Status Report

NASA Spaceline Current Awareness List #859 26 July 2019 (Space Life Science Research Results)

By SpaceRef Editor
July 26, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Please note: The next issue of SPACELINE Current Awareness (List #860) will be sent on August 9.


Papers deriving from NASA support:



Bryan NC, Christner BC, Guzik TG, Granger DJ, Stewart MF.

Abundance and survival of microbial aerosols in the troposphere and stratosphere.

ISME J. 2019 Jul 17. [Epub ahead of print]

Note: Balloon flight results.

Journal Impact Factor: 9.493

Funding: “This work was supported by a grant from the National Aeronautics and Space Administration (NNX10AN07A), Established Program to Stimulate Competitive Research (EPSCoR), and the Louisiana Board of Regents (to BC and TG). Partial support was also provided by a Graduate Student Research Assistance Award from the Louisiana Space Grant Consortium (to NB) and from NSF awards 1241161 and 1643288 (to BC). Flight operations in Texas and New Mexico were supported by the NASA Balloon Program Office (BPO), the Columbia Scientific Balloon Facility (CSBF), and the High Altitude Student Platform (HASP).”



Fu Q, Shibata S, Hastings JL, Platts SH, Hamilton DM, Bungo MW, Stenger MB, Ribeiro C, Adams-Huet B, Levine BD.

Impact of prolonged spaceflight on orthostatic tolerance during ambulation, and blood pressure profiles in astronauts.

Circulation. 2019 Jul 19. [Epub ahead of print]

PI: B.D. Levine

Note: ISS results.

Journal Impact Factor: 23.054

Funding: “This study was funded by the National Aeronautics and Space Administration (NASA) grant NNJ04HH01A to Drs. Levine and Bungo.”



Caro TA, Wendeln M, Freeland M, Bryan N, Waters SM, McIntyre A, Nicoll P, Madronich S, Smith DJ.

Ultraviolet light measurements (280–400 nm) acquired from stratospheric balloon flight to assess influence on bioaerosols.

Aerobiologia. 2019 June 24. [Article in Press]

PI: D.J. Smith

Note: Balloon flight results.

Journal Impact Factor: 1.931

Funding: “Our study was supported by the NASA Astrobiology Program and a grant from NASA Planetary Protection (15-PPR15-0007).” PI reports funding through NNH16ZTT001N-MS, PS, AB.



Clément G, Wood SJ, Paloski WH, Reschke MF.

Changes in gain of horizontal vestibulo-ocular reflex during spaceflight.

J Vestib Res. 2019 Jul 6. [Epub a head of print]

PI: M.F. Reschke

Note: Space Shuttle results.

Journal Impact Factor: 2.774

Funding: “This study was supported by the National Aeronautics and Space Administration (NASA).”



Romsdahl J, Wang CCC.

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

Medchemcomm. 2019 Jun 1;10(6):840-66. Review.

PI: C.C.C. Wang

Journal Impact Factor: 2.394

Funding: “Research in the Wang group is supported in part by R21 AI127640 from the National Institute of Allergy and Infectious Diseases, by NNX15AB49G from the National Aeronautics and Space Administration, and by WP-2339 from the U.S. Department of Defense, Strategic Environmental Research and Development Program.”



Singh NK, Wood JM, Mhatre SS, Venkateswaran K.

Correction to: Metagenome to phenome approach enables isolation and genomics characterization of Kalamiella piersonii gen. nov., sp. nov. from the International Space Station.

Appl Microbiol Biotechnol. 2019 Jul 13. [Epub ahead of print]

PI: K. Venkateswaran

Note: The authors correct a taxonomic description format error. The correction may be obtained online without charge. The original article appeared in SPACELINE Current Awareness List #847, 3 May 2019,

Journal Impact Factor: 3.670

Funding: From the original article: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with National Aeronautics and Space Administration. This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the post-doctoral fellowships for NKS, JMW and SSM.”



Zeitlin C, Hassler DM, Ehresmann B, Rafkin SCR, Guo J, Wimmer-Schweingruber RF, Berger T, Matthiä D.

Measurements of radiation quality factor on Mars with the Mars Science Laboratory Radiation Assessment Detector.

Life Sci Space Res. 2019 Jul 19. [Article in Press] 

Journal Impact Factor: 2.066

Funding: “This work was supported at the NASA Johnson Space Center by the NASA Human Health and Performance Contract, NNJ15HK11B. The MSL-RAD project is supported in the United States by the National Aeronautics and Space Administration’s Human Exploration and Operations Mission Directorate, under Jet Propulsion Laboratory subcontract 1273039 to Southwest Research Institute, and in Germany by the German Aerospace Center (DLR) and DLR’s Space Administration grant numbers 50QM0501, 50QM1201, and 50QM1701 to the Christian Albrechts University, Kiel.”



Doarn CR, Travis TW, Currie-Gregg NK, Nicogossian AE, Weyland M, Shepanek M, Null C, Buckland DM, Miller SB, Liskowsky D, Fuller D, Francisco D, Walton M, Antonsen E, Rochlis J, Witt EG, Williams RS. 

Engineering, life sciences, and health/medicine synergy in aerospace human systems integration: The Rosetta Stone Project—An executive summary.

New Space. 2019 Jun;7(2):110-3.

Note: The article is the Executive Summary of the NASA report: Williams RS, Doarn CR, editors. Engineering, Life Sciences, and Health/Medicine Synergy in Aerospace Human Systems Integration: The Rosetta Stone Project, Washington, DC: National Aeronautics and Space Administration, 2017. 142 p. NASA/SP-2017-633. It is available without charge through the NASA Technical Reports Server (NTRS) at

Journal Impact Factor: Not available for this journal

Funding: No funding cited. Most of the authors have affiliations with NASA Headquarters and NASA Centers.



Romoser AA, Ryder VE, McCoy JT.

Spacecraft maximum allowable concentrations for manganese compounds in Mars dust.

Aerosp Med Hum Perform. 2019 Aug 1;90(8):709-19. Review.

Journal Impact Factor: 0.889

Funding: No funding cited. V.E. Ryder and J.T. McCoy are affiliated with NASA Johnson Space Center.



Snyder JE, Walsh D, Carr PA, Rothschild LJ.

A makerspace for life support systems in space.

Trends Biotechnol. 2019 Jul 4. [Epub ahead of print]

Journal Impact Factor: 13.578

Funding: “The authors are grateful to the Game Changing Division of the NASA HQ Science Technology Mission Directorate (STMD) to conduct this study.”



Lin YC, Chen HJ, Wang Y, Min J, Wu HC, Carvajal NA, Yang HY.

NASA Mission X program for healthy eating and active living among Taiwanese elementary school students.

J Pediatr Nurs. 2019 Jul 12. [Epub ahead of print]

Journal Impact Factor: 1.563

Funding: “The study was supported by Taiwan Ministry of Science and Technology (MOST 104-2314-B-715-006-MY3, MOST 105-2314-B-010 -012) and Mackay Medical College (1051B10, 1052B05). The authors thank Professor Wen-Harn Pan’s for her review and comments on the first draft of the manuscript. Drs. Youfa Wang and Jungwon Min’s effort was funded in part by the National Institutes of Health (NIH, U54 HD070725) and the US National Aeronautics and Space Administration (NASA). The U54 project (U54 HD070725) is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the Office of the Director, National Institutes of Health (OD).”




Other papers of interest:



Hoffmann U, Koschate J, Appell Coriolano HJ, Drescher U, Thieschafer L, Dumitrescu D, Werner A.

Adaptation of systemic and pulmonary circulation to acute changes in gravity and body position.

Aerosp Med Hum Perform. 2019 Aug 1;90(8):688-95.

Note: Parabolic flight results. A tilt seat and long arm human centrifuge were used.



Holubarsch J, Helm M, Ringhof S, Gollhofer A, Freyler K, Ritzmann R.

Stumbling reactions in hypo and hyper gravity – muscle synergies are robust across different perturbations of human stance during parabolic flights.

Sci Rep. 2019 Jul 19;9(1):10490.

Note: Parabolic flight results. This article may be obtained online without charge.



Fukazawa T, Tanimoto K, Shrestha L, Imura T, Takahashi S, Sueda T, Hirohashi N, Hiyama E, Yuge L.

Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells.

PLoS One. 2019 Jul 19;14(7):e0219363.

Note: A 3D-clinostat was used. This article may be obtained online without charge.



Ogneva IV, Usik MA, Biryukov NS, Kremenetskii NO, Zhdankina YS.

Modeling of the primary acts of the interaction between a cell and an external mechanical field.

Appl Math (AM). 2019 Jul;10(7):527-44.



Shao J, Li Z, Zhou J, Li K, Qin R, Chen K.

[Effect of low-frequency pulsed electromagnetic fields on activity of rat calvarial osteoblasts through IGF-1R/NO signaling pathway].

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Apr 25;48(2):158-64. Chinese.



Horve PF, Lloyd S, Mhuireach GA, Dietz L, Fretz M, MacCrone G, Van Den Wymelenberg K, Ishaq SL.

Building upon current knowledge and techniques of indoor microbiology to construct the next era of theory into microorganisms, health, and the built environment.

J Expo Sci Environ Epidemiol. 2019 Jul 15. [Epub ahead of print] Review.

Note: The presence of certain microorganisms on the International Space Station is discussed.



Jiang C, Guo D, Li Z, Lei S, Shi J, Shao D.

Metabolomics differential analysis reveals clinostat rotation affects metabolite transportation and increases organic acid production of Aspergillus carbonarius.

Appl Environ Microbiol. 2019 Jul 12. [Epub ahead of print]

Note: A clinostat was used.



Wostyn P.

“Houston, we have a problem”: “We are losing our eyesight.”

Exp Eye Res. 2019 Jul 14;186:107725.

Note: The author comments on recent research regarding cerebrospinal fluid transport in the optic nerve and its relevance to neuro-ocular changes experienced by astronauts who have flown long duration missions aboard the International Space Station.



Boppart MD, Mahmassani ZS.

Integrin signaling: Linking mechanical stimulation to skeletal muscle hypertrophy.

Am J Physiol Cell Physiol. 2019 Jul 17. [Epub ahead of print] Review.



He MY, Xu SB, Qu ZH, Guo YM, Liu XC, Cong XX, Wang JF, Low BC, Li L, Wu Q, Lin P, Yan SG, Bao Z, Zhou YT, Zheng LL.

Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.

Aging Cell. 2019 Jul 17. [Epub ahead of print]

Note: This article may be obtained online without charge.



Miller BF, Baehr LM, Musci RV, Reid JJ, Peelor FF 3rd, Hamilton KL, Bodine SC.

Muscle-specific changes in protein synthesis with aging and reloading after disuse atrophy.

J Cachexia Sarcopenia Muscle. 2019 Jul 16. [Epub ahead of print]

Note: Hindlimb unloading study. This article may be obtained online without charge.



Mochalova EP, Belova SP, Mirzoev TM, Shenkman BS, Nemirovskaya TL.

Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase 1 in rat soleus muscle under hindlimb unloading.

Sci Rep. 2019 Jul 16;9(1):10263.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Wei Y, Okazaki YO, So RHY, Chu WCW, Kitajo K.

Motion sickness-susceptible participants exposed to coherent rotating dot patterns show excessive N2 amplitudes and impaired theta-band phase synchronization.

Neuroimage. 2019 Jul 18. [Epub ahead of print]



Fong K.

Moon landing: Space medicine and the legacy of Project Apollo.

Lancet. 2019 Jul 20;394(10194):205-7.

Note: This article may be obtained online without charge with registration at The Lancet website:



Sirek A, Samoil K, Harrison MF.

Space medicine training in Canada.

Aerosp Med Hum Perform. 2019 Aug 1;90(8):725-9.



Wahby M, Heinrich MK, Hofstadler DN, Petzold J, Kuksin I, Zahadat P, Schmickl T, Ayres P, Hamann H.

Robotic sensing and stimuli provision for guided plant growth.

J Vis Exp. 2019 Jul 1(149):e59835.

Note: This article may be obtained online without charge.



Demmig-Adams B, Stewart JJ, Adams WW 3rd.

Less photoprotection can be good in some genetic and environmental contexts.

Biochem J. 2019 Jul 18;476(14):2017-29. Review.



Moulia B, Bastien R, Chauvet-Thiry H, Leblanc-Fournier N.

Posture control in land plants: Growth, position sensing, proprioception, balance, and elasticity.

J Exp Bot. 2019 Jul 23;70(14):3467-94. Review.



Neill EM, Byrd MCR, Billman T, Brandizzi F, Stapleton AE.

Plant growth regulators interact with elevated temperature to alter heat stress signaling via the Unfolded Protein Response in maize.

Sci Rep. 2019 Jul 17;9(1):10392.

Note: This article may be obtained online without charge.


SpaceRef staff editor.