NASA Spaceline Current Awareness List #786 16 February 2018 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at
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Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,
SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Colmenares SU, Swenson JM, Langley SA, Kennedy C, Costes SV, Karpen GH.
Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in
controlling heterochromatin integrity.
Dev Cell. 2017 Jul 24;42(2):156-69.e5.
https://www.ncbi.nlm.nih.gov/
PI: S.V. Costes
Journal Impact Factor: 9.174
Funding:
“This work was supported by the Ruth Kirchstein NIH Postdoctoral
Fellowship (1F32GM086111)
and Laboratory Directed Research and Development Program (LB13037) to
S.U.C. and NIH R01 grants R01 GM086613 and GM117420 to G.H.K.” The PI
reports NASA support under grant NNJ16HP24I.
2
Cortese
F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C,
Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanheaelen Q, Alchinova
I, Karganov M, Kovalchuk
O, Wilkins RC, Shtemberg A, Moreels M, Baatout S, Izumchenko E, de
Magalhães JP, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ,
Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A.
Vive
la radiorésistance!: Converging research in radiobiology and
biogerontology to enhance human radioresistance for deep space
exploration and colonization.
Oncotarget. 2018 Feb 9. [Epub ahead of print]
PI: S.V. Costes
Note:
From the abstract: “Herein, we lay the foundations of a roadmap toward
enhancing human
radioresistance for the purposes of deep space colonization and
exploration. We outline future research directions toward the goal of
enhancing human radioresistance, including upregulation of endogenous
repair and radioprotective mechanisms, possible leeways
into gene therapy in order to enhance radioresistance via the
translation of exogenous and engineered DNA repair and radioprotective
mechanisms, the substitution of organic molecules with fortified
isoforms, and methods of slowing metabolic activity while
preserving cognitive function.” This article may be obtained online
without charge.
Journal Impact Factor: 5.168
Funding:
“The
studies were partially supported by the Russian Foundation for Basic
Research grant #17-29-01002 ofi_m.” The PI reports NASA support under
grant NNJ16HP24I.
3
Jandial R, Hoshide R, Waters JD, Limoli CL.
Space-brain: The negative effects of space exposure on the central nervous system.
Surg Neurol Int. 2018 Jan 16;9:9.
https://www.ncbi.nlm.nih.gov/
PI:
C.L. Limoli/NSCOR
Note:
This article may be obtained online without charge.
Journal Impact Factor:
1.41
Funding: “This work was supported by NASA Grant NNX15AI22G (CLL).”
Note:
The following three articles comment on Roberts DR, Albrecht MH,
Collins HR, Asemani
D, Chatterjee AR, Spampinato MV, Zhu X, Chimowitz MI, Antonucci MU.
Effects of spaceflight on astronaut brain structure as indicated on MRI.
N Engl J Med. 2017 Nov 2;377(18):1746-53.
https://www.ncbi.nlm.nih.gov/
article may be obtained online without charge.
4
Wilson MH, Hargens AR, Imray CH.
Effects of spaceflight on astronaut brain structure.
N Engl J Med. 2018 Feb 8;378(6):581.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
5
Hinkelbein J, Komorowski M, Grau S.
Effects of spaceflight on astronaut brain structure.
N Engl J Med. 2018 Feb 8;378(6):582.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Roberts DR, Antonucci MU.
Effects of spaceflight on astronaut brain structure. [Author reply]
N Engl J Med. 2018 Feb 8;378(6):581-3.
https://www.ncbi.nlm.nih.gov/
PI: D.R. Roberts
Note:
This article may be obtained online without charge.
Journal Impact Factor: 72.406
Funding: The original paper was “Supported by a grant (NNX13AJ92G) from the National Aeronautics
and Space Administration (NASA).”
______________________________
Other papers of interest:
1
Dittrich A, Grimm D, Sahana J, Bauer J, Krüger M, Infanger M, Magnusson NE.
Key
proteins involved in spheroid formation and angiogenesis in endothelial
cells after long-term exposure to simulated microgravity.
Cell Physiol Biochem. 2018 Jan 24;45(2):429-45.
https://www.ncbi.nlm.nih.gov/
Note: A Random Positioning Machine was used. This article may be obtained online without
charge.
2
Hinkelbein J, Russomano T, Hinkelbein F, Komorowski M.
Cardiac arrest during space missions: Specificities and challenges.
Trends Anaesth Crit Care. 2018 Feb 7. [Article in Press]
http://www.
Note:
From the abstract: “Here, we discuss the case of a cardiac arrest
occurring during
spaceflight, and present challenges around the recognition, immediate
management including delivering cardio-pulmonary resuscitation and
secondary measures such as organ support or evacuation.”
3
Jiang S, Zhao XC, Jiao B, Yue ZJ, Yu ZB.
Simulated microgravity hampers Notch signaling in the fight against myocardial ischemia-reperfusion injury.
Mol Med Rep. 2018 Jan 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
Hindlimb unloading study. This article may be obtained online without charge.
4
Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ.
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Cell Death Dis. 2018 Feb 2;9(2):147.
https://www.ncbi.nlm.nih.gov/
Note:
A 2D-clinostat was used. This article may be obtained online without charge.
5
Wang H, Hu Z, Shi F, Dong J, Dang L, Wang Y, Sun Z, Zhou H, Zhang S, Cao X, Zhang G.
Osteoblast-targeted delivery of miR-33-5p attenuates osteopenia development induced by mechanical unloading in mice.
Cell Death Dis. 2018 Feb 7;9(2):170.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading was used. This article may be obtained online without charge.
6
Chen L, Tang H, Du Y, Dai Z, Wang T, Wu L, Zhou L, Bian P.
Induction of reproductive cell death in
Caenorhabditis elegans across entire linear-energy-transfer range of carbon-ion irradiation.
DNA Repair (Amst). 2018 Feb 1;63:39-46.
https://www.ncbi.nlm.nih.gov/
7
Gulay KCM, Tanaka IB 3rd, Komura J, Tanaka S.
Effects of continuous gamma-ray exposure in utero in B6C3F1 mice on gestation day 18 and at 10 weeks of age.
Radiat Res. 2018 Feb 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
8
Yu N, Wang S, Song X, Gao L, Li W, Yu H, Zhou C, Wang Z, Li F, Jiang Q.
Low-dose radiation promotes dendritic cell migration and IL-12 production via the ATM/NF-kappaB pathway.
Radiat Res. 2018 Feb 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Tamás LT, Lundberg YW, Büki B.
Vergence
increases the gain of the human angular vestibulo-ocular reflex during
peripheral hyposensitivity elicited by cold thermal irrigation.
J Vestib Res. 2018;27(5-6):265-70.
https://www.ncbi.nlm.nih.gov/
10
Neupane AK, Gururaj K, Sinha SK.
Higher asymmetry ratio and refixation saccades in individuals with motion sickness.
J Am Acad Audiol. 2018 Feb;29(2):175-86.
https://www.ncbi.nlm.nih.gov/
11
Kimura T, Haga K, Shimizu-Mitao Y, Takebayashi Y, Kasahara H, Hayashi KI, Kakimoto T, Sakai T.
Asymmetric auxin distribution is not required to establish root phototropism in Arabidopsis.
Plant Cell Physiol. 2018 Feb 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
12
Krishnamurthy RS, Hatton J.
Space science and technologies to advance health-related sustainable development goals.
Bull World Health Organ. 2018 Jan 1;96(1):3-3A.
https://www.ncbi.nlm.nih.gov/
Note:
The
Editorial calls on nations to strengthen health and space policy to
encourage collaboration in the use of space science and technology to
advance public health. This article may
be obtained online without charge.
