NASA Spaceline Current Awareness List #867 27 September 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Overbey EG, da Silveira WA, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW.
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.
Sci Rep. 2019 Sep 16;9(1):13304.
https://www.ncbi.nlm.nih.gov/
PI: X.W. Mao
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.011
Funding: “This study was supported by NASA Space Biology grant # NNX15AB41G and LLU Department of Basic Sciences. This work was also partially supported by the Ardmore Institute of Health grant 2150141 (C.W.) and Dr. Charles A. Sims’ gift to LLU Center for Genomics….G.H. acknowledges support from U01-DA045300 (NIDA) and SC EPSCoR. Authors would also like to thank Center for Dental Research for Micro-CT service.”
2
McNamara KP, Greene KA, Tooze JA, Dang J, Khattab K, Lenchik L, Weaver AA.
Neck muscle changes following long-duration spaceflight.
Front Physiol. 2019 Sep 13;10:1115.
https://www.frontiersin.org/
PI: A.A. Weaver
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.201
Funding: “This study was supported by the NASA Human Research Program (Award No. NNX16AP89G) and the National Science Foundation [REU Site: Imaging and Mechanics-Based Projects on Accidental Cases of Trauma (IMPACT), Award No. 1559700].”
3
Diaz-Artiles A, Navarro Tichell P, Perez F.
Cardiopulmonary responses to sub-maximal ergometer exercise in a hypo-gravity analog using head-down tilt and head-up tilt.
Front Physiol. 2019 Jun 17;10:720.
https://www.ncbi.nlm.nih.gov/
Note: Head-up and head-down tilt study. This article may be obtained online without charge.
Journal Impact Factor: 3.201
Funding: “This project was partially supported by the NASA/New York Space Grant Consortium – Faculty Grants (2017–2018).”
4
Tahimic CGT, Paul AM, Schreurs AS, Torres SM, Rubinstein L, Steczina S, Lowe M, Bhattacharya S, Alwood JS, Ronca AE, Globus RK.
Influence of social isolation during prolonged simulated weightlessness by hindlimb unloading.
Front Physiol. 2019 Sep 13;10:1147.
https://www.frontiersin.org/
PIs: R.K. Globus; S. Govind; R. Bodmer; A. Paul, A.-S. Schreurs, and L. Rubinstein, NASA Postdoctoral Fellowship Program
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 3.201
Funding: “This work was supported by grants from the NASA Space Biology Program NNH14ZTT001N (RG). SB was supported by the NASA Space Biology grants NNX15AB42G and NNX13AN38G. AP, AS, and LR were supported by fellowships from the NASA Space Biology Postdoctoral Program (NPP).”
5
Edmonds JW, Sackett JD, Lomprey H, Hudson HL, Moser DP.
The aeroponic rhizosphere microbiome: Community dynamics in early succession suggest strong selectional forces.
Antonie Van Leeuwenhoek. 2019 Sep 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 1.934
Funding: “This work was supported by a SEED Grant from Nevada’s National Aeronautics and Space Administration (NASA) Established Program to Stimulate Competitive Research, (EPSCoR) to Nevada State College, cooperative agreement number NNX13AB18A. Additional funding was provided by the Nevada State College provost office, the Desert Research Institute’s Clean Technologies and Renewable Energy Center (CTREC), and a Grant from the USDA (AWD-05-00000017) in collaboration with the University of Nevada Las Vegas.”
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Other papers of interest:
1
Maupin KA, Childress P, Brinker A, Khan F, Abeysekera I, Aguilar IN, Olivos DJ, Adam G, Savaglio MK, Ganesh V, Gorden R, Mannfeld R, Beckner E, Horan DJ, Robling AG, Chakraborty N, Gautam A, Hammamieh R, Kacena MA.
Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station.
npj Microgravity. 2019 Sep 24;5(1):21.
https://www.nature.com/
Note: ISS results. This article may be obtained online without charge.
2
Stervbo U, Roch T, Westhoff TH, Gayova L, Kurchenko A, Seibert FS, Babel N.
Repeated changes to the gravitational field negatively affect the serum concentration of select growth factors and cytokines.
Front Physiol. 2019 Apr 17;10:402.
https://www.ncbi.nlm.nih.gov/
Note: Parabolic flight results. This article may be obtained online without charge.
3
Yeung CK, Koenig P, Countryman S, Thummel KE, Himmelfarb J, Kelly EJ.
Tissue chips in space—Challenges and opportunities.
Clin Transl Sci. 2019 Sep 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
4
Steele J, Androulakis-Korakakis P, Perrin C, Fisher JP, Gentil P, Scott C, Rosenberger A.
Comparisons of resistance training and “cardio” exercise modalities as countermeasures to microgravity-induced physical deconditioning: New perspectives and lessons learned from terrestrial studies.
Front Physiol. 2019 Sep 10;10:1150. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
5
Imbert JP, Egi SM, Germonpre P, Balestra C.
Static metabolic bubbles as precursors of vascular gas emboli during divers’ decompression: A hypothesis explaining bubbling variability.
Front Physiol. 2019 Jul 11;10:807.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Childers CL, Tessier SN, Storey KB.
The heart of a hibernator: EGFR and MAPK signaling in cardiac muscle during the hibernation of thirteen-lined ground squirrels, Ictidomys tridecemlineatus.
PeerJ. 2019 Sep 5;7:e7587.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
7
Greaves D, Arbeille P, Guillon L, Zuj K, Caiani EG.
Effects of exercise countermeasure on myocardial contractility measured by 4D speckle tracking during a 21-day head-down bed rest.
Eur J Appl Physiol. 2019 Sep 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Head-up and head-down bed rest study.
8
Ludwig HC, Frahm J, Gärtner J, Dreha-Kulaczewski S.
Breathing drives CSF: Impact on spaceflight disease and hydrocephalus.
Proc Natl Acad Sci U S A. 2019 Sep 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on: Van Ombergen A, Jillings S, Jeurissen B, Tomilovskaya E, Rumshiskaya A, Litvinova L, Nosikova I, Pechenkova E, Rukavishnikov I, Manko O, Danylichev S, Rühl RM, Kozlovskaya IB, Sunaert S, Parizel PM, Sinitsyn V, Laureys S, Sijbers J, Zu Eulenburg P, Wuyts FL. Brain ventricular volume changes induced by long-duration spaceflight. Proc Natl Acad Sci U S A. 2019 May 21;116(21);10531-6. https://www.ncbi.nlm.nih.gov/
9
Zu Eulenburg P, Van Ombergen A, Tomilovskaya E, Wuyts FL.
Reply to Ludwig et al.: A potential mechanism for intracranial cerebrospinal fluid accumulation during long-duration spaceflight.
Proc Natl Acad Sci U S A. 2019 Sep 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors reply to #8 above. Both articles may be obtained online without charge.
10
Dong HS, Lan HY, Yu YB, Li HF, Lin JM.
Altered fecal microbiomes and short chain fatty acids of crew members with periodic intake of prepackaged food in a ground-based space station simulator for 50 days.
Travel Med Infect Dis. 2019 Sep 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
11
Liang F, Lv K, Wang Y, Yuan Y, Lu L, Feng Q, Jing X, Wang H, Liu C, Rayner S, Ling S, Chen H, Wan Y, Zhou W, He L, Wu B, Qu L, Chen S, Xiong J, Li Y.
Personalized epigenome remodeling under biochemical and psychological changes during long-term isolation environment.
Front Physiol. 2019 Jul 31;10:932.
https://www.ncbi.nlm.nih.gov/
Note: Data are from the Mars-500 Project. This article may be obtained online without charge.
12
Quan Y, Liang F, Zhu Y, Chen Y, Xu Z, Du F, Lv K, Chen H, Qu L, Xu R, Zhang HY, Xiong J, Li Y.
Integrated analysis of DNA methylation and biochemical/metabolic parameter during the long-term isolation environment.
Front Physiol. 2019 Jul 24;10:917.
https://www.ncbi.nlm.nih.gov/
Note: Data are from a 180-day closed ecological life support system (CELSS) experiment conducted in 2016. This article may be obtained online without charge.
13
Clark-Matott J, Nagy JA, Sanchez B, Taylor R, Riveros D, Abraham NA, Simon DK, Rutkove SB.
Altered muscle electrical tissue properties in a mouse model of premature aging.
Muscle Nerve. 2019 Sep 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
14
Iepsen UW, Pedersen BK.
Development of limb muscle dysfunction in COPD—Smoking, inflammation or simply disuse?
Am J Respir Cell Mol Biol. 2019 Sep 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Kim C, Kim MB, Hwang JK.
Red bean extract inhibits immobilization-induced muscle atrophy in C57BL/6N mice.
J Med Food. 2019 Sep 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimbs were immobilized via surgical staples.
16
Klotz T, Gizzi L, Yavuz US, Röhrle O.
Modelling the electrical activity of skeletal muscle tissue using a multi-domain approach.
Biomech Model Mechanobiol. 2019 Sep 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Reidy PT, Dupont-Versteegden EE, Drummond MJ.
Macrophage regulation of muscle regrowth from disuse in aging.
Exerc Sport Sci Rev. 2019 Oct;47(4):246-50.
https://www.ncbi.nlm.nih.gov/
18
Stierwalt HD, Ehrlicher SE, Robinson MM, Newsom SA.
Diet and exercise training influence skeletal muscle long-chain acyl-CoA synthetases.
Med Sci Sports Exerc. 2019 Sep 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
19
Ulanova A, Gritsyna Y, Salmov N, Lomonosova Y, Belova S, Nemirovskaya T, Shenkman B, Vikhlyantsev I.
Effect of L-arginine on titin expression in rat soleus muscle after hindlimb unloading.
Front Physiol. 2019 Sep 20;10:1221.
https://www.frontiersin.org/
Note: Hindlimb unloading study. This article may be obtained online without charge.
20
Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Kumar Yadav V, Rahmouni K, Gao XB, Karsenty G.
Mediation of the acute stress response by the skeleton.
Cell Metab. 2019 Sep 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
21
Morse A, Ko F, McDonald MM, Lee L, Schindeler A, van der Meulen MCH, Little DG.
Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading.
Bone. 2019 Sep 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
22
Abbasi S, Mortazavi SAR, Mortazavi SMJ.
Martian residents: Mass media and Ramsar high background radiation areas.
J Biomed Phys Eng. 2019 Aug;9(4):483-6.
https://www.ncbi.nlm.nih.gov/
Note: The authors suggest that, due to high natural radioactivity in the area, Ramsar, Iran, can be used as a model for possible health effects of radiation dosage on Mars. This article may be obtained online without charge.
23
Brahme A, Hultén M, Bengtsson C, Hultgren A, Zetterberg A.
Radiation-induced chromosomal breaks may be DNA repair fragile sites with larger-scale correlations to eight double-strand-break related data sets over the human genome.
Radiat Res. 2019 Sep 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
24
Lund M, Jevremovic T.
Enhanced GEANT4 Monte Carlo simulations of the space radiation effects on the International Space Station and Apollo missions using high-performance computing environment.
Acta Astronaut. 2019 Dec;165:219-28. Epub 2019 Sep 19.
http://www.sciencedirect.com/
25
Smith CM.
Principles of Space Anthropology: Establishing a Science of Human Space Settlement.
Chaum, Switzerland: Springer, 2019. 364 p.
https://www.springer.com/gp/
Note: The author explores how humans adapt and how it may affect space settlement. Chapters include: An Introduction to space anthropology, Individual hominin biology beyond Earth, Population genetics of human space settlement, Cultural adaptations in human space settlement, Humanity and the migration experience beyond Earth, Adaptive lessons from ancient technologies and culture, and Human adaptation and permanent human space settlement.
26
Alfieri R, Vassalli M, Viti F.
Flow-induced mechanotransduction in skeletal cells.
Biophys Rev. 2019 Sep 16. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
27
Cannon KM, Britt DT.
Feeding one million people on Mars.
New Space. 2019 Aug 30. [Article in Press]
https://www.liebertpub.com/
Note: The authors examine methods to produce enough food to sustain a population on Mars that approached 1,000,000 people.
