Status Report

NASA Spaceline Current Awareness List #764 8 September 2017 (Space Life Science Research Results))

By SpaceRef Editor
September 8, 2017
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SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Evans JM, Wang S, Greb C, Kostas V, Knapp CF, Zhang Q, Roemmele ES, Stenger MB, Randall DC.

Body size predicts cardiac and vascular resistance effects on men’s and women’s blood pressure.

Front Physiol. 2017 Aug 9;8:561.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.031

Funding: “Supported by KY NASA EPSCoR Grants 516204, #NNX07AT58A and #NNX07AL55A and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000117.”



Zhang Q, Evans JM, Stenger MB, Moore FB, Knapp CF.

Autonomic cardiovascular responses to orthostatic stress after a short artificial gravity exposure.

Aerosp Med Hum Perform. 2017 Sep 1;88(9):827-33.

PI: M.B. Stenger

Journal Impact Factor: 0.933

Funding: “This study was supported by KY NASA EPSCoR Grant #NNX07AT58A, KY State Matching Grants, the NASA Johnson Space Center Human Research Program, and the NASA Ames Research Center.”



Jain D, Meydan C, Lange J, Claeys Bouuaert C, Mason CE, Anderson KV, Keeney S.

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline.

PLoS Genet. 2017 Aug 30;13(8):e1006964.

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.100

Funding: “Memorial Sloan-Kettering Cancer Center core facilities were supported by National Institutes of Health grant P30 CA008748. DJ was supported by a fellowship from Human Frontier Science Program. SK is an investigator with the Howard Hughes Medical Institute. KVA is supported by National Institutes of Health grant R37 HD035455. CEM and CM thank the Starr Cancer Consortium (I9-A9-071), the Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), and the Bill and Melinda Gates Foundation (OPP1151054).”



Yu K, Doherty AH, Genik PC, Gookin SE, Roteliuk DM, Wojda SJ, Jiang ZS, McGee-Lawrence ME, Weil MM, Donahue SW.

Mimicking the effects of spaceflight on bone: Combined effects of disuse and chronic low-dose rate radiation exposure on bone mass in mice.

Life Sci Space Res. 2017 Nov;15:62-8. Epub 2017 Aug 12.

Note: Hindlimb unloading study.

Journal Impact Factor: 1.97

Funding: M.M. Weil reports that this study was conducted in an irradiation facility established with collaborative funding provided by NASA and the Department of Energy (R. Ullrich’s NSCOR NAG 9-1569 and DE-F02-05ER63946).



Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FA, Hu K.

Reduced tolerance to night shift in chronic shift workers: Insight from fractal regulation.

Sleep. 2017 Jul 1;40(7):zsx092.

PI: C.J. Morris, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 4.923

Funding: “This work was supported by NIH grants R01HL094806 (to F.A.J.L.S.) and R00-HL102241 (to K.H.). P.L. was supported by the International Postdoctoral Exchange Fellowship 20150042 from the China Postdoctoral Council; C.J.M. was supported by the NSBRI through NASA Grant NCC 9–58, R01-HL094806, R01-DK099512, and R01-HL118601; F.A.J.L.S was supported by R01-HL094806, R01-DK099512, and R01-HL118601, and K.H. was supported by R00-HL102241, R01AG048108, and P01AG009975.”



McClements DJ, Saliva-Trujillo L, Zhang R, Zhang Z, Zou L, Yao M, Xiao H.

Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions.

Food Res Int. 2016 Oct;88(Pt A):140-52. Review.

PI: H. Xiao

Journal Impact Factor: 3.086

Funding: “This material was partly based upon work supported by the Cooperative State Research, Extension, Education Service, USDA, Massachusetts Agricultural Experiment Station and USDA, NRI Grants (2011-03539, 2013-03795, 2011-67021, and 2014-67021).We also thank the National Aero and Space Administration (NASA) for partial funding of this research (NNX14AP32G), as well as the National Natural Science Foundation of China (NSFC31428017), and the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah (330-130-1435-DSR).”



Other papers of interest:



Stabler RA, Rosado H, Doyle R, Negus D, Carvil PA, Kristjánsson JG, Green DA, Franco-Cendejas R, Davies C, Mogensen A, Scott J, Taylor PW.

Impact of the Mk VI SkinSuit on skin microbiota of terrestrial volunteers and an International Space Station-bound astronaut.

npj Microgravity. 2017 Sep 9;3(1):23.

Note: ISS results. This article may be obtained online without charge.



Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G.

Gpr158 mediates osteocalcin’s regulation of cognition.

J Exp Med. 2017 Aug 29. [Epub ahead of print]



Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Kruger M, Hemmersbach R, Infanger M, Lutzenberg R, Grimm D.

Cytokine release and focal adhesion proteins in normal thyroid cells cultured on the random positioning machine.

Cell Physiol Biochem. 2017;43(1):257-70.

Note: A random positioning machine was used. This article may be obtained online without charge.



Drew RC.

Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: An exercise in integrative physiology.

Am J Physiol Regul Integr Comp Physiol. 2017 Aug 30. [Epub ahead of print]



Taibi A, Gadda G, Gambaccini M, Menegatti E, Sisini F, Zamboni P.

Investigation of cerebral venous outflow in microgravity.

Physiol Meas. 2017 Aug 31. [Epub ahead of print]

Note: Hindlimb unloading study.



Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS.

SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination.

Cell Rep. 2017 Aug 22;20(8):1921-35.

Note: This article may be obtained online without charge.



Belova SP, Shenkman BS, Kostrominova TY, Nemirovskaya TL.

Paradoxical effect of IKKβ inhibition on the expression of E3 ubiquitin ligases and unloading-induced skeletal muscle atrophy.

Physiol Rep. 2017 Aug;5(16):e13291.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Ito T, Yamamoto N, Nakajima S, Schaffer SW.

Beta-catenin and SMAD3 are associated with skeletal muscle aging in the taurine transporter knockout mouse.

Adv Exp Med Biol. 2017 Aug 29;975:497-502.



Smith CM, Housh TJ, Hill EC, Keller JL, Johnson GO, Schmidt RJ.

Are there mode-specific and fatigue-related electromechanical delay responses for maximal isokinetic and isometric muscle actions?

J Electromyogr Kinesiol. 2017 Dec;37:9-14. Epub 2017 Aug 23.



Smith CM, Housh TJ, Hill EC, Keller JL, Johnson GO, Schmidt RJ.

Effects of fatigue and recovery on electromechanical delay during isokinetic muscle actions.

Physiol Meas. 2017 Aug 31. [Epub ahead of print] 857748



Zhu M, Liu Z, Gao M, Zhang Y, Li Y, Ling S, Zhang P, Zhao C, Jiang L, Liu Y, Li Q, Li D, Hu S, Li Y.

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness-induced muscle atrophy and its mechanisms.

Mol Med Rep. 2017 Aug 18. [Epub ahead of print]

Note: Hindlimb unloading study. This article may be obtained online without charge.



Gohil SV, Wang L, Rowe DW, Nair LS.

Spatially controlled rhBMP-2 mediated calvarial bone formation in a transgenic mouse model.

Int J Biol Macromol. 2017 Aug 25. [Epub ahead of print]



Pflanz D, Birkhold AI, Albiol L, Thiele T, Julien C, Seliger A, Thomson E, Kramer I, Kneissel M, Duda GN, Kornak U, Checa S, Willie BM.

Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression. 

Sci Rep. 2017 Aug 25;7(1):9435.

Note: This article may be obtained online without charge.



Pirkkanen JS, Boreham DR, Mendonca MS.

The CGL1 (HeLa x normal skin fibroblast) human hybrid cell line: A history of ionizing radiation induced effects on neoplastic transformation and novel future directions in SNOLAB. 

Radiat Res. 2017 Sep 5. [Epub ahead of print] Review.



Puukila S, Lemon JA, Lees SJ, Tai TC, Boreham DR, Khaper N.

Impact of ionizing radiation on the cardiovascular system: A review.

Radiat Res. 2017 Sep 5. [Epub ahead of print] Review. med/28873026



Vimal VP, DiZio P, Lackner JR.

Learning dynamic balancing in the roll plane with and without gravitational cues.

Exp Brain Res. 2017 Aug 28. [Epub ahead of print]



Schlager D, Hein S, Obaid MA, Wilhelm K, Miernik A, Schoenthaler M.

Performance of single-use Flexor(R)Vue vs. reusable BoaVision ureteroscope for visualization of calyces and stone extraction in an artificial kidney model.

J Endourol. 2017 Aug 26. [Epub ahead of print]

Note: The NASA Task Load Index was used.

SpaceRef staff editor.