NASA Spaceline Current Awareness List #803 15 June 2018 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at
https://taskbook.nasaprs.com/
Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,
SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Seuylemezian A, Aronson HS, Tan J, Lin M, Schubert W, Vaishampayan P.
Development
of a custom MALDI-TOF MS database for species-level identification of
bacterial isolates collected from spacecraft and associated surfaces.
Front Microbiol. 2018 Jun 6;9:780.
https://www.ncbi.nlm.nih.gov/
Note: Samples were taken from spacecraft assembly clean rooms during various NASA missions.
This article may be obtained online without charge.
Journal Impact Factor:
4.076
Funding:
The authors are affiliated with NASA Jet Propulsion Laboratory.
2
Dagdeviren D, Kalajzic Z, Adams DJ, Kalajzic I, Lurie A, Mednieks MI, Hand AR.
Responses to spaceflight of mouse mandibular bone and teeth.
Arch Oral Biol. 2018 Jun 7. [Article in Press]
http://www.sciencedirect.com/
PI:
M.I. Mednieks
Note: STS-135 and Bion-M1 results.
Journal Impact Factor:
1.748
Funding:
“This
work was supported by NASA (grant number NNX09AP13G [MIM]), the
Connecticut Space Grant College Consortium (grant number P-777 [ARH])
and UConn Health.”
3
Blaber EA, Parker GC.
Special issue: Stem cells and microgravity.
Stem Cells Dev. 2018 Jun 15;27(12):783-6.
https://www.ncbi.nlm.nih.gov/
Note: From the Editorial: “In this first of two issues of the
Stem Cells and Microgravity special edition of Stem Cells and Development,
we have included seven excellent articles, including six original
research reports and one concise review, which detail the effects of the
spaceflight environment on stem
cell populations. These studies detail the effects of microgravity on
stem cells from the cardiovascular system, central nervous system, and
musculoskeletal system, and during development.” All of the papers in
this issue (Volume 27, Number 12) have been cited
in prior SPACELINE Current Awareness Lists, as they were released as
online publications prior to print. The papers in this issue are: Tissue
engineering under microgravity conditions—Use of stem cells and
specialized cells by Grimm, et al.; Spaceflight activates
protein kinase C alpha signaling and modifies the developmental stage
of human neonatal cardiovascular progenitor cells by Baio, et al.;
Simulated microgravity impairs cardiac autonomic neurogenesis from
neural crest cells by Hatzistergos, et al.; Angiogenic
activity of human adipose-derived mesenchymal stem cells under
simulated microgravity by Ratushnyy, et al.; Modulation of
differentiation processes in murine embryonic stem cells exposed to
parabolic flight-induced acute hypergravity and microgravity by Acharya,
et al.; Generation of neural organoids from human embryonic stem cells
using the rotary cell culture system: effects of microgravity on
neuronal progenitor cell fate by Mattei, et al.; and Continuous exposure
to simulated hypergravity-induced changes in proliferation,
morphology, and gene expression of human tendon cells by Costa-Almeida,
et al. The issue can be found at
https://www.liebertpub.com/
Journal Impact Factor: 3.562
Funding: No funding cited. E.A. Blaber is affiliated with NASA Ames Research Center.
4
Thosar SS, Butler MP, Shea SA.
Role of the circadian system in cardiovascular disease.
J Clin Invest. 2018 Jun 1;128(6):2157-67. Review.
https://www.ncbi.nlm.nih.gov/
PI: S.S. Thosar, NSBRI Postdoctoral Fellowship Program
Journal Impact Factor: 12.784
Funding:
“The authors acknowledge funding from the National Space Biomedical
Research Institute
through NCC 9-58; NIH grants R01HL125893, R01HL140577, R01HL142064,
R21HL140377, and F32HL131308; the Oregon Institute of Occupational
Health Sciences; the Medical Research Foundation of Oregon; and the
American Sleep Medicine Foundation.”
5
Rianon NJ, Smith SM, Lee M, Pervin H, Musgrave P, Watt GP, Nader S, Khosla S, Ambrose CG, McCormick JB, Fisher-Hoch SP.
Glycemic control and bone turnover in older Mexican Americans with type 2 diabetes.
J Osteoporos. 2018 May 13;2018:7153021.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.87
Funding:
“The authors gratefully acknowledge support provided by a grants from
(1) the Clinical
Center for Translational Sciences (CCTS), the University of Texas
Health Science Center at Houston; and (2) Albert and Ethel Herzstein
Charitable Foundation for Geriatric Studies for Junior Faculty Program.
The authors thank the NASA Nutritional Biochemistry
Lab for support of the biochemical testing,” S.M. Smith is affiliated
with NASA Johnson Space Center.
6
Elgart SR, Little MP, Chappell LJ, Milder CM, Shavers MR, Huff JL, Patel ZS.
Radiation exposure and mortality from cardiovascular disease and cancer in early NASA astronauts.
Sci Rep. 2018 May 31;8(1):8480.
https://www.ncbi.nlm.nih.gov/
Note: Astronauts participated in Mercury, Gemini, Apollo, Skylab, Apollo-Soyuz, and Shuttle
programs. This article may be obtained online without charge.
Journal Impact Factor: 4.259
Funding:
“This
study was supported by funding through NASA Human Health and
Performance Contract #NNJ15HK11B (S.R.E., L.J.C., M.R.S., J.L.H.,
Z.S.P.) and NASA directly (C.M.M.).”
______________________________
Other papers of interest:
1
Gaignier F, Legrand-Frossi C, Stragier E, Mathiot J, Merlin JL, Cohen-Salmon C, Lanfumey L, Frippiat JP.
A
model of chronic exposure to unpredictable mild socio-environmental
stressors replicates some spaceflight-induced immunological changes.
Front Physiol. 2018 May 9;9:514.
https://www.ncbi.nlm.nih.gov/
Note:
Mice were exposed to chronic unpredictable psychosocial and
environmental stressors
of various nature and mild intensity separated by resting periods
(CUMS) model. This article may be obtained online without charge.
2
Arfat Y, Basra MAR, Shahzad M, Majeed K, Mahmood N, Munir H.
miR-208a-3p suppresses osteoblast differentiation and inhibits bone formation by targeting ACVR1.
Mol Ther Nucleic Acids. 2018 Jun 1;11:323-36.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
3
Haugen S, He J, Sundaresan A, Stunes AK, Aasarød KM, Tiainen H, Syversen U, Skallerud B, Reseland JE.
Adiponectin reduces bone stiffness: Verified in a three-dimensional artificial human bone model in vitro.
Front Endocrinol (Lausanne). 2018 May 14;9:236.
https://www.ncbi.nlm.nih.gov/
Note:
A rotating cell culture system was used. This article may be obtained online without charge.
4
Huang Y, Fan Y, Salanova M, Yang X, Sun L, Blottner D.
Effects of plantar vibration on bone and deep fascia in a rat hindlimb unloading model of disuse.
Front Physiol. 2018 May 23;9:616.
https://www.ncbi.nlm.nih.gov/
Note:
Hindlimb unloading study. This article may be obtained online without charge.
5
Karim L, Moulton J, Van Vliet M, Velie K, Robbins A, Malekipour F, Abdeen A, Ayres D, Bouxsein ML.
Bone
microarchitecture, biomechanical properties, and advanced glycation
end-products in the proximal femur of adults with type 2 diabetes.
Bone. 2018 May 30;114:32-9.
https://www.ncbi.nlm.nih.gov/
6
Vegger JB, Brüel A, Thomsen JS.
Zoledronic acid prevents disuse osteopenia and augments gene expression of osteoclastic differentiation markers in mice.
J Musculoskelet Neuronal Interact. 2018 Jun 1;18(2):165-75.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
7
Witcher PC, Miner SE, Horan DJ, Bullock WA, Lim KE, Kang KS, Adaniya AL, Ross RD, Loots GG, Robling AG.
Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition.
JCI Insight. 2018 Jun 7;3(11).
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
8
Yang PF, Huang LW, Nie XT, Yang Y, Wang Z, Ren L, Xu HY, Shang P.
Moderate
tibia axial loading promotes discordant response of bone composition
parameters and mechanical properties in a hindlimb unloading rat model.
J Musculoskelet Neuronal Interact. 2018 Jun 1;18(2):152-64.
https://www.ncbi.nlm.nih.gov/
Note:
Hindlimb unloading study. This article may be obtained online without charge.
9
Phillips JO, Ling L, Nowack AL, Phillips CM, Nie K, Rubinstein JT.
The dynamics of prosthetically elicited vestibulo-ocular reflex function across frequency and context in the rhesus monkey.
Front Neurosci. 2018 May 15;12:88.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
10
Todd CJ, Hubner PP, Hubner P, Schubert MC, Migliaccio AA.
StableEyes-A portable vestibular rehabilitation device.
IEEE Trans Neural Syst Rehabil Eng. 2018 Jun;26(6):1223-32.
https://www.ncbi.nlm.nih.gov/
11
Melanson EL, Ritchie HK, Dear TB, Catenacci V, Shea K, Connick E, Moehlman TM, Stothard ER, Higgins J, McHill AW, Wright KP Jr.
Daytime
bright light exposure, metabolism, and individual differences in wake
and sleep energy expenditure during circadian entrainment and
misalignment.
Neurobiol Sleep Circadian Rhythms. 2018 Jan;4:49-56.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
12
Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FA.
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans.
Diabetes Obes Metab. 2018 Jun 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
13
Daltorio K, Fox J.
Haltere removal alters responses to gravity in standing flies.
J Exp Biol. 2018 May 31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: An electromagnet was used.
14
Wan J, Zhang P, Wang R, Sun L, Wang W, Zhou H, Xu J.
UV-B radiation induces root bending through the flavonoid-mediated auxin pathway in
Arabidopsis.
Front Plant Sci. 2018 May 17;9:618.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
15
Tian Y, Zhang H, Wang L, Ding L, Li D.
Effects of EVA glove on hand dexterity at low temperature and low pressure.
Appl Ergon. 2018 Jul;70:98-103.
https://www.ncbi.nlm.nih.gov/
16
Mesko B.
Digital health technologies to support human missions to Mars.
New Space. 2018;6(2):109-16.
https://www.liebertpub.com/
17
Ozkan NF, Kahya E.
Classification of BCI users based on cognition.
Comput Intell Neurosci. 2018 May 9;2018:6315187.
https://www.ncbi.nlm.nih.gov/
Note:
The NASA Task Load Index was used. This article may be obtained online without charge.
Please Note:
Into Space: A Journey of How Humans Adapt and Live in Microgravity,
is a new book from IntechOpen Press. From the Introduction: “… an
overview of some of the physiological, anatomical and cellular changes
that occur in space and their effects on different
body systems, such as the cardiovascular and musculoskeletal, and
touches on cultural and psychosocial aspects of leaving behind family
and the safety of Earth. It further addresses the complexity of manned
space flights, showing how interdisciplinary this
subject is and discussing the challenges that space physiologists,
physicians and scientists must face as humans seek to conquer the final
frontier.” The monograph and individual chapters are listed below.
NASA-funded research is noted.
1
Into Space: A Journey of How Humans Adapt and Live in Microgravity.
Russomano T, editor.
London: IntechOpen, 2018. 296 p.
https://www.intechopen.com/
Note:
The individual chapters may be obtained online without charge.
2
Langston SM.
Reimagining Icarus: Ethics, law and policy considerations for commercial human spaceflight.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 1-16.
https://www .intechopen.com/books/into-
Note:
This chapter may be obtained online without charge.
3
Milligan T.
Basic methodology for space ethics.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 17-29.
Note:
This chapter may be obtained online without charge.
4
Tafforin C.
From the individual to the cultural space group.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. 3. London: IntechOpen, 2018. p. 31-44.
Note:
This chapter may be obtained online without charge.
5
Sherman PM, Sladky J.
Acute and chronic effects of hypobaric exposure upon the brain.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 45-70.
Note:
This chapter may be obtained online without charge.
6
Michael AP.
Spaceflight induced changes in the central nervous system.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 71-86.
Note: Shuttle and ISS results. This chapter may be obtained online without charge.
7
Kohn FPM, Koch C, Ritzmann R.
The effect of gravity on the nervous system.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 87-101.
Note:
This chapter may be obtained online without charge.
8
Kulkarni AD, Doursout M-F, Kulkarni A, Sundaresan A, Miura T, Wakame K, Fujii H.
Spacelight: Immune effects and nutritional countermeasure.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 103-20.
Note:
A
number of space programs and missions are discusses. Also discussed are
hindlimb unloading and bioreactor studies. This chapter may be obtained
online without charge.
Journal Impact Factor:
Not applicable to this publication
Funding:
NASA funding is acknowledged, but not specified.
9
Winnard A, Debuse D, Caplan N.
Countermeasure development for lumbopelvic deconditioning in space.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 121-38.
Note: ISS results. This chapter may be obtained online without charge.
10
Chen J.
Tumor cells in microgravity.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 139-51.
Note:
Clinostat studies are reviewed. This chapter may be obtained online without charge.
11
Stankovic B.
Plants in space.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 153-70.
Note:
This chapter may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding:
“Funding was generously provided by NASA.”
12
Knie M, Ribeiro BW, Fischer J, Schmitz B, Van Damme K, Hemmersbach R, Häder D-P, Laforsch C.
Approaches to assess the suitability of zooplankton for bioregenerative life support systems.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 171-207.
Note: ISS, Shuttle, parabolic flight, drop tower, sounding rocket, and clinostat results.
This chapter may be obtained online without charge.
13
Smith SA, Paszczynski A, Childers SE.
Are we alone? The search life on Mars and other planetary bodies.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 209-28.
Note:
This chapter may be obtained online without charge.
Journal Impact Factor:
Not applicable to this publication
Funding:
“This work was funded by NASA ROSES award #15-PPR15-0006 NASA EPSCoR award #NNX11AQ30A.”
14
Galdamez L.
Exploring the stratosphere: What we missed by shooting for the Moon.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 229-51.
Note:
This chapter may be obtained online without charge.
15
Reynolds RJ, Day SM.
The mortality of space explorers.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 253-85.
Note:
This chapter may be obtained online without charge.
Note:
Into Space: A Journey of How Humans Adapt and Live in Microgravity,
is a new book from IntechOpen Press. From the Introduction, it “gives
an overview of some of the physiological, anatomical and cellular
changes that occur in space and their effects
on different body systems, such as the cardiovascular and
musculoskeletal, and touches on cultural and psychosocial aspects of
leaving behind family and the safety of Earth. It further addresses the
complexity of manned space flights, showing how interdisciplinary
this subject is and discussing the challenges that space physiologists,
physicians and scientists must face as humans seek to conquer the final
frontier.” The monograph and individual chapters are listed below.
NASA-funded research is noted.
1
Into Space: A Journey of How Humans Adapt and Live in Microgravity.
Russomano T, editor.
London: IntechOpen, 2018. 296 p.
https://www.intechopen.com/
Note:
The individual chapters may be obtained online without charge.
2
Langston SM.
Reimagining Icarus: Ethics, law and policy considerations for commercial human spaceflight.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 1-16.
Note:
This chapter may be obtained online without charge.
3
Milligan T.
Basic methodology for space ethics.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 17-29.
Note:
This chapter may be obtained online without charge.
4
Tafforin C.
From the individual to the cultural space group.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. 3. London: IntechOpen, 2018. p. 31-44.
Note:
This chapter may be obtained online without charge.
5
Sherman PM, Sladky J.
Acute and chronic effects of hypobaric exposure upon the brain.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 45-70.
Note:
This chapter may be obtained online without charge.
6
Michael AP.
Spaceflight induced changes in the central nervous system.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 71-86.
Note: Shuttle and ISS results. This chapter may be obtained online without charge.
7
Kohn FPM, Koch C, Ritzmann R.
The effect of gravity on the nervous system.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 87-101.
Note:
This chapter may be obtained online without charge.
8
Kulkarni AD, Doursout M-F, Kulkarni A, Sundaresan A, Miura T, Wakame K, Fujii H.
Spacelight: Immune effects and nutritional countermeasure.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 103-20.
Note:
A
number of space programs and missions are discusses. Also discussed are
hindlimb unloading and bioreactor studies. This chapter may be obtained
online without charge.
Journal Impact Factor:
Not applicable to this publication
Funding:
NASA funding is acknowledged, but not specified.
9
Winnard A, Debuse D, Caplan N.
Countermeasure development for lumbopelvic deconditioning in space.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 121-38.
Note: ISS results. This chapter may be obtained online without charge.
10
Chen J.
Tumor cells in microgravity.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 139-51.
Note:
Clinostat studies are reviewed. This chapter may be obtained online without charge.
11
Stankovic B.
Plants in space.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 153-70.
Note:
This chapter may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding:
“Funding was generously provided by NASA.”
12
Knie M, Ribeiro BW, Fischer J, Schmitz B, Van Damme K, Hemmersbach R, Häder D-P, Laforsch C.
Approaches to assess the suitability of zooplankton for bioregenerative life support systems.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 171-207.
Note: ISS, Shuttle, parabolic flight, drop tower, sounding rocket, and clinostat results.
This chapter may be obtained online without charge.
13
Smith SA, Paszczynski A, Childers SE.
Are we alone? The search life on Mars and other planetary bodies.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 209-28.
Note:
This chapter may be obtained online without charge.
Journal Impact Factor:
Not applicable to this publication
Funding:
“This work was funded by NASA ROSES award #15-PPR15-0006 NASA EPSCoR award #NNX11AQ30A.”
14
Galdamez L.
Exploring the stratosphere: What we missed by shooting for the Moon.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 229-51.
Note:
This chapter may be obtained online without charge.
15
Reynolds RJ, Day SM.
The mortality of space explorers.
In: Russomano T, ed. Into Space: A Journey of How Humans Adapt and Live in Microgravity. London: IntechOpen, 2018. p. 253-85.
Note:
This chapter may be obtained online without charge.
