Status Report

NASA Spaceline Current Awareness List #765 15 September 2017 (Space Life Science Research Results))

By SpaceRef Editor
September 15, 2017
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SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Parra M, Jung J, Boone TD, Tran L, Blaber EA, Brown M, Chin M, Chinn T, Cohen J, Doebler R, Hoang D, Hyde E, Lera M, Luzod LT, Mallinson M, Marcu O, Mohamedaly Y, Ricco AJ, Rubins K, Sgarlato GD, Talavera RO, Tong P, Uribe E, Williams J, Wu D, Yousuf R, Richey CS, Schonfeld J, Almeida EAC.

Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station.

PLoS One. 2017 Sep 6;12(9):e0183480.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 2.806

Funding: “Funding for this research was provided by the National Aeronautics and Space Administration’s International Space Station (ISS) Program at Johnson Space Center for development of a microgravity RT-qPCR analysis facility. The project was independently conducted by NASA Ames Research Center Space Biosciences and Engineering Systems Divisions.”



Kunz H, Quiriarte H, Simpson RJ, Ploutz-Snyder R, McMonigal K, Sams C, Crucian B.

Alterations in hematologic indices during long-duration spaceflight.

BMC Hematology. 2017 Sep 8;17(1):12.

PIs: C. Sams, R.J. Simpson

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by a grant from the NASA Human Research Program’s Human Health and Countermeasures Element to CS/BEC (SMO-015) and NASA grant NNJ10ZSA003N awarded to RJS.”



Boothby TC, Pielak GJ.

Intrinsically disordered proteins and desiccation tolerance: Elucidating functional and mechanistic underpinnings of anhydrobiosis.

Bioessays. 2017 Sep 13. [Epub ahead of print]

PI: T.C. Boothby

Journal Impact Factor: 4.441

Funding: “TCB is supported by the Simons Foundation in conjunction with the Life Sciences Research Foundation and NASA (NNX15AB44G). GJP is supported by the National Science Foundation (MCB 1410854, CHE 1607359).”



Heavner ME, Ramroop J, Gueguen G, Ramrattan G, Dolios G, Scarpati M, Kwiat J, Bhattacharya S, Wang R, Singh S, Govind S.

Novel organelles with elements of bacterial and eukaryotic secretion systems weaponize parasites of Drosophila

Curr Biol. 2017 Sep 6. [Epub ahead of print]

PI: S. Govind

Journal Impact Factor:  8.496

Funding: “This work was supported by grants from NASA (NNX15AB42G), the NSF (IOS-1121817), and the NIH (1F31GM111052-01A1 and G12MD007603-30).”



Be NA, Avila-Herrera A, Allen JE, Singh N, Sielaff AC, Jaing C, Venkateswaran K.

Erratum to: Whole metagenome profiles of particulates collected from the International Space Station.

Microbiome. 2017 Sep 1;5(1):111.

PIs: K. Venkateswaran, C. Jaing

Note: From the Erratum: “Following publication of the original article [1], the authors reported that the X-axis label was missing from Fig. 4. The new Fig. 4 is attached.” The original article was listed in SPACELINE Current Awareness List #759, 2017 Jul 27. This article may be obtained online without charge.

Journal Impact Factor: 8.496

Funding: From original citation: “This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV which also funded post-doctoral fellowship for AC and a JPL subcontract 1506453 to GEF. This work was performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. In addition, the research carried out at the Lawrence Livermore National Laboratory was funded by a 2014 Space Biology NNH14ZTT002N grant no. NNX15AJ29G award to CJ which also funded JA, NB, and AAH.”



Challa ST, Hargens AR, Uzosike A, Macias BR.

Muscle microvascular blood flow, oxygenation, pH, and perfusion pressure decrease in simulated acute compartment syndrome.

J Bone Joint Surg Am. 2017 Sep 6;99(17):1453-9.

PI: B.R. Macias

Journal Impact Factor: 4.84

Funding: “Study participants received monetary compensation for participation through a grant from the National Institutes of Health. One of the authors (B.R.M.) received funding from NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute. In addition, one of the authors (A.U.) received funding through a fellowship from the American Physiological Society. Another of the authors (S.T.C.) received a summer research stipend from Sotera Wireless, the provider of the near-infrared spectroscopy-pH probes used in this project.”



Yuan M, Wang Y, Qin YX.

SPIO-Au core-shell nanoparticles for promoting osteogenic differentiation of MC3T3-E1 cells: Concentration-dependence study.

J Biomed Mater Res A. 2017 Sep 4. [Epub ahead of print]

PI: Y.X. Qin

Journal Impact Factor: 3.076

Funding: “The authors would like to thank the support of DOE-AR0000531 and ONRN000141410230, and the support of NIH (R01 AR 52379 and AR 61821), and National Space Biomedical Research Institute through NASA Contract NCC 9-58.”



Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J.

Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation.

Sci Rep. 2017 Aug 31;7(1):10227.

PI: J. Raber

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.259

Funding: “This work was supported by NASA grant NNJ12ZSA001N.”



McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB.

Later circadian timing of food intake is associated with increased body fat.

Am J Clin Nutr. 2017 Sep 6. [Epub ahead of print]

PIs: E.B. Klerman, D. Shreckenghost

Journal Impact Factor: 6.926

Funding: “Supported by the NIH (grants F32DK107146, T32HL007901, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392, R00HL119618, R01DK099512, R01DK105072, R01HL118601, and 1UL1TR001102) and the National Space Biomedical Research Institute (grants HFP02802, HFP04201, and HDP0006).”



Brillada C, Rojas-Pierce M.

Vacuolar trafficking and biogenesis: A maturation in the field.

Curr Opin Plant Biol. 2017 Dec;40:77-81. Epub 2017 Aug 31.

PI: M. Rojas-Pierce

Journal Impact Factor: 7.357

Funding: “Research in the Rojas-Pierce laboratory is funded by NASA Space Life and Physical Sciences Division (NNX13AM49G to MRP).”



Other papers of interest:



Soga K, Yamazaki C, Kamada M, Tanigawa N, Kasahara H, Yano S, Kojo KH, Kutsuna N, Kato T, Hashimoto T, Kotake T, Wakabayashi K, Hoson T.

Modification of growth anisotropy and cortical microtubule dynamics in Arabidopsis hypocotyls grown under microgravity conditions in space.

Physiol Plant. 2017 Sep 1. [Epub ahead of print]

Note: ISS results.



Richter C, Braunstein B, Winnard A, Nasser M, Weber T.

Human biomechanical and cardiopulmonary responses to partial gravity – A systematic review.

Front Physiol. 2017 Aug 15;8:583. Review.

Note: This article may be obtained online without charge.



Wostyn P, De Deyn PP.

Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronauts.

Biomark Med. 2017 Sep 04. [Epub ahead of print]



Koy T, Ganse B, Zange J, Rittweger J, Pohle-Fröhlich R, Fings-Meuthen P, Johannes B, Felsenberg D, Eysel P, Bansmann PM, Belavý DL.

T2-relaxation time increases in lumbar intervertebral discs after 21d head-down tilt bed-rest.

J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):140-5.

Note: Head-down tilt bed rest study. This article may be obtained online without charge.



Guo Q, Mi X, Sun X, Li X, Fu W, Xu S, Wang Q, Arfat Y, Wang H, Chang H, Gao Y.

Remarkable plasticity of Na+, K+-ATPase, Ca2+-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels.

Sci Rep. 2017 Sep 5;7(1):10509.

Note: This article may be obtained online without charge.



Jee H, Kim JH.

A mini-overview of single muscle fibre mechanics: The effects of age, inactivity and exercise in animals and humans.

Swiss Med Wkly. 2017 Sep 5;147:w14488. Review.

Note: This article may be obtained online without charge.



Paillard T.

Relationship between muscle function, muscle typology and postural performance according to different postural conditions in young and older adults.

Front Physiol. 2017 Aug 15;8:585.

Note: This article may be obtained online without charge.



DeSouza R, Javaheri B, Collinson RS, Chenu C, Shefelbine SJ, Lee PD, Pitsillides AA.

Prolonging disuse in aged mice amplifies cortical but not trabecular bones’ response to mechanical loading.

J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):218-25.

Note: This article may be obtained online without charge.



Hart NH, Nimphius S, Rantalainen T, Ireland A, Siafarikas A, Newton RU.

Mechanical basis of bone strength: Influence of bone material, bone structure and muscle action.

J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):114-39. Review.

Note: This article may be obtained online without charge.



Misof BM, Blouin S, Lueger S, Paschalis EP, Recker RR, Phipps R, Klaushofer K, Roschger P.

Baseline mineralizing surface determines the magnitude of the bisphosphonate effect on cortical bone mineralization in postmenopausal osteoporotic patients.

J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):183-91.

Note: This article may be obtained online without charge.



Piemontese M, Almeida M, Robling AG, Kim HN, Xiong J, Thostenson JD, Weinstein RS, Manolagas SC, O’Brien CA, Jilka RL.

Old age causes de novo intracortical bone remodeling and porosity in mice.

JCI Insight. 2017 Sep 7;2(17):93771.

Note: This article may be obtained online without charge.



Cho HJ, Lee WH, Hwang OMH, Sonntag WE, Lee YW.

Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain.

Int J Radiat Biol. 2017 Sep 7. [Epub ahead of print]



Eom HS, Park HS, You GE, Kim JY, Nam SY.

Identification of cellular responses to low-dose radiation by the profiling of phosphorylated proteins in human B-lymphoblast IM-9 cells.

Int J Radiat Biol. 2017 Sep 7. [Epub ahead of print]



Cignetti F, Chabeauti PY, Menant J, Anton JJJ, Schmitz C, Vaugoyeau M, Assaiante C.

Gravity cues embedded in the kinematics of human motion are detected in form-from-motion areas of the visual system and in motor-related areas.

Front Psychol. 2017 Aug 17;8:1396.

Note: This article may be obtained online without charge.



Clarke AH.

Vestibulo-oculomotor research in space.

Chaum, Switzerland: Springer International Publishing, 2017. 88 p.

Note: The Introduction includes an overview of the vestibular system and discussion on Visual-Vestibular Interactions, Adaptation, Motion Sickness, and an Historical Perspective.  Other chapters focus on The Role of the Otoliths, The Three-Dimensional Vestiblo-Ocular Reflex During Prolonged Microgravity, Listing’s Plane and the 3D-VOR in Microgravity (both parabolic flight and spaceflight), Technology Developments and Transfer, and Clinical Applications and Related Projects.



Griko YV, Rask JC, Raychev R.

Advantage of animal models with metabolic flexibility for space research beyond low Earth orbit.

New Space. 2017 Sep 1;5(3):110-20.


SpaceRef staff editor.