Status Report

NASA Spaceline Current Awareness List #799 18 May 2018 (Space Life Science Research Results)

By SpaceRef Editor
May 18, 2018
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at
Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Bigley AB, Baker FL, Simpson RJ.

Cytomegalovirus: An unlikely ally in the fight against blood cancers?

Clin Exp Immunol. 2018 May 8. [Epub ahead of print]

PI: R.J. Simpson

Journal Impact Factor:

Funding: “This work was supported by an NIH grant R21 CA197527-01A1 to A.B. Bigley and R.J.
Simpson; and NASA grants NNX12AB48G and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson.”



Yoganandan N, Chirvi S, Pintar FA, Baisden JL, Banerjee A.

Preliminary female cervical spine injury risk curves from PMHS tests.

J Mech Behav Biomed Mater. 2018 Jul;83:143-7. Epub 2018 Apr 24.

PI: J. Somers

Journal Impact Factor:

“This material is the result of work supported with resources and use
of facilities
at the Zablocki VA Medical Center (ZVAMC), Milwaukee, Wisconsin, the
Department of Neurosurgery at the Medical College of Wisconsin (MCW),
and the U.S. Army Medical Research and Materiel Command Fort Detrick,
Maryland, W81XWH-16-1-0010, and the NASA Human
Research Program through the HHPC contract (NNJ15HK11B).”



Yoganandan N, Chirvi S, Voo L, Pintar FA, Banerjee A.

Role of age and injury mechanism on cervical spine injury tolerance from head contact loading.

Traffic Inj Prev. 2018 Feb 17;19(2):165-72.

J. Somers

Journal Impact Factor: 1.29

material is the result of work supported with resources and use of
facilities at the Zablocki VA Medical Center (ZVAMC), Milwaukee,
Wisconsin, the Department of Neurosurgery
at the Medical College of Wisconsin (MCW), USDODW81XWH-12-2-0041 and
W81XWH-16-01-0010, and the NASA Human Research Program through the HHPC
contract (NNJ15HK11B). The MCW authors are part time employees of the
ZVAMC. This research was done as part of the
Biomechanics Product Team led by the Johns Hopkins Applied Physics
Laboratory for the WIAMan Project under contract #N00024-13-D-6400, U.S.
Army Research, Development and Engineering Command.”



MN, Anur P, Wang N, Robinson E, Ray FA, Bedford JS, Loucas BD, Williams
ES, Peto M, Spellman P, Kollipara R, Kittler R, Gray JW, Bailey SM.

Molecular cytogenetics guides massively parallel sequencing of a radiation-induced chromosome translocation in human cells.

Radiat Res. 2018 May 11. [Epub ahead of print]

PIs: M.N. Cornforth; S.M. Bailey; M. Weil/NSCOR

Journal Impact Factor: 2.539

work has received support from the following grants: National
Institutes of Health: NIAID R01080486-02 (SMB, MNC); National
Aeronautics and Space Administration: NNX15AG74G
(MNC), NNX14AB02G (SMB), NNX15AK13G (JSB); The Center for Spatial
Systems Biomedicine, Knight Cancer Institute (JWG, PS).”



Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler R.

Vestibular brain changes within 70 days of head down bed rest.

Hum Brain Mapp. 2018 Mar 12. [Epub ahead of print]

R.D. Seidler; R.L. Cromwell; V. Koppelmans, NSBRI Postdoctoral Fellowship Program

Bed rest study.

Journal Impact Factor: 4.53

“National Space Biomedical Research Institute, Grant/Award Numbers:
NASA NCC 9‐58,
MA02701, PF04101; National Aeronautics and Space Administration (NASA),
Grant/Award Number: NNX11AR02G; NASA’s Flight Analogs Project; National
Institutes of Health and National Center for Advancing Translational
Sciences, Grant/Award Number: 1UL1RR029876‐01.”




Other papers of interest:



Ogoh S, Marais M, Lericollais R, Denise P, Raven PB, Normand H.

Interaction between graviception and carotid baroreflex function in humans during parabolic flight-induced microgravity.

J Appl Physiol (1985). 2018 May 10. [Epub ahead of print]

Note: Parabolic flight results.



Senatore G, Mastroleo F, Leys N, Mauriello G.

Effect of microgravity & space radiation on microbes.

Future Microbiol. 2018 May 10. [Epub ahead of print] Review.

Note: Microbiological studies from over 100 spaceflight experiments are reviewed.



G, Di Girolamo FG, Heer M, Sturma M, Mazzucco S, Agostini F, Situlin R,
Vinci P, Giordano M, Buehlmeier J, Frings-Meuthen P, Mearelli F, Fiotti

with potassium bicarbonate improves glutathione status and protein
kinetics in young volunteers during 21-day bed rest

Clin Nutr. 2018 Apr 12. [Epub ahead of print]

Bed rest study.



Chen G, Zhang Y, Yuan M, He S, Ying J, Li C.

[Effect of simulated microgravity on peripheral oxygen saturation in rats].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 Feb 1;35(1):57-9.

Hindlimb unloading study.



de Souza TAJ, Pereira TC.

Caenorhabditis elegans
tolerates hyperaccelerations up to 400,000 x g.

Astrobiology. 2018 May 10. [Epub ahead of print]

Note: Centrifugation was used.



Anil-Inevi M, Yaman S, Yildiz AA, Mese G, Yalcin-Ozuysal O, Tekin HC, Ozcivici E.

Biofabrication of
in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation

Sci Rep. 2018 May 8;8(1):7239.

A magnetic levitation platform was used.  This article may be obtained online without charge.



Gioia M, Michaletti A, Scimeca M, Marini M, Tarantino U, Zolla L, Coletta M.

Simulated microgravity induces a cellular regression of the mature phenotype in human primary osteoblasts.

Cell Death Discov. 2018 May 10;4:59.

A random positioning machine was used. This article may be obtained online without charge.



Anderson AP, Butterfield JS, Subramanian PS, Clark TK.

pressure and cardiovascular alterations investigated in artificial
gravity as a countermeasure to spaceflight associated neuro-ocular

J Appl Physiol (1985). 2018 May 10. [Epub ahead of print]

Note: A short-radius centrifuge was used.



Feletti F, Mucci V, Aliverti A.

ultrasonography in modern day extreme settings: From military setting
and natural disasters to space flights and extreme sports

Can Respir J. 2018 Mar 15;2018:8739704. Review.

This article may be obtained online without charge.



Hughes DC, Marcotte GR, Baehr LM, West DWD, Marshall AG, Ebert SM, Davidyan A, Adams CM, Bodine SC, Baar K.

Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading: Impact of microRNA-31.

J Physiol. 2018 May 3. [Epub ahead of print]

Note: Hindlimb unloading was used.



Chen Z, Coy SL, Pannkuk EL, Laiakis EC, Fornace AJ Jr, Vouros P.

mobility spectrometry-mass spectrometry (DMS-MS) in radiation
biodosimetry: Rapid and high-throughput quantitation of multiple
radiation biomarkers in nonhuman
primate urine

J Am Soc Mass Spectrom. 2018 May 7. [Epub ahead of print]



CN, Prasanna PGS, Bernhard EJ, Buchsbaum JC, Ahmed MM, Capala J,
Obcemea C, Deye JA, Pistenmma DA, Vikram B, Bernier J, Dosanjh M.

precision radiation medicine: A meta-strategy for impacting cancer
care, global health, and nuclear policy and mitigating radiation injury
from necessary medical
use, space exploration, and potential terrorism

Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):250-3.



Kumar MAS, Laiakis EC, Ghandhi SA, Morton SR, Fornace AJ Jr, Amundson SA.

Gene expression in
Parp1 deficient mice exposed to a median lethal dose of gamma rays

Radiat Res. 2018 May 10. [Epub ahead of print]



Spetz J, Moslehi J, Sarosiek K.

Radiation-induced cardiovascular toxicity: Mechanisms, prevention, and treatment.

Curr Treat Options Cardiovasc Med. 2018 Mar 20;20(4):31. Review.



Suzuki F, Loucas BD, Ito I, Asai A, Suzuki S, Kobayashi M.

Survival of mice with gastrointestinal acute radiation syndrome through control of bacterial translocation.

J Immunol. 2018 May 9. [Epub ahead of print]



Johnson PJ, Suedfeld P, Gushin VI.

Being a father during the space career: Retired cosmonauts’ involvement.

Acta Astronaut. 2018 May 15. [Article in Press]

Note: From the abstract: “This study assesses retired cosmonauts’ views of actual and desired
involvement with their children during their spaceflight career.”



Kuldavletova O, Marie S, Denise P, Normand H.

Influence of graviceptors stimulation initiated by off-vertical axis rotation on ventilation.

Exp Physiol. 2018 May 8. [Epub ahead of print]



Paris R, Vazquez MM, Graziano M, Terrile MC, Miller ND, Spalding EP, Otegui MS, Casalongue CA.

Distribution of endogenous NO regulates early gravitropic response and PIN2 localization in Arabidopsis roots.

Front Plant Sci. 2018 Apr 20;9:495.

Note: This article may be obtained online without charge.


The following three articles comment on Basner M, Dinges DF. Sleep
duration in the
United States 2003-2016: First signs of success in the fight against
sleep deficiency? Sleep. 2018 Apr 1;41(4):zsy012, published ahead of
print on Jan 8, 2018. The original article was cited in Current Awareness List #783, Jan 26, 2018.



Glozier N, Grunstein R.

When a win is a draw.

Sleep. 2018 May 1;41(5):zsy073.



Hertenstein E, Riemann D, Nissen C.

Sleep duration in the United States: A letter to the editor commenting on the recent publication by M. Basner and D. Dinges.

Sleep. 2018 May 1;41(5):zsy036.



Basner M, Dinges DF.

to Letters to the Editor by Dr. Glozier and Grunstein and by Drs.
Hertenstein, Riemann, and Nissen in response to our article “Sleep
duration in the United States
2003-2016: first signs of success in the fight against sleep

[Author reply]

Sleep. 2018 May 1;41(5):zsy074.


SpaceRef staff editor.