Status Report

NASA Spaceline Current Awareness List #733 27 January 2017 (Space Life Science Research Results)

By SpaceRef Editor
January 27, 2017
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SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, [email protected]
Papers deriving from NASA support:
Lawley JS, Petersen LG, Howden EJ, Sarma S, Cornwell WK, Zhang R, Whitworth LA, Williams MA, Levine BD.
Effect of gravity and microgravity on intracranial pressure.
J Physiol. 2017 Jan 16. [Epub ahead of print]
PI: B.D. Levine
Note: Parabolic flight and bed rest study.
Journal Impact Factor: 4.731
Funding: “This work was supported by the National Space Biomedical Research Institute through NCC 9-58.”
LaVoy EC, Hussain M, Reed J, Kunz H, Pistillo M, Bigley AB, Simpson RJ.
T-cell redeployment and intracellular cytokine expression following exercise: Effects of exercise intensity and cytomegalovirus infection.
Physiol Rep. 2017 Jan;5(1).
PI: R.J. Simpson
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.61
Funding: “This work was supported by NASA grants NNJ10ZSA003N and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson and NASA grant NNJ14ZSA001N-MIXEDTOPICS to R. J. Simpson and E. C. LaVoy.”
Bruno AG, Mokhtarzadeh H, Allaire BT, Velie KR, De Paolis Kaluza MC, Anderson DE, Bouxsein ML.
Incorporation of CT-based measurements of trunk anatomy into subject-specific musculoskeletal models of the spine influences vertebral loading predictions.
J Orthop Res. 2017 Jan 16. [Epub ahead of print]
Journal Impact Factor: 2.807
Funding: “This work was supported by grants from the National Institutes of Health (R01AR053986, F31AG041629, and K99AG042458), by the National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study (NIH/NHLBI Contract N01-HC-25195), and by the National Space Biomedical Research Institute through NASA NCC 9-58 [NSBRI Mentored Research Program].”
Deymier AC, An Y, Boyle JJ, Schwartz AG, Birman V, Genin GM, Thomopoulos S, Barber AH.
Micro-mechanical properties of the tendon-to-bone attachment.
Acta Biomater. 2017 Jan 11. [Epub ahead of print]
PI: A.C. Deymier, NSBRI First Award Fellowship
Journal Impact Factor: 6.008
Funding: “Deymier was funded in part by the NSBRI First Award Fellowship NSBRI PD13-0019. Additional funding was provided by NIH U01 EB016422.”
Heer M, Baecker N, Frings-Meuthen P, Graf S, Zwart SR, Biolo G, Smith SM.
Effects of high protein intake on bone turnover in long-term bed rest in women.
Appl Physiol Nutr Metab. 2017 Jan 19. [Article in Press]
PI: S.M. Smith
Note: Bed rest study.
Journal Impact Factor: 2.339
Funding: “The study was supported by the European (ESA), the American (NASA), the French (CNES), and the German (DLR) space agencies.”
Shuryak I, Loucas BD, Cornforth MN.
Seeking beta: Experimental considerations and theoretical implications regarding the detection of curvature in dose-response relationships for chromosome aberrations.
Radiat Res. 2017 Jan 13. [Epub ahead of print]
PIs: B.D. Loucas, M.N. Cornforth
Journal Impact Factor: 3.022
Funding: “This work was supported by the following grants from the National Aeronautics and Space Administration [grant nos. NNX15AG74G (MC) and NNX14AC76G (BL)].”
Britten RA, Jewell JS, Duncan VD, Davis LK, Hadley MM, Wyrobek AJ.
Spatial memory performance of socially mature Wistar rats is impaired after exposure to low (5 cGy) doses of 1 GeV/n 48Ti particles.
Radiat Res. 2017 Jan 13. [Epub ahead of print]
PIs: R.A. Britten, A.J. Wyrobek
Journal Impact Factor: 3.022
Funding: “This work was funded by NASA (grant nos. NNX11AC56G and NNX14AE73G), AJW was supported by NASA grant NNJ14HP06I).”
Other papers of interest:
Gao Y, Xu D, Zhao L, Sun Y.
The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight.
Mutat Res. 2017 Jan 7;795:15-26. [Epub ahead of print]
Note: Shenzhou-8 results.
Xu C, He P, Liu C.
Effects of space environment on intestinal flora.
Space Med Med Eng. 2016;2016(4):297-300. Chinese.
Note: Specific spaceflights are not identified in the English abstract.
Kulikova EA, Kulikov VA, Sinyakova NA, Kulikov AV, Popova NK.
The effect of long-term hindlimb unloading on the expression of risk neurogenes encoding elements of serotonin-, dopaminergic systems and apoptosis; comparison with the effect of actual spaceflight on mouse brain.
Neurosci Lett. 2017 Feb 15;640:88-92. Epub 2017 Jan 12.
Note: Bion M-1 results; hindlimb unloading study.
Porseva VV, Shilkin VV, Strelkov AA, Krasnov IB, Masliukov PM.
Changes in the neurochemical composition of motor neurons of the spinal cord in mice under conditions of space flight.
Bull Exp Biol Med. 2017 Jan 14;162(3):336-9.
Note: Bion-M1 results.
Guo S, Wu Y.
Research progress in space plant growing technique.
Space Med Med Eng. 2016;2016(4):301-6. Chinese.
Note: Specific spacecraft and missions are not provided in the English abstract.
Najrana T, Sanchez-Esteban J.
Mechanotransduction as an adaptation to gravity.
Front Pediatr. 2016 Dec 26;4:140. Review.
Note: Specific spaceflights are not mentioned in the review. This article may be obtained online without charge.
Louis F, Bouleftour W, Rattner A, Linossier M-T, Vico L, Guignandon A.
RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.
npj Microgravity. 2017 Jan 25;3(1):7.
Note: A rotating wall vessel bioreactor was used. This article may be obtained online without charge.
Cavey T, Pierre N, Nay K, Allain C, Ropert M, Loreal O, Derbré F.
Simulated microgravity decreases circulating iron in rats: Role of inflammation-induced hepcidin upregulation.
Exp Physiol. 2017 Jan 13. [Epub ahead of print]
Note: Hindlimb unloading study.
Bronzwaer AG, Verbree J, Stok WJ, Daemen MJ, van Buchem MA, van Osch MJ, van Lieshout JJ.
The cerebrovascular response to lower body negative pressure versus head-up tilt.
J Appl Physiol (1985). 2017 Jan 12:jap.00797.2016. [Epub ahead of print]
Shi H, Cai Y, Ma H, Liu L, Li J, Zhang X, Chen Z, Zheng Y.
Effects of simulated weightlessness on c-fos gene expression in spinal cord of rhesus monkey.
Space Med Med Eng. 2016;2016(4):240-4 Chinese.
Note: The method of weightlessness simulation is not provided in the English abstract.
Deschenes MR, McCoy RW, Mangis KA.
Chronic resistance training does not ameliorate unloading-induced decrements in neuromuscular function.
Am J Phys Med Rehabil. 2017 Jan 17. [Epub ahead of print]
Note: A Biodex dynamometer was used.
Li J, Liu H, Zhang P, He J, Li W, Wang F, Ren W, Chen S, Chen Z.
Effects of 45 d-6° head-down bed rest on lower limb muscle atrophy and interferences of traditional Chinese medicine Rhodiola rosea.
Space Med Med Eng. 2016;2016(4):256-9. Chinese.
Note: Bed rest study.
Pulga A, Porte Y, Morel JL.
Changes in C57BL6 mouse hippocampal transcriptome induced by hypergravity mimic acute corticosterone-induced stress.
Front Mol Neurosci. 2016 Dec 26;9:153.
Note: A 3D centrifuge was used. This article may be obtained online without charge.
Wang Z, Zhang Y, Wang Y, Chen H, Ji G, Lv Z, Li Y, Qu L.
Effects of tail-suspension on memory and apoptosis related protein expression in rat hippocampus.
Space Med Med Eng. 2016;2016(4):235-9. Chinese.
Note: Hindlimb suspension study.
Hu B, Wang X, Hu S, Ying X, Wang P, Zhang X, Wang J, Wang H, Wang Y.
MiR-21-mediated radioresistance is via promoting repair of DNA double strand breaks.
J Biol Chem. 2017 Jan 17. [Epub ahead of print]
Note: This article may be obtained online without charge.
Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A.
Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system.
Life Sci Space Res. 2017 Jan 23. [Article in Press]
Çoban K, Aydin E, Özlüoğlu LN.
Audio-vestibular findings in increased intracranial hypertension syndrome.
J Int Adv Otol. 2017 Jan 13. [Epub ahead of print]
Note: This article may be obtained online without charge.
Otero-Millan J, Treviño C, Winnick A, Zee DS, Carey JP, Kheradmand A.
The video ocular counter-roll (vOCR): A clinical test to detect loss of otolith-ocular function.
Acta Otolaryngol. 2017 Jan 13:1-8. [Epub ahead of print]
Asaoka Y, Nishina H, Furutani-Seiki M.
YAP is essential for 3D organogenesis withstanding gravity.
Dev Growth Differ. 2017 Jan;59(1):52-8. Review.
Suswillo RF, Javaheri B, Rawlinson SC, Dowthwaite GP, Lanyon LE, Pitsillides AA.
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Cell Biochem Funct. 2017 Jan;35(1):56-65.
Note: This article may be obtained online without charge.

SpaceRef staff editor.