NASA Spaceline Current Awareness List #793 6 April 2018 (Space Life Science Research Results)
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Papers deriving from NASA support:
1
Goodwin TJ, Christofidou-Solomidou M.
Oxidative stress and space biology: An organ-based approach.
Int J Mol Sci. 2018 Mar 23;19(4):E959.
https://www.ncbi.nlm.nih.gov/
Note:
This
article introduces the Special Issue, “Oxidative Stress and Space
Biology: An Organ-Based Approach,” edited by Thomas Goodwin and Melpo
Christofidou-Solomidou. (http://www.mdpi.com/journal/
Other articles in the special issue have appeared in prior SPACELINE
Current Awareness Lists. This article may be obtained online without
charge.
Journal Impact Factor: 3.227
Funding:
“This
work was funded in part by: 1P42ES023720-01 (MCS), and by pilot project
support from 1P30 ES013508-02 awarded to MCS.” T.J. Goodwin was
affiliated with NASA Johnson Space Center.
2
Cromwell RL, Scott JM, Downs M, Yarbough PO, Zanello SB, Ploutz-Snyder L.
Overview of the NASA 70-day bed rest study.
Med Sci Sports Exerc. 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI:
R.L. Cromwell; L.L. Ploutz-Snyder
Note: Head-down tilt bed rest study.
Journal Impact Factor: 4.141
Funding:
“Study
infrastructure and operations were supported by the NASA HRP Flight
Analogs Project, and the University of Texas Medical Branch, Institute
for Translational Sciences – Clinical
Research Center (ITS-CRC) through an NIH/NCATS Center for Translational
Science Award (UL1TR000071). Individual research studies were supported
by the NASA Human Research Program (HRP) and the National Space
Biomedical Research Institute.”
3
Scott JM, Martin D, Ploutz-Snyder R, Downs M, Dillon EL, Sheffield-Moore M, Urban RJ, Ploutz-Snyder LL.
Efficacy of exercise and testosterone to mitigate atrophic cardiovascular remodeling.
Med Sci Sports Exerc. 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: R.J. Urban, L.L. Ploutz-Snyder
Note:
Head-down tilt bed rest study.
Journal Impact Factor:
4.141
Funding:
“This study was supported by the Human Research Program of the National
Aeronautics
and Space Administration (NASA), and the Institute for Translational
Sciences at the University of Texas Medical Branch, supported in part by
a Clinical and Translational Science Award (UL1TR000071) from the
National Center for Advancing Translational Sciences,
National Institutes of Health. . . .JMS is supported by grants from
AKTIV Against Cancer, and the Memorial Sloan Kettering Cancer Center
Support Grant/Core Grant (P30 CA008748).” The authors report that the
following grants should also be acknowledged: NASA
(NNX10AP86G) to Dr. Randall J. Urban, NASA (NNX16AO74G) to Dr. Lori L.
Ploutz-Snyder, NSBRI (MA02801) to Dr. Lori L. Ploutz-Snyder, and
National Center for Advancing Translational Sciences (UL1TR000071) to
Dr. Allan R. Brasier.
4
Murach KA, Minchev K, Grosicki GJ, Lavin K, Perkins RK, Ryder JW, Scott J, Ploutz-Snyder L, Trappe TA, Trappe S.
Myocellular responses to concurrent flywheel training during 70 days of bed rest.
Med Sci Sports Exerc. 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt bed rest study.
Journal Impact Factor:
4.141
Funding:
“This work was supported by: the National Aeronautics and Space
Administration,
NNJ06HF59G; the Institute for Translational Sciences at the University
of Texas Medical Branch, supported in part by a Clinical and
Translational Science Award (UL1TR000071) from the National Center for
Advancing Translational Sciences, National Institutes
of Health; and the NASA Flight Analogs Project (planning and
implementation).”
5
Minich
JJ, Zhu Q, Janssen S, Hendrickson R, Amir A, Vetter R, Hyde J, Doty MM,
Stillwell K, Benardini J, Kim JH, Allen EE, Venkateswaran K, Knight R.
KatharoSeq enables high-throughput microbiome analysis from low-biomass samples.
mSystems. 2018 Mar 13;3(3):e00218-17.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor:
Not available for this journal
Funding:
“Part of the research described in this publication was carried out at
JPL, California
Institute of Technology, under a contract with NASA. We thank the UCSD
Chancellor’s Initiative in the Microbiome and Microbial Sciences for
providing the seed grant funding. We also thank the Alfred P. Sloan
Foundation for funding and training.”
6
Seuylemezian A, Cooper K, Schubert W, Vaishampayan P.
Draft genome sequences of 12 dry-heat-resistant
Bacillus strains isolated from the cleanrooms where the Viking spacecraft were assembled.
Genome Announc. 2018 Mar 22;6(12):e00094-18.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
Journal Impact Factor: 1.18
Funding: “The research described in this publication was carried out at the Jet Propulsion
Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.”
7
Cromer WE, Zaweija DC.
Acute
exposure to space flight results in evidence of reduced lymph
transport, tissue fluid shifts, and immune alterations in the rat
gastrointestinal system.
Life Sci Space Res. 2018 Mar 28. [Article in Press]
https://www.sciencedirect.com/
PIs:
D.C. Zaweija; W.E. Cromer, NSBRI Postdoctoral Fellowship Program
Journal Impact Factor:
1.97
Funding:
“This
work is partially supported by the National Space Biomedical Research
Institute through NCC 9-58 and NASA through tissue sharing opportunity
NNX15AG54G.”
8
Ko FC, Li J, Brooks DJ, Rutkove SB, Bouxsein ML.
Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Mar 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI:
S.B. Rutkove
Journal Impact Factor:
3.054
Funding:
“This work was supported by NASA [NNX16AL36G] and NIH [R01-NS055099].”
9
Narayanan SA, Metzger CE, Bloomfield SA, Zawieja DC.
Inflammation-induced
lymphatic architecture and bone turnover changes are ameliorated by
irisin treatment in chronic inflammatory bowel disease.
FASEB J. 2018 Mar 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 5.498
Funding:
“This work was supported by Texas A&M University College of
Education and Human
Development Transforming Lives Seed Grant (to S.A.B.), and U.S.
National Institutes of Health, National Heart, Lung, and Blood Institute
Grant U01HL123420 (to D.C.Z.). Additional funds were provided by the
Sydney and J. L. Huffines Institute for Sports Medicine
and Human Performance (to C.E.M.). S.A.N. was supported, in part, by
the National Space Biomedical Research Institute Space Life Sciences
Fellowship (NCC 9-58).”
10
Chancellor JC, Blue RS, Cengel KA, Auñón-Chancellor SM, Rubins KH, Katzgraber HG, Kennedy AR.
Limitations in predicting the space radiation health risk for exploration astronauts.
npj Microgravity. 2018 Apr 3;4(1):8.
https://www.nature.com/
Note:
This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding:
“H.G.K. acknowledges support from the NSF (Grant No. DMR-1151387). Part
of the
work of H.G.K. and J.C.C. has been based upon work supported by the
Office of the Director of National Intelligence (ODNI), Intelligence
Advanced Research Projects Activity (IARPA), via Interagency Umbrella
Agreement IA1-1198.” R.S. Blue, S.M. Auñón-Chancellor,
and K.H. Rubins are affiliated with NASA Johnson Space Center.
11
Moreno-Villanueva M, von Scheven G, Feiveson A, Bürkle A, Wu H, Goel N.
The
degree of radiation-induced DNA strand breaks is altered by acute sleep
deprivation and psychological stress and is associated with cognitive
performance in humans.
Sleep. 2018 Mar 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI:
N. Goel
Journal Impact Factor: 4.923
Funding:
“This work was supported by NASA NNX14AN49G (N.G.) and by the German Research Foundation (DFG) (Grant # MO 2243-2-2).”
12
Min J, Kim G, Lim H, Carvajal NA, Lloyd CW, Wang Y.
A
kindergarten-based child health promotion program: The adapted National
Aeronautics and Space Administration (NASA) Mission X for improving
physical fitness in South
Korea.
Glob Health Promot. 2018 Mar 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
The objectives are “To adapt the NASA Mission X: Train Like an
Astronaut program for
use with South Korean children, and to evaluate its feasibility and
effectiveness for promoting children’s physical fitness.”
Kindergarten-aged children and their parents were recruited for a 6-week
intervention program. Changes in children’s physical activity
and interest as well as parental attitudes and beliefs were assessed.
Journal Impact Factor: 1.442
Funding:
“This
study was funded by the Korea Institute of Child Care and Education in
the Republic of Korea, the US National Institute of Health (NIH), the
Eunice Kennedy Shriver National
Institute of Child Health & Human Development (NICHD,
1R01HD064685-01A1 and U54HD070725), the NICHD and the Office of
Behavioral and Social Sciences Research (OBSSR).” N.A. Carvajal and C.W.
Lloyd are affiliated with NASA Johnson Space Center.
______________________________
Other papers of interest:
1
Giuliani A, Mazzoni S, Ruggiu A, Canciani B, Cancedda R, Tavella S.
High-resolution
X-ray tomography: A 3D exploration into the skeletal architecture in
mouse models submitted to microgravity constraints.
Front Physiol. 2018 Mar 6;9:181. Review.
https://www.ncbi.nlm.nih.gov/
Note: ISS, STS, and Bion results are reviewed. This article may be obtained online without
charge.
2
Ruden D, Bolnick A, Awonuga A, Abdulhasan M, Perez G, Puscheck EE, Rappolee DA.
Effects of gravity, microgravity or microgravity simulation on early mammalian development.
Stem Cells Dev. 2018 Mar 21. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: A variety of spaceflight and microgravity simulation studies are cited in the review.
3
Ou J, Ball JM, Luan Y, Zhao T, Miyagishima KJ, Xu Y, Zhou H, Chen J, Merriman DK, Xie Z, Mallon BS, Li W.
iPSCs from a hibernator provide a platform for studying cold adaptation and its potential medical applications.
Cell. 2018 Mar 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
4
Dinarelli S, Longo G, Dietler G, Francioso A, Mosca L, Pannitteri G, Boumis G, Bellelli A, Girasole M.
Erythrocyte’s aging in microgravity highlights how environmental stimuli shape metabolism and morphology.
Sci Rep. 2018 Mar 27;8(1):5277.
https://www.ncbi.nlm.nih.gov/
Note:
A 3D clinostat was used. This article may be obtained online without charge.
5
Grimm D, Egli M, Krüger M, Riwaldt S, Corydon TJ, Kopp S, Wehland M, Wise P, Infanger M, Mann V, Sundaresan A.
Tissue engineering under microgravity conditions-use of stem cells and specialized cells.
Stem Cells Dev. 2018 Mar 29. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note:
Studies reviewed used random positioning machines, clinostats, and rotating wall vessel bioreactors.
6
Qiu J, Fang Q, Xu T, Wu C, Xu L, Wang L, Yang X, Yu S, Zhang Q, Ding F, Sun H.
Mechanistic
role of reactive oxygen species and therapeutic potential of
antioxidants in denervation- or fasting-induced skeletal muscle atrophy.
Front Physiol. 2018 Mar 14;9:215.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
7
Morrell AE, Brown GN, Robinson ST, Sattler RL, Baik AD, Zhen G, Cao X, Bonewald LF, Jin W, Kam LC, Guo XE.
Mechanically induced Ca(2+) oscillations in osteocytes release extracellular vesicles and enhance bone formation.
Bone Res. 2018 Mar 19;6:6.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
8
Vera NB, Chen Z, Pannkuk E, Laiakis EC, Fornace AJ Jr, Erion DM, Coy SL, Pfefferkorn JA, Vouros P.
Differential
mobility spectrometry (DMS) reveals the elevation of urinary
acetylcarnitine in non-human primates (NHPs) exposed to radiation.
J Mass Spectrom. 2018 Mar 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Zhang Y, Wang Q, Chen H, Liu X, Lv K, Wang T, Wang Y, Ji G, Cao H, Kan G, Li Y, Qu L.
Involvement
of cholinergic dysfunction and oxidative damage in the effects of
simulated weightlessness on learning and memory in rats.
Biomed Res Int. 2018 Feb 8;2018:2547532.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
10
Haggerty SE, King WM.
The interaction of pre-programmed eye movements with the vestibulo-ocular reflex.
Front Syst Neurosci. 2018 Mar 9;12:4.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
11
Mackenzie SW, Reynolds RF.
Differential effects of vision upon the accuracy and precision of vestibular-evoked balance responses.
J Physiol. 2018 Mar 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
12
Li R, Walter H, Curry C, Rath R, Peterson N, Stoffregen TA.
Postural time-to-contact as a precursor of visually induced motion sickness.
Exp Brain Res. 2018 Mar 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
13
Weech S, Moon J, Troje NF.
Influence of bone-conducted vibration on simulator sickness in virtual reality.
PLoS One. 2018 Mar 28;13(3):e0194137.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
14
Stone JE, Sletten TL, Magee M, Ganesan S, Mulhall MD, Collins A, Howard M, Lockley SW, Rajaratnam SMW.
Temporal
dynamics of circadian phase shifting response to consecutive night
shifts in healthcare workers: role of light-dark exposure.
J Physiol. 2018 Mar 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
de Visser EJ, Pak R, Shaw TH.
From “automation” to “autonomy:” The importance of trust repair in human-machine interaction.
Ergonomics. 2018 Mar 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
16
Manzano A, Herranz R, den Toom LA, te Slaa S, Borst G, Visser M, Medina FJ, van Loon JJWA.
Novel,
Moon and Mars, partial gravity simulation paradigms and their effects
on the balance between cell growth and cell proliferation during early
plant development.
npj Microgravity. 2018 Apr 4;4(1):9.
https://www.nature.com/
Note:
Centrifugation and Random Positioning Machines were used.
17
Bevelacqua JJ, Welsh J, Mortazavi SMJ.
Comments on ‘An overview of space medicine.’
Br J Anaesth. 2018 Apr;120(4):874-6.
https://www.ncbi.nlm.nih.gov/
Note:
The
authors comment on Hodkinson PD, Anderton RA, Posselt BN, Fong KJ. An
overview of space medicine. Br J Anaesth. 2017 Dec 1;119(Suppl
1):i143-i53. Review.
https://www.ncbi.nlm.nih.gov/
#776, 1 December 2017. This article may be obtained online without charge.
18
Hodkinson PD, Anderton RA, Posselt BN, Fong KJ.
Authors’ response to: ‘Comments on “An overview of space medicine” ‘.
Br J Anaesth. 2018 Apr;120(4):876-7.
https://www.ncbi.nlm.nih.gov/
Note:
The
authors reply to Bevelacqua JJ, Welsh J, Mortazavi SMJ. Comments on “An
overview of space medicine.” Br J Anaesth. 2018 Apr;120(4):874-6.
https://www.ncbi.nlm.nih.gov/
