Status Report

NASA Spaceline Current Awareness List #857 12 July 2019 (Space Life Science Research Results)

By SpaceRef Editor
July 12, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Peyvan K, Karouia F, Cooper JJ, Chamberlain J, Suciu D, Slota M, Pohorille A.

Gene Expression Measurement Module (GEMM) for space application: Design and validation.

Life Sci Space Res. 2019 Jul 9. [Article in Press]

Journal Impact Factor: 2.066

Funding: “This work was supported by a grant from the NASA Advanced Science and Technology Instrument Development Program. Additional support was provided by the NASA Exobiology Program and the Ames Research Center Office of the Chief Technologist.”



Robinson E, McKenna MJ, Bedford JS, Goodwin EH, Cornforth MN, Bailey SM, Ray FA.

Directional genomic hybridization (dGH) for detection of intrachromosomal rearrangements.

Methods Mol Biol. 2019;1984:107-16.

PIs: E.H. Goodwin, F.A. Ray

Journal Impact Factor: Not available for this journal

Funding: “The authors gratefully acknowledge support from the Colorado State University College Research Council, NASA (NNX09CE42P, NNX10CB05C, NNX12AM92G), and NIH (RO1AI080486-02).”



Keune JA, Branscum AJ, Wong CP, Iwaniec UT, Turner RT.

Effect of leptin deficiency on the skeletal response to hindlimb unloading in adult male mice.

Sci Rep. 2019 Jun 27;9(1):9336.

PI: R.T. Turner

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “This work was supported by a grant from the National Aeronautics and Space Administration (NNX12AL24G), the National Institutes of Health (AR 054609), and the National Science Foundation Research Traineeship Program (DGE-0956280).”



Norbury JW, Slaba TC, Aghara S, Badavi FF, Blattnig SR, Clowdsley MS, Heilbronn LH, Lee K, Maung KM, Mertens CJ, Miller J, Norman RB, Sandridge CA, Singleterry R, Sobolevsky N, Spangler JL, Townsend LW, Werneth CM, Whitman K, Wilson JW, Xu SX, Zeitlin C.

Advances in space radiation physics and transport at NASA.

Life Sci Space Res. 2019 Jul 10. [Article in Press] Review.

PI: J.W. Norbury

Journal Impact Factor: 2.066

Funding: “This work was supported by the Human Research Program (HRP) and the Advanced Exploration Systems (AES) Division under the Human Exploration and Operations Mission Directorate of NASA.”



Rabin BM, Miller MG, Larsen A, Spadafora C, Zolnerowich NN, Dell’Acqua LA, Shukitt-Hale B.

Effects of exposure to 12C and 4He particles on cognitive performance of intact and ovariectomized female rats.

Life Sci Space Res. 2019 Jul 10. [Article in Press]

PI: B.M. Rabin

Journal Impact Factor: 2.066

Funding: “This work was supported by NASA Grant NNX16AE06G.”



Suman S, Kallakury BVS, Fornace AJ Jr, Datta K.

Fractionated and acute proton radiation show differential intestinal tumorigenesis and DNA damage and repair pathway response in ApcMin/+ mice.

Int J Radiat Oncol Biol Phys. 2019 Jul 1. [Epub ahead of print]

PIs: K. Datta; A.J. Fornace Jr/K. Datta/NSCOR

Journal Impact Factor: 6.203

Funding: “This work was supported by the National Aeronautics and Space Administration [Grant# NNX13AD58G and NNX15AI21G].”



Ohayon MM, Stolc V, Freund FT, Milesi C, Sullivan SS.

The potential for impact of man-made super low and extremely low frequency electromagnetic fields on sleep.

Sleep Med Rev. 2019 Oct;47:28-38. Epub 2019 Jun 8.

Journal Impact Factor: 10.517

Funding: “MM Ohayon was supported by grants from the Arrillaga Foundation and the Philip Stein Foundation.” V. Stolc and C. Milesi are affiliated with NASA Ames Research Center.



Laughlin MS, Murray JD, Wear ML, Tarver WJ, Edwards TB, Elkousy HA, Van Baalen M.

Shoulder consultations and surgery incidence rates in NASA astronauts and a cohort population of working individuals.

Acta Astronaut. 2019 Jul 10. [Article in Press]

Journal Impact Factor: 2.482

Funding: No funding cited. W.J. Tarver and M. Van Baalen are affiliated with NASA Johnson Space Center.




Other papers of interest:



Barabanov VM, Gulimova VI, Berdiev RK, Saveliev SV.

Individual features of play behavior in thick-toed geckos in weightlessness and normal gravity conditions.

Life Sci Space Res. 2019 Jul 2. [Article in Press]

Note: Bion-M1 results.



Brzhozovskiy AG, Kononikhin AS, Pastushkova LC, Kashirina DN, Indeykina MI, Popov IA, Custaud MA, Larina IM, Nikolaev EN.

The effects of spaceflight factors on the human plasma proteome, including both real space missions and ground-based experiments.

Int J Mol Sci. 2019 Jun 29;20(13):E3194.

Note: ISS results; bed rest and dry immersion also were used. This article may be obtained online without charge.



Matsuda C, Kato T, Inoue-Suzuki S, Kikuchi J, Ohta T, Kagawa M, Hattori M, Kobayashi H, Shiba Di, Shirakawa M, Mizuno H, Furukawa S, Mukai C, Ohno H.

Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g.

npj Microgravity. 2019 Jul 8;5(1):16.

Note: ISS results. A centrifuge is used within the MARS for artificial gravity. This article may be obtained online without charge.



Nassef MZ, Kopp S, Wehland M, Melnik D, Sahana J, Kruger M, Corydon TJ, Oltmann H, Schmitz B, Schütte A, Bauer TJ, Infanger M, Grimm D.

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells.

Int J Mol Sci. 2019 Jun 28;20(13):E3156.

Note: TEXUS-54 results. This article may be obtained online without charge.



Ogneva IV, Usik MA, Loktev SS, Zhdankina YS, Biryukov NS, Orlov OI, Sychev VN.

Testes and duct deferens of mice during space flight: Cytoskeleton structure, sperm-specific proteins and epigenetic events.

Sci Rep. 2019 Jul 5;9(1):9730.

Note: ISS results. This article may be obtained online without charge.



Cadena SM, Zhang Y, Fang J, Brachat S, Kuss P, Giorgetti E, Stodieck LS, Kneissel M, Glass DJ.

Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space.

Sci Rep. 2019 Jun 28;9(1):9397.

Note: ISS results. This article may be obtained online without charge.



Kamada M, Oka M, Inoue R, Fujitaka Y, Miyamoto K, Uheda E, Yamazaki C, Shimazu T, Sano H, Kasahara H, Suzuki T, Higashibata A, Ueda J.

Gravity-regulated localization of PsPIN1 is important for polar auxin transport in etiolated pea seedlings: Relevance to the International Space Station experiment.

Life Sci Space Res. 2019 Aug 1;22:29-37.

Note: ISS results.



Dong W, Duan W, Liu W, Zhang Y.

Microgravity disturbance analysis on Chinese space laboratory.

npj Microgravity. 2019 Jul 8;5(1):18.

Note: Tianzhou-1 and Tiangong-2 results. This article may be obtained online without charge.



Frare C, Jenkins ME, McClure KM, Drew KL.

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to 6N-cyclohexyladenosine-induced hibernation in the Arctic ground squirrel (Urocitellus parryii).

J Neurochem. 2019 Jul 5. [Epub ahead of print]



Markin AA, Zhuravleva OA, Kuzichkin DS, Koloteva MI, Ponomarev SA, Loginov VI, Zabolotskaya IV, Vostrikova LV, Zhuravleva TV, Smirnova TA.

Metabolic responses of the female body during a short-term isolation in hermetic environment.

Hum Physiol. 2019 May 1;45(3):304-9.

Note: From the Introduction: “The goal of this study was the analysis of the metabolic responses in female participants during an eight-day IHE (hermetically sealed environment) experiment with exposure to a set of simulated space mission factors in the framework of the Moon-2015 project.” Originally published in Russian in Fiziologiya Cheloveka, 2019;45(3):85–91.



Alauzet C, Cunat L, Wack M, Lozniewski A, Busby H, Agrinier N, Cailliez-Grimal C, Frippiat JP.

Hypergravity disrupts murine intestinal microbiota.

Sci Rep. 2019 Jun 28;9(1):9410.

Note: Centrifugation was used. This article may be obtained online without charge.



Loucas BD.

Analysis of radiation-induced chromosome exchanges using combinatorial chromosome painting.

Methods Mol Biol. 2019;1984:123-35.



Mori E, Asaithamby A.

Nuclear foci assays in live cells.

Methods Mol Biol. 2019;1984:75-85.



Alcazar J, Csapo R, Ara I, Alegre LM.

On the shape of the force-velocity relationship in skeletal muscles: The linear, the hyperbolic, and the double-hyperbolic.

Front Physiol. 2019 Jun 19;10:769. Review.

Note: This article may be obtained online without charge.



Fu ZH, Wang Z, Wu J, Yang HY, Zhang X, Gao F, Li J.

[A modified protocol for generating the simulated weightlessness rat model].

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Feb;35(2):189-92. Chinese.

Note: Hindlimb unloading study.



Ishihara A.

Effects of exposure to mild hyperbaric oxygen during unloading on muscle properties in rats.

J Muscle Res Cell Motil. 2019 Jul 1. [Epub ahead of print]

Note: Hindlimb unloading study.



Kanazashi M, Tanaka M, Nakanishi R, Maeshige N, Fujino H.

Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats.

J Physiol Sci. 2019 Jul 4. [Epub ahead of print]

Note: Hindlimb unloading study.



Kehler DS, Theou O, Rockwood K.

Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A review.

Exp Gerontol. 2019 Jun 28;124:110643. Review.

Note: Bed rest studies are discussed.



McDonnell AC, Eiken O, Frings-Meuthen P, Rittweger J, Mekjavic IB.

The LunHab project: Muscle and bone alterations in male participants following a 10 day lunar habitat simulation.

Exp Physiol. 2019 Jul 4. [Epub ahead of print]

Note: Bed rest study. The LunHab is a lunar habitat simulation research program developed by the European Space Agency.



Geoghegan IP, Hoey DA, McNamara LM.

Integrins in osteocyte biology and mechanotransduction.

Curr Osteoporos Rep. 2019 Jun 27. [Epub ahead of print] Review.



Bhayani D, Naik H, Nathaniel TN, Khan S, Mehta P.

Simulated space radiation: Investigating ionizing radiation effects on the stability of amlodipine besylate API and tablets.

Eur J Pharm Sci. 2019 Jul 2. [Epub ahead of print]



Boice JD Jr, Held K, Shore R.

Radiation epidemiology and low dose health effects following low-LET radiation.

J Radiol Prot. 2019 Jul 4. [Epub ahead of print]



Hinzman CP, Baulch JE, Mehta KY, Girgis M, Bansal S, Gill K, Li Y, Limoli CL, Cheema AK.

Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice.

Sci Rep. 2019 Jul 1;9(1):9460.

Note: This article may be obtained online without charge.



Reynolds RJ, Bukhtiyarov IV, Tikhonova GI, Day SM, Ushakov IB, Gorchakova TYU.

Contrapositive logic suggests space radiation not having a strong impact on mortality of US astronauts and Soviet and Russian cosmonauts.

Sci Rep. 2019 Jul 4;9(1):8583.

Note: This article may be obtained online without charge.



Wiese CW, Burke CS.

Understanding team learning dynamics over time.

Front Psychol. 2019 Jun 19;10:1417. Review.

Note: This article may be obtained online without charge.



Astaburuaga R, Basti A, Li Y, Herms D, Relógio A.

Circadian regulation of physiology: Relevance for space medicine.

REACH. 2019 Jun-Sep;14-15:100029. Review.



Schwartz WJ, Klerman EB.

Circadian neurobiology and the physiologic regulation of sleep and wakefulness.

Neurol Clin. 2019 Aug;37(3):475-86.



Niehof N, Perdreau F, Koppen M, Medendorp WP.

Time course of the subjective visual vertical during sustained optokinetic and galvanic vestibular stimulation.

J Neurophysiol. 2019 Jul 3. [Epub ahead of print]



Wang T, Niwa M, Sayyid ZN, Hosseini DK, Pham N, Jones SM, Ricci AJ, Cheng AG.

Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells.

PLoS Biol. 2019 Jul;17(7):e3000326.

Note: This article may be obtained online without charge.



Jenness MK, Carraro N, Pritchard CA, Murphy AS.

The Arabidopsis ATP-BINDING CASSETTE transporter ABCB21 regulates auxin levels in cotyledons, the root pericycle, and leaves.

Front Plant Sci. 2019 Jun 19;10:806.

Note: This article may be obtained online without charge.

SpaceRef staff editor.