Status Report

NASA Spaceline Current Awareness List #841 22 March 2019 (Space Life Science Research Results)

By SpaceRef Editor
March 22, 2019
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Zhou M, Sng NJ, LeFrois CE, Paul A-L, Ferl RJ.

Epigenomics in an extraterrestrial environment: Organ-specific alteration of DNA methylation and gene expression elicited by spaceflight in Arabidopsis thaliana.

BMC Genomics. 2019 Mar 12;20(1):205.

PIs: R.J. Ferl, A-L. Paul

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.730

Funding: “This work was funded by grants NNX12AN69G and NNX14AT24G to RF and AP from NASA Space Life and Physical Sciences, managed through Kennedy Space Center.”



Deyhle RT Jr, Wong CP, Martin SA, McDougall MQ, Olson DA, Branscum AJ, Menn SA, Iwaniec UT, Hamby DM, Turner RT.

Maintenance of near normal bone mass and architecture in lethally irradiated female mice following adoptive transfer with as few as 750 purified hematopoietic stem cells.

Radiat Res. 2019 Mar 14. [Epub ahead of print]

PI: R.T. Turner

Journal Impact Factor: 2.53

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NNX12AL24G) and the National Institutes of Health (AR060913).”



Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R.

Gamma-tocotrienol protects the intestine from radiation potentially by accelerating mesenchymal immune cell recovery.

Antioxidants (Basel). 2019 Mar 6;8(3):57.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This study was supported by Arkansas Space Grant Consortium grant NNX15AR71H (RP); an Institutional Development Award (IDeA) from the NIGMS of the National Institutes of Health under grant number P20 GM109005 (RP, AGB, SAP, and MHJ); NIFA-USDA grant ARKW-2017-07886 (AGB); and VA Merit Review grant I01 BX002425 (AGB); Peer Reviewed Medical Research Program award from Department of Defense (SAP).”



McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer F, Klerman EB.

Caloric and macronutrient intake differ with circadian phase and between lean and overweight young adults.

Nutrients. 2019 Mar 11;11(3):587.

PIs: E.B. Klerman, D. Schreckenghost

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.196

Funding: “This work was supported by NIH (F32DK107146, T32HL007901, KL2TR002370, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392, R00HL119618, R01DK099512, R01DK105072 and R01HL118601) and NSBRI (HFP02802, HFP04201, HDP0006). F.A.J.L.S. was supported in part by NIH grants R01HL118601, R01DK099512, R01DK102696, and R01DK105072 and R01HL140574. M.G. was supported by the Spanish Government of Investigation, Development and Innovation (SAF2017-84135-R) including FEDER co-funding, and NIDDK R01DK105072.”



Piszkiewicz S, Gunn KH, Warmuth O, Propst A, Mehta A, Nguyen KH, Kuhlman E, Guseman AJ, Stadmiller SS, Boothby TC, Neher SB, Pielak GJ.

Protecting activity of desiccated enzymes.

Protein Sci. 2019 Mar 13. [Epub ahead of print]

PI: T.C. Boothby

Journal Impact Factor: 2.41

Funding: “Our research is supported by the National Science Foundation [MCB 1410854 and CHE 1607359 to GJP], the National Institutes of Health [NIGMS 5T32GM008570-20 to UNC, R01HL12564 to SBN, and R01GM127291 to GJP], the National Aeronautics and Space Administration [NNX15AB44G to TCB], the Life Sciences Research Foundation [Fellowship to TCB], the UNC Office of Graduate Education [Dissertation Completion Fellowship to SP], the UNC Office of Undergraduate Research [Summer Undergraduate Research Fellowship to AM], and the WinSPIRE Summer High School Research Program [Fellowship to AP].”




Other papers of interest:



Yu Y, Zhao X, Guo Y, Zhang X, Bai P, Zhang B, Wang J, Liu C.

Identification of potential tobramycin-resistant mutagenesis of Escherichia coli strains after spaceflight.

Future Microbiol. 2019 Mar 11. [Epub ahead of print]

Note: Tiangong-2 results.



Kashirina DN, Percy AJ, Pastushkova LK, Borchers CH, Kireev KS, Ivanisenko VA, Kononikhin AS, Nikolaev EN, Larina IM.

The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins.

BMC Med Genomics. 2019 Mar 13;12(Suppl 2):45.

Note: ISS results. This article may be obtained online without charge.



Li K, Wu F, Yang C, Xu Z, Zhang H, Wang H, Yang H, Tan Y, Li Y, Dai Z.

[Identification and functional analysis of gravity-sensitive novel miRNA HN22 in MG63 during spaceflight].

Space Med Med Eng. 2019;2019(1):7-13. Chinese.

Note: The spaceflight mission is not identified in the English abstract.



Deng Z, Papukashvili D, Rcheulishvili N, Yin Z, Hao X, Zhang Y, Deng Y.

[Research progress in effects of weightlessness/simulated weightlessness on central nervous system].

Space Med Med Eng. 2019;2019(1):89-94. Chinese.

Note: The spaceflight mission and method of simulating microgravity are not identified in the English abstract.



Cui J, Xia W, Zhang M, Wang W, Sun Y, Lu W.

Photosynthetic performance of rice seedlings originated from seeds exposed to spaceflight conditions.

Photochem Photobiol. 2019 Mar 13. [Epub ahead of print]

Note: ShiJian-10 (SJ-10) recoverable satellite results.



Pan Y, Li C, Gao Y, Shi F, Wang Y, Sun X.

[Differential expression analysis of long non-coding RNAs in human vascular endothelial cells after 48h simulated weightlessness].

Space Med Med Eng. 2019;2019(1):80-3. Chinese.

Note: The method of weightlessness simulation is not identified in the English abstract.



Ross R, Goodpaster BH, Koch LG, Sarzynski MA, Kohrt WM, Johannsen NM, Skinner JS, Castro A, Irving BA, Noland RC, Sparks LM, Spielmann G, Day AG, Pitsch W, Hopkins WG, Bouchard C. 

Precision exercise medicine: Understanding exercise response variability.

Br J Sports Med. 2019 Mar 12. [Epub ahead of print]

Note: This article may be obtained online without charge.



Chen L, Liu G, Li W, Wu X.

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system.

Cell Mol Biol Lett. 2019 Feb 26;24:16.

Note: A rotary cell culture system was used. This article may be obtained online without charge.



Xie X, Lei D, Zhang Q, Wang Y, Wen L, Ye Z, Ud Din A, Jia D, Apicella A, Wang G.

Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation.

J Biomech. 2019 Feb 28. [Epub ahead of print]

Note: A rotating bioreactor was used.



Turner DC, Seaborne RA, Sharples AP.

Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory.

Sci Rep. 2019 Mar 12;9(1):4251.

Note: This article may be obtained online without charge.



Tyganov S, Mirzoev T, Shenkman B.

An anabolic signaling response of rat soleus muscle to eccentric contractions following hindlimb unloading: A potential role of stretch-activated ion channels.

Int J Mol Sci. 2019 Mar 7;20(5):1165.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Yang M, Zhang K, Zhang X, Zhang Z, Yin X, He G, Li L, Yang X, He B.

Treatment with hydrogen sulfide donor attenuates bone loss induced by modeled microgravity.

Can J Physiol Pharmacol. 2019 Mar 14. [Epub ahead of print]

Note: Hindlimb unloading and a rotary wall vessel bioreactor were used.



Torok A, Gallagher M, Lasbareilles C, Ferrè ER.

Getting ready for Mars: How the brain perceives new simulated gravitational environments.

Q J Exp Psychol (Hove). 2019 Mar 10. [Epub ahead of print]

Note: This article may be obtained online without charge.



Liu M, Huang W, Wang Y, Gong X, Fan J, Wu P, Tian L, Wu B.

[Study on team size model and selection strategy of astronauts for space station mission].

Space Med Med Eng. 2019;2019(1):14-8. Chinese.



Zou Y, Chao J, Lin W.

[Research on grasping rules of moving objects in astronaut virtual training].

Space Med Med Eng. 2019;2019(1):48-55. Chinese.



Basner M, Asch DA, Shea JA, Bellini LM, Carlin M, Ecker AJ, Malone SK, Desai SV, Sternberg AL, Tonascia J, Shade DM, Katz JT, Bates DW, Even-Shoshan O, Silber JH, Small DS, Volpp KG, Mott CG, Coats S, Mollicone DJ, Dinges DF, for the iCOMPARE Research Group.

Sleep and alertness in a duty-hour flexibility trial in internal medicine.

N Engl J Med. 2019 Mar 7;380(10):915-23.

Note: The aim of the study was: “to establish whether sleep and alertness among interns in flexible programs were noninferior to those among interns in standard programs according to prespecified noninferiority margins. In addition to these analyses that were based on averages across all 14 days of the measurement period in each intern, a secondary goal was to investigate how sleep and alertness were affected by the different shift types in flexible and standard programs, with a focus on extended overnight shifts.”



Silber JH, Bellini LM, Shea JA, Desai SV, Dinges DF, Basner M, Even-Shoshan O, Hill AS, Hochman LL, Katz JT, Ross RN, Shade DM, Small DS, Sternberg AL, Tonascia J, Volpp KG, Asch DA, for the iCOMPARE Research Group. 

Patient safety outcomes under flexible and standard resident duty-hour rules.

N Engl J Med. 2019 Mar 7;380(10):905-14.

Note: This is a companion article to the previous article by Basner, et al. The aim of the iCOMPARE trial (Individualized Comparative Effectiveness of Models Optimizing Patient Safety and Resident Education) was to assess patient safety in relation to standard duty hours for medical residents and interns in hospital settings.



Stepanek J, Blue RS, Parazynski S.

Space medicine in the era of civilian spaceflight.

N Engl J Med. 2019 Mar 14;380(11):1053-60. Review.

Note: From the abstract: “This review…focuses on the nominal and expected challenges of spaceflight and aims to provide the practicing clinician with an appreciation of the unique medical and environmental challenges in light of the expected increase in civilian spaceflight.”



Li J, Zhang N, Luo J, Yu Q, Ai W, Yang J, Tang Y.

[Production and quality analysis of perennial leafy vegetables in CELSS].

Space Med Med Eng. 2019;2019(1):42-7. Chinese.

Note: The experiment was conducted in the SPACEnter, a 4-subject 180-day closed ecological life support system (CELSS) integration experiment.



Grigor’iev GY, Lagutin AS, Nabiev SS, Vasiliev AA, Orlov OI, Mukhamedieva LN, Pakhomova AA, Rodin AV, Semenov VM, Stavrovskii DB, Golubkov MG.

Atmosphere composition control during long-duration space missions.

Acta Astronaut. 2019 Mar 16. [Article in Press]



Zhang Y, Li J, Ding P, Cai L, Cui G, Tang H, Liang Y, Dong J.

[Research on calcium elimination methods in water recycling system in space environment].

Space Med Med Eng. 2019;2019(1):36-41. Chinese.



Zhou H, Ye X, Huang W, Wu M, Mao LN, Yu B, Xu S, Levchenko I, Bazaka K.

Wearable, flexible, disposable plasma-reduced graphene oxide stress sensors for monitoring activities in austere environments.

ACS Appl Mater Interfaces. 2019 Mar 14. [Epub ahead of print]



Mendes V, Bruyere F, Escoffre JM, Binet A, Lardy H, Marret H, Marchal F, Hebert T.

Experience implication in subjective surgical ergonomics comparison between laparoscopic and robot-assisted surgeries.

J Robot Surg. 2019 Mar 12. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Merkle F, Kurtovic D, Starck C, Pawelke C, Gierig S, Falk V.

Evaluation of attention, perception, and stress levels of clinical cardiovascular perfusionists during cardiac operations: A pilot study.

Perfusion. 2019 Mar 14. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Richardson KM, Fouquet SD, Kerns E, McCulloh RJ.

Impact of mobile device-based clinical decision support tool on guideline adherence and mental workload.

Acad Pediatr. 2019 Mar 7. [Epub ahead of print]

Note: The NASA Task Load Index was used.

SpaceRef staff editor.