Status Report

NASA Spaceline Current Awareness List #854 21 June 2019 (Space Life Science Research Results)

By SpaceRef Editor
June 21, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Chiang AJ, Malli Mohan GB, Singh NK, Vaishampayan PA, Kalkum M, Venkateswaran K.

Alteration of proteomes in first-generation cultures of Bacillus pumilus spores exposed to outer space.

mSystems. 2019 Jun 11;4(4):e00195-19.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “The research described in this publication was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. This research was funded by a NASA Research Announcement Research Opportunities in Space and Earth Sciences (NRA ROSES) grant. A.J.C. and M.K. were supported by JPL subcontract no. 1576895. The Mass Spectrometry & Proteomics Core facility of City of Hope was supported in part by the National Cancer Institute of the National Institutes of Health under award no. P30CA033572. Government sponsorship is acknowledged.”



Mednieks MK, Hand AR.

Oral tissue responses to travel in space.

In. Space Medicine. London: InTechOpen, 2019 Jun 14 [Online First]. p. 1-26.

PI: M.I. Mednieks

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: “The authors’ studies were supported by NASA (grant number NNX09AP13G [MIM]), the Connecticut Space Grant College Consortium (grant numbers P-536 and P-777 [ARH]), NIH (Shared Instrumentation Grant number 1S10RR024742 [ARH]) and UConn Health.”



Scully RR, Basner M, Nasrini J, Lam C, Hermosillo E, Gur RC, Moore T, Alexander DJ, Satish U, Ryder VE.

Effects of acute exposures to carbon dioxide on decision making and cognition in astronaut-like subjects.

npj Microgravity. 2019 Jun 19;5(1):17.

PIs: M. Basner, V.E. Ryder

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.00

Funding: “This work was supported by the NASA Human Research Program and NASA grant NNX14AH98G.”



Levy M, Bertram JR, Eller KA, Chatterjee A, Nagpal P.

Near-infrared light triggered antimicrobial indium phosphide quantum dots.

Angew Chem Int Ed Engl. 2019 Jun 11. [Epub ahead of print]

PI: A. Chatterjee

Journal Impact Factor: 12.102

Funding: “The authors acknowledge financial support from National Science Foundation’s CAREER award (CBET-1351281), and partial support from NASA-TRISH (Grant NNX16A069A).”



Goel R, Nakagome S, Rao N, Paloski WH, Contreras-Vidal JL, Parikh PJ.

Fronto-parietal brain areas contribute to the online control of posture during a continuous balance task.

Neuroscience. 2019 Jun 11. [Epub ahead of print]

Journal Impact Factor: 3.382

Funding: “This study was supported by a grant from the Core for Advanced MRI (CAMRI) at Baylor College of Medicine to PP.” W.H. Paloski is affiliated with NASA Johnson Space Center.



Dillon EL, Soman KV, Wiktorowicz JE, Sur R, Jupiter D, Danesi CP, Randolph KM, Gilkison CR, Durham WJ, Urban RJ, Sheffield-Moore M.

Proteomic investigation of human skeletal muscle before and after 70 days of head down bed rest with or without exercise and testosterone countermeasures.

PLoS One. 2019 Jun 13;14(6):e0217690.

PI: R.J. Urban

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 2.766

Funding: “This research was part of an integrated study registered with (NCT00891449) and was funded by the National Aeronautics and Space Administration (#NNX10AP86G, RJU/MSM). The study was conducted with the support of the Institute for Translational Sciences at the University of Texas Medical Branch through funding by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health and (RO1CA127971, MSM) from the National Cancer Institute.”



Rettig TA, Nishiyama NC, Pecaut MJ, Chapes SK.

Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

Life Sci Space Res. 2019 Aug;22:16-28. Epub 2019 Jun 14.

PIs: M.J. Pecaut, S.K. Chapes

Note: Hindlimb unloading study.

Journal Impact Factor: 1.97

Funding: “This work was supported by the National Aeronautics and Space Administration [grant numbers NNX13AN34G and NNX15AB45G]; the National Institute of Health [grant number GM103418]; College of Veterinary Medicine at Kansas State University; and Kansas State University Johnson Cancer Center.”



Samendinger S, Hill CR, Kerr NL, Winn B, Ede A, Pivarnik JM, Ploutz-Snyder L, Feltz DL.

Group dynamics motivation to increase exercise intensity with a virtual partner.

J Sport Health Sci. 2019 May;8(3):289-97.

PI: D.L. Feltz

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.591

Funding: “This work was supported by research grant #MA03401 (Feltz, PI), NASA/National Space Biomedical Research.”



Lehner BAE, Schlechten J, Filosa A, Canals Pou A, Mazzotta DG, Spina F, Teeney L, Snyder J, Tjon SY, Meyer AS, Brouns SJJ, Cowley A, Rothschild LJ.

End-to-end mission design for microbial ISRU activities as preparation for a Moon village.

Acta Astronaut. 2019 Sep;162:216-26. Epub 2019 Jun 14.

Journal Impact Factor: 2.227

Funding: “This work was supported by the NASA Ames Research Center grants to the 2012 Stanford-Brown iGEM team to LJR and with NASA HQ funds from several programs, including the NASA Innovative Advanced Concepts (NIAC) program, and Advanced Exploration System (AES). This work was supported by the ESA Spaceship EAC initiative.”




Other papers of interest:



Wadsworth J, Rettberg P, Cockell CS.

Aggregated cell masses provide protection against space extremes and a microhabitat for hitchhiking co-inhabitants.

Astrobiology. 2019 Jun 13. [Epub ahead of print]

Note: ISS results.



Kashirina DN, Kononikhin AS, Larina IM, Buravkova LB.

Secretome of cultured human endothelial cells in simulated microgravity.

Bull Exp Biol Med. 2019 Jun 8. [Epub ahead of print]

Note: A Random Positioning Machine was used. Originally published in Russian in Byulleten’ Eksperimental’noi Biologii i Meditsiny, 2019 Jan;167(1):38-41.



Shields GS, Slavich GM, Perlman G, Klein DN, Kotov R.

The short-term reliability and long-term stability of salivary immune markers.

Brain Behav Immun. 2019 Jun 5. [Epub ahead of print]



Fujitani M, Mizushige T, Kawabata F, Uozumi K, Yasui M, Hayamizu K, Uchida K, Okada S, Keshab B, Kishida T.

Dietary Alaska pollack [sic] protein improves skeletal muscle weight recovery after immobilization-induced atrophy in rats.

PLoS One. 2019 Jun 14;14(6):e0217917.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Oikawa SY, Holloway TM, Phillips SM.

The impact of step reduction on muscle health in aging: Protein and exercise as countermeasures.

Front Nutr. 2019 May 24;6:75. Review.

Note: This article may be obtained online without charge.



Pagano AF, Arc-Chagnaud C, Brioche T, Chopard A, Py G.

Muscle resting and TGF-beta inhibitor treatment prevent fatty infiltration following skeletal muscle injury.

Cell Physiol Biochem. 2019;53(1):62-75.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Port M, Ostheim P, Majewski M, Voss T, Haupt J, Lamkowski A, Abend M.

Rapid high-throughput diagnostic triage after a mass radiation exposure event using early gene expression changes.

Radiat Res. 2019 Jun 18. [Epub ahead of print]



Jamali M, Carriot J, Chacron MJ, Cullen KE.

Coding strategies in the otolith system differ for translational head motion vs static orientation relative to gravity.

Elife. 2019 Jun 14;8:e45573.

Note: This article may be obtained online without charge.



Smith BJH, Usherwood JR.

An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity.

Biol Open. 2019 Jun 14;8(6):bio043018.

Note: Centrifugation was used. This article may be obtained online without charge.



Hurst C, Scott JPR, Weston KL, Weston M.

High-intensity interval training: A potential exercise countermeasure during human spaceflight.

Front Physiol. 2019 May 22;10:581. Review.

Note: This article may be obtained online without charge.



Böhmer M, Schleiff E.

Microgravity research in plants: A range of platforms and options allow research on plants in zero or low gravity that can yield important insights into plant physiology.

EMBO Rep. 2019 Jun 14. [Epub ahead of print]

Note: The authors discuss facilities used to conduct experiments in real microgravity, including drop towers, parabolic flight, sounding rockets, and the International Space Station.



Li Z, Liang Y, Yuan Y, Wang L, Meng X, Xiong G, Zhou J, Cai Y, Han N, Hua L, Liu G, Li J, Wang Y.

OsBRXL4 regulates shoot gravitropism and rice tiller angle through affecting LAZY1 nuclear localization.

Mol Plant. 2019 Jun 11. [Epub ahead of print]

SpaceRef staff editor.