Status Report

NASA Spaceline Current Awareness List #811 17 August 2018 (Space Life Science Research Results)

By SpaceRef Editor
August 17, 2018
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Ramachandran V, Wang R, Ramachandran SS, Ahmed AS, Phan K, Antonsen EL.

Effects of spaceflight on cartilage: Implications on spinal physiology.

J Spine Surg. 2018 Jun;4(2):433-45. Review.

Note: Cosmos, Space Shuttle results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. E.L. Antonsen is affiliated with NASA Johnson Space Center.



Carr CE., Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT.

Acceleration profiles and processing methods for parabolic flight.

npj Microgravity. 2018 Aug 7;4(1):14. 

PI: N.C. Bryan, NASA Postdoctoral Fellowship Program

Note: Parabolic flight results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by NASA award NNX15AF85G. N.C.B. was supported by NASA Postdoctoral Fellowship award 80NSSC17K0688.”



Olafson KN, Clark RJ, Vekilov PG, Palmer JC, Rimer JD.

Structuring of organic solvents at solid interfaces and its ramifications for antimalarial adsorption on beta-hematin crystals.

ACS Appl Mater Interfaces. 2018 Aug 8. [Epub ahead of print]

PI: P.G. Vekilov

Journal Impact Factor: 7.504

Funding: “All authors acknowledge support from the National Science Foundation (Award No. DMR-1710354). J.D.R. and P.G.V. received support from the National Institutes of Health (Award No. 1R21AI126215-01). J.D.R and J.C.P. received additional support from the Welch Foundation (Awards E-1794 and E-1882, respectively) and P.G.V from NASA (Award Nos. NNX14AD68G and NNX14AE79G).”



Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A.

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.

PLoS Pathog. 2018 Aug 2;14(8):e1007229.

PI: N.P. Keller

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.608

Funding: “This work was supported by R35GM118027-01 from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) to AH, 5R01AI065728-10 from the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH to NPK, and grant 19-12829-26 from the National Aeronautics and Space Administration (NASA) to NPK. EER was supported by an individual fellowship from NIAID/NIH under award F32AI113956. NR was supported by the NIGMS-funded Biotechnology Training Program (5T32GM008349-28).”



Çelen I, Doh JH, Sabanayagam CR.

Effects of liquid cultivation on gene expression and phenotype of C. elegans.

BMC Genomics. 2018 Jul 31;19(1):562.

PI: C. Sabagayagam

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.729

Funding: “This work was supported by NASA grants NNX12AR59G, NNX10AN63H, and NNX13AM08G. The BIOMIX computing cluster and the Bioimaging center are supported by Delaware INBRE grant (NIH/NIGMS GM103446) and Delaware EPSCoR grants (NSF EPS-0814251 and NSF IIA-1330446).”



Ahmed AS, Ramakrishnan R, Ramachandran V, Ramachandran SS, Phan K, Antonsen EL.

Ultrasound diagnosis and therapeutic intervention in the spine.

J Spine Surg. 2018 Jun;4(2):423-32.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. E.L. Antonsen is affiliated with NASA Johnson Space Center.



Langer MD, Lewis GK Jr.

Sustained acoustic medicine: A novel long duration approach to biomodulation utilizing low intensity therapeutic ultrasound.

Proc SPIE Int Soc Opt Eng. 2015 May;9467:946701.

PI: G.K. Lewis Jr

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this publication

Funding: No funding cited. PI reports funding under NASA grant NCC 9-58-SMST03901.



Shimkus KL, Shirazi-Fard Y, Wiggs MP, Ullah ST, Pohlenz C, Gatlin DM 3rd, Carroll CC, Hogan HA, Fluckey JD.

Responses of skeletal muscle size and anabolism are reproducible with multiple periods of unloading/reloading.

J Appl Physiol (1985). 2018 Aug 9. [Epub ahead of print]

PI: H.A. Hogan

Note: Hindlimb unloading study.

Journal Impact Factor: 3.351

Funding: “This study was funded by the National Aeronautics and Space Administration (NASA) Grant Number NNX08AQ35G (HA Hogan, Project PI). KL Shimkus was supported by the NSBRI-RFP-05-02 Graduate Training Fellowship. Analyses were partially funded by the Sydney and J.L. Huffines Institute of Sports Medicine and Human Performance and a NASA Space Physiology Research Grant from the American College of Sports Medicine Foundation (KL Shimkus).”



Cheema AK, Byrum SD, Sharma NK, Altadill T, Kumar VP, Biswas S, Balgley BM, Hauer-Jensen M, Tackett AJ, Ghosh SP.

Proteomic changes in mouse spleen after radiation-induced injury and its modulation by gamma-tocotrienol.

Radiat Res. 2018 Aug 2. [Epub ahead of print]

PIs: M. Boerma/M. Hauer-Jensen/A.J. Tackett/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation 

Journal Impact Factor: 2.539

Funding: “This study was supported by the U.S. Department of Defense Threat Reduction Agency (H.10016_09_AR_R, administered by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the AFRRI Intramural funding). Additional funding was provided by: the National Institutes of Health (grant nos. R01GM106024, R21ES025268, UL1TR000039, P20GM103625, S10OD018445 and P20GM103429 to AJT); the National Space Biomedical Research (grant no. RE03701) and the NIAID/NIH (grant no. 1U01AI133561-01), to AKC; and by an Institutional Development Award from the National Institute of General Medical Sciences of the National Institutes of Health (grant no. P20 GM109005 to MHJ).”



Thosar SS, Berman AM, Herzig MX, Roberts SA, Lasarev MR, Shea SA.

Morning impairment in vascular function is unrelated to overnight sleep or the inactivity that accompanies sleep.

Am J Physiol Regul Integr Comp Physiol. 2018 Aug 8. [Epub ahead of print]

PI: S.S. Thosar, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 2.982

Funding: “This work was supported by the National Institutes of Health [grant numbers R01-HL125893, R01-HL142064, HL125893-03S1, and R01 HL140577 to S.A.S.; F32-HL131308; National Space Biomedical Research Institute through NCC 9-58 and Medical Research Foundation of Oregon to S.S.T.; Oregon Institute of Occupational Health Sciences; and National Institutes of Health Clinical Translational Science Award [grant number UL1TR000128. We thank Noal Clemons for assistance in data collection and study management.”



Barrett AH, Richardson MJ, Froio DF, Connor LFO, Anderson DJ, Ndou TV.

Long-term vitamin stabilization in low moisture products for NASA: Techniques and three-year vitamin retention, sensory, and texture results.

J Food Sci. 2018 Jul 30. [Epub ahead of print]

PI: A. Barrett

Journal Impact Factor: 1.815

Funding: “This work was funded through a grant from the National Space and Aeronautics Agency Human Research Program.”



Levulis SJ, DeLucia PR, Kim SY.

Effects of touch, voice, and multimodal input, and task load on multiple-UAV monitoring performance during simulated manned-unmanned teaming in a military helicopter.

Hum Factors. 2018 Jul 31. [Epub ahead of print]

Note: The NASA Task Load Index was used.

Journal Impact Factor: 1.99

Funding: “This work was supported by a grant from General Electric.” S.Y. Kim is affiliated with NASA Jet Propulsion Laboratory.




Other papers of interest:



Seibert FS, Bernhard F, Stervbo U, Vairavanathan S, Bauer F, Rohn B, Pagonas N, Babel N, Jankowski J, Westhoff TH.

The effect of microgravity on central aortic blood pressure.

Am J Hypertens. 2018 Jul 25. [Epub ahead of print]

Note: Parabolic flight results.



Sudevan S, Hashizume T, Yano S, Kuriyama K, Momma K, Harada S, Umehara M, Higashibata A, Higashitani A.

Nematode muscles project in spaceflight experiment.

Biol Sci Space. 2018 Aug 3;32:6-10.

Note: ISS results. This article may be obtained online without charge.



Opsomer L, Theate V, Lefèvre P, Thonnard JL.

Dexterous manipulation during rhythmic arm movements in Mars, Moon, and micro-gravity.

Front Physiol. 2018 Jul 17;9:938.

Note: Parabolic flight results. This article may be obtained online without charge.



Bizet F, Pereda-Loth V, Chauvet H, Gérard J, Eche B, Girousse C, Courtade M, Perbal G, Legué V.

Both gravistimulation onset and removal trigger an increase of cytoplasmic free calcium in statocytes of roots grown in microgravity.

Sci Rep. 2018 Jul 30;8(1):11442.

Note: ISS results. Centrifugation was used for ground studies. This article may be obtained online without charge.



Zhang Y, Xin C-X, Wang X, Deng Y-L.

Detection of microorganism from China’s spacecraft assembly cleanroom.

Acta Astronaut. 2018 Aug 14. [Article in Press]



Zhang Y, Hu C, Chen M.

Induced exopolysaccharide synthesis and the molecular mechanism in Synechocystis sp. PCC 6803 under clinorotation.

Microgravity Sci Technol. 2018 Aug 6. [Article in Press]

Note: A 2-D clinostat was used.



Gennser M, Blogg SL, Eiken O, Mekjavic IB.

Indices of increased decompression stress following long-term bed rest.

Front Physiol. 2018 Jul 18;9:442.

Note: Bed rest study. This article may be obtained online without charge.



Fonte C, Kaminski S, Vanet A, Lanfumey L, Cohen-Salmon C, Ghislin S, Frippiat JP.

Socioenvironmental stressors encountered during spaceflight partially affect the murine TCR-β repertoire and increase its self-reactivity.

FASEB J. 2018 Jul 27. [Epub ahead of print]

Note: From the abstract: “…pregnant mice were subjected throughout gestation to chronic unpredictable mild stressors (CUMS), a model used to mimic socioenvironmental stresses encountered during space missions. Then, newborn T lymphopoiesis and the TCR-b repertoire were studied by flow cytometry and high-throughput sequencing, respectively.”



Bauer J, Wehland M, Infanger M, Grimm D, Gombocz E.

Semantic analysis of posttranslational modification of proteins accumulated in thyroid cancer cells exposed to simulated microgravity.

Int J Mol Sci. 2018 Aug 1;19(8).

Note: A random positioning machine was used. This article may be obtained online without charge.



Apte S, Plooij M, Vallery H.

Correction to: Influence of body weight unloading on human gait characteristics: A systematic review.

J Neuroeng Rehabil. 2018 Aug 8;15(1):73.

Note: “The original article contained a major error whereby Fig. 1 mistakenly displayed a duplicate of Fig. 5. The correct version of Fig. 1 has now been restored …” The original article appeared in SPACELINE Current Awareness List #806, 6 Jul 2018. Both articles may be obtained online without charge.



Bradley CP, Emamy N, Ertl T, Göddeke D, Hessenthaler A, Klotz T, Krämer A, Krone M, Maier B, Mehl M, Rau T, Röhrle O.

Enabling detailed, biophysics-based skeletal muscle models on HPC systems.

Front Physiol. 2018 Jul 12;9:816.

Note: This article may be obtained online without charge.



Van Pelt DW, Confides AL, Judge AR, Vanderklish PW, Dupont-Versteegden EE.

Cold shock protein RBM3 attenuates atrophy and induces hypertrophy in skeletal muscle.

J Muscle Res Cell Motil. 2018 Jul 26. [Epub ahead of print]

Note: Hindlimb unloading study.



Jiang F, Jalali A, Deguchi C, Chen A, Liu S, Kondo R, Minami K, Horiuchi T, Li BY, Robling AG, Chen J, Yokota H.

Finite-element analysis of the mouse proximal ulna in response to elbow loading.

J Bone Miner Metab. 2018 Jul 30. [Epub ahead of print]



Picke AK, Campbell GM, Bluher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A. 

Thy-1 (CD90) promotes bone formation and protects against obesity.

Sci Transl Med. 2018 Aug 8;10(453):eaao6806.



Sun L-W, Li S, Yang X, Pu F, Qi H, Fan Y.

Contribution of bone micromechanical behavior beyond lamellar length scale to the macroscopic bone quality of hind limb unloading rats.

Acta Astronaut. 2018 Aug 15. [Article in Press]

Note: Hindlimb unloading study.



Bensimon Etzol J, Bouvet S, Bettencourt C, Altmeyer S, Paget V, Ugolin N, Chevillard S.

DosiKit, a new immunoassay for fast radiation biodosimetry of hair and blood samples.

Radiat Res. 2018 Aug 3. [Epub ahead of print]



Cartwright IM, Su C, Haskins JS, Salinas VA, Sunada S, Yu H, Uesaka M, Hirakawa H, Chen DJ, Fujimori A, Kato TA.

DNA repair deficient Chinese Hamster Ovary cells exhibiting differential sensitivity to charged particle radiation under aerobic and hypoxic conditions.

Int J Mol Sci. 2018 Jul 30;19(8):E2228.

Note: This article may be obtained online without charge.



Cucinotta FA, Cacao E, Kim M-HY, Saganti PB.

Cancer and circulatory disease risks for a human mission to Mars: Private mission considerations.

Acta Astronaut. 2018 Aug 13. [Article in Press]



Hinzman CP, Baulch JE, Mehta KY, Gill K, Limoli CL, Cheema AK.

Exposure to ionizing radiation causes endoplasmic reticulum stress in the mouse hippocampus.

Radiat Res. 2018 Aug 7. [Epub ahead of print]



McNamara AL, Ramos-Mendez J, Perl J, Held K, Dominguez N, Moreno EB, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J.

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.

Phys Med Biol. 2018 Aug 8. [Epub ahead of print]



Meeks RK, Bell PM.

Aerospace, physiology, spatial orientation.

In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2018. 6 p.

Note: This publication may be obtained online without charge.



Jagadeesh MK, Roszkowska M, Kaczmarek Ł.

Tardigrade indexing approach on exoplanets.

Life Sci Space Res. 2018 Aug 8. [Article in Press]

Note: From the abstract: “In our study, we have established a metric tool for distinguishing the potential survivability of active and cryptobiotic tardigrades on rocky-water and water-gas planets in our solar system and exoplanets, taking into consideration the geometrical means of six physical parameters such as radius, density, escape velocity, revolution period, surface temperature, and surface pressure of the considered planets.”



Blue RS, Jennings RT, Antunano MJ, Mathers CH.

Commercial spaceflight: Progress and challenges in expanding human access to space.

REACH. 2017 Dec;7-8:6-13. Epub 2018 Aug 11.



Kanas N.

Spirituality, humanism, and the Overview Effect during manned space missions.

Acta Astronaut. 2018 Aug 4. [Article in Press]

Note: The Overview Effect is described as “cognitive shift in awareness as a result of seeing the Earth as a tiny, fragile ball of life in space that may transform an astronaut’s perspective of the planet and humanity’s place in the universe.”



Poulet L, Fontaine JP, Dussap CG.

A physical modeling approach for higher plant growth in reduced gravity environments.

Astrobiology. 2018 Aug 1. [Epub ahead of print]

Note: The study was conducted in the Micro-Ecological Life-Support System Alternative (MELiSSA) developed by the European Space Agency.



Tanabe H, Soga K, Wakabayashi K, Hoson T.

Dynamics of actin filaments in epidermal cells of azuki bean epicotyls under hypergravity conditions.

Biol Sci Space. 2018 Aug 3;32:11-6.

Note: Centrifugation was used. This article may be obtained online without charge.



Benaroya H.

Lunar habitats: A brief overview of issues and concepts.

REACH. 2018 Aug 12. [Article in Press] Review.



Tikhomirov A, Ushakova SA, Tikhomirova N, Velichko V, Trifonov S, Anishchenko OV.

Establishing cycling processes in an experimental model of a closed ecosystem.

Acta Astronaut. 2018 Aug 13. [Article in Press]



Ushakova SA, Tikhomirova N, Velichko V, Trifonov S, Morozov Y, Kalacheva G, Pavlova A, Tikhomirov A.

Analysis of the gas exchange and water balance in a closed experimental model of the artificial ecosystem intended for an estimated portion of a human.

Acta Astronaut. 2018 Aug 2. [Article in Press]



Brown LL, Lin Y, Tofil NM, Overly F, Duff JP, Bhanji F, Nadkarni VM, Hunt EA, Bragg A, Kessler D, Bank I, Cheng A; International Network for Simulation-based Pediatric Innovation, Research, Education CPR Investigators (INSPIRE). 

Impact of a CPR feedback device on healthcare provider workload during simulated cardiac arrest.

Resuscitation. 2018 Sep;130:111-7. Epub 2018 Jul 28.

Note: The NASA Task Load Index was used.



Schneider F, Martin J, Schneider G, Schulz CM.

The impact of the patient’s initial NACA score on subjective and physiological indicators of workload during pre-hospital emergency care.

PLoS One. 2018 Aug 9;13(8):e0202215.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.