Status Report

NASA Spaceline Current Awareness List #872 1 November 2019 (Space Life Science Research Results)

By SpaceRef Editor
November 1, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Cao L, Gurevich A, Alexander KL, Naman CB, Leão T, Glukhov E, Luzzatto-Knaan T, Vargas F, Quinn R, Bouslimani A, Nothias LF, Singh NK, Sanders JG, Benitez RAS, Thompson LR, Hamid MN, Morton JT, Mikheenko A, Shlemov A, Korobeynikov A, Friedberg I, Knight R, Venkateswaran K, Gerwick WH, Gerwick L, Dorrestein PC, Pevzner PA, Mohimani H.

MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities.

Cell Syst. 2019 Nov 27;9:1-9. Epub 2019 Oct 16.

PI: K. Venkateswaran

Note: ISS results.

Journal Impact Factor: 8.640

Funding: “The work of H.M. and L.C. was supported by a start-up fund from Carnegie Mellon University, a research fellowship from the Alfred P. Sloan Foundation, and a National Institutes of Health New Innovator Award DP2GM137413. The work of P.C.D. and P.A.P. was supported by NIH 2-P41-GM103484. P.C.D. is supported by GM097509. A.G. was supported by the Russian Science Foundation (grant 19-16-00049). A.M. was supported by St. Petersburg State University, Russia (grant ID PURE 28396291). A.S. and A.K. were supported by the Russian Science Foundation (grant 19-14-00172). T.L.-K., P.C.D., L.G., and W.H.G. were supported by NIH 2R01GM107550. L.G. and W.H.G. were supported by NIH R01GM118815. J.T.M. was funded by NSF GRFP DGE-1144086. … Part of the research described in this publication was performed at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. The work of N.K.S. and K.V. was funded by NASA 19-12829-26 and 19-12829-27. C.B.N. was supported by postdoctoral fellowship from NCI/NIH Training Program in the Biochemistry of Growth Regulation and Oncogenesis (T32 CA009523). T.L.-K was supported by Vaadia-BARD Postdoctoral fellowship award no. FI-494-13. T.L. was supported by CAPES Foundation for Research fellowship (13425-13-7). The work of I.F. was supported, in part, by NSF awards ABI-1551363 and ABI-1458359.”



Galdamez LA, Brunstetter TJ, Lee AG, Tarver WJ.

Origins of cerebral edema: Implications for spaceflight-associated neuro-ocular syndrome.

J Neuroophthalmol. 2019 Oct 15. [Epub ahead of print] Review.

Journal Impact Factor: 2.509

Funding: No funding cited. W.J. Tarver is affiliated with NASA Johnson Space Center.



Lesanpezeshki L, Hewitt JE, Laranjeiro R, Antebi A, Driscoll M, Szewczyk NJ, Blawzdziewicz J, Lacerda CMR, Vanapalli SA.

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans.

Sci Rep. 2019 Oct 23;9(1):15246.

PI: S.A. Vanapalli

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “This work is partially supported by funding from the National Institutes of Health (RO1 AG051995-04 to M.D. & S.V.), Cancer Prevention and Research Institute of Texas (RP160806 to S.V.), National Aeronautics and Space Administration (NNX15AL16G to S.V. & J.B.) and the Biotechnology and Biological Sciences Research Council (BB/N015894/1 to N.J.S.). J.E.H. acknowledges funding support from the Fulbright U.S. Student Program and the Germanistic Society of America. R.L. has been funded by postdoctoral fellowships from Life Sciences Research Foundation (sponsored by Simons Foundation) (award # Laranjeiro-2015) and American Heart Association (award # 18POST33960502). A.A. was supported by the Max Planck Society.”



Blue RS, Chancellor JC, Suresh R, Carnell LS, Reyes DP, Nowadly CD, Antonsen EL.

Challenges in clinical management of radiation-induced illnesses during exploration spaceflight.

Aerosp Med Hum Perform. 2019 Nov;90(11):966-77. Review.

Journal Impact Factor: 0.889

Funding: No funding cited. L.S. Carnell is affiliated with NASA Langley Research Center; R.S. Blue, R. Suresh, D.P. Reyes, and E.L. Antonsen are affiliated with NASA Johnson Space Center.



Driskell JE, Salas E.

Sustaining individual motivation in high-demand team environments.

In: Karau S, ed. Individual Motivation within Groups: Social Loafing and Motivation Gains in Work, Academic, and Sports Teams. Cambridge, MA: Academic Press, 2019. p. 191-222.

PI: E. Salas

Journal Impact Factor: Not applicable to this publication

Funding: PI reports funding under NASA NCC 9-58-NBPF03402.



Stankovic AS, Alvarenga DL, Coleman Daniels VR, Simmons RG, Buckey JC, Putcha L.

Intranasal scopolamine for motion sickness.

Aerosp Med Hum Perform. 2019 Nov;90(11):917-24.

PI: L. Putcha

Journal Impact Factor: 0.886

Funding: “This work was supported through project NA00404 “Pharmacotherapeutics of Intranasal Scopolamine” from the National Space Biomedical Research Institute (P.I. Lakshmi Putcha, Ph.D.) through NCC 9-58.”




Other papers of interest:



Baranova EN, Levinskikh MA, Gulevich AA.

Wheat space odyssey: “From seed to seed.” Kernel morphology.

Life. 2019 Oct 25;9(4):81.

Note: ISS results.



Pollock RD, Firth RV, Storey JA, Phillips KE, Connolly DM, Green NDC, Stevenson AT.

Hemodynamic responses and G protection afforded by three different anti-G systems.

Aerosp Med Hum Perform. 2019 Nov;90(11):925-33.

Note: Centrifugation was used.



Jannas-Vela S, Brownell S, Petrick HL, Heigenhauser GJF, Spriet LL, Holloway GP.

Assessment of Na+/K+ ATPase activity in small rodent and human skeletal muscle samples.

Med Sci Sports Exerc. 2019 Nov;51(11):2403-9.



Luu BE, Lefai E, Giroud S, Swenson JE, Chazarin B, Gauquelin-Koch G, Arnemo JM, Evans AL, Bertile F, Storey KB.

MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears.

J Cell Physiol. 2019 Oct 23. [Epub ahead of print]



Jia H, Tian A, Zhang X, Ma X, Ma J, Wang J, Sun L, Lu B.

The effect of tail suspension and treadmill exercise on LRP6 expression, bone mass and biomechanical properties of hindlimb bones in SD rats.

Am J Transl Res. 2019 Sep 15;11(9):5847-57.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Kaupp S, Horan DJ, Lim KE, Feldman HA, Robling AG, Warman ML, Jacobsen CM.

Combination therapy in the Col2a1G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone.

Bone. 2019 Oct 21. [Epub ahead of print]



Metzger CE, Narayanan SA, Elizondo JP, Carter AM, Zawieja DC, Hogan HA, Bloomfield SA.

DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone.

Sci Rep. 2019 Oct 22;9(1):15144.

Note: This article may be obtained online without charge.



Rice H, Weir G, Trudeau MB, Meardon S, Derrick T, Hamill J.

Estimating tibial stress throughout the duration of a treadmill run.

Med Sci Sports Exerc. 2019 Nov;51(11):2257-64.



Xie Y, Zhang L, Xiong Q, Gao Y, Ge W, Tang P.

Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation.

Bone Res. 2019;7:25. Review.

Note: This article may be obtained online without charge.



Figtree WVC, Schubert MC, Migliaccio AA.

Horizontal vestibulo-ocular reflex gain measures during convergence using a monocular video technique.

Otol Neurotol. 2019 Oct 18. [Epub ahead of print]



Booker LA, Barnes M, Alvaro P, Collins A, Chai-Coetzer CL, McMahon M, Lockley SW, Rajaratnam SMW, Howard ME, Sletten TL.

The role of sleep hygiene in the risk of Shift Work Disorder in nurses.

Sleep. 2019 Oct 22. [Epub ahead of print]



Bai J, He X, Jiang Y, Zhang T, Bao M.

Rotating one’s head modulates the perceived velocity of motion aftereffect.

Multisens Res. 2019 Oct 10. [Epub ahead of print]

Note: This article may be obtained online without charge.



Grasso GS, Beretta EP, Miserocchi GA, Riva MA.

Rodolfo Margaria and the first walk on the Moon.

Aerosp Med Hum Perform. 2019 Nov;90(11):982-5.



Godard B.

The place of health innovation in space to improve the lives of earthlings.

Ann Civil Environ Eng. 2019 Aug 27;3(1):045-53.

Note: This article may be obtained online without charge.



Chawla R, Gupta R, Lele TP, Lele PP.

A skeptic’s guide to bacterial mechanosensing.

J Mol Biol. 2019 Oct 17. [Epub ahead of print]

Note: This article may be obtained online without charge.



Hu M, Lee W, Jiao J, Li X, Gibbons DE, Hassan CR, Tian GW, Qin YX.

Mechanobiological modulation of in situ and in vivo osteocyte calcium oscillation by acoustic radiation force.

Ann N Y Acad Sci. 2019 Oct 23. [Epub ahead of print]


SpaceRef staff editor.