NASA Spaceline Current Awareness List #792 30March 2018 (Space Life Science Research Results)
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Papers deriving from NASA support:
1
Vico L, Hargens A.
Skeletal changes during and after spaceflight.
Nat Rev Rheumatol. 2018 Mar 21;14(4):229-45. Review.
https://www.ncbi.nlm.nih.gov/
PI: A.R. Hargens
Note:
Results from a variety of space missions are included.
Journal Impact Factor:
12.188
Funding:
“The work of L.V. is supported in part by the Centre National d’Etudes
Spatiales
(CNES) and by the European Space Agency (ESA). The work of A.H. is
supported in part by NASA (National Aeronautics and Space
Administration), grant numbers NNX14AP25G, NNX13AM89G and NNX13AJ12G.”
2
Mortreux M, Nagy JA, Ko FC, Bouxsein ML, Rutkove SB.
A novel partial gravity ground-based analogue for rats via quadrupedal unloading.
J Appl Physiol (1985). 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI:
S.B. Rutkove
Note: A pelvic harness was used for quadrupedal unloading.
Journal Impact Factor: 3.351
Funding:
“This work was funded by the National Aeronautics and Space Administration 392 (NASA; NNX16AL36G).”
3
Moccetti F, Weinkauf CC, Davidson BP, Belcik JT, Marinelli ER, Unger E, Lindner JR.
Ultrasound
molecular imaging of atherosclerosis using small-peptide targeting
ligands against endothelial markers of inflammation and oxidative stress.
Ultrasound Med Biol. 2018 Mar 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: J.R. Lindner
Journal Impact Factor: 2.494
Funding:
“The study was funded by Grant SBIRHHSN26820140045 C from the National
Institutes
of Health (NIH), Bethesda, Maryland. J.R.L. is also supported by Grants
R01-HL078610, R01-HL111969 and R01-HL120046 from the NIH and a grant
(14 NSBRI1-0025) from the National Space Biomedical Research Institute
(National Aeronautics and Space Administration).
F.M. is supported by a grant from the Swiss National Science
Foundation.”
4
Lee AG, Mader TH, Gibson CR.
Why space flight-associated neuro-ocular syndrome may differ from idiopathic intracranial hypertension—Reply.
JAMA Ophthalmol. 2018 Mar 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
The
authors reply to the letter: Wostyn P, De Deyn PP. Why space
flight-associated neuro-ocular syndrome may differ from idiopathic
intracranial hypertension. JAMA Ophthalmol. 2018
Mar 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
(See #9 in the Other section of this List.) The letter and author reply
are in reference to Lee AG, Mader TH, Gibson CR, Tarver W. Space
flight-associated neuro-ocular syndrome.
JAMA Ophthalmol. 2017 Sep 1;135(9):992-994.
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 5.625
Funding: No funding cited. T.H. Mader and W. Tarver are affiliated with NASA Johnson Space
Center.
5
Suman S, Kumar S, Fornace AJ Jr, Datta K.
The effect of carbon irradiation is associated with greater oxidative stress in mouse intestine and colon relative to γ-rays.
Free Radic Res. 2018 Mar 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: K. Datta; A.J. Fornace, Jr./K. Datta/NSCOR
Journal Impact Factor: 3.188
Funding:
“This study has been funded through the National Aeronautics and Space Administration (NASA) Grant# NNX13AD58G and NNX15AI21G.”
6
Gottlieb DJ, Ellenbogen JM, Bianchi MT, Czeisler CA.
Sleep deficiency and motor vehicle crash risk in the general population: A prospective cohort study.
BMC Med. 2018 Mar 20;16(1):44.
https://www.ncbi.nlm.nih.gov/
PIs: C.A. Czeisler, S.W. Lockley, E.B. Klerman
Note:
This article may be obtained online without charge.
Journal Impact Factor: 7.901
Funding:
“The
Sleep Heart Health Study was supported by National Heart, Lung and
Blood Institute cooperative agreements U01HL53940 (University of
Washington), U01HL53941 (Boston University),
U01HL53938 (University of Arizona), U01HL53916 (University of
California, Davis), U01HL53934 (University of Minnesota), U01HL53931
(New York University), U01HL53937 and U01HL64360 (Johns Hopkins
University), U01HL63463 (Case Western Reserve University), and
U01HL63429 (Missouri Breaks Research). . . .This work was also
supported in part by the following grants: HL095472, HL94654, and
U01HL111478 from the National Heart Lung and Blood Institute;
P01AG009975 from the National Institute on Aging; GM105018 from the
National Institute of General Medical Sciences; NCC9–119, NNX10AF47G,
and cooperative agreement NCC9–58 from the National Aeronautics and
Space Administration; HFP02801 and HFP02802 from the National Space
Biomedical Research Institute; and EMW-2010-FP-00521
from the Federal Emergency Management Agency.”
7
Lee JL, Burnett J, Xia R, Smith SM, Dyer CB.
Feasibility of intervention in elder self-neglecters: Setting the stage for future research.
J Elder Abuse Negl. 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 2.83
Funding:
“This work was supported by the National Institute on Aging at the
National Institutes
of Health: [Grant Number R21 AG033261].” From the Acknowledgements: “We
would also like to thank the NASA Nutritional Biochemistry Laboratory
for their support of the sample analyses.” S.M. Smith is affiliated with
NASA Johnson Space Center.
______________________________
Other papers of interest:
1
Inozemtsev KO, Kushin VV, Strádi A, Ambrožová I, Kodaira S, Szabó J, Tolochek RV, Shurshakov VA.
Measurement of different components of secondary radiation onboard International Space Station by means of passive detectors.
Radiat Prot Dosimetry. 2018 Mar 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
2
Rudwill
F, O’Gorman D, Lefai E, Chery I, Zahariev A, Normand S, Pagano AF,
Chopard A, Damiot A, Laurens C, Hodson L, Canet-Soulas E, Heer M, Frings
Meuthen P, Buehlmeier
J, Baecker N, Meiller L, Gauquelin-Koch G, Blanc S, Simon C,
Bergouignan A.
Metabolic inflexibility is an early marker of bed-rest induced glucose intolerance even when fat mass is stable.
J Clin Endocrinol Metab. 2018 Mar 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
Bed rest study.
3
Ivanova K, Eiermann P, Tsiockas W, Hemmersbach R, Gerzer R.
Differential
regulation of cGMP signaling in human melanoma cells at altered
gravity: Simulated microgravity down-regulates cancer-related gene
expression and motility.
Microgravity Sci Technol. 2018 Mar 29. [Article in Press]
https://link.springer.com/
Note:
Centrifugation and a fast-rotating 2D clinostat were used. This article may be obtained online without charge.
4
Wuest SL, Gantenbein B, Ille F, Egli M.
Electrophysiological experiments in microgravity: Lessons learned and future challenges.
npj Microgravity. 2018 Mar 29;4(1):7. Review.
https://www.nature.com/
Note:
The
review discusses results from unspecified space missions, parabolic
flight, TEXUS, MAXUS, drop towers, and centrifugation. This article may
be obtained online without charge.
5
Mazur A, Guernec A, Lautridou J, Dupas J, Dugrenot E, Belhomme M, Theron M, Guerrero F.
Angiotensin converting enzyme inhibitor has a protective effect on decompression sickness in rats.
Front Physiol. 2018 Mar 1;9:64.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Mitchell SJ, Bennett MH, Bryson P, Butler FK, Doolette DJ, Holm JR, Kot J, Lafere P.
Pre-hospital management of decompression illness: Expert review of key principles and controversies.
Diving Hyperb Med. 2018 Mar 20;48(1):45-55.
https://www.ncbi.nlm.nih.gov/
7
Lind AL, Lim FY, Soukup AA, Keller NP, Rokas A.
An LaeA- and BrlA-dependent cellular network governs tissue-specific secondary metabolism in the human pathogen
Aspergillus fumigatus.
mSphere. 2018 Mar 14;3(2):e00050-18.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
8
Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A, Keller NP.
CoIN: Co-inducible nitrate expression system for secondary metabolites in
Aspergillus nidulans.
Fungal Biol Biotechnol. 2018 Mar 13;5:6.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
9
Wostyn P, De Deyn PP.
Why space flight-associated neuro-ocular syndrome may differ from idiopathic intracranial hypertension.
JAMA Ophthalmol. 2018 Mar 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on the article: Lee AG, Mader TH, Gibson CR, Tarver W. Space flight-associated
neuro-ocular syndrome. JAMA Ophthalmol. 2017 Sep 1;135(9):992-994.
https://www.ncbi.nlm.nih.gov/
which appeared ahead of print in SPACELINE Current Awareness List #759,
28 Jul 2017. (See #4 in the NASA section of this List for the authors’
reply.)
10
Johannesdottir F, Allaire B, Anderson DE, Samelson EJ, Kiel DP, Bouxsein ML.
Population-based
study of age- and sex-related differences in muscle density and size in
thoracic and lumbar spine: The Framingham study.
Osteoporos Int. 2018 Mar 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
11
Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM.
Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice.
J Gerontol A Biol Sci Med Sci. 2018 Mar 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
12
Castro AA, Garland T Jr.
Evolution of hindlimb bone dimensions and muscle masses in house mice selectively bred for high voluntary wheel‐running behavior.
J Morphol. 2018 Mar 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
13
Li B, Zhao J, Ma JX, Li GM, Zhang Y, Xing GS, Liu J, Ma XL.
Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis.
Bone. 2018 Mar 16. 111:82-91.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
14
Ngan Tran K, Choi JI.
Gene expression profiling of rat livers after continuous whole-body exposure to low-dose-rate gamma-ray.
Int J Radiat Biol. 2018 Mar 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Padmanaban N, Ruban T, Sitzmann V, Norcia AM, Wetzstein G.
Towards a machine-learning approach for sickness prediction in 360° stereoscopic videos.
IEEE Trans Vis Comput Graph. 2018 Apr;24(4):1594-603.
https://www.ncbi.nlm.nih.gov/
Note: The authors sought to design a motion sickness predictor to estimate the nauseogenicity
of virtual reality systems.
16
Chen X, DeAngelis GC, Angelaki DE.
Flexible egocentric and allocentric representations of heading signals in parietal cortex.
Proc Natl Acad Sci U S A. 2018 Mar 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Wang B, Smith SM, Li J.
Genetic regulation of shoot architecture.
Annu Rev Plant Biol. 2018 Mar 19. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: The following articles were published in the Russian aerospace journal
Aviakosmicheskaia i ekologicheskaia meditsina in 2016. They recently were added to the PubMed database at the National Library of Medicine.
18
Fomina EV, Savinkina AO, Chumachenko VV.
[Locomotion
strategies and intensity of support reactions as an approach to
individualization of countermeasures against the negative effects of
microgravity].
Aviakosm Ekolog Med. 2016;50(6):31-6. Russian.
https://www.ncbi.nlm.nih.gov/
Note:
ISS results.
19
Ilyin VK, Shumilina GA, Solovieva ZO, Nosovsky AM, Kaminskaya EV.
[Some characteristics of the oral cavity and teeth of cosmonauts on missions to the International Space Station].
Aviakosm Ekolog Med. 2016;50(6):25-30. Russian.
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
20
Kotovskaya AR, Fomina GA.
[Changes in main vein characteristics of cosmonaut’s lower extremities in the course of year-long space missions].
Aviakosm Ekolog Med. 2016;50(6):5-10. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Mir and ISS results.
21
Ponomarev SA, Berendeeva TA, Kalinin SA, Muranova AV.
[Status
of the system of signaling pattern recognition receptors of monocytes
and granulocytes in cosmonauts’ peripheral blood before and after
long-duration missions
to the International Space Station].
Aviakosm Ekolog Med. 2016;50(5):18-23. Russian.
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
22
Volova LT, Rossinskaya VV, Milyakova MN, Boltovskaya VV, Nefedova IE, Kulagina LN, Pugachev EI.
[Studies of spaceflight effects on a 3D model of chondroblast culture].
Aviakosm Ekolog Med. 2016;50(5):11-7. Russian.
https://www.ncbi.nlm.nih.gov/
Note:
Foton-M4 results.
23
Povvsheva TV, Chelyshev YA.
[Spaceflight effects on glial cells of mouse bone marrow].
Aviakosm Ekolog Med. 2016;50(6):45-50. Russian.
https://www.ncbi.nlm.nih.gov/
Note:
The specific spaceflight is not identified in the English abstract.
24
No author.
[Assessment
of the effect of dynamic light-emitting diode illumination on the
functional state of visual analyzer in an environmentally controlled
chamber].
Aviakosm Ekolog Med. 2016;50(5):37-42. Russian
https://www.ncbi.nlm.nih.gov/
25
Bogomolov VV, Kondratenko SN, Kovachevich IV, Repenkova LG.
[Propranolol pharmacokinetics and hemodynamic indices in antiorthostatic hypokinesia].
Aviakosm Ekolog Med. 2016;50(5):5-10. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt bed rest study.
26
Fomina EV, Uskov KV.
[Effectiveness of different training programs for physical performance maintenance in the condition of low motor activity].
Aviakosm Ekolog Med. 2016;50(5):47-55. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Results are from the MARS-500 Project isolation study.
27
Guizzatullina EA, Bryndina IG.
[Intraocular pressure and eye hydrodynamics during brief head-down tilt].
Aviakosm Ekolog Med. 2016;50(5):43-6. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt study.
28
Ilyin EA.
[Bioethics in human and animal researches].
Aviakosm Ekolog Med. 2016;50(5):69-77. Russian.
https://www.ncbi.nlm.nih.gov/
29
Krasichkov AS, Grigoriev EB, Nifontov EM, Shapovalov VV.
[Algorithm of cardio complex detection and sorting for processing the data of continuous cardio signal monitoring].
Aviakosm Ekolog Med. 2016;50(6):70-8. Russian.
https://www.ncbi.nlm.nih.gov/
30
Medenkov AA.
[At the origin of space psychology (in commemoration of the 100th birthday of F.D. Gorbov)].
Aviakosm Ekolog Med. 2016;50(6):79-82. Russian.
https://www.ncbi.nlm.nih.gov/
31
Mukhamedieva LN, Tsarkov DS, Ozerov DS, Markin AA, Nosovsky AM.
[Human’s breath during modeled prolonged hypodynamia].
Aviakosm Ekolog Med. 2016;50(6):37-44. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Results are from the MARS-500 Project isolation study.
32
Popova II, Repenkova LG, Rukavishnikov IV.
[Monitoring of the functional state of human subjects in isolation in experiment Luna-2015].
Aviakosm Ekolog Med. 2016;50(6):21-4. Russian.
https://www.ncbi.nlm.nih.gov/
Note: Results are from the 9-day Luna-2015 isolation study.
33
Ratushnyy AY, Buravkova LB.
[Functional state of multipotent mesenchymal stromal cells during modeling the effects of microgravity].
Aviakosm Ekolog Med. 2016;50(5):24-9. Russian.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used.
34
Stepanova GP, Degterenkova NV, Stepanova KY.
[Reaction
of the cardiovascular, system to orthostatic testing during extended
head-down bed rest as a function of the countermeasures start date].
Aviakosm Ekolog Med. 2016;50(6):11-20, Russian.
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt bed rest study.
35
Tsetlin VV, Moisa SS, Levinskikh MA, Nefedova EL.
[Effects
of very small doses of ionizing radiation and hypomagnetic field change
physiological characteristics of higher plant seeds].
Aviakosm Ekolog Med. 2016;50(6):51-8. Russian.
