NASA Spaceline Current Awareness List #745 21 April 2017 (Space Life Science Research Results)

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Papers deriving from NASA support:
 
1
Casaburi G, Goncharenko-Foster I, Duscher AA, Foster JS.
Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions.
Sci Rep. 2017 Apr 10;7:46318.
https://www.ncbi.nlm.nih.gov/pubmed/28393904
PI: J.S. Foster
Note: STS-134, STS-135 results; a rotary culture system also was used. This article may be obtained online without charge.
Journal Impact Factor: 5.228
Funding: “This work was supported by the NASA Space Biology program (NNX13AM44G) and the flight experiment was supported by the NASA Florida Space Grant Consortium.”
 
2
Gu P, Wang Y, Bisht KK, Wu L, Kukova L, Smith EM, Xiao Y, Bailey SM, Lei M, Nandakumar J, Chang S.
Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.
Oncogene. 2017 Apr 6;36(14):1939-51.
https://www.ncbi.nlm.nih.gov/pubmed/27869160
PI: S.M. Bailey
Journal Impact Factor: 7.932
Funding: “This work was supported by the NCI (RO1 CA129037, R01 CA202816, R21 CA200506 and R21 CA182280) and the CT Department of Public Health (15-002167) to Sandy Chang. Support for Jayakrishnan Nandakumar is from the NIH (NIH R00-CA-167644-03, NIH R01-AG050509 (Jayakrishnan Nandakumar, co-investigator).” The PI reports funding under NASA grant NNX14AH51G.
 
3
McKenna MJ, Robinson E, Goodwin EH, Cornforth MN, Bailey SM.
Telomeres and NextGen CO-FISH: Directional genomic hybridization (Telo-dGH).
Methods Mol Biol. 2017;1587:103-12.
https://www.ncbi.nlm.nih.gov/pubmed/28324502
PI: S.M. Bailey
Journal Impact Factor: 0.790
Funding: No funding cited. PI reports funding under NASA grant NNX14AH51G.
 
4
Feola AJ, Coudrillier B, Mulvihill J, Geraldes DM, Vo NT, Albon J, Abel RL, Samuels BC, Ethier CR.
Deformation of the lamina cribrosa and optic nerve due to changes in cerebrospinal fluid pressure.
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2070-8.
https://www.ncbi.nlm.nih.gov/pubmed/28389675
PI: C.R. Ethier
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.426
Funding: “Supported by Science and Technology Facilities Council Grants EE8491, EE9825, and EE11407; the Georgia Research Alliance; and National Aeronautics and Space Administration Grant NNX13AP91G.”
 
5
Keune JA, Wong CP, Branscum AJ, Iwaniec UT, Turner RT.
Bone marrow adipose tissue deficiency increases disuse-induced bone loss in male mice.
Sci Rep. 2017 Apr 12;7:46325.
https://www.ncbi.nlm.nih.gov/pubmed/28402337
PI: R.T. Turner
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 5.228
Funding: “This work was supported by a grant from the National Aeronautics and Space Administration (NNX12AL24G) and the National Science Foundation Research Traineeship Program (DGE-0956280).”
 
6
Yu X, Huang J, Zhang S, Metaxas DN.
Face landmark fitting via optimized part mixtures and cascaded deformable model.
IEEE Trans Pattern Anal Mach Intell. 2016 Nov;38(11):2212-26.
https://www.ncbi.nlm.nih.gov/pubmed/26700972
PI: D.F. Dinges
Note: >From the abstract: “We present a two-stage cascaded deformable shape model to effectively and efficiently localize facial landmarks with large head pose variations.”
Journal Impact Factor: 6.077
Funding: “This paper is based upon work supported in part by National Science Foundation: Information and Intelligent Systems (IIS)-1064965, IIS-1451292, IIS-1423056, Industrial Innovation and Partnerships (IIP)-1069258, Division of Graduate Education (DGE)-0549115, Civil Mechanical and Manufacturing Innovation (CMMI)-1434401 and Computer, Network Systems (CNS)-1405985 and National Aeronautics and Space Administration (NCC) 9-58.”
 
7
Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB.
Circadian phase resetting by a single short-duration light exposure.
JCI Insight. 2017 Apr 6;2(7):e89494.
https://www.ncbi.nlm.nih.gov/pubmed/28405608
PI: E.B. Klerman
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “Funding for this study was provided by NSBRI HFP02802 and NIH P01-AG09975, R01-HL114088 (EBK), RC2-HL101340-0 (EBK, SWL, SAR, REK), K02-HD045459 (EBK), K24-HL105664 (EBK), T32-HL07901 (MSH, SAR), HL094654 (CAC), and AG044416 (JFD). The project described was supported by NIH grant 1UL1 TR001102-01, 8UL1TR000170-05, UL1 RR 025758, Harvard Clinical and Translational Science Center, from the National Center for Advancing Translational Science.”
 
8
Roy R, Bassham DC.
TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana.
BMC Plant Biol. 2017 Apr 11;17(1):73.
https://www.ncbi.nlm.nih.gov/pubmed/28399805
PI: D. Bassham
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.631
Funding: “This work was supported by a grant from the National Aeronautics and Space Administration (Grant no. NNX09AK78G) to DCB.”
______________________________________________________
 
Other papers of interest:
 
1
Kirkpatrick AW, McKee JL, Tien CH, LaPorta AJ, Lavell K, Leslie T, McBeth PB, Roberts DJ, Ball CG.
Abbreviated closure for remote damage control laparotomy in extreme environments: A randomized trial of sutures versus wound clamps comparing terrestrial and weightless conditions.
Am J Surg. 2017 Mar 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28390649
Note: Parabolic flight results.
 
2
Keramidas ME, Mekjavic IB, Eiken O.
LunHab: Interactive effects of a 10-day sustained exposure to hypoxia and bedrest on aerobic exercise capacity in male lowlanders.
Exp Physiol. 2017 Apr 09. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28393459
Note: Bed rest study. From the article: “The study was part of the “LunHab: Lunar Habitat Simulation” project investigating the effects of a 10-day hypoxic bedrest on several functions of cardiorespiratory and musculoskeletal systems.”                              
 
3
Li XT, Yang CB, Zhu YS, Sun J, Shi F, Wang YC, Gao Y, Zhao JD, Sun XQ.
Moderate exercise based on artificial gravity preserves orthostatic tolerance and exercise capacity during short-term head-down bed rest.
Physiol Res. 2017 Apr 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28406700
Note: Bed rest study; centrifugation was used. This article may be obtained online without charge.
 
4
Thombre R, Shinde V, Dixit J, Jagtap S, Vidyasagar PB.
Response of extreme haloarchaeon Haloarcula argentinensis RR10 to simulated microgravity in clinorotation.
3 Biotech. 2017 May;7(1):30.
https://www.ncbi.nlm.nih.gov/pubmed/28401467
Note: A clinostat was used. This article may be obtained online without charge.
 
5
Reynolds RJ, Day SM.
Mortality due to cardiovascular disease among Apollo lunar astronauts.
Aerosp Med Hum Perform. 2017 May;88(5):492-6.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000005/art00010
Note: >From the introduction: “Using a prospective cohort-based analysis, we sought to determine whether or not Apollo astronauts face greater risk of death from CVD in comparison to all other astronauts, all other flight astronauts, and all other nonflight astronauts. We also compared Apollo astronauts to the general population and compare results to those reported in earlier studies.”
 
6
Arbeille P, Avan P, Treffel L, Zuj K, Normand H, Denise P.
Jugular and portal vein volume, middle cerebral vein velocity, and intracranial pressure in dry immersion.
Aerosp Med Hum Perform. 2017 May;88(5):457-62.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000005/art00004
Note: Dry immersion was used.
 
7
Mureli S, Thanigaivelan I, Schaffer ML, Fox JL.
Cross-modal influence of mechanosensory input on gaze responses to visual motion in Drosophila.
J Exp Biol. 2017 Apr 6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28385799
Note: This article may be obtained online without charge.
 
8
Somers S, Spector A, DiGirolamo D, Grayson WL.
Biophysical stimulation for engineering functional skeletal muscle.
Tissue Eng Part B Rev. 2017 Apr 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28401807
 
9
Lee B, Iwaniec UT, Turner RT, Lin YW, Clarke BL, Gingery A, Wei LN.
RIP140 in monocytes/macrophages regulates osteoclast differentiation and bone homeostasis.
JCI Insight. 2017 Apr 6;2(7):e90517.
https://www.ncbi.nlm.nih.gov/pubmed/28405613
Note: This article may be obtained online without charge.
 
10
Ezzati AO, Mahmoud-Pashazadeh A, Studenski MT.
Monte Carlo simulation of the RBE of I-131 radiation using DNA damage as biomarker.
Australas Phys Eng Sci Med. 2017 Apr 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28397060
 
11
Kodaira M, Asakawa JI, Nakamura N.
Radiation-induced deletions in mouse spermatogonia are usually large (over 200 kb) and contain little sequence similarity at the junctions.
Radiat Res. 2017 Apr 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28418813
 
12
Kniep R, Zahn D, Wulfes J, Walther LE.
The sense of balance in humans: Structural features of otoconia and their response to linear acceleration.
PLoS One. 2017 Apr 13;12(4):e0175769.
https://www.ncbi.nlm.nih.gov/pubmed/28406968
Note: This article may be obtained online without charge.
 
13
Panichi R, Occhigrossi C, Ferraresi A, Faralli M, Lucertini M, Pettorossi VE.
Adaptive changes in the perception of fast and slow movement at different head positions.
Aerosp Med Hum Perform. 2017 May;88(5):463-8.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000005/art00005
Note: A rotating chair was used.
 
14
Nolan TM, Brennan B, Yang M, Chen J, Zhang M, Li Z, Wang X, Bassham DC, Walley J, Yin Y.
Selective autophagy of BES1 mediated by DSK2 balances plant growth and survival.
Dev Cell. 2017 Apr 10;41(1):33-46.e7.
https://www.ncbi.nlm.nih.gov/pubmed/28399398
Note: This article may be obtained online without charge.
 
15
Yamamoto KT, Watahiki MK, Matsuzaki J, Satoh S, Shimizu H.
Space-time analysis of gravitropism in etiolated Arabidopsis hypocotyls using bioluminescence imaging of the IAA19 promoter fusion with a destabilized luciferase reporter.
J Plant Res. 2017 Apr 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28396964
 
16
Zheng Y, Lu Y, Jie Y, Fu S.
Flight crew workload evaluation based on the workload function distribution method.
Aerosp Med Hum Perform. 2017 May;88(5):481-6.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000005/art00008
Note: The NASA Task Load Index was used.