Status Report

NASA Spaceline Current Awareness List #870 18 October 2019 (Space Life Science Research Results)

By SpaceRef Editor
October 18, 2019
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Kunz HE, Makedonas G, Mehta SK, Tyring SK, Vangipuram R, Quiriarte H, Nelman-Gonzalez M, Pierson DL, Crucian BE.

Zoster patients on Earth and astronauts in space share similar immunologic profiles.

Life Sci Space Res. 2019 Oct 14. [Article in Press]

Note: ISS results.

Journal Impact Factor: 2.066

Funding: “The study was funded by the NASA Human Research Program Human Health Countermeasures Element.”



Martin SA, Philbrick K, Wong CP, Olson DA, Branscum AJ, Jump D, Marik C, DenHerder J, Sargent J, Turner RT, Iwaniec UT.

Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice.

Endocr Connect. 2019 Oct 1. [Epub ahead of print]

PI: R.T. Turner

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.474

Funding: “This work was supported by the NIH (AR060913 [UI]; DK112360 [DBJ]) and NASA (80NSSC19K0430 [RT]).”



Pickett MT, Roberson L, Calabria J, Bullard T, Turner G, Yeh DH.

Regenerative water purification for space applications: needs, challenges, and technologies towards closing the loop.

Life Sci Space Res. 2019 Oct 15. [Article in Press]

Journal Impact Factor: 2.066

Funding: “We thank the U. S. National Science Foundation (Awards 1602087 and 1243510) and National Aeronautics and Space Administration (Grant 80NSSC18K1442) for support in the preparation of this paper.”




Other papers of interest:



Torres Menendez H, Heckel M, Sack A, Pöschel T.

X-ray tomography in micro-gravity.

Rev Sci Instrum. 2019 Oct;90(10):105103.

Note: Parabolic flight results. This article may be obtained online without charge.



Grimm D.

Guest Edited Collection: Gravitational Biology and Space Medicine.

Sci Rep. 2019 Oct 8;9(1):14399.

Note: This article introduces the Gravitational Biology and Space Medicine Collection at Scientific Reports. From the website: “This Collection focuses on the challenges to the health of humans in space during long-term space missions and the physiological changes during short-term altered gravity conditions.” The collection contains 23 studies; two appear in this issue of SPACELINE Current Awareness Lists, the rest have been cited in previous issues. The Collection can be found at The articles may be obtained online without charge.



Rashdan NA, Sim AM, Cui L, Phadwal K, Roberts FL, Carter R, Ozdemir DD, Hohenstein P, Hung J, Kaczynski J, Newby DE, Baker AH, Karsenty G, Morton NM, MacRae VE.

Osteocalcin regulates arterial calcification via altered Wnt signalling and glucose metabolism.

J Bone Miner Res. 2019 Oct 9. [Epub ahead of print]



Ahn CB, Lee JH, Han DG, Kang HW, Lee SH, Lee JI, Son KH, Lee JW.

Simulated microgravity with floating environment promotes migration of non-small cell lung cancers.

Sci Rep. 2019 Oct 10;9(1):14553.

Note: A 3D clinostat was used. This article may be obtained online without charge.



Bradley JH, Barwick S, Horn GQ, Ullrich E, Best B, Arnold JP, Gregg RK.

Simulated microgravity-mediated reversion of murine lymphoma immune evasion.

Sci Rep. 2019 Oct 10;9(1):14623.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Koaykul C, Kim MH, Kawahara Y, Yuge L, Kino-Oka M.

Maintenance of neurogenic differentiation potential in passaged bone marrow-derived human mesenchymal stem cells under simulated microgravity conditions.

Stem Cells Dev. 2019 Oct 5. [Epub ahead of print]

Note: A 3D clinostat was used.



Martin-Yebra A, Monasterio V, Landreani F, Laguna P, Martinez JP, Caiani EG.

Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization.

Physiol Meas. 2019 Oct 8. [Epub ahead of print]

Note: Head-down bed rest study.



Brem C, Lutz J, Vollmar C, Feuerecker M, Strewe C, Nichiporuk I, Vassilieva G, Schelling G, Choukér A.

Changes of brain DTI in healthy human subjects after 520 days isolation and confinement on a simulated mission to Mars.

Life Sci Space Res. 2019 Oct 15. [Article in Press]

Note: Results are from the MARS500 Project.



Marzuca-Nassr GN, Fortes MAS, Guimaraes-Ferreira L, Murata GM, Vitzel KF, Vasconcelos DAA, Bassit RA, Curi R.

Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension.

Braz J Med Biol Res. 2019 Oct 7;52(10):e8391.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Mobach T, Brooks J, Breiner A, Warman-Chardon J, Papp S, Gammon B, Nandedkar SD, Bourque PR.

Impact of disuse muscular atrophy on the compound muscle action potential.

Muscle Nerve. 2019 Oct 6. [Epub ahead of print]

Note: Casting of distal radius or scaphoid fractures was used to study the effects of immobilization of the arm.



Ackerman KE, Singhal V, Slattery M, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M.

Effects of estrogen replacement on bone geometry and microarchitecture in adolescent and young adult oligo-amenorrheic athletesA randomized trial. 

J Bone Miner Res. 2019 Oct 11. [Epub ahead of print]



Sun S, Sun L, Kang Y, Tang L, Qin YX, Ta D.

Therapeutic effects of low-intensity pulsed ultrasound on osteoporosis in ovariectomized rats: Intensity-dependent study.

Ultrasound Med Biol. 2019 Oct 4. [Epub ahead of print]

Note: Pulsed ultrasound was used.



Cucinotta FA, Cacao E.

Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions.

Life Sci Space Res. 2019 Oct 16. [Article in Press]



Sproull M, Shankavaram U, Camphausen K.

Comparison of proteomic biodosimetry biomarkers across five different murine strains.

Radiat Res. 2019 Oct 16. [Epub ahead of print]



Kuiper OX, Bos JE, Schmidt EA, Diels C, Wolter S.

Knowing what’s coming: Unpredictable motion causes more motion sickness.

Hum Factors. 2019 Oct 7. [Epub ahead of print]



Cirelli C, Tononi G.

Linking the need to sleep with synaptic function.

Science. 2019 Oct 11;366(6462):189-90.



Möller F, Hoffmann U, Dalecki M, Dräger T, Doppelmayr M, Steinberg F.

Physical exercise intensity during submersion selectively affects executive functions.

Hum Factors. 2019 Oct 9. [Epub ahead of print]



Jin Y, Guo W, Hu X, Liu M, Xu X, Hu F, Lan Y, Lv C, Fang Y, Liu M, Shi T, Ma S, Fang Z, Huang J.

Static magnetic field regulates Arabidopsis root growth via auxin signaling.

Sci Rep. 2019 Oct 7;9(1):14384.

Note: This article may be obtained online without charge.



Zhang Y, Friml J.

Auxin guides roots to avoid obstacles during gravitropic growth.

New Phytol. 2019 Oct 11. [Epub ahead of print]



Liu D, Xie B, Dong Y, Liu H.

Semi-continuous fermentation of solid waste in closed artificial ecosystem: Microbial diversity, function genes evaluation.

Life Sci Space Res. 2019 Oct 16. [Article in Press]



Gianoli F, Risler T, Kozlov AS.

The development of cooperative channels explains the maturation of hair cell’s mechanotransduction.

Biophys J. 2019 Oct 15;117(8):1536-48.

Note: This article may be obtained online without charge.



Harvey B.

Manned flight.

In: China in Space: The Great Leap Forward. Cham: Springer International Publishing, 2019. p. 359-442.

Note: The history of the Shenzhou Program is discussed.



Zhang HC, Patel J, Bhunia K, Al-Ghamdi S, Sonar CR, Ross CF, Tang JM, Sablani SS.

Color, vitamin C, β-carotene and sensory quality retention in microwave-assisted thermally sterilized sweet potato puree: Effects of polymeric package gas barrier during storage.

Food Packag Shelf Life. 2019 Sep;21:100324.

SpaceRef staff editor.