Status Report

NASA Spaceline Current Awareness List #844 12 April 2019 (Space Life Science Research Results)

By SpaceRef Editor
April 12, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW.

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Science. 2019 Apr 12;364(6436):eaau8650.

PIs: S.M. Bailey, M. Basner, A.P. Feinberg, S.M.C. Lee, C.E. Mason, E. Mignot, B.K. Rana, S.M. Smith, M.P. Snyder, F.W. Turek, A.R. Hargens

Note: ISS results. The research is featured on the cover of the journal issue with the caption: “A study of identical twins identifies molecular, physiological, and cognitive changes specific to one twin who spent a year living aboard the International Space Station. The cover depicts the twins and their respective Earth-bound and space residencies, with a rocket and the International Space Station in the background.” (See the side bar at This article may be obtained online without charge.

Journal Impact Factor: 37.205

Funding: “The study was supported by NASA: NNX14AH51G [all Twins Study principal investigators (PIs)]; NNX14AB02G (S.M.B.); NNX14AH27G/NCC 9-58 (M.B.); NN13AJ12G (A.R.H.); NNX14AN75G (S.M.C.L.); NNX17AB26G, NNX17AB26G, and TRISH: NNX16AO69A:0107 and NNX16AO69A:0061 (C.E.M.); NNX14AH52G (M.P.S.); and NNX14AH26G (F.W.T.). Additional support was provided by NIH grants AG035031, NIH/NIDDK P30 DK017047, and P30 DK035816 (K.S.); NSF grant CCF-1656201 (J.G.); and DLR space program grant 50WB1535 (M.H.), as well as the Bert L. and N. Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, and the Bill and Melinda Gates Foundation (OPP1151054) for funding (C.E.M.) “



Löbrich M, Jeggo PA.

Hazards of human spaceflight.

Science. 2019 Apr 12;364(6436):127-8.

Note: The authors comment on the feature article cited above: The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 Apr 12;364(6436):eaau8650.



Snitow ME, Zanni G, Ciesielski B, Burgess-Jones P, Eisch AJ, O’Brien WT, Klein PS.

Adult hippocampal neurogenesis is not necessary for the response to lithium in the forced swim test.

Neurosci Lett. 2019 Mar 30;704:67-72.

PI: A.J. Eisch

Journal Impact Factor: 2.180

Funding: “This work was funded by T32MH14654-40 and F32MH113334 (MES), R01MH100923 (PSK), and NIH DA023555 and NASA NNX15AE09G/80NSSC17K0060 (AJE).”



Bisbey TM, Reyes DL, Traylor AM, Salas E.

Teams of psychologists helping teams: The evolution of the science of team training.

Am Psychol. 2019 Apr;74(3):278-89.

PIs: E. Salas, S. Burke

Journal Impact Factor: 4.856

Funding: “This material is based upon work supported in part by National Aeronautics and Space Administration Grants NNX16AP96G and NNX16AB08G to Rice University, National Science Foundation Graduate Research Fellowship Program Grant DGE 1450681, and the Ann and John Doerr Institute for New Leaders at Rice University.”



Shuffler ML, Diazgranados D, Maynard MT, Salas E.

Developing, sustaining, and maximizing team effectiveness: An integrative, dynamic perspective of team development interventions.

Acad Manag Ann. 2018 Jun;12(2):688-724.

PIs: E. Salas, S. Burke, M. Rosen

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.174

Funding: “This work was partially supported by funding from the Greenville Health System and grants NNX16AP96G and NNX16AB08G from the National Aeronautics and Space Administration (NASA) to Rice University and grant NX17AB55G to John Hopkins University in partnership with Rice University; UL1TR000058 from the National Institutes of Health’s National Center for Advancing Translational Science; and National Science Foundation CAREER grant 1654054.”



Weber J, Javelle F, Klein T, Foitschik T, Crucian B, Schneider S, Abeln V.

Neurophysiological, neuropsychological, and cognitive effects of 30 days of isolation.

Exp Brain Res. 2019 Mar 29. [Epub ahead of print]

Note: Participants were isolated in the Human Exploration Research Analog at NASA Johnson Space Center.

Journal Impact Factor: 2.395

Funding: “This study was supported by a grant from the German Ministry of Economic Affairs and Energy (BMWi) as handled by German Space Agency (DLR), grant No. 50WB1516 to Vera Abeln.” B. Crucian is affiliated with NASA Johnson Space Center.



Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer F, Saxena R.

Chronotype genetic variant in PER2 is associated with intrinsic circadian period in humans.

Sci Rep. 2019 Mar 29;9(1):5350.

PI: C.A. Czeisler

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.122

Funding: “This analysis was supported by National Institutes of Health (NIH) grant R21DK089378 and by a pilot grant from the Harvard Catalyst, The Harvard Clinical and Translational Science Center (UL1 TR001102) and financial contributions from Harvard University and its affiliated academic healthcare centers to F.A.J.L.S. and R.S. Collection of DNA from study participants was supported by NIH grants F32HL078360, R01HL080978, P01AG009975, and R21DK089378. Data collection in the inpatient protocol was supported by the following grants: NIH R01AG06072, R01HL077453, P01AG009975, R21AT002571, R01HL080978, R01NS054277, R01MH45130, R01HL093279, R01HL094654, R01HL077399, and UL1 TR001102; AFOSR FA9550-06-0080; NSBRI HFP01601; and NARSAD Young Investigator Award. A-M.C. was further supported by T32HL007901, F32HL078360, and K01HL115458; E.B.K. by NIH K24HL105664, P01AG009975, R01GM105018, R01HL114088, and R21HD086392 and NSBRI HFP02802; J.M.L. by F32DK102323; K.S. by T32HL07901 and F32AG031690; F.A.J.L.S. by R01HL140574, R01HL094806, R01DK099512, R01HL118601, R01DK102696, and R01DK105072; and R.S. by R01DK107859, R01DK102696, R01DK105072, R21HL121728 and R01HL113338.”



Vandenbrink JP, Kiss JZ.

Plant responses to gravity.

Semin Cell Dev Biol. 2019 Apr 2. [Epub ahead of print] Review.

PI: J.Z. Kiss

Journal Impact Factor: 6.138

Funding: “Funding provided by grant 80NSSC17K0546 from the National Aeronautics and Space Administration (NASA).”




Other papers of interest:



Sobisch LY, Rogowski KM, Fuchs J, Schmieder W, Vaishampayan A, Oles P, Novikova N, Grohmann E.

Biofilm forming antibiotic resistant gram-positive pathogens isolated from surfaces on the International Space Station.

Front Microbiol. 2019 Mar 19;10:543.

Note: ISS results. This article may be obtained online without charge.



Guéguinou N, Jeandel J, Kaminski S, Baatout S, Ghislin S, Frippiat JP.

Modulation of Iberian ribbed newt complement component C3 by stressors similar to those encountered during a stay onboard the International Space Station.

Int J Mol Sci. 2019 Mar 29;20(7):E1579.

Note: Hindlimb unloading was used in mice and a random positioning machine was used for the Pleurodeles waltl larvae. Larvae were also exposed to darkness, confinement, vibration, and a simulation of space radiation. This article may be obtained online without charge.



Chen ZY, Guo S, Li BB, Jiang N, Li A, Yan HF, Yang HM, Zhou JL, Li CL, Cui Y.

Effect of weightlessness on the 3D structure formation and physiologic function of human cancer cells.

Biomed Res Int. 2019 Apr 3;2019:4894083. Review.

Note: A random positioning machine and a rotating wall vessel were used. This article may be obtained online without charge.



Costantini D, Overi D, Casadei L, Cardinale V, Nevi L, Carpino G, Di Matteo S, Safarikia S, Valerio M, Melandro F, Bizzarri M, Manetti C, Berloco PB, Gaudio E, Alvaro D.

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells.

Sci Rep. 2019 Apr 3;9(1):5559.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Venkatesh N, Keller NP.

Mycotoxins in conversation with bacteria and fungi.

Front Microbiol. 2019 Mar 19;10:403. Review.

Note: This article may be obtained online without charge.



Elmore LC, Rosenberg A, DeAngelis GC, Angelaki DE.

Choice-related activity during visual slant discrimination in macaque CIP but not V3A.

eNeuro. 2019 Mar-Apr;6(2):ENEURO.0248-18.2019.

Note: This article may be obtained online without charge.



McGuire SA, Ryan MC, Sherman PM, Sladky JH, Rowland LM, Wijtenburg SA, Hong LE, Kochunov PV.

White matter and hypoxic hypobaria in humans.

Hum Brain Mapp. 2019 Mar 29. [Epub ahead of print]



Sato S, Gao S, Puppa MJ, Kostek MC, Wilson LB, Carson JA.

High-frequency stimulation on skeletal muscle maintenance in female cachectic mice.

Med Sci Sports Exerc. 2019 Mar 30. [Epub ahead of print]



Bakshi A, DiZio P, Lackner JR.

Rapid adaptation to Coriolis force perturbations of voluntary body sway.

J Neurophysiol. 2019 Apr 3. [Epub ahead of print]



Bakshi A, DiZio P, Lackner JR.

Adaptation to Coriolis force perturbations of postural sway requires an asymmetric two-leg model.

J Neurophysiol. 2019 Apr 3. [Epub ahead of print]



Tafforin C, Yuan M, Lloret JC, Xiong J, He L, Xu Z, Gauquelin-Koch G, Li Y.

Behavioral analysis of a Chinese crew’s daily activity over the 180-day controlled environmental and life support system (CELSS) experiment.

Acta Astronaut. 2019 Apr 7. [Article in Press]

Note: The controlled ecological life support system was built in Shenzhen International Low-Carbon City, China, with a total volume of 1340 m3. The crew of four stayed from June 17 through December 14, 2016.



Lucertini M, Bianca E, Marciano E, Pettorossi VE.

Analysis of the nystagmus evoked by cross-coupled acceleration (Coriolis phenomenon).

Acta Otorhinolaryngol Ital. 2019 Mar 25. [Epub ahead of print]



Xie C, Zhang G, An L, Chen X, Fang R.

Phytochrome-interacting factor-like protein OsPIL15 integrates light and gravitropism to regulate tiller angle in rice.

Planta. 2019 Mar 29. [Epub ahead of print]

SpaceRef staff editor.