NASA Spaceline Current Awareness List #782 19 January 2018 (Space Life Science Research Results)
SPACELINE
Current Awareness Lists are distributed via listserv. Please send any
correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior
Editor,
rertwine@nasaprs.com.
Papers deriving from NASA support:
1
Griko Y, Regan MD.
Synthetic
torpor: A method for safely and practically transporting experimental
animals aboard spaceflight missions to deep space.
Life Sci Space Res. 2018 Jan 12. [Article in Press]
https://www.sciencedirect.com/
Journal Impact Factor:
1.97
Funding:
“Supported
in part by the NASA Human Research Program (HRP), San Jose State
University Bridges Program, and NASA contract to the Carnegie Mellon
University Silicon Valley #NNX08 –AB13A.”
2
Carlson C, Singh NK, Bibra M, Sani RK, Venkateswaran K.
Pervasiveness of UVC254-resistant
Geobacillus strains in extreme environments.
Appl Microbiol Biotechnol. 2018 Jan 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 3.42
Funding: “This study was funded by Dr. Rajesh Sani’s research funds (grant no. NNX16AQ98A)
and the NASA South Dakota Space Grant Consortium (grant no. NNX15AJ13H).”
3
Rettig TA, Ward C, Bye BA, Pecaut MJ, Chapes SK.
Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing.
PLoS One. 2018 Jan 10;13(1):e0190982.
https://www.ncbi.nlm.nih.gov/
PIs:
M.J. Pecaut, S.K. Chapes
Note: GeneLab: The data has been uploaded through NASA’s GeneLab and is available under
accession number GLDS-141 at
https://genelab-data.ndc.nasa.
Journal Impact Factor:
2.806
Funding: “This work was supported by NNX13AN34G and NNX15AB45G from National Aeronautics
and Space Administration (https://www.nasa.gov/) (SKC and MJP); GM103418 from the National Institute of Health (https://www.nih.gov/)
(SKC); College of Veterinary Medicine at Kansas State University (http://www.vet.k-state.edu/); and Kansas State University Johnson Cancer – Research Center (http://cancer.k-state.edu/).”
4
Johansen BD, Blue RS, Castleberry TL, Antonsen EL, Vanderploeg JM.
Point-of-care ultrasound for pulmonary concerns in remote spaceflight triage environments.
Aerosp Med Hum Perform. 2018 Feb;89(2):122-9. Review.
http://www.ingentaconnect.com/
PI:
J.M. Vanderploeg
Journal Impact Factor: 0.933
Funding:
“The authors acknowledge the support of the University of Texas Medical
Branch
and the Center for Space Medicine at Baylor College of Medicine. This
work was further supported in part by a grant from the FAA Center of
Excellence for Commercial Space Transportation. The authors acknowledge
the additional support from the National Space
Biomedical Research Institute (NSBRI) through NASA NCC 9-58.”
5
Kuczmarski
JM, Hord JM, Lee Y, Guzzoni V, Rodriguez D, Lawler MS, Garcia-Villatoro
EL, Holly D, Ryan P, Falcon K, Garcia M, Janini Gomes M, Fluckey JD,
Lawler JM.
Effect of EUK-134 on Akt-mTOR signaling in the rat soleus during 7 days of mechanical unloading.
Exp Physiol. 2018 Jan 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: J.M. Lawler; J.M. Kuczmarski, NSBRI Postdoctoral Fellowship Program
Note:
Hindlimb unloading study.
Journal Impact Factor:
2.912
Funding:
“Support for this study was provided by funding from the NASA Space
Biology program
(NNX13AE45G) (JML), National Space Biomedical Research Institute
through NCC 9-58 (JML, JMK), NIH (AR054084) (JML), and the Huffines
Institute for Sports Medicine (JML).”
6
Mange A, Cao Y, Zhang S, Hienz RD, Davis CM.
Whole-body oxygen (16O) ion-exposure-induced impairments in social odor recognition memory in rats are dose and time dependent.
Radiat Res. 2018 Jan 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: C.M. Davis, R.D. Hienz
Journal Impact Factor:
2.539
Funding:
“This
research was supported by NASA grant no. NNX15AC71G and a NASA
cooperative agreement, no. NCC 9-58, with the National Space Biomedical
Research Institute supported through NASA
nos. NCC 9-58-PF02602 and NCC 9-58-NBPF02802.”
7
Antonsen EL, Mulcahy RA, Rubin D, Blue RS, Canga MA, Shah R.
Prototype development of a tradespace analysis tool for spaceflight medical resources.
Aerosp Med Hum Perform. 2018 Feb;89(2):108-14.
http://www.ingentaconnect.com/
Journal Impact Factor: 0.933
Funding: No funding cited. E.L. Antonsen, M.A. Canga, and R. Shah are affiliated with NASA
Johnson Space Center.
8
Olafson KN, Nguyen TQ, Vekilov PG, Rimer JD.
Deconstructing
quinoline-class antimalarials to identify fundamental physicochemical
properties of beta-hematin crystal growth inhibitors.
Chemistry. 2017 Oct 4;23(55):13638-47.
https://www.ncbi.nlm.nih.gov/
PI: P.G. Vekilov
Journal Impact Factor: 5.317
Funding:
“This
work was supported by NIH (Grant 1R21AI126215-01), The Welch Foundation
(Grant E-1794), and NASA (NNX14AD68G and NNX14AE79G).”
9
Olafson KN, Rimer JD, Vekilov PG.
Early onset of kinetic roughening due to a finite step width in hematin crystallization.
Phys Rev Lett. 2017 Nov 10;119(19):198101.
https://www.ncbi.nlm.nih.gov/
PI:
P.G. Vekilov
Journal Impact Factor:
8.462
Funding:
“This
work was supported by National Institutes of Health (NIH) (Grant No.
1R21AI126215-01), National Science Foundation (NSF) (DMR-1710354),
National Aeronautics and Space Administration
(NASA) (NNX14AD68G and NNX14AE79G), and The Welch Foundation (Grant No.
E-1794).”
10
Safari MS, Byington MC, Conrad JC, Vekilov PG.
Polymorphism of lysozyme condensates.
J Phys Chem B. 2017 Oct 5;121(39):9091-101.
https://www.ncbi.nlm.nih.gov/
PI:
P.G. Vekilov
Journal Impact Factor:
3.177
Funding:
“This
work was supported by grants from NASA (NNX14AD68G and NNX14AE79G), NSF
(MCB-1518204, DMR-1710354, and DMR-1131155), and the Welch Foundation
(E-1869).”
______________________________
Other papers of interest:
1
Krause L, Braun M, Hauslage J, Hemmersbach R.
Analysis of statoliths displacement in
Chara rhizoids for validating the microgravity-simulation quality of clinorotation modes.
Microgravity Sci Technol. 2018 Jan 13. [Article in Press]
https://link.springer.com/
Note: MAXUS sounding rocket results. A Random Positioning Machine was used for ground-based
experiments.
2
Masiello MG, Verna R, Cucina A, Bizzarri M.
Physical constraints in cell fate specification. A case in point: Microgravity and phenotypes differentiation.
Prog Biophys Mol Biol. 2018 Jan 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Specific spaceflights and microgravity simulation methods are not identified.
3
Al-horani RA, Wingo JE, Ng J, Bishop P, Richardson M.
Precooling and warm-up effects on time trial cycling during heat stress.
Aerosp Med Hum Perform. 2018 Feb;89(2):87-93.
http://www.ingentaconnect.com/
4
Dey S, Choudhury S.
Physiological significance of gravity receptors on larval cephalic cuticle in the silk moth,
Antheraea proylei Jolly.
Microsc Res Tech. 2018 Jan 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Faherty SL, Villanueva-Cañas JL, Blanco MB, Albà MM, Yoder AD.
Transcriptomics in the wild: Hibernation physiology in free-ranging dwarf lemurs.
Mol Ecol. 2018 Jan 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
6
Radugina E, Grigoryan E.
Heat shock response and shape regulation during newt tail regeneration.
J Therm Biol. 2018 Jan;71:171-9.
https://www.ncbi.nlm.nih.gov/
Note: Results are compared to prior studies that used centrifugation during regeneration.
This article may be obtained online without charge.
7
Szivak TK, Lee EC, Saenz C, Flanagan SD, Focht BC, Volek JS, Maresh CM, Kraemer WJ.
Adrenal stress and physical performance during military survival training.
Aerosp Med Hum Perform. 2018 Feb;89(2):99-107.
http://www.ingentaconnect.com/
8
Xie X, Liu D, Lei D, Liu Y, Wang Q, Wen Z, Qiu J, Jia D, Gregersen H, Wang G.
Effects of simulated microgravity on vascular development in zebrafish.
Mol Cell Biomech. 2017;14(3):171-86.
http://www.techscience.com/
Note:
An MG-IIA bioreactor was used. This article may be obtained online without charge.
9
Kim D, Kim YH, Kwon S.
Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity.
Sci Rep. 2018 Jan 9;8(1):168.
https://www.ncbi.nlm.nih.gov/
Note:
Centrifugation was used.
10
Li EW, McKee-Muir OC, Gilbert PM.
Cellular biomechanics in skeletal muscle regeneration.
Curr Top Dev Biol. 2018;126:125-76. Review.
https://www.ncbi.nlm.nih.gov/
11
Bauer DC, Black DM, Bouxsein ML, Lui LY, Cauley JA, de Papp AE, Grauer A, Khosla S, McCulloch CE, Eastell R.
Treatment-related
changes in bone turnover and fracture risk reduction in clinical trials
of anti-resorptive drugs: A meta-regression.
J Bone Miner Res. 2018 Jan 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
12
Fitzgerald J.
Cartilage breakdown in microgravity—a problem for long-term spaceflight?
npj Regen Med. 2017 Apr 11;2:10.
https://www.ncbi.nlm.nih.gov/
Note: The Editorial discusses recent research about the mechanisms of joint tissue damage
in microgravity and repair after return to Earth. This article may be obtained online without charge.
13
Liu
C, Carrera R, Flamini V, Kenny L, Cabahug-Zuckerman P, George BM,
Hunter D, Liu B, Singh G, Leucht P, Mann KA, Helms JA, Castillo AB.
Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing.
Bone. 2018 Mar;108:145-55.
https://www.ncbi.nlm.nih.gov/
14
St Hilaire MA, Rahman SA, Gooley JJ, Witt-Enderby PA, Lockley SW.
Relationship between melatonin and bone resorption rhythms in premenopausal women.
J Bone Miner Metab. 2018 Jan 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Barthel J, Sarigul-Klijn N.
Radiation
production and absorption in human spacecraft shielding systems under
high charge and energy Galactic Cosmic Rays: Material medium, shielding
depth, and byproduct
aspects.
Acta Astronaut. 2018 Mar;144:254-62.
http://www.sciencedirect.com/
16
Hagiwara Y, Niimi A, Isono M, Yamauchi M, Yasuhara T, Limsirichaikul S, Oike T, Sato H, Held KD, Nakano T, Shibata A.
3D-structured
illumination microscopy reveals clustered DNA double-strand break
formation in widespread γH2AX foci after high LET heavy-ion particle
radiation.
Oncotarget. 2017 Nov 25;8(65):109370-81.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
17
Heselich A, Frieß JL, Ritter S, Benz NP, Layer PG, Thielemann C.
High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro.
Life Sci Space Res. 2018 Jan 11. [Article in Press]
https://www.sciencedirect.com/
18
Kartashov DA, Shurshakov V.
Analysis of space radiation exposure levels at different shielding configurations by ray-tracing dose estimation method.
Acta Astronaut. 2018 Jan 10. [Article in Press]
https://www.sciencedirect.com/
19
Previc FH.
Intravestibular balance and motion sickness.
Aerosp Med Hum Perform. 2018 Feb;89(2):130-40.
http://www.ingentaconnect.com/
20
Liu D, Xie B, Dong C, Liu G, Hu D, Qin YX, Li H, Liu H.
Effect of fertilizer prepared from human feces and straw on germination, growth and development of wheat.
Acta Astronaut. 2018 Jan 10. [Article in Press]
https://www.sciencedirect.com/
