Status Report

NASA Spaceline Current Awareness List #753 16 June 2017 (Space Life Science Research Results)

By SpaceRef Editor
June 16, 2017
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SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Peleg M, Normand MD, Corradini MG.

A new look at kinetics in relation to food storage.

Annu Rev Food Sci Technol. 2017 Feb 28;8:135-53. Review.

PI: H. Xiao

Journal Impact Factor: 6.950

Funding: “Several of the early kinetics models and calculation methods described in this review were developed in projects supported by the Massachusetts Agricultural Experiment at Amherst. Those for nutrients degradation were developed for NASA under grant number NNX14AP32G.”



Peleg M, Normand MD, Dixon WR, Goulette TR.

Modeling the degradation kinetics of ascorbic acid.

Crit Rev Food Sci Nutr. 2016 Nov 28:1-17. [Epub ahead of print]

PI: H. Xiao

Journal Impact Factor: 5.492

Funding: “The authors gratefully acknowledge NASA’s support of the study under grant No. NNX14AP32G.”



Singh NK, Carlson C, Sani RK, Venkateswaran K.

Draft genome sequences of thermophiles isolated from Yates Shaft, a deep-subsurface environment.

Genome Announc. 2017 Jun 1;5(22): e00405-17.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “Part of the research reported here was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA and at the South Dakota School of Mines and Technology, under a contract with NASA (grant no. NNX16AQ98A).”



Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I.

One-carbon metabolism and ionizing radiation: A multifaceted interaction.

Biomol Concepts. 2017 May 24;8(2):83-92.

PIs: M. Boerma/M. Hauer-Jensen/I. Koturbash/NSBRI Center for Research on Cardiac Vascular and Acute Effects of Space Radiation

Journal Impact Factor: 1.86

Funding: “Research reported in this publication was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number 1P20GM109005 and the National Space Biomedical Research Institute through the National Aeronautics and Space Administration NCC 9-58, grant number RE03701. J.T. was supported by T32 GM106999.”



Sasi SP, Yan X, Zuriaga-Herrero M, Gee H, Lee J, Song J, Onufrak J, Morgan J, Enderling H, Walsh K, Kishore R, Goukassian DA.

Different sequences of fractionated low-dose proton and single iron-radiation-induced divergent biological responses in the heart.

Radiat Res. 2017 Jun 14. [Epub ahead of print]

PI: D.A. Goukassian

Journal Impact Factor: 2.539

Funding: “This work was supported by NASA grant no. NNX11AD22G and the American Heart Association, grant no. 14GRNT18860032 to D. A. G. Additional support was provided in part by grants from the NIH National Heart, Lung, and Blood Institute (NHLBI), grant nos. HL106098 to X. Y. and HL091983 to R. K.”



Cooper M, Perchonok M, Douglas GL.

Initial assessment of the nutritional quality of the space food system over three years of ambient storage.

npj Microgravity. 2017 Jun 9;3(1):17.

PIs: M. Cooper, M. Perchonok

Note: According to the authors, “Data are available from the NASA Life Sciences Data Archive:” This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by the National Aeronautics and Space Administration Human Research Program’s Space Human Factors and Habitability Element.”



Bergmann D, Clare D, Samuels L, Kiss JZ.

A celebration of Fred David Sack.

Plant Physiol. 2017 Jun;174(2):470-2.

Note: This article is a memorial to Fred Sack, a plant biologist and former NASA principal investigator. The June issue of Plant Physiology is a Special Focus Issue on Stomata and is dedicated to the memory of Dr. Sack. The focus is on the evolution, development, and physiology of guard cells and their fundamental relevance to plants and to society. This article may be obtained online without charge.

Journal Impact Factor: 6.280

Funding: No funding cited.



Other papers of interest:



Tascher G, Brioche T, Maes P, Chopard A, O’Gorman D, Gauquelin-Koch G, Blanc S, Bertile F.

Proteome-wide adaptations of mouse skeletal muscles during a full month in space.

J Proteome Res. 2017 Jun 7. [Epub ahead of print]

Note: Bion-M1 results.



Gerbaix M, Gnyubkin V, Farlay D, Olivier C, Ammann P, Courbon G, Laroche N, Gential R, Follet H, Peyrin F, Shenkman B, Gauquelin-Koch G, Vico L.

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.

Sci Rep. 2017 Jun 1;7(1):2659.

Note: Bion-M1 results. This article may be obtained online without charge.



Vico L, Van Rietbergen B, Vilayphiou N, Linossier MT, Locrelle H, Normand M, Zouch M, Gerbaix M, Bonnet N, Novikov V, Thom CT, Vassilieva G.

Cortical and trabecular bone microstructure did not recover at weight-bearing skeletal sites and progressively deteriorated at non-weight-bearing sites during the year following International Space Station missions. 

J Bone Miner Res. 2017 Jun 2. [Epub ahead of print] 

Note: ISS results. This article may be obtained online without charge.



Wakabayashi K, Soga K, Hoson T, Kotake T, Kojima M, Sakakibara H, Yamazaki T, Higashibata A, Ishioka N, Shimazu T, Kamada M.

Persistence of plant hormone levels in rice shoots grown under microgravity conditions in space: Its relationship to maintenance of shoot growth.

Physiol Plant. 2017 Jun 1. [Epub ahead of print]

Note: ISS results.



Xiong H, Guo H, Xie Y, Zhao L, Gu J, Zhao S, Li J, Liu L.

RNAseq analysis reveals pathways and candidate genes associated with salinity tolerance in a spaceflight-induced wheat mutant.

Sci Rep. 2017 Jun 2;7(1):2731.

Note: Wheat seeds were flown on the Shijian-8 satellite. This article may be obtained online without charge.



Swoap SJ, Körtner G, Geiser F.

Heart rate dynamics in a marsupial hibernator.

J Exp Biol. 2017 Jun 2. [Epub ahead of print]



Arfat Y, Hui C, Yunfang G.

Stress-responsive microRNAs are involved in re-programming of metabolic functions in hibernators.

J Cell Physiol. 2017 Jun 2. [Epub ahead of print]



Ishikawa C, Li H, Ogura R, Yoshimura Y, Kudo T, Shirakawa M, Shiba D, Takahashi S, Morita H, Shiga T.

Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.

PLoS One. 2017 Jun 7;12(6):e0177833.

Note: Centrifugation was used. This article may be obtained online without charge.



Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Mase M, Gabata T.

MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics.

J Magn Reson Imaging. 2017 Jun 3. [Epub ahead of print]

Note: Head-down tilt study.



De Brandt J, Spruit MA, Hansen D, Franssen FM, Derave W, Sillen MJ, Burtin C.

Changes in lower limb muscle function and muscle mass following exercise-based interventions in patients with chronic obstructive pulmonary disease: A review of the English-language literature. 

Chron Respir Dis. 2017 Jan 1. [Epub ahead of print] Review.

Note: This article may be obtained online without charge.



Fajardo VA, Rietze BA, Chambers PJ, Bellissimo C, Bombardier E, Quadrilatero J, Tupling AR.

Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.

Am J Physiol Cell Physiol. 2017 Jun 7. [Epub ahead of print]

Note: Loading and unloading were accomplished via surgical transection of the soleus and gastrocnemius tendons.



Handsfield GG, Bolsterlee B, Inouye JM, Herbert RD, Besier TF, Fernandez JW.

Determining skeletal muscle architecture with Laplacian simulations: A comparison with diffusion tensor imaging.

Biomech Model Mechanobiol. 2017 Jun 2. [Epub ahead of print]



Happee R, de Bruijn E, Forbes PA, van der Helm FCT.

Dynamic head-neck stabilization and modulation with perturbation bandwidth investigated using a multisegment neuromuscular model.

J Biomech. 2017 Jun 14;58:203-11.

Note: This article may be obtained online without charge.



Marcucci L, Reggiani C, Natali AN, Pavan PG.

From single muscle fiber to whole muscle mechanics: A finite element model of a muscle bundle with fast and slow fibers.

Biomech Model Mechanobiol. 2017 Jun 5. [Epub ahead of print]



Colaianni G, Mongelli T, Cuscito C, Pignataro P, Lippo L, Spiro G, Notarnicola A, Severi I, Passeri G, Mori G, Brunetti G, Moretti B, Tarantino U, Colucci SC, Reseland JE, Vettor R, Cinti S, Grano M. 

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

Sci Rep. 2017 Jun 6;7(1):2811.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Li B, Bi J, Li W, Su T, Zhang S, Zhao J, Meng Q, Fei J.

Effects of pulsed electromagnetic fields on histomorphometry and osteocalcin in disuse osteoporosis rats.

Technol Health Care. 2017 May 31. [Epub ahead of print]

Note: Disuse was accomplished via immobilization by tibia-tail fixation. This article may be obtained online without charge.



McMichael BK, Jeong YH, Auerbach JA, Han CM, Sedlar R, Shettigar V, Bahler M, Agarwal S, Kim DG, Lee BS.

The RhoGAP Myo9b promotes bone growth by mediating osteoblastic responsiveness to IGF-1.

J Bone Miner Res. 2017 Jun 6. [Epub ahead of print]

Note: This article may be obtained online without charge.



Nakajima H, Furukawa C, Chang YC, Ogata H, Magae J.

Delayed growth suppression and radioresistance induced by long-term continuous gamma irradiation.

Radiat Res. 2017 Jun 9. [Epub ahead of print]



Cavuoto LA, Hussein AA, Vasan V, Ahmed Y, Durrani A, Khan S, Cole A, Wang D, Kozlowski J, Ahmad B, Guru KA.

Improving teamwork: Evaluating workload of surgical team during robot-assisted surgery.

Urology. 2017 Jun 1. [Epub ahead of print]

Note: The NASA Task Load Index was used.

SpaceRef staff editor.