NASA Spaceline Current Awareness List #776 1 December 2017 (Space Life Science Research Results)
SPACELINE
Current Awareness Lists are distributed via listserv. Please send any
correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior
Editor,
rertwine@nasaprs.com.
Papers deriving from NASA support:
1
Stahn
AC, Werner A, Opatz O, Maggioni MA, Steinach M, von Ahlefeld VW, Moore
A, Crucian BE, Smith SM, Zwart SR, Schlabs T, Mendt S, Trippel T,
Koralewski E, Koch J, Choukèr
A, Reitz G, Shang P, Röcker L, Kirsch KA, Gunga HC.
Increased core body temperature in astronauts during long-duration space missions.
Sci Rep. 2017 Nov 23;7(1):16180.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor:
4.259
Funding: “This investigation was supported by the ELIPS 3 and 4 programs of ESA and DLR
grants 50WB0724 and 50WB1030.” B.E. Crucian, S.M. Smith, and S.R. Zwart are affiliated with NASA Johnson Space Center.
2
Aseyev
N, Vinarskaya AK, Roshchin M, Korshunova TA, Malyshev AY, Zuzina AB,
Ierusalimsky VN, Lemak MS, Zakharov IS, Novikov IA, Kolosov P,
Chesnokova E, Volkova S, Kasianov
A, Uroshlev L, Popova Y, Boyle RD, Balaban PM.
Adaptive changes in the vestibular system of land snail to a 30-day spaceflight and readaptation on return to Earth.
Front Cell Neurosci. 2017 Nov 1;11:348.
https://www.ncbi.nlm.nih.gov/
PI:
R.D. Boyle
Note: Bion M-1 results. This article may be obtained online without charge.
Journal Impact Factor: 4.555
Funding:
“This
study was supported by RFBR grant No 12-04-01166-a, and by RSF grant
14-25-00072 (transcriptome analysis). . . .RB supported in part by NASA
grant (11_Omni_2_0002) and from
NASA Human Research and Space Biology Programs. YP supported by NASA
Postdoctoral Program administered by the Oak Ridge Associated
Universities.”
3
DasSarma P, DasSarma S.
Survival of microbes in Earth’s stratosphere.
Curr Opin Microbiol. 2017 Nov 17;43:24-30.
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 6.635
Funding:
“Research in the authors’ laboratory is supported by National Aeronautics and Space Administration grant NNX15AM07G.”
4
Balasubramanian S, Tepelus T, Stenger MB, Lee SMC, Laurie SS, Liu JHK, Feiveson AH, Sadda SR, Huang AS, Macias BR.
Thigh cuffs as a countermeasure for ocular changes in simulated weightlessness.
Ophthalmology. 2017 Nov 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: B.R. Macias
Note:
Postures used were sitting, supine, 15° head-down tilt, and 15° head-down tilt with thigh cuffs.
Journal Impact Factor: 8.204
Funding:
“Supported
by the National Space Biomedical Research Institute (NSBRI; Houston,
TX) through National Aeronautics and Space Administration (NASA)
Cooperative Agreement no. NCC 9-58
(B.R.M., A.S.H.), and an unrestricted grant from Research to Prevent
Blindness to UCLA (New York, NY).”
5
Zhang LF, Hargens AR.
Spaceflight-induced intracranial hypertension and visual impairment: Pathophysiology and countermeasures.
Physiol Rev. 2018 Jan 1;98(1):59-87. Review. Epub 2017 Nov 24.
https://www.ncbi.nlm.nih.gov/
PI:
A.R. Hargens
Journal Impact Factor:
27.312
Funding:
“This
work was supported by the National Natural Science Foundation of China
(to L.-F. Zhang) and NASA Grants NNX13AJ12G, NNX13AM89G, and NNX14AP25G
(to A. R. Hargens).”
6
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H.
Combined effects of simulated microgravity and radiation exposure on osteoclast cell fusion.
Int J Mol Sci. 2017 Nov 18;18(11):E2443.
https://www.ncbi.nlm.nih.gov/
PI:
H. Wu
Note: A rotating wall vessel was used. This article may be obtained online without charge.
Journal Impact Factor: 3.226
Funding:
“This
work was supported in part by the NASA Human Research Program and the
University of Houston Institute for Space Systems Operations (ISSO)
Program.”
7
Zhang J, Shim G, de Toledo SM, Azzam EI.
The translationally controlled tumor protein and the cellular response to ionizing radiation-induced DNA damage.
Results Probl Cell Differ. 2017;64:227-53.
https://www.ncbi.nlm.nih.gov/
PI: E.I. Azzam
Journal Impact Factor: 2.12
Funding:
“This work was supported by grant CA049062 from the National Institutes
of Health,
grant NNX15AD62G from the National Aeronautics and Space
Administration, and the Program for Changjiang Scholars and Innovative
Research Team, University of Ministry of Education, China.”
8
Karmali F, Bermúdez Rey MC, Clark TK, Wang W, Merfeld DM.
Multivariate analyses of balance test performance, vestibular thresholds, and age.
Front Neurol. 2017 Nov 8;8:578.
https://www.ncbi.nlm.nih.gov/
PI: T.K. Clark, NSBRI Postdoctoral Fellowship Program
Note: This article may be obtained online without charge.
Journal Impact Factor:
3.184
Funding:
“This
research was supported by NIH/NIDCD R01-DC01458, R01-DC014924 and
R03-DC013635.” PI reports funding under NSBRI NCC 9-58-PF03502.
9
Clément G.
International roadmap for artificial gravity research.
npj Microgravity. 2017 Nov 24;3(1):29. Review.
https://www.nature.com/
Note: This article may be obtained online without charge.
Journal Impact Factor:
Not available for this journal
Funding:
No funding cited. C. Clément is affiliated with NASA Johnson Space Center.
______________________________
Other papers of interest:
1
Lacquaniti F, Ivanenko YP, Sylos-Labini F, La Scaleia V, La Scaleia B, Willems PA, Zago M.
Human locomotion in hypogravity: From basic research to clinical applications.
Front Physiol. 2017 Nov 7;8:893. Review.
https://www.ncbi.nlm.nih.gov/
Note:
Apollo and parabolic flight results. Discussion of simulators focuses
on body weight
support systems, lower body positive pressure, passive gravity
balancing systems, and exoskeletons. This article may be obtained online
without charge.
2
Costa-Almeida R, Granja PL, Gomes ME.
Gravity, tissue engineering, and the missing link.
Trends Biotechnol. 2017 Nov 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Discussion focuses on spaceflight, rotation, and centrifugation.
3
Barnes KR, Janecke JN.
Physiological and biomechanical responses of highly trained distance runners to lower-body positive pressure treadmill running.
Sports Med Open. 2017 Nov 21;3(1):41.
https://www.ncbi.nlm.nih.gov/
4
Mayo B, Miles C, Sims S, Driller M.
The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes.
High Alt Med Biol. 2017 Nov 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Williams CT, Buck CL, Sheriff MJ, Richter MM, Krause JS, Barnes BM.
Sex-dependent phenological plasticity in an Arctic hibernator.
Am Nat. 2017 Dec;190(6):854-9.
https://www.ncbi.nlm.nih.gov/
6
Goswami N, Blaber AP, Hinghofer-Szalkay H, Montani JP.
Orthostatic intolerance in older persons: Etiology and countermeasures.
Front Physiol. 2017 Nov 9;8:803.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
7
Wang S, Yin Z, Zhao B, Qi Y, Liu J, Rahimi SA, Lee LY, Li S.
Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis.
Stem Cell Res. 2017 Dec;25:157-65.
https://www.ncbi.nlm.nih.gov/
Note: A 2-D clinostat was used. This article may be obtained online without charge.
8
Murphy FG, Hada EA, Doolette DJ, Howle LE.
Probabilistic pharmacokinetic models of decompression sickness in humans: Part 2, Coupled perfusion-diffusion models.
Comput Biol Med. 2018 Jan;92:90-7. Epub 2017 Nov 15.
https://www.ncbi.nlm.nih.gov/
9
Guitart M, Lloreta J, Mañas-Garcia L, Barreiro E.
Muscle regeneration potential and satellite cell activation profile during recovery following hindlimb immobilization in mice.
J Cell Physiol. 2017 Nov 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
Hindlimb unloading study.
10
Hu X, Charles JP, Akay T, Hutchinson JR, Blemker SS.
Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans.
Skelet Muscle. 2017 Nov 16;7(1):26.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
11
Curtis KJ, Coughlin TR, Mason DE, Boerckel JD, Niebur GL.
Bone
marrow mechanotransduction in porcine explants alters kinase activation
and enhances trabecular bone formation in the absence of osteocyte
signaling.
Bone. 2018 Feb;107:78-87. Epub 2017 Nov 14.
https://www.ncbi.nlm.nih.gov/
12
Khrimian L, Obri A, Karsenty G.
Modulation of cognition and anxiety-like behavior by bone remodeling.
Mol Metab. 2017 Dec;6(12):1610-5.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
13
Pelin T, Aramesh T, Constantin D, Mirjam N, Mihir S, Siamak S, Roland S, Michael S, Devakar E.
Early mechanical stimulation only permits timely bone healing in sheep.
J Orthop Res. 2017 Nov 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
14
Schofield PN, Kondratowicz M.
Evolving paradigms for the biological response to low dose ionising radiation; the role of epigenetics.
Int J Radiat Biol. 2017 Nov 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Mullick AA, Turpin NA, Hsu SC, Subramanian SK, Feldman AG, Levin MF.
Referent control of the orientation of posture and movement in the gravitational field.
Exp Brain Res. 2017 Nov 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
16
Hodkinson PD, Anderton RA, Posselt BN, Fong KJ.
An overview of space medicine.
Br J Anaesth. 2017 Dec 1;119(Suppl 1):i143-i53. Review.
https://www.ncbi.nlm.nih.gov/
Note:
From the abstract: “This review introduces the field of space medicine
and describes
the different types of spaceflight, environmental challenges,
associated medical and physiological effects, and operational medical
considerations. It will describe the varied roles of the space medicine
doctor, including the conduct of surgery and anaesthesia,
and concludes with a vision of the future for space medicine in the
UK.”
