NASA Spaceline Current Awareness List #837 22 February 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
In case you missed it: A newly published article in Quanta Magazine (https://www.quantamagazine.
Papers deriving from NASA support:
1
Fitzgerald J, Endicott J, Hansen U, Janowitz C.
Articular cartilage and sternal fibrocartilage respond differently to extended microgravity.
npj Microgravity. 2019 Feb 18;5(1):3.
https://www.nature.com/
PI: J. Fitzgerald
Note: Bion M-1 results. GeneLab: Microarray datasets generated and analyzed during the current study are available in the NASA GeneLab repository, https://genelab.nasa.gov/. This article may be obtained online without charge.
Journal Impact Factor: 2.00
Funding: “This study was supported by NASA Grant #NNX09AQ03G.”
2
Scarpati M, Qi Y, Govind S, Singh S.
A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.
PLoS One. 2019 Feb 12;14(2):e0211897.
https://www.ncbi.nlm.nih.gov/
PI: S. Govind
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.766
Funding: “This work was supported in part by PSC CUNY 61298-00 49 and NSF 0618233 to SMS and NASA NNX15AB42G to SG.”
3
Rettig TA, Pecaut MJ, Chapes SK.
A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.
FASEB Bioadv. 2019 Jan;1(1):6-17.
https://www.ncbi.nlm.nih.gov/
PIs: M.J. Pecaut, S.K. Chapes
Journal Impact Factor: Not available for this journal
Funding: “Supported by NASA grants NNX13AN34G and NNX15AB45G, NIH grant GM103418, the Molecular Biology Core supported by the College of Veterinary Medicine at Kansas State University, and the Kansas State University Johnson Cancer Research Center.”
4
Kiffer F, Boerma M, Allen A.
Behavioral effects of space radiation: A comprehensive review of animal studies.
Life Sci Space Res. 2019 Feb 19. [Article in Press]
http://www.sciencedirect.com/
PIs: A. Allen; M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.97
Funding: “This work was supported by the NSBRI (grant no. RE03701 through NASA cooperative agreement NCC 9-58) and Translational Research Institute for Space Health (TRISH) funded project #T0401.“
5
Li T, Yan A, Bhatia N, Altinok A, Afik E, Durand-Smet P, Tarr PT, Schroeder JI, Heisler MG, Meyerowitz EM.
Calcium signals are necessary to establish auxin transporter polarity in a plant stem cell niche.
Nat Commun. 2019 Feb 13;10(1):726.
https://www.ncbi.nlm.nih.gov/
PI: E.M. Meyerowitz
Note: This article may be obtained online without charge.
Journal Impact Factor: 12.353
Funding: “The authors’ work was funded by the Howard Hughes Medical Institute and by NASA grant NNX17AD53G to E.M.M., by the European Research Council (ERC) grant 261081 to M.G.H., in part by NIH grant GM060396 to J.I.S., Marie Skłodowska-Curie Action fellowship to P.D-.S., and a California Institute of Technology Biology and Biological Engineering Fellowship and a Zuckerman STEM Leadership Program postdoctoral scholarship to E.A.”
6
Safari MS, Wang Z, Tailor K, Kolomeisky AB, Conrad JC, Vekilov PG.
Anomalous dense liquid condensates host the nucleation of tumor suppressor p53 fibrils.
iScience. 2019 Feb;12:342-55.
https://www.ncbi.nlm.nih.gov/
PI: P.G. Vekilov
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by grants from NASA (NNX14AD68G and NNX14AE79G), NSF (MCB-1518204, DMR-1710354, and DMR-1131155), and the Welch Foundation (E-1869).”
7
Alexander TM.
A case based human reliability assessment using HFACS for complex space operations.
J Space Safety Eng. 2019 Feb 14. [Article in Press]
http://www.sciencedirect.com/
Note: From the Introduction: “The purpose of this article is to provide a high-level overview and comparison of relevant human error assessment methods and tools for human error analysis and error prediction, with the objective of highlighting one of the tools and providing an example of how this tool can be used to perform a human error analysis for complex space operations. These methods and their comparisons can be found in Appendix A. Out of the 15 HRAs listed in this article, the Human Factors Analysis and Classification System (HFACS) will be highlighted and a case study provided to demonstrate its applicability to human error analysis in Space Operations.”
Journal Impact Factor: Not available for this journal
Funding: No funding cited. T.M. Alexander is affiliated with NASA Kennedy Space Center.
______________________________
Other papers of interest:
1
Pastushkova LK, Kashirina DN, Brzhozovskiy AG, Kononikhin AS, Tiys ES, Ivanisenko VA, Koloteva MI, Nikolaev EN, Larina IM.
Evaluation of cardiovascular system state by urine proteome after manned space flight.
Acta Astronaut. 2019 Feb 16. [Article in Press]
http://www.sciencedirect.com/
Note: ISS results.
2
Klein T, Wollseiffen P, Sanders M, Claassen J, Carnahan H, Abeln V, Vogt T, Strüder HK, Schneider S.
The influence of microgravity on cerebral blood flow and electrocortical activity.
Exp Brain Res. 2019 Feb 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Parabolic flight results.
3
Behringer M, Willberg C.
Application of blood flow restriction to optimize exercise countermeasures for human space flight.
Front Physiol. 2019 Jan 25;10:33. Review.
https://www.ncbi.nlm.nih.gov/
Note: Results of exercise programs on Skylab and ISS are discussed. This article may be obtained online without charge.
4
Rundfeldt LC, Gunga HC, Steinach M.
Anabolic signaling and response in sarcopenia as a model for microgravity induced muscle deconditioning: A systematic review.
REACH. 2019 Feb 15. [Article in Press] Review.
http://www.sciencedirect.com/
Note: Both spaceflight results and bed rest studies are discussed in the review.
5
Chayama Y, Ando L, Sato Y, Shigenobu S, Anegawa D, Fujimoto T, Taii H, Tamura Y, Miura M, Yamaguchi Y.
Molecular basis of white adipose tissue remodeling that precedes and coincides with hibernation in the Syrian hamster, a food-storing hibernator.
Front Physiol. 2018 Jan 28;9:1973.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Sun Z, Li Y, Wang H, Cai M, Gao S, Liu J, Tong L, Hu Z, Wang Y, Wang K, Zhang L, Cao X, Zhang S, Shi F, Zhao J.
miR-181c-5p mediates simulated microgravity-induced impaired osteoblast proliferation by promoting cell cycle arrested in the G2 phase.
J Cell Mol Med. 2019 Feb 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: A clinostat was used. This article may be obtained online without charge.
7
Thom SR, Bhopale VM, Yang M.
Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: Effects on microparticles and interleukin-1β.
J Appl Physiol (1985). 2019 Feb 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
8
de Sousa N, Rodriguez-Esteban G, Colagè I, D’Ambrosio P, van Loon J, Saló E, Adell T, Auletta G.
Transcriptomic analysis of planarians under simulated microgravity or 8 g demonstrates that alteration of gravity induces genomic and cellular alterations that could facilitate tumoral transformation.
Int J Mol Sci. 2019 Feb 8;20(3):E720.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used. This article may be obtained online without charge.
9
Mahmassani ZS, Reidy PT, McKenzie AI, Stubben C, Howard MT, Drummond MJ.
Disuse-induced insulin resistance susceptibility coincides with a dysregulated skeletal muscle metabolic transcriptome.
J Appl Physiol (1985). 2019 Feb 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study.
10
Weber T, Green DA, Attias J, Sies W, Frechette A, Braunstein B, Rittweger J.
Hopping in hypogravity—A rationale for a plyometric exercise countermeasure in planetary exploration missions.
PLoS One. 2019 Feb 13;14(2):e0211263.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “This study investigated the effects of simulated hypogravity (0.16G, 0.27G, 0.38G, and 0.7G) upon sub-maximal plyometric hopping on the Verticalised Treadmill Facility, simulating different hypogravity levels.” This article may be obtained online without charge.
11
Heuser A, Frings-Meuthen P, Rittweger J, Galer SJG.
Calcium isotopes in human urine as a diagnostic tool for bone loss: Additional evidence for time delays in bone response to experimental bed rest.
Front Physiol. 2019 Jan 25;10:12.
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study. This article may be obtained online without charge.
12
Belov OV, Belokopytova KV, Kudrin VS, Molokanov AG, Shtemberg AS, Bazyan AS.
Neurochemical insights into the radiation protection of astronauts: Distinction between low- and moderate-LET radiation components.
Phys Med. 2019 Jan;57:7-16.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
13
Liu F, Wang Z, Li W, Wei Y.
Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation.
Mutat Res. 2019 Mar;839:49-58.
https://www.ncbi.nlm.nih.gov/
14
Ricciotti E, Sarantopoulou D, Grant GR, Sanzari JK, Krigsfeld GS, Kiliti AJ, Kennedy AR, Grosser T.
Distinct vascular genomic response of proton and gamma radiation—A pilot investigation.
PLoS One. 2019 Feb 11;14(2):e0207503.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
15
Xu P, Liu Y, Wang L, Wu Y, Zhou X, Xiao J, Zheng J, Xue M.
Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness.
Sci Rep. 2019 Feb 13;9(1):2000.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
16
Aluko MK, Onabowale.
Effect of gravity variation on the growth of wheat and guinea corn seedlings.
J Exp Agric Int. 2019;29(3):1-9.
http://www.sciencedomain.org/
Note: A clinostat was used. This article may be obtained online without charge.
17
Galli A, Losch A.
Beyond planetary protection: What is planetary sustainability and what are its implications for space research?
Life Sci Space Res. 2019 Feb 19. [Article in Press]
http://www.sciencedirect.com/
Note: From the abstract: “This paper presents recent developments in the interdisciplinary topic of “planetary sustainability” and discusses its potential implications for space research.” This article may be obtained online without charge.
18
Pavlidis I, Zavlin D, Khatri AR, Wesley A, Panagopoulos G, Echo A.
Absence of stressful conditions accelerates dexterous skill acquisition in surgery.
Sci Rep. 2019 Feb 11;9(1):1747.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
