effects of long-duration spaceflight on vertebral strength and risk of spine fracture.
J Bone Miner Res. 2019 Oct 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: M.L. Bouxsein
Note: ISS results.
Journal Impact Factor: 5.711
Funding: “This study was supported by National Aeronautics and Space Administration (NASA) grant NNX16AC15G; National Institutes of Health R01 AR053986; and National Space Biomedical Research Institute through NASA NCC 9-58.”
2
Padgen MR, Lera MP, Parra MP, Ricco AJ, Chin M, Chinn TN, Cohen A, Friedericks CR, Henschke MB, Snyder TV, Spremo SM, Wang J-H, Matin AC.
EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity.
Life Sci Space Res. 2019 Oct 31. [Article in Press]
http://www.sciencedirect.com/
PI: A.C. Matin
Note: Escherichia coli Antimicrobial Satellite (EcAMSat) results.
Journal Impact Factor: 2.066
Funding: “This research was supported by NASA grant NNX10AM90A to A.C.M. at Stanford and by NASA’s Space Life and Physical Sciences Research Division, Human Exploration and Operations Mission Directorate, at NASA/ARC.”
3
Turner JC, Collins G, Blaber E, Almeida E, Arinzeh TL.
Evaluating the cytocompatibility and differentiation of bone progenitors on electrospun zein scaffolds.
J Tissue Eng Regen Med. 2019 Oct 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 3.319
Funding: “The authors acknowledge support from National Aeronautics and Space Administration, NASA Space Technology Research Fellowship (NSTRF) NNX13AL56H, and the National Science Foundation, NSF Science and Technology Center – Center for Engineering Mechanobiology, CMMI-1548571.”
4
Colangelo NW, Azzam EI.
The importance and clinical implications of flash ultra-high dose-rate studies for proton and heavy ion radiotherapy.
Radiat Res. 2019 Oct 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: E.A. Azzam
Journal Impact Factor: 2.530
Funding: “This work was supported by the National Institutes of Health (NIH grant no. F30CA206389 to NWC) and the National Aeronautics and Space Administration (NASA grant no. NNX15AD62G to EIA and NWC).”
5
Hu S, Barzilla JE, Semones E.
Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Life Sci Space Res. 2019 Oct 31. [Article in Press]
http://www.sciencedirect.com/
Journal Impact Factor: 2.066
Funding: “This work was supported by KBR Human Health and Performance Contract (HHPC) NNJ15HK11B.”
6
Grant LK, Gooley JJ, St Hilaire MA, Rajaratnam SMW, Brainard GC, Czeisler CA, Lockley SW, Rahman SA.
Menstrual phase-dependent differences in neurobehavioral performance: The role of temperature and the progesterone/estradiol ratio.
Sleep. 2019 Oct 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: C.A. Czeisler
Journal Impact Factor: 4.571
Funding: “This work was supported by the National Institute of Neurological Disorders and Stroke (R01 NS36590 to G.C.B.), the National Institute of Mental Health (2R01 MH45130-11A1 to C.A.C. and S.W.L.), the National Center for Complementary and Alternative Medicine (R01 AT002129 to C.A.C. and S.W.L.), and the National Institute of Environmental Health Sciences (R21 ES017112-01A1 to S.W.L.). G.C.B, C.A.C., and S.W.L. were supported in part by the National Space Biomedical Research Institute through NASA NCC 9–58. The project was supported by the National Center for Research Resources through grants to Brigham and Women’s Hospital General Clinical Research Center (NCRR M01 RR02635) and the Harvard Clinical and Translational Science Center (NCRR UL1 RR025758). L.K.G. was supported by an Australian Government Research Training Program (RTP) Scholarship (Australian Government, Department of Education).”
7
Fuerch JH, Sanderson P, Barshi I, Liley H.
Developing safe devices for neonatal care.
Semin Perinatol. 2019 Aug 10. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “This chapter serves to review the design and research methods that can be utilized to improve the safety of neonatal device development and as an example, discusses the US regulatory process for evaluating the safety of medical devices and approving them for use.”
Journal Impact Factor: 2.838
Funding: No funding cited. I. Barshi is affiliated with NASA Ames Research Center.
______________________________
Other papers of interest:
1
Koryak YA.
Changes in human skeletal muscle architecture and function induced by extended spaceflight.
J Biomech. 2019 Oct 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
2
Fine LG.
Looking back 50 years at the biology of mankind in space: The renal-cardiovascular fluid shift conundrum.
J Am Soc Nephrol. 2019 Nov 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
3
Nicholson WL.
A bumpy pathway to stationary-phase survival in Bacillus subtilis.
MBio. 2019 Oct 29;10(5):e0246-19.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
4
Yang Y, Xie Y, Sun Y, Cao K, Li S, Fan S, Huang L, Wu S, Wang N.
Intraocular pressure changes of healthy lowlanders at different altitude levels: A systematic review and meta-analysis.
Front Physiol. 2019 Nov 6;10:1366. Review.
https://www.frontiersin.org/
Note: This article may be obtained online without charge.
5
Iliakis G, Mladenov E, Mladenova V.
Necessities in the processing of DNA double strand breaks and their effects on genomic instability and cancer.
Cancers (Basel). 2019 Oct 28;11(11):E1671.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Counts BR, Hardee JP, Fix DK, VanderVeen BN, Montalvo RN, Carson JA.
Cachexia disrupts diurnal regulation of activity, feeding, and muscle mTORC1 in mice.
Med Sci Sports Exerc. 2019 Oct 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
7
Kawao N, Ishida M, Kaji H.
Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice.
PLoS One. 2019 Oct 24;14(10):e0224403.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
8
Van Pelt DW, Confides AL, Abshire SM, Hunt ER, Dupont-Versteegden EE, Butterfield TA.
Age-related responses to a bout of mechanotherapy in skeletal muscle of rats.
J Appl Physiol (1985). 2019 Oct 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Blottner D, Huang Y, Trautmann G, Sun L.
Continuum linking bone and myofascial bag for global and local body movement control on Earth and in space. A scoping review.
REACH. 2019 Nov 2. [Article in Press] Review.
http://www.sciencedirect.com/
Note: From the abstract: “The present scoping review elaborates on structure, function and biomechanical properties (tone, stiffness, viscoelasticity) of fascia mainly selected from recent literature data in order to highlight the role of the loading-sensitive i.e. structural and biomechanical support mechanisms of this ensheathment structure that can influence shape, body motions and performance on Earth.”
10
Corrigan MA, Coyle S, Eichholz KF, Riffault M, Lenehan B, Hoey DA.
Aged osteoporotic bone marrow stromal cells demonstrate defective recruitment, mechanosensitivity, and matrix deposition.
Cells Tissues Organs. 2019 Oct 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
11
Draghici AE, Taylor JA, Bouxsein ML, Shefelbine SJ.
Effects of FES-rowing exercise on the time-dependent changes in bone microarchitecture after spinal cord injury: A cross-sectional investigation.
JBMR Plus. 2019 Sep;3(9):e10200.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “…we evaluated bone microstructure of the distal tibia and radius using HR‐pQCT in men with SCI (N = 13) who regularly trained with functional electrical stimulation‐ (FES‐) rowing.” This article may be obtained online without charge.
12
Trudel G, Melkus G, Sheikh A, Ramsay T, Laneuville O.
Marrow adipose tissue gradient is preserved through high protein diet and bed rest. A randomized crossover study.
Bone Rep. 2019 Oct 31. [Epub ahead of print]
http://www.sciencedirect.com/
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
13
Willie BM, Zimmermann E, Vitienes I, Main RP, Komarova SV.
Bone adaptation: Safety factors and load predictability in shaping skeletal form.
Bone. 2019 Oct 21. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
14
Baddour AAD, Apodaca LA, Alikhani L, Lu C, Minasyan H, Batra RS, Acharya MM, Baulch JE.
Sex-specific effects of a wartime-like radiation exposure on cognitive function.
Radiat Res. 2019 Oct 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Fu H, Su F, Zhu J, Zheng X, Ge C.
Effect of simulated microgravity and ionizing radiation on expression profiles of miRNA, lncRNA, and mRNA in human lymphoblastoid cells.
Life Sci Space Res. 2019 Oct 31. [Article in Press]
http://www.sciencedirect.com/
Note: A Rotary Cell Culture System was used.
16
Jones B, Hill MA.
Physical characteristics at the turnover-points of relative biological effect (RBE) with linear energy transfer (LET).
Phys Med Biol. 2019 Oct 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Kang KJ, Jung KH, Choi EJ, Kim H, Do SH, Ko IO, Oh SJ, Lee YJ, Kim JY, Park JA.
Monitoring physiological changes in neutron-exposed normal mouse brain using FDG-PET and DW-MRI.
Radiat Res. 2019 Nov 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
18
Abel JH, Chakrabarty A, Klerman EB, Doyle FJ 3rd.
Pharmaceutical-based entrainment of circadian phase via nonlinear model predictive control.
Automatica (Oxf). 2019 Feb;100:336-48.
https://www.ncbi.nlm.nih.gov/
19
Dirk KL, Belfry GR, Heath M.
Exercise and executive function during follicular and luteal menstrual cycle phases.
Med Sci Sports Exerc. 2019 Oct 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
20
Ilgrande C, Defoirdt T, Vlaeminck SE, Boon N, Clauwaert P.
Media optimization, strain compatibility, and low-shear modeled microgravity exposure of synthetic microbial communities for urine nitrification in regenerative life-support systems.
Astrobiology. 2019 Nov;19(11):1353-62.
https://www.ncbi.nlm.nih.gov/
Note: A clinostat was used.
21
Kamari Ghanavati F, Choobineh A, Keshavarzi S, Nasihatkon AA, Jafari Roodbandi AS.
Assessment of mental workload and its association with work ability in control room operators.
Med Lav. 2019 Oct 29;110(5):389-97.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
