NASA Spaceline Current Awareness List #860 9 August 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Bretl KN, McCusker AT, Sherman SO, Mitchell TR, Dixon JB, Clark TK.
Tolerable acclimation to the cross-coupled illusion through a 10-day, incremental, personalized protocol.
J Vestib Res. 2019;29(2-3):97-110.
https://www.ncbi.nlm.nih.gov/
Note: A short-radius centrifuge was used.
Journal Impact Factor: 2.865
Funding: “This work was supported by a NASA Space Technology Research Fellowship.”
2
Yuan M, Wang Y, Qin YX.
Engineered nanomedicine for neuroregeneration: Light emitting diode-mediated superparamagnetic iron oxide-gold core-shell nanoparticles functionalized by nerve growth factor.
Nanomedicine. 2019 Jul 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: Y.X. Qin
Journal Impact Factor: 5.570
Funding: “This work was supported by the U.S. National Science Foundation CAREER program [grant number 1751435], the U.S. Department of Energy ARPA-E [grant numbers DE-AR0000531 and DE-AR0000945], the National Institutes of Health [grant numbers R01 AR 52379 and AR 61821), and the National Space Biomedical Research Institute through NASA Contract [grant number NCC 9-58].”
3
Diaz Artiles A, Heldt T, Young LR.
Computational model of cardiovascular response to centrifugation and lower-body cycling exercise.
J Appl Physiol (1985). 2019 Jul 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: L.R. Young
Note: Centrifugation was used.
Journal Impact Factor: 3.140
Funding: “This project was supported by the MIT/Skolkovo development project (Seed Grant 6925991), and the National Space Biomedical Research Institute through NASA NCC 9-58. In addition, the Fulbright Commission has provided additional support.”
4
Guo G, Gong K, Puliyapaddamba VT, Panchani N, Pan E, Mukherjee B, Damanwalla Z, Bharia S, Hatanpaa KJ, Gerber DE, Mickey BE, Patel TR, Sarkaria JN, Zhao D, Burma S, Habib AA.
Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma.
Neuro Oncol. 2019 Jul 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: S. Burma
Note: This article may be obtained online without charge.
Journal Impact Factor: 10.091
Funding: “This work was supported in part by the Office of Medical Research, Departments of Veterans Affairs, and from the Dallas VA Research Corporation (AAH), by NIH grant 1R01CA194578 to DZ. SB is supported by grants from the National Institutes of Health (RO1CA197796 and R21CA202403) and NASA (NNX16AD78G).”
5
Rosa-Caldwell ME, Brown JL, Perry RA Jr, Shimkus KL, Shirazi-Fard Y, Brown LA, Hogan HA, Fluckey JD, Washington TA, Wiggs MP, Greene NP.
Regulation of mitochondrial quality following repeated bouts of hindlimb unloading.
Appl Physiol Nutr Metab. 2019 Jul 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: H.A. Hogan
Note: Hindlimb unloading study.
Journal Impact Factor: 2.518
Funding: “Funded by NASA Grant Number NNX08AQ35G and NIH R15AR069913/ AR/NIAMS.”
6
Acharya MM, Baulch JE, Klein PM, Baddour AAD, Apodaca LA, Kramar EA, Alikhani L, Garcia C Jr, Angulo MC, Batra RS, Fallgren CM, Borak TB, Stark CEL, Wood MA, Britten RA, Soltesz I, Limoli CL.
New concerns for neurocognitive function during deep space exposures to chronic, low dose rate, neutron radiation.
eNeuro. 2019 Aug 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: C.L. Limoli/M.M. Acharya/J.E. Baulch/R.A. Britten/I. Soltesz/NSCOR; M. Weil/T.B. Borak/NSCOR
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by UCI Institute for Clinical and Translational Sciences (ICTS) KL2 training award KL2TR001416 (MMA), NASA Specialized Center of Research (NSCOR) grant NNX15AK13G for funding the neutron irradiator and NASA Specialized Center of Research (NSCOR) grant NNX15AI22G (RAB, IS, CLL).”
7
Luitel K, Kim SB, Barron S, Richardson JA, Shay JW.
Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention.
Life Sci Space Res. 2019 Aug 1. [Article in Press]
http://www.sciencedirect.com/
PIs: J.W. Shay; A.J. Fornace/J.W. Shay/NSCOR
Journal Impact Factor: 2.066
Funding: “This work was supported by NASA Grants # NNX16AE08G and NNX15AI21G to J.W.S. K.L. was supported by Cancer Training Grant T32CA124334. This work was performed in laboratories constructed with support from NIH grant C06 RR30414.”
8
Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB.
An exploration of the temporal dynamics of circadian resetting responses to short- and long-duration light exposures: Cross-species consistencies and differences.
J Biol Rhythms. 2019 Aug 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: E.B. Klerman, C.A. Czeisler
Journal Impact Factor: 2.473
Funding: “The work presented in this study was funded by NSBRI HFP02802 and NIH P01-AG009975, R01-HL114088 (E.B.K.), RC2-HL101340-0 (R.E.K., S.A.R., E.B.K.), K02-HD045459 (E.B.K.), K24-HL105664 (E.B.K.), T32-HL07901 (M.S.H., S.A.R.), R01-HL094654 (C.A.C.). The human studies described in this work were supported by National Institutes of Health grants R01-MH045130, R01-HL077453, 1UL1-TR001102-01, 8UL1-TR000170-05, and UL1-RR025758, Harvard Clinical and Translational Science Center, from the National Center for Advancing Translational Science, and the National Aeronautics and Space Administration grant NAG 5-3952.”
9
Pendergraft JG, Carter DR, Tseng S, Landon LB, Slack KJ, Shuffler ML.
Learning from the past to advance the future: The adaptation and resilience of NASA’s spaceflight multiteam systems across four eras of spaceflight.
Front Psychol. 2019 Jul 12;10:1633.
https://www.ncbi.nlm.nih.gov/
PI: D.R. Carter
Note: This case study of the NASA’s Spaceflight Multiteam Systems (SFMTSs) looks at human spaceflight history of SFMTSs and how that might impact future long-duration mission challenges. This article may be obtained online without charge.
Journal Impact Factor: 2.129
Funding: “This study is based in part upon work supported by the National Aeronautics and Space Administration (#80NSSC18K0511).”
10
Phelan MA, Gianforcaro AL, Gerstenhaber JA, Lelkes PI.
An air bubble-isolating rotating wall vessel bioreactor for improved spheroid/organoid formation.
Tissue Eng Part C Methods. 2019 Aug;25(8):479-88.
https://www.ncbi.nlm.nih.gov/
PI: P.I. Lelkes
Note: A rotating wall vessel bioreactor was used.
Journal Impact Factor: 2.638
Funding: “Our research is supported by the National Aeronautics and Space Agency (NASA), Grant # 80NSSC18K1480 and the Intramural Research Program of the National Eye Institute (EY000450, EY000474, EY000546).”
______________________________
Other papers of interest:
1
Mann V, Sundaresan A, Chaganti M.
Cellular changes in the nervous system when exposed to gravitational variation.
Neurol India. 2019 May-Jun;67(3):684-91. Review.
https://www.ncbi.nlm.nih.gov/
Note: ISS results are discussed. This article may be obtained online without charge.
2
Kuznetsov MS, Lisukov AN, Rizvanov AA, Tyapkina OV, Gusev OA, Rezvyakov PN, Kozlovskaya IB, Tomilovskaya ES, Nikolskiy EE, Islamov RR.
Bioinformatic study of transcriptome changes in the mice lumbar spinal cord after the 30-day spaceflight and subsequent 7-day readaptation on Earth: New insights into molecular mechanisms of the hypogravity motor syndrome.
Front Pharmacol. 2019 Jul 11;10:747.
https://www.ncbi.nlm.nih.gov/
Note: Bion-M1 results. This article may be obtained online without charge.
3
Pechenkova E, Nosikova I, Rumshiskaya A, Litvinova L, Rukavishnikov I, Mershina E, Sinitsyn V, Van Ombergen A, Jeurissen B, Jillings S, Laureys S, Sijbers J, Grishin A, Chernikova L, Naumov I, Kornilova L, Wuyts FL, Tomilovskaya E, Kozlovskaya I.
Alterations of functional brain connectivity after long-duration spaceflight as revealed by fMRI.
Front Physiol. 2019 Jul 4;10:761.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. This article may be obtained online without charge.
4
Welsh J, Bevelacqua JJ, Keshavarz M, Mortazavi SAR, Mortazavi SMJ.
Is telomere length a biomarker of adaptive response in space? Curious findings from NASA and residents of high background radiation areas.
J Biomed Phys Eng. 2019 Jun;9(3):381-8.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. The authors discuss results from the NASA Twins Study. This article may be obtained online without charge.
5
Kong Y, Liu H, Li W, Wang D.
Intestine-specific activity of insulin signaling pathway in response to microgravity stress in Caenorhabditis elegans.
Biochem Biophys Res Commun. 2019 Jul 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: A rotary cell culture system was used.
6
Wang X, Watt CF, Sinclair KJ, McKenzie CA, Staples JF, MacCannell ADV.
Thermoneutral temperature reduces liver volume but increases fat content in a mammalian hibernator.
J Therm Biol. 2019 Jul;83:172-7.
https://www.ncbi.nlm.nih.gov/
7
Arun RP, Sivanesan D, Patra B, Varadaraj S, Verma RS.
Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP.
Sci Rep. 2019 Jul 23;9(1):10684.
https://www.ncbi.nlm.nih.gov/
Note: A rotary cell culture system was used. This article may be obtained online without charge.
8
Bonfiglio T, Biggi F, Bassi AM, Ferrando S, Gallus L, Loiacono F, Ravera S, Rottigni M, Scarfi S, Strollo F, Vernazza S, Sabbatini M, Masini MA.
Simulated microgravity induces nuclear translocation of Bax and BCL-2 in glial cultured C6 cells.
Heliyon. 2019 Jun;5(6):e01798.
https://www.ncbi.nlm.nih.gov/
Note: A 3D random positioning machine was used. This article may be obtained online without charge.
9
Dietz C, Infanger M, Romswinkel A, Strube F, Kraus A.
Apoptosis induction and alteration of cell adherence in human lung cancer cells under simulated microgravity.
Int J Mol Sci. 2019 Jul 23;20(14):E3601.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used. This article may be obtained online without charge.
10
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Apoptosis. 2019 Jul 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: A 2D clinostat was used. This article may be obtained online without charge.
11
Sun Y, Zhang L, Liu J, Zhang X, Su Y, Yin Q, He S.
Effects of lunar dust simulant on cardiac function and fibrosis in rats.
Toxicol Res (Camb). 2019 Jul 1;8(4):499-508.
https://www.ncbi.nlm.nih.gov/
12
Wostyn P, Mader TH, Gibson CR, De Deyn PP.
The buffering capacity of the brain and optic nerve against spaceflight-associated neuro-ocular syndrome.
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15770-1.
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on the article: Van Ombergen A, Jillings S, Jeurissen B, Tomilovskaya E, Rumshiskaya A, Litvinova L, Nosikova I, Pechenkova E, Rukavishnikov I, Manko O, Danylichev S, Rühl RM, Kozlovskaya IB, Sunaert S, Parizel PM, Sinitsyn V, Laureys S, Sijbers J, Zu Eulenburg P, Wuyts FL. Brain ventricular volume changes induced by long-duration spaceflight. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10531-6. https://www.ncbi.nlm.nih.gov/
13
Van Ombergen A, Jillings S, Tomilovskaya E, Wuyts FL, Zu Eulenburg P.
Reply to Wostyn et al.: Investigating the spaceflight-associated neuro-ocular syndrome and the human brain in lockstep.
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15772-3.
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on: Wostyn P, Mader TH, Gibson CR, De Deyn PP. The buffering capacity of the brain and optic nerve against spaceflight-associated neuro-ocular syndrome. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15770-1. https://www.ncbi.nlm.nih.gov/
14
Ko CL, Lin JA, Chen KY, Hsu AC, Wu SY, Tai YT, Lin KH, Chung WC, Li MH.
Netrin-1 dampens hypobaric hypoxia-induced lung injury in mice.
High Alt Med Biol. 2019 Jul 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Sozzi S, Nardone A, Schieppati M.
Vision does not necessarily stabilize the head in space during continuous postural perturbations.
Front Neurol. 2019 Jul 10;10:748.
https://www.ncbi.nlm.nih.gov/
Note: A moving platform was used. This article may be obtained online without charge.
16
Chen B, Zhang YS, Li G, Cho JL, Deng YL, Li YJ.
The impacts of simulated microgravity on rat brain depended on durations and regions.
Biomed Environ Sci. 2019 Jul;32(7):496-507.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
17
Hides J, Hodges P, Lambrecht G.
State-of-the-art exercise concepts for lumbopelvic and spinal muscles—Transferability to microgravity.
Front Physiol. 2019 Jul 4;10:837. Review.
https://www.ncbi.nlm.nih.gov/
Note: This mini review draws parallels between changes that occur to the neuromuscular system in microgravity and conditions such as low back pain (LBP) that occur on Earth. Drawing these parallels between the changes in microgravity and which exercises best restore size and function could help health professionals tailor improved interventions for terrestrial populations. This article may be obtained online without charge.
18
Holloway TM, McGlory C, McKellar S, Morgan A, Hamill M, Afeyan R, Comb W, Confer S, Zhao P, Hinton M, Kubassova O, Chakravarthy MV, Phillips SM.
A novel amino acid composition ameliorates short-term muscle disuse atrophy in healthy young men.
Front Nutr. 2019 Jul 10;6:105.
https://www.ncbi.nlm.nih.gov/
Note: Unilateral knee immobilization was used. This article may be obtained online without charge.
19
Song J, Baer LA, Threlkeld MRS, Geng C, Wade CE, Wolf SE.
Insulin and exercise improved muscle function in rats with severe burns and hindlimb unloading.
Physiol Rep. 2019 Jul;7(14):e14158.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
20
Sundberg CW, Fitts RH.
Bioenergetic basis of skeletal muscle fatigue.
Curr Opin Physiol. 2019 Aug;10:118-27. Review.
https://www.ncbi.nlm.nih.gov/
21
Wyckelsma VL, Perry BD, Bangsbo J, McKenna MJ.
Inactivity and exercise training differentially regulate the abundance of Na+, K+-ATPase in human skeletal muscle.
J Appl Physiol (1985). 2019 Aug 1. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
22
Bernhardt A, Wolf S, Weiser E, Vater C, Gelinsky M.
An improved method to isolate primary human osteocytes from bone.
Biomed Tech (Berl). 2019 Jul 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
23
Lad SE, McGraw WS, Daegling DJ.
Haversian remodeling corresponds to load frequency but not strain magnitude in the macaque (Macaca fascicularis) skeleton.
Bone. 2019 Jul 25;127:571-6.
https://www.ncbi.nlm.nih.gov/
24
Schreivogel S, Kuchibhotla V, Knaus P, Duda GN, Petersen A.
Load-induced osteogenic differentiation of mesenchymal stromal cells is caused by mechano-regulated autocrine signaling.
J Tissue Eng Regen Med. 2019 Jul 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
25
Tamaki H, Yotani K, Ogita F, Hayao K, Kirimto H, Onishi H, Kasuga N, Yamamoto N.
Low-frequency electrical stimulation of denervated skeletal muscle retards muscle and trabecular bone loss in aged rats.
Int J Med Sci. 2019 Jun 2;16(6):822-30.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
26
Weinkamer R, Eberl C, Fratzl P.
Mechanoregulation of bone remodeling and healing as inspiration for self-repair in materials.
Biomimetics (Basel). 2019 Jul 9;4(3):E46.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge at: https://www.mdpi.com/2313-
27
Calvi LM, Frisch BJ, Kingsley PD, Koniski AD, Love TM, Williams JP, Palis J.
Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.
Int J Radiat Biol. 2019 Jul 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
28
Laiakis EC, Nishita D, Bujold K, Jayatilake MM, Bakke J, Gahagen J, Authier S, Chang P, Fornace AJ Jr.
Salivary metabolomics of total body irradiated non-human primates reveals long term normal tissue responses to radiation.
Int J Radiat Oncol Biol Phys. 2019 Jul 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
29
Li S, Lu X, Feng JB, Tian M, Wang J, Chen H, Chen DQ, Liu QJ.
Developing gender-specific gene expression biodosimetry using a panel of radiation-responsive genes for determining radiation dose in human peripheral blood.
Radiat Res. 2019 Aug 2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
30
Rørvik E, Thörnqvist S, Ytre-Hauge KS.
The experimental dose ranges influence the LETd dependency of the proton minimum RBE (RBEmin).
Phys Med Biol. 2019 Jul 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
31
Rinaudo CN, Schubert MC, Figtree WVC, Todd CJ, Migliaccio AA.
Human vestibulo-ocular reflex adaptation is frequency-selective.
J Neurophysiol. 2019 Jul 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
32
Stone JE, Aubert XL, Maass H, Phillips AJK, Magee M, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL.
Application of a limit-cycle oscillator model for prediction of circadian phase in rotating night shift workers.
Sci Rep. 2019 Jul 30;9(1):11032.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
33
Stone JE, Phillips AJK, Ftouni S, Magee M, Howard M, Lockley SW, Sletten TL, Anderson C, Rajaratnam SMW, Postnova S.
Generalizability of a neural network model for circadian phase prediction in real-world conditions.
Sci Rep. 2019 Jul 29;9(1):11001.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
34
Lee HJ, Kim HS, Park JM, Cho HS, Jeon JH.
PIN-mediated polar auxin transport facilitates root obstacle avoidance.
New Phytol. 2019 Jul 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
35
Michniewicz M, Ho CH, Enders TA, Floro E, Damodaran S, Gunther LK, Powers SK, Frick EM, Topp CN, Frommer WB, Strader LC.
TRANSPORTER OF IBA1 links auxin and cytokinin to influence root architecture.
Dev Cell. 2019 Jul 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
36
Zhang Y, Xiao G, Wang X, Zhang X, Friml J.
Evolution of fast root gravitropism in seed plants.
Nat Commun. 2019 Aug 2;10(1):3480.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
37
Yang L, Li H, Liu Ti, Zhong Y, Ji C, Lu Q, Fan L, Li J, Leng L, Li K, Zhou W.
Microalgae biotechnology as an attempt for bioregenerative life support systems: Problems and prospects.
J Chem Technol Biotechnol. 2019 Jul 22. [Article in Press] Review.
https://onlinelibrary.wiley.
38
Semin N.
One giant step for physicians: A Texas physician’s role in space-race medicine.
Tex Med. 2019 Aug 1;115(8):32-5.
https://www.ncbi.nlm.nih.gov/
Note: The author recounts contributions of Lawrence Lamb, MD, to the Apollo Program.
39
Kim J, Kim G, Park J, Wang Y, Lim H.
Effectiveness of teacher-led nutritional lessons in altering dietary habits and nutritional status in preschool children: Adoption of a NASA Mission X-Based Program.
Nutrients. 2019 Jul 13;11(7):E1590.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
40
Mullen T, Twist C, Highton J.
Stochastic ordering of simulated rugby match activity produces reliable movements and associated measures of subjective task load, cognitive and neuromuscular function.
J Sports Sci. 2019 Jul 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
41
Nickman NA, Drews FA, Tyler LS, Kelly MP, Ragsdale RJ, Rim M.
Use of multiple methods to measure impact of a centralized call center on academic health system community pharmacies.
Am J Health Syst Pharm. 2019 Feb 21;76(6):353-9.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
