NASA Spaceline Current Awareness List #780 5 January 2018 (Space Life Science Research Results)
SPACELINE
Current Awareness Lists are distributed via listserv. Please send any
correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior
Editor,
rertwine@nasaprs.com.
Papers deriving from NASA support:
1
Castro-Wallace
SL, Chiu CY, John KK, Stahl SE, Rubins KH, McIntyre ABR, Dworkin JP,
Lupisella ML, Smith DJ, Botkin DJ, Stephenson TA, Juul S, Turner DJ,
Izquierdo F, Federman
S, Stryke D, Somasekar S, Alexander N, Yu G, Mason CE, Burton AS.
Nanopore DNA sequencing and genome assembly on the International Space Station.
Sci Rep. 2017 Dec 21;7(1):18022.
https://www.ncbi.nlm.nih.gov/
PI: C.E. Mason
Note: ISS results.
GeneLab: “The datasets generated or analyzed during the current
study are available from the authors on reasonable request;
base-called.fastq files are available in the NASA GeneLab database under
accession number 84;
https://genelab-data.ndc.nasa.
Journal Impact Factor:
4.259
Funding:
“A.S.B. and S.C.W. acknowledge the ISS program office for funding.
K.K.J. acknowledges
support from the NASA Postdoctoral Program administered through the
Universities Space Research Association. J.P.D., M.K.L. and T.A.S.
acknowledge support from the NASA Astrobiology Institute through the
Goddard Center for Astrobiology. For A.B.R.M., N.A.,
C.E.M., we would like to thank the Epigenomics Core Facility at Weill
Cornell Medicine, as well as the Starr Cancer Consortium grant
(I9-A9-071) and funding from the Irma T. Hirschl and Monique
Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation,
the WorldQuant Foundation, The Pershing Square Sohn Cancer Research
Alliance, NASA (NNX14AH50G, 15Omni2-0063), the National Institutes of
Health (R25EB020393, R01ES021006), the Bill and Melinda Gates Foundation
(OPP1151054), and the Alfred P. Sloan Foundation
(G-2015-13964). C.Y.C., S.F., D.S., S.S., and G.Y. are supported by the
National Institutes of Health (R01-HL105704, R21-AI120977) and Abbott
Laboratories, Inc.”
2
Hammond TG, Allen PL, Gunter MA, Chiang J, Giaever G, Nislow C, Birdsall HH.
Physical
forces modulate oxidative status and stress defense meditated metabolic
adaptation of yeast colonies: Spaceflight and microgravity simulations.
Microgravity Sci Technol. 2017 Dec 29. [Article in Press]
https://link.springer.com/
PI:
T.G. Hammond
Note: This article may be obtained online without charge.
Journal Impact Factor:
1.188
Funding: “National Aeronautics and Space Association Grants NNX13AN32G, and NNX12AM93G,
supported these studies.”
3
Harding SM, Singh NJ, Walton KD.
A sensitive period for the development of motor function in rats: A microgravity study.
Gravit Space Res. 2017 Dec;5(2):57-79.
http://
PIs:
K.D. Walton, R. Kalb
Note:
STS-9, STS-72, STS-90 results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This study was supported by NINDS, NICHD NS/HD33467, NASA, NAF2-662, NAG2-951,
and the Department of the Navy NAG2-978 (to KW & Rodolfo Llinás).”
4
Tarver WJ, Cooper JS.
Aerospace, pressure effects hypobaric. [Updated 2017 Nov 7].
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
Journal Impact Factor: Not available for this publication
Funding:
No funding cited. W.J. Tarver is affiliated with NASA Johnson Space Center.
5
Ozdemir RA, Contreras-Vidal JL, Paloski WH.
Cortical control of upright stance in elderly.
Mech Ageing Dev. 2017 Dec 22;169:19-31.
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor:
3.087
Funding:
No funding cited. W.H. Paloski is affiliated with NASA Johnson Space Center.
6
Cassady
K, Ruitenberg M, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood
S, Riascos Castenada R, Kofman I, Bloomberg J, Mulavara A, Seidler R.
Neural predictors of sensorimotor adaptation rate and savings.
Hum Brain Mapp. 2017 Dec 23. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: R.D. Seidler; V. Koppelmans, NSBRI Postdoctoral Fellowship Program
Journal Impact Factor: 4.53
Funding:
“National
Space Biomedical Research Institute (NASA), Grant/Award Numbers: NCC
9-58, MA02701, PF04101; National Aeronautics and Space Administration
(NASA), Grant/Award Number: NNX11AR02G;
NASA Flight Analogs Project; National Institutes of Health; National
Center for Advancing Translational Sciences, Grant/Award Number:
1UL1RR029876-01.”
7
Barker R, Gilroy S.
Life in space isn’t easy, even if you are green.
The Biochemist. 2017 Dec;39(6):10-3.
http://www.biochemist.org/bio/
PI: S. Gilroy
Note:
The article is from an issue devoted to extreme environments. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The authors’ spaceflight research is funded through NASA NNX17AD52G and NNX14AT25G.”
______________________________
Other papers of interest:
1
Reidt U, Helwig A, Müller G, Plobner L, Lugmayr V, Kharin S, Smirnov Y, Novikova N, Lenic J, Fetter V, Hummel T.
Detection of microorganisms onboard the International Space Station using an electronic nose.
Gravit Space Res. 2017 Dec;5(2):89-111.
http://
Note: ISS results. This article may be obtained online without charge.
2
Zamboni P, Sisini F, Menegatti E, Taibi A, Gadda G, Tavoni V, Malagoni AM, Tessari M, Gianesini S, Gambaccini M.
Ultrasound monitoring of jugular venous pulse during space missions: Proof of concept.
Ultrasound Med Biol. 2017 Dec 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
3
León-Espinosa G, Regalado-Reyes M, DeFelipe J, Muñoz A.
Changes in neocortical and hippocampal microglial cells during hibernation.
Brain Struct Funct. 2017 Dec 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
4
Palma-Jiménez M, Ureña YC, Bermúdez CV, Vega-Baudrit JR.
Microgravity and nanomaterials.
Int J Biophysics. 2017;7(4):60-8. Review.
http://article.sapub.org/10.
Note: A 2-D clinostat was used. This article may be obtained online without charge.
5
Porcelli S, Marzorati M, Healey B, Terraneo L, Vezzoli A, Bella SD, Dicasillati R, Samaja M.
Lack of acclimatization to chronic hypoxia in humans in the Antarctica.
Sci Rep. 2017 Dec 22;7(1):18090.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “The aim was to investigate the respiratory and haematological
responses to hypoxia in healthy subjects living at constant altitude.” This article may be obtained online without charge.
6
Schneider S, Zander VS, Vogt T, Albeln V, Strüder JK, Jacubowski A, Carnahan H, Wollseiffen P.
Hemodynamic and neuroendocrinological responses to artificial gravity.
Gravit Space Res. 2017 Dec;5(2):80-8.
http://
Note: Centrifugation was used. This article may be obtained online without charge.
7
Wuest
SL, Plüss T, Hardegger C, Felder M, Kunz A, Fleishli B, Komotar C,
Rüdlinger L, Albisser A, Gisler T, Frauchiger DA, Egli M.
Electrophysiological recordings on a sounding rocket: Report of a first attempt using
Xenopus laevis oocytes.
Gravit Space Res. 2017 Dec;5(2):43-56.
http://
Note:
Sounding rocket results. This article may be obtained online without charge.
8
Walsh C, Stride E, Cheema U, Ovenden N.
A combined three-dimensional
in vitro-in silico approach to modelling bubble dynamics in decompression sickness.
J R Soc Interface. 2017 Dec;14(137).
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
9
Trudel G, Uhthoff HK, Laneuville O.
Hemolysis during and after 21 days of head-down-tilt bed rest.
Physiol Rep. 2017 Dec;5(24).
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
10
Van Walleghem M, Tabury K, Fernandez-Gonzalo R, Janssen A, Buchheim JI, Choukèr A, Baatout S, Moreels M.
Gravity-related immunological changes in human whole blood cultured under simulated microgravity using an
in vitro cytokine release assay.
J Interferon Cytokine Res. 2017 Dec;37(12):531-40.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used.
11
Anderson JE, Zhu A, Mizuno TM.
Nitric oxide treatment attenuates muscle atrophy during hind limb suspension in mice.
Free Radic Biol Med. 2017 Dec 19;115:458-70.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
12
Ghosh S, Cimino JG, Scott AK, Damen FW, Phillips EH, Veress AI, Neu CP, Goergen CJ.
In vivo multiscale and spatially-dependent biomechanics reveals differential strain
transfer hierarchy in skeletal muscle.
ACS Biomater Sci Eng. 2017 Nov 13;3(11):2798-805.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
13
Kataoka H, Nakano J, Kondo Y, Honda Y, Sakamoto J, Origuchi T, Okita M.
The influence of aging on the effectiveness of heat stress in preventing disuse muscle atrophy.
Physiol Int. 2017 Dec 1;104(4):316-28.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb casting was used.
14
Mera P, Laue K, Wei J, Berger JM, Karsenty G.
Corrigendum to “Osteocalcin is necessary and sufficient to maintain muscle mass in older mice” [Mol Metabol 5 (2017) 1042-1047].
Mol Metab. 2017 Aug;6(8):941.
https://www.ncbi.nlm.nih.gov/
Note:
The corrigendum corrects data in Figure 4C. The original article was cited in Current Awareness List #719, 14 Oct 2016.
https://www.ncbi.nlm.nih.gov/
15
Antipova VN, Lomaeva MG, Zyrina NV.
Mitochondrial DNA deletions in tissues of mice after ionizing radiation exposure.
Int J Radiat Biol. 2017 Dec 19:1-18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
16
Bykov VN, Drachev IS, Kraev SY, Maydin MA, Gubareva EA, Pigarev SE, Anisimov VN, Baldueva IA, Fedoros EI, Panchenko AV.
Radioprotective
and radiomitigative effects of BP-C2, a novel lignin-derived
polyphenolic composition with ammonium molybdate, in two mouse strains
exposed to total body
irradiation.
Int J Radiat Biol. 2017 Dec 21:1-10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
17
Du Y, Luo S, Yu L, Cui T, Chen X, Yang J, Li X, Li W, Wang J, Zhou L.
Strategies for identification of mutations induced by carbon-ion beam irradiation in
Arabidopsis thaliana by whole genome re-sequencing.
Mutat Res. 2017 Dec 9;807:21-30.
https://www.ncbi.nlm.nih.gov/
18
Durante M, Cucinotta FA, Loeffler JS.
Editorial: Charged Particles in Oncology.
Front Oncol. 2017 Dec 8;7:301.
https://www.ncbi.nlm.nih.gov/
Note:
The Editorial introduces the Research Topic, Charged Particles in
Oncology, which
includes 59 additional articles in the areas of physics, biology,
medicine, and facilities and networks. The articles can be found at:
https://www.frontiersin.org/
19
Gautam SD, Hardie ME, Murray V.
The sequence preference of gamma-radiation-induced damage in end-labeled DNA after heat treatment.
Radiat Res. 2017 Dec 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
20
Smirnova OA, Cucinotta FA.
Dynamical modeling approach to risk assessment for radiogenic leukemia among astronauts engaged in interplanetary space missions.
Life Sci Space Res. 2018 Feb;16:76-83.
http://www.sciencedirect.com/
21
Wang H, Duan J, Liao Y, Wang C, Li H, Liu X.
Objects mental rotation under 7 days simulated weightlessness condition: An ERP study.
Front Hum Neurosci. 2017 Dec 6;11:553.
https://www.ncbi.nlm.nih.gov/
Note:
Head-down tilt bed rest study. This article may be obtained online without charge.
22
Fydanaki O, Kousoulis P, Dardiotis E, Bizakis I, Hajiioannou I.
Electroacupuncture could reduce motion sickness susceptibility in healthy male adults: A double-blinded study.
Med Acupunct. 2017 Dec 1;29(6):377-82.
https://www.ncbi.nlm.nih.gov/
Note:
A rotating chair was used. This article may be obtained online without charge.
23
Hermann R, Pelisson D, Dumas O, Urquizar C, Truy E, Tilikete C.
Are covert saccade functionally relevant in vestibular hypofunction?
Cerebellum. 2017 Dec 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
24
Kato T, Horibata A.
Relationship between the spreading-stub phenotype of rice and negative gravitropism of stems at tillering stage.
J Crop Res. 2017;62:1-5.
https://www.jstage.jst.go.jp/
Note: Plant pots were slanted 45° from perpendicular. This article may be obtained online
without charge.
25
Lotz C, Froböse T, Wanner A, Overmeyer L, Ertmer W.
Einstein-Elevator: A new facility for research from μg to 5 g.
Gravit Space Res. 2017 Dec;5(2):11-27.
http://
Note:
The
Einstein-Elevator is a drop tower facility being built in Hannover,
Germany, which will be capable of simulating micro-, hypo-, and
hypergravity conditions with a high repetition
rate. This article may be obtained online without charge.
26
Radüntz T.
Dual frequency head maps: A new method for indexing mental workload continuously during execution of cognitive tasks.
Front Physiol. 2017 Dec 8;8:1019.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
27
Van’t Hullenaar CDP, Mertens AC, Ruurda JP, Broeders I.
Validation of ergonomic instructions in robot-assisted surgery simulator training.
Surg Endosc. 2017 Dec 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
28
Biotechnology in Space.
Ruyters G, Betzel C, Grimm D, editors.
Chaum, Switzerland: Springer, 2017. 122 p.
https://link.springer.com/
Note:
From the Forward: “. . .the authors demonstrate in seven chapters
following the introduction.
. . that there is indeed a strong relationship between these terms
[biotechnology and gravity]: in fact, gravity has not only influenced
the origin, distribution, and the evolution of life in general; also
changes in gravity, especially the lack of gravity,
i.e., the microgravity conditions of spaceflight, exert a marked
influence on bio(techno)logical processes.” Citations for the 8 chapters
follow.
29
Ruyters G, Betzel C, Grimm D.
Biotechnology, cell biology and microgravity.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 1-10.
https://link.springer.com/
30
Ruyters G, Betzel C.
Protein crystallization in space: Early successes and drawbacks in the German Space Life Sciences Program.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 11-26.
https://link.springer.com/
Note:
The
chapter includes discussion of protein crystallization studies
conducted on TEXUS sounding rockets, Space Shuttle, Spacelab missions,
and ISS.
31
Betzel C, Martirosyan A, Ruyters G.
Protein crystallization on the International Space Station ISS.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 27-39.
https://link.springer.com/
Note: ISS results.
32
Betzel C, Martirosyan A.
Drug design.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 41-58.
https://link.springer.com/
Note: Chinese satellite, Space Shuttle, and ISS results.
33
Grimm D.
Cell biology in space.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 59-72.
https://link.springer.com/
Note:
Space Shuttle and ISS results.
34
Wehland M, Grimm D.
Tissue engineering in microgravity.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 73-85.
https://link.springer.com/
Note: Rotating Wall Vessel bioreactor studies are discussed.
35
Krüger M, Bauer J, Grimm D.
Cancer research in space.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 87-106.
https://link.springer.com/
Note: Parabolic flight, Shenzhou missions, and ISS results are discussed. Methods of microgravity
simulation discussed include clinostats, rotating wall vessels, and random positioning machines.
36
Ruyters G, Braun M, Betzel C, Grimm D.
Outlook: Future potential of biotechnology research in space.
In: Ruyters G, Betzel C, Grimm D, eds. Biotechnology in Space. Chaum, Switzerland: Springer, 2017. p. 107-9.
https://link.springer.com/
