NASA Spaceline Current Awareness List #722 4 November 2016 (Space Life Science Research Results)

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag 

Please note: The next issue of SPACELINE Current Awareness (List #723) will be sent on Monday, November 14, 2016.

In case you missed it: On October 29th at the American Society for Gravitational and Space Research (ASGSR) meeting in Cleveland, banquet attendees watched a video of a special plaque dedicated to Space Biology pioneers Thora Halstead and Ken Souza being affixed by Astronaut Kate Rubin to the Veggie hardware onboard the International Space Station. This was reported in SpaceRef where Keith Cowing also posted a tribute to Halstead and Souza. Please see: http://spaceref.com/biology/space-biologists-thora-halstead-and-ken-souza-honored-aboard-international-space-station.html 

Papers deriving from NASA support:

1
Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller NP, Venkateswaran K.
Aspergillus fumigatus isolates from air and surfaces of the International Space Station.
mSphere. 2016 Oct 26;1(5):e00227-16.
http://msphere.asm.org/content/msph/1/5/e00227-16.full.pdf
PI: K. Ventakeswaran
Note: ISS results.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported in part by the National Science Foundation-Emerging Frontiers in Research and Innovation-MIKS: grant 1136903 (C.C.C.W., N.P.K., and A.H.) and by 2012 Space Biology NNH12ZTT001N grant 19-12829-26 under task order NNN13D111T awarded to K.V., which also funded a graduate fellowship to A.B., and JPL subcontract 1511581 to C.C.C.W.”

2
Gokhale NS, McIntyre AB, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willer J, Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM.
N6-methyladenosine in Flaviviridae viral RNA genomes regulates infection.
Cell Host Microbe. 2016 Oct 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27773535
PI: C.E. Mason
Journal Impact Factor: 12.552
Funding: “This work was supported by funds from the NIH: R01AI125416 (S.M.H. and C.E.M.); 5P30AI064518 (S.M.H.); T32-CA009111 (A.E.R.); R25EB020393, R01NS076465, and R01ES021006 (C.E.M.); R01AI089526 and R01AI101431 (M.A.G.-B.); R01DK0951250 (M.J.E.); and U19AI083019 and R56AI110516 (M.S.S.). Additional funding sources were the Duke Whitehead Scholarship (S.M.H.), the Ford Foundation (C.V.), the Tri-Institutional Training Program in Computational Biology and Medicine (A.B.R.M.), STARR (I7-A765 and I9-A9-071; C.E.M.), the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, the Bert L. and N. Kuggie Vallee Foundation, World-Quant, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50Gand 15-15Omni2-0063), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964), the U-TX STARs Award (M.A.G.-B.), UTMB (M.A.G.-B. and S.S.B.), Pew Charitable Trusts (USPHS-AI07647 and ACS-RSG-12-176-01-MPC; M.J.E.), and the Burroughs Wellcome Fund.”

3
Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J.
Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression.
BMC Genomics. 2016 Oct 24;17(1):825.
https://www.ncbi.nlm.nih.gov/pubmed/27776477
PI: J. Raber
Journal Impact Factor: 3.867
Funding: “This work was supported by NASA grant NNJ12ZSA001N.”
_______________________________________________________

Other papers of interest:

1
Kirkpatrick AW, McKee JL, Tien H, LaPorta AJ, Lavell K, Leslie T, King DR, McBeth PB, Brien S, Roberts DJ, Franciose R, Wong J, McAlistatair V, Bouchard D, Ball CG.
Damage control surgery in weightlessness: A comparative study of simulated torso hemorrhage control comparing terrestrical and weightless conditions.
J Trauma Acute Care Surg. 2016 Oct 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27787439
Note: Parabolic flight results.

2
Weronika E, ?ukasz K.
Tardigrades in space research – Past and future.
Orig Life Evol Biosph. 2016 Oct 20. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/27766455
Note: FOTON-M3 and STS results. This article may be obtained online without charge.

3
Brocca L, Toniolo L, Reggiani C, Bottinelli R, Sandri M, Pellegrino MA.
FoxO-dependent atrogenes vary among catabolic conditions and play a key role in muscle atrophy induced by hindlimb suspension.
J Physiol. 2016 Oct 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27767211
Note: Hindlimb unloading study.

4
Luu BE, Biggar KK, Wu CW, Storey KB.
Torpor-responsive expression of novel microRNA regulating metabolism and other cellular pathways in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus.
FEBS Lett. 2016 Oct;590(20):3574-82.
https://www.ncbi.nlm.nih.gov/pubmed/27670641

5
Wang W, Dounskaia N.
Neural control of arm movements reveals a tendency to use gravity to simplify joint coordination rather than to decrease muscle effort.
Neuroscience. 2016 Oct 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27751958
Note: Researchers “tested three alternative interpretations suggested by previous research: (1) that muscular control includes two components, tonic which compensates for gravity and phasic which produces the movement; (2) that there is a tendency to exploit gravity to reduce muscle effort; and (3) that there is a tendency to use a trailing pattern of joint control during which either the shoulder or elbow is rotated actively and the other joint rotates predominantly passively, and to exploit gravity for control of the passively rotated joint.”

6
Galea GL, Lanyon LE, Price JS.
Sclerostin’s role in bone’s adaptive response to mechanical loading.
Bone. 2016 Oct 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27742499
Note: Axial loading was used. This article may be obtained online without charge.

7
Laurent MR, Jardi F, Dubois V, Schollaert D, Khalil R, Gielen E, Carmeliet G, Claessens F, Vanderschueren D.
Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.
Bone. 2016 Dec;93:33-42.
https://www.ncbi.nlm.nih.gov/pubmed/27622887
Note: Hindlimb unloading study.

8
Wang J, Ishimoto T, Nakano T.
Unloading-induced degradation of the anisotropic arrangement of collagen/apatite in rat femurs.
Calcif Tissue Int. 2016 Oct 22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27771736
Note: Hindlimb unloading was accomplished via sciatic neurectomy.

9
Chen H, Lv K, Dai Z, Ji G, Wang T, Wang Y, Zhang Y, Kan G, Li Y, Qu L.
Intramuscular injection of mechano growth factor E domain peptide regulated expression of memory-related sod, miR-134 and miR-125b-3p in rat hippocampus under simulated weightlessness.
Biotechnol Lett. 2016 Dec;38(12):2071-80.
https://www.ncbi.nlm.nih.gov/pubmed/27623796
Note: Hindlimb unloading study.

10
Kokhan VS, Matveeva MI, Bazyan AS, Kudrin VS, Mukhametov A, Shtemberg AS.
Combined effects of antiorthostatic suspension and ionizing radiation on the behaviour and neurotransmitters changes in different brain structures of rats.
Behav Brain Res. 2016 Oct 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27776994
Note: Hindlimb unloading study.

11
Laurens J, Kim B, Dickman JD, Angelaki DE.
Gravity orientation tuning in macaque anterior thalamus.
Nat Neurosci. 2016 Oct 24. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27775722
Note: Rotation was used.

12
Mysoet J, Canu MH, Gillet C, Fourneau J, Garnier C, Bastide B, Dupont E.
Reorganization of motor cortex and impairment of motor performance induced by hindlimb unloading are partially reversed by cortical IGF-1 administration.
Behav Brain Res. 2016 Oct 4;317:434-43. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27717815
Note: Hindlimb unloading study.

13
Shang X, Xu B, Li Q, Zhai B, Xu X, Zhang T.
Neural oscillations as a bridge between glutamatergic system and emotional behaviors in simulated microgravity-induced mice.
Behav Brain Res. 2016 Sep 28;317:286-91. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27693609
Note: Hindlimb unloading study.

14
Gürkov R, Speierer G, Wittwer L, Kalla R.
Effect of elevated intracranial pressure on amplitudes and frequency tuning of ocular vestibular evoked myogenic potentials elicited by bone-conducted vibration.
Ear Hear. 2016 Nov/Dec;37(6):e409-e13.
https://www.ncbi.nlm.nih.gov/pubmed/27467406

15
Rakusová H, Abbas M, Han H, Song S, Robert HS, Friml J.
Termination of shoot gravitropic responses by auxin feedback on PIN3 polarity.
Curr Biol. 2016 Oct 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27773568

16
Ocampo RP, Klaus DM.
A quantitative framework for defining “How safe is safe enough?” in crewed spacecraft.
New Space. 2016 Jun;4(2):75-82.
http://online.liebertpub.com/doi/10.1089/space.2015.0040

17
Ocampo RP, Klaus DM.
Comparing the relative risk of spaceflight to terrestrial modes of transportation and adventure sport activities.
New Space. 2016 Sep;4(3):190-7.
http://online.liebertpub.com/doi/full/10.1089/space.2016.0012

18
Choukèr A, Ullrich O, editors
The immune system in space: Are we prepared?
Chaum, Switzerland: Springer; 2016. 136 p. SpringerBriefs in Space Life Sciences series.
http://link.springer.com/book/10.1007%2F978-3-319-41466-9
Note: Sections include: How Does Space and Space Like Conditions Affect Immunity?, The Upcoming Venues and New Perspectives, and a Summary.

Listed below are chapters from The immune system in space: Are we prepared? Edited by G. Ruyters and M. Braun. Chaum, Switzerland: Springer, 2016.

19
Yi B, Thiel M, Choukèr A.
The immune system in evolution.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer , 2016. p. 1-5.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_1

20
Yi B, Choukèr A.
The immune system and man-environment interaction: A general understanding.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 9-12.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_2

21
Yi B, Choukèr A.
The immune system in space and space-like conditions: From the human study perspective.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 13-7.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_3

22
Tauber S, Ullrich O.
Cellular effects of altered gravity on the innate immune system and the endothelial barrier.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 19-45.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_4

23
Hauschild S, Tauber S, Lauber BA, Thiel CS, Layer LE, Ullrich O.
Cellular effects of altered gravity on the human adaptive immune system.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 47-75.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_5

24
Lauber BA, Bolshakova O, Ullrich O.
Spacecraft microbiology.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 77-86.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_6

25
Lauber BA, Ullrich O.
Spacecraft contamination monitoring and control.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 89-96.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_7

26
Layer LE, Ullrich O.
Cell-based therapy during exploration class missions.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 97-109.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_8

27
Zangl Q, Choukèr A.
Metabolic control: Immune control?
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 111-9.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_9

28
Choukèr A, Ullrich O.
The immune system in space: Are We Prepared? Conclusions, Outlook, and Recommendations.
In: The immune system in space: Are we prepared? Chaum, Switzerland: Springer, 2016. p. 123-7.
http://link.springer.com/chapter/10.1007%2F978-3-319-41466-9_10