Status Report

NASA Spaceline Current Awareness List #728 16 December 2016 (Space Life Science Research Results)

By SpaceRef Editor
December 16, 2016
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SpaceRef Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: 


SPACELINE Current Awareness Lists are now distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, [email protected].

Papers deriving from NASA support:



Barrila J, Ott CM, LeBlanc C, Mehta SK, Crabbé A, Stafford P, Pierson DL, Nickerson CA.

Spaceflight modulates gene expression in the whole blood of astronauts.

npj Microgravity. 2016 Dec 8;2:16039.

Note: STS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by USRA Sponsor Award 09930-286-01 (017991-001).”



Mader TH, Gibson CR, Otto CA, Sargsyan AE, Miller NR, Subramanian PS, Hart SF, Lipsky W, Patel NB, Lee AG.

Persistent asymmetric optic disc swelling after long-duration space flight: Implications for pathogenesis.

J Neuroophthalmol. 2016 Dec 5. [Epub ahead of print]

Note: ISS results.

Journal Impact Factor: 1.576

Funding: No funding cited. T.H. Mader, C.A. Otto, A.E. Sargsyan, S.F. Hart, N.B. Patel, and A.G. Lee are affiliated with NASA Johnson Space Center.



Broxterman RM, Skiba PF, Craig JC, Wilcox SL, Ade CJ, Barstow TJ.

W’ expenditure and reconstitution during severe intensity constant power exercise: Mechanistic insight into the determinants of W’.

Physiol Rep. 2016 Oct;4(19).

PI: T.J. Barstow

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) under Grant NNX10AK60G awarded to TJB and by NASA Experimental Program to Stimulate Competitive Research (EPSCoR) under Grant NNX11AM05A supporting RMB.”



Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M.

Effects of ionizing radiation on the heart.

Mutat Res. 2016 Oct-Dec;770(Pt B):319-27.

PIs: M. Boerma/X.W. Mao/G.A. Nelson/I. Koturbash/A.J. Tackett/M. Hauer-Jensen/NASA Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 5.261

Funding: “This work was supported by the National Institutes of Health [CA148679], the American Cancer Society [RSG-10-125-01-CCE], and the National Space Biomedical Research Institute [RE03701 through NCC 9-58].”



Flynn-Evans EE, Caddick ZA, Gregory K.

Sleep environment recommendations for future spaceflight vehicles.

Houston, TX: NASA Johnson Space Center, 2016 Dec. 108 p. NASA/TM-2016-219282.

Note: This publication may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication.

Funding: No funding cited. E.E. Flynn-Evans is affiliated with NASA Ames Research Center.



John SP, Hasenstein KH.

The role of peltate scales in desiccation tolerance of Pleopeltis polypodioides.

Planta. 2016 Dec 7. [Epub ahead of print]

PI: K.H. Hasenstein

Journal Impact Factor: 3.239

Funding: “This research was partially supported by NASA grants NNX10AP91G and NNX13AN05A.”



Anderson A, Mengüc Y, Wood RJ, Newman D.

Development of the Polipo pressure sensing system for dynamic space-suited motion.

IEEE Sens J. 2015 Nov;15(11):6229-37.

PI: D. Newman

Journal Impact Factor: 1.889

Funding: “This work was supported in part by the Johnson Space Center through the National Aeronautics and Space Administration under Grant NNX12AC09G within the Spacesuit Trauma Countermeasure System for Intravehicular and Extravehicular Activities, in part by the National Science Foundation Graduate Research Fellowship Program, in part by the MIT Portugal Program, and in part by the Wyss Institute for Biologically Inspired Engineering.”



Other papers of interest:



Kawano F, Ono Y, Fujita R, Watanabe A, Masuzawa R, Shibata K, Hasegawa S, Nakata K, Nakai N.

Prenatal myonuclei play a crucial role for skeletal muscle hypertrophy in rodents.

Am J Physiol Cell Physiol. 2016 Dec 7:ajpcell.00151.2016. [Epub ahead of print]



Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB.

Bisphosphonate withdrawal: Effects on bone formation and bone resorption in maturing male mice.

J Bone Miner Res. 2016 Dec 7. [Epub ahead of print]



Nomura M, Sakitani N, Iwasawa H, Kohara Y, Takano S, Wakimoto Y, Kuroki H, Moriyama H.

Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice.

Osteoarthritis Cartilage. 2016 Dec 01. [Epub ahead of print]

Note: Hindlimb unloading study.



Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O’Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

SIKs control osteocyte responses to parathyroid hormone.

Nat Commun. 2016 Oct 19;7:13176.

Note: This article may be obtained online without charge.



Balcer-Kubiczek EK.

The role of the apoptotic machinery in ionizing radiation-induced carcinogenesis.

Crit Rev Oncog. 2016;21(3-4):169-84.



Cacao E, Cucinotta FA.

Modeling heavy-ion impairment of hippocampal neurogenesis after acute and fractionated irradiation.

Radiat Res. 2016 Dec 7. [Epub ahead of print]



Smirnova OA, Cucinotta FA.

Skin response to single and fractionated irradiation: Dynamic modeling approach.

Health Phys. 2016 Dec;111(6):513-27.



Dauchy RT, Wren-Dail MA, Hoffman AE, Hanifin JP, Warfield B, Brainard GC, Hill SM, Belancio VP, Dauchy EM, Blask DE.

Effects of daytime exposure to light from blue-enriched light-emitting diodes on the nighttime melatonin amplitude and circadian regulation of rodent metabolism and physiology.

Comp Med. 2016 Oct;66(5):373-83.



Fiore SM, Wiltshire TJ.

Technology as teammate: Examining the role of external cognition in support of team cognitive processes.

Front Psychol. 2016 Dec 7;7:1531.

Note: This article may be obtained online without charge.



Bermúdez Rey MC, Clark TK, Wang W, Leeder T, Bian Y, Merfeld DM.

Vestibular perceptual thresholds increase above the age of 40.

Front Neurol. 2016 Oct 3;7:162.

Note: This article may be obtained online without charge.



Ionescu CM, Copot C, Verellen D.

Motion compensation for robotic lung tumour radiotherapy in remote locations: A personalised medicine approach.

Acta Astronaut. 2017 Mar;132:59-66.



McMullan SP, Thomas-Hawkins C, Shirey MR.

Certified registered nurse anesthetist perceptions of factors impacting patient safety.

Nurs Adm Q. 2017 Jan/Mar;41(1):56-69.

Note: The NASA Task Load Index was used.



Anton NE, Howley LD, Pimentel M, Davis CK, Brown C, Stefanidis D.

Effectiveness of a mental skills curriculum to reduce novices’ stress.

J Surg Res. 2016 Nov;206(1):199-205.

Note: The NASA Task Load Index was used.


Note: The November 25th issue of Science was a special issue entitled ‘Circadian Physiology,’ exploring physiological consequences of circadian misalignment. The citations in the special section are listed below.



Ray LB, Travis J.

On the clock.

Science. 2016 Nov 25;354(6315):986-7.



Kean S.

The scientific night shift.

Science. 2016 Nov 25;354(6315):988-91.



Turek FW.

Circadian clocks: Not your grandfather’s clock.

Science. 2016 Nov 25;354(6315):992-3.



Bass J, Lazar MA.

Circadian time signatures of fitness and disease.

Science. 2016 Nov 25;354(6315):994-9.



Man K, Loudon A, Chawla A.

Immunity around the clock.

Science. 2016 Nov 25;354(6315):999-1003.



Musiek ES, Holtzman DM.

Mechanisms linking circadian clocks, sleep, and neurodegeneration.

Science. 2016 Nov 25;354(6315):1004-8.



Panda S.

Circadian physiology of metabolism.

Science. 2016 Nov 25;354(6315):1008-15.


SpaceRef staff editor.