Status Report

NASA Spaceline Current Awareness List #795 20 April 2018 (Space Life Science Research Results)

By SpaceRef Editor
April 20, 2018
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at
Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

In case you missed it: Here’s a link to an NPR story about the EDEN ISS greenhouse project
at Neumayer Station III, Antarctica. NASA investigators Robert Ferl and
Anna-Lisa Paul comment on the challenges and relationships between
Antarctic and space farming.
. The story appeared in NPR’s The Salt blog on April 18.

Papers deriving from NASA support:


Shaaban H, Westfall DA, Mohammad R, Danko D, Bezdan D, Afshinnekoo E, Segata N, Mason CE.

The Microbe Directory: An annotated, searchable inventory of microbes’ characteristics.

Gates Open Res. 2018 Jan 5;2:3.

PI: C.E. Mason

From the abstract: “The Microbe Directory is a collective research
effort to profile
and annotate more than 7,500 unique microbial species from the
MetaPhlAn2 database that includes bacteria, archaea, viruses, fungi, and
protozoa. By collecting and summarizing data on various microbes’
characteristics, the project comprises a database that
can be used downstream of large-scale metagenomic taxonomic analyses,
allowing one to interpret and explore their taxonomic classifications to
have a deeper understanding of the microbial ecosystem they are
studying.” Publication note appended to title: [version
1; referees: 1 approved, 3 approved with reservations]. This article
may be obtained online without charge.

Journal Impact Factor: Not available for this journal

would like to thank the Epigenomics Core Facility at Weill Cornell
Medicine, funding from the Irma T. Hirschl and Monique Weill-Caulier
Charitable Trusts, Bert L and N Kuggie
Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn
Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National
Institutes of Health (R25EB020393, R01NS076465, R21AI129851), the Bill
and Melinda Gates Foundation (OPP1151054), and
the Alfred P. Sloan Foundation (G-2015-13964).”



Beheshti A, Miller J, Kidane Y, Berrios D, Gebre SG, Costes SV.

NASA GeneLab Project: Bridging space radiation omics with ground studies.

Radiat Res. 2018 Apr 13. [Epub ahead of print]

Journal Impact Factor: 2.539

Funding: “Research funding was provided by the GeneLab Project at NASA Ames Research Center,
through NASA’s Space Biology Program in the Division of Space Life and Physical Sciences Research and Applications (SLPSRA).”



Rithidech KN, Reungpatthanaphong P, Tungjai M, Jangiam W, Honikel L, Whorton EB.

Persistent depletion of plasma gelsolin (pGSN) after exposure of mice to heavy silicon ions.

Life Sci Space Res. 2018 Apr 19. [Article in Press]

PI: K.N. Rithidech

Journal Impact Factor: 1.97 

Funding: “This research was supported by the National Aeronautics and Space Administration
(NASA) Grant #NNX11AK91G and Stony Brook University.”



Kadhim MA, Bright SJ, Al-Mayah AHJ, Goodwin EH.

The emerging role of exosomes in the biological processes initiated by ionizing radiation.

THREE. 2018 Apr 11.

This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

No funding cited. THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.



Yuan M, Wang Y, Qin YX.

neuroregeneration by applying dynamic magnetic fields to a novel
nanomedicine: Superparamagnetic iron oxide (SPIO)-gold nanoparticles
bounded with nerve growth
factor (NGF)

Nanomedicine. 2018 Apr 5. [Epub ahead of print]

PI: Y.X. Qin

Journal Impact Factor:

“This work was supported by the U.S. Department of Energy ARPA-E
the U.S. Office of Naval Research (ONR-N000141410230); the National
Institutes of Health (R01 AR 52379 and AR 61821), and National Space
Biomedical Research Institute through NASA Contract NCC 9-58.”




Other papers of interest:



A, Brungs S, Henry M, Rotshteyn T, Singh Yaduvanshi N, Wegener L,
Jentzsch S, Hescheler J, Hemmersbach R, Boeuf H, Sachinidis A.

of differentiation processes in murine embryonic stem cells exposed to
parabolic flight-induced acute hypergravity and microgravity

Stem Cells Dev. 2018 Apr 9. [Epub ahead of print]

Parabolic flight results.



Xun W, Yang D, Huang Z, Sha H, Chang H.

Cellular immunity monitoring in long-duration spaceflights based on an automatic miniature flow cytometer.

Sens Actuators B Chem. 2018 Aug 15;267:419-29. Epub 2018 Apr 13.

Note: Parabolic flight results. The sensor was tested during a 180-day controlled ecological
support system experiment and verified during parabolic flight.



Rytlewski JD, Childress PJ, Scofield DC, Khan F, Alvarez MB, Tucker AT, Harris JS, Peveler JL, Hickman DL, Chu TG, Kacena MA.

Cohousing male mice with and without segmental bone defects.

Comp Med. 2018 Apr;68(2):131-8.

Note: ISS results.



Stavrou NAM, Debevec T, Eiken O, Mekjavic IB.

Hypoxia worsens affective responses and feeling of fatigue during prolonged bed rest.

Front Psychol. 2018 Mar 23;9:362.

rest study. The study was part of the European Space Agency’s PlanHab
simulation project. This article may be obtained online without charge.



Costa-Almeida R, Carvalho DTO, Ferreira MJS, Pesqueira T, Monici M, van Loon J, Granja PL, Gomes ME.

exposure to simulated hypergravity induced changes in proliferation,
morphology and gene expression of human tendon cells

Stem Cells Dev. 2018 Mar 16. [Epub ahead of print] 

Centrifugation was used.



Mattei C, Alshawaf A, D’Abaco G, Nayagam B, Dottori M.

of neural organoids from human embryonic stem cells using the rotary
cell culture system: Effects of microgravity on neural progenitor cell

Stem Cells Dev. 2018 Apr 16. [Epub ahead of print]

A rotary cell culture system was used.



Luan H, Huang Y, Li J, Sun L, Fan Y.

of local vibration and passive exercise on the hormones and
neurotransmitters of hypothalamic–pituitary–adrenal axis in hindlimb
unloading rats

Microgravity Sci Technol. 2018 April 14. [Article in Press] 

Note: Hindlimb unloading study.



Jóhannesson G, Eklund A, Lindén C.

Intracranial and intraocular pressure at the lamina cribrosa: Gradient effects.

Curr Neurol Neurosci Rep. 2018 Apr 12;18(5):25. Review.

This article may be obtained online without charge.



Moralez G, Jouett NP, Tian J, Zimmerman MC, Bhella P, Raven PB.

of centrally acting angiotensin converting enzyme inhibitor on the
exercise-induced increases in muscle sympathetic nerve activity

J Physiol. 2018 Apr 10. [Epub ahead of print]



Riley DA, Van Dyke JM, Vogel V, Curry BD, Bain JLW, Schuett R, Costill DL, Trappe TA, Minchev K, Trappe SW.

Soleus muscle stability in wild hibernating black bears.

Am J Physiol Regul Integr Comp Physiol. 2018 Apr 11. [Epub ahead of print]



Kiang JG, Smith JT, Hegge SR, Ossetrova NI.

cytokine/chemokine concentrations respond to ionizing radiation doses
but not radiation dose rates: Granulocyte-colony stimulating factor and

Radiat Res. 2018 Apr 13. [Epub ahead of print]



Seedhouse E.

Space Radiation and Astronaut Safety.

Chaum, Switzerland: Springer, published in collaboration with the International Space University, 2018. 122 p. 

Chapters include: Radiation: A primer, Biomedical consequences of
exposure to space
radiation, Setting acceptable risk levels for astronauts, Space
Radiation Analysis Group, Radiation dosimetry and detection, Shielding,
Acute radiation sickness, Treating acute radiation syndrome,
Pharmacological countermeasures, and Genetic profiling and



Hidalgo-Muñoz AR, Mouratille D, Matton N, Causse M, Rouillard Y, El-Yagoubi R.

Cardiovascular correlates of emotional state, cognitive workload and time-on-task effect during a realistic flight simulation.

Int J Psychophysiol. 2018 Apr 5;128:62-9.



Zhang Q, Li S, Wong HC, He XJ, Beirl A, Petralia RS, Wang YX, Kindt KS.

Synaptically silent sensory hair cells in zebrafish are recruited after damage.

Nat Commun. 2018 Apr 11;9(1):1388.

This article may be obtained online without charge.

SpaceRef staff editor.