NASA Spaceline Current Awareness List #719 14 October 2016 (Space Life Science Research Results)
Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag
Papers deriving from NASA support:
1
Espinosa-Jeffrey A, Nguyen K, Kumar S, Toshimasa O, Hirose R, Reue K, Vergnes L, Kinchen J, Vellis J.
Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism.
J Neurosci Res. 2016 Sep 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27680492
PI: A. Espinosa
Note: Centrifugation was used.
Journal Impact Factor: 2.689
Funding: “The authors thank the Cell Culture Core, supported by grant #PP1498: Neural Cell Culture Core and NIH #04612 Intellectual & Developmental Disabilities. The authors also received partial support from NICHD of the NIH through the Functional Visualization Core (grant #: U54HD087101-01. NIH HD004612) the Cellular and Bioenergetics Core is supported by S10RR026744 from the National Center for the Research Resources (grant S10RR026744).” The PI reports NASA funding under NNX15AB43G.
2
Benjamin CL, Stowe RP, St John L, Sams CF, Mehta SK, Crucian BE, Pierson DL, Komanduri KV.
Decreases in thymopoiesis of astronauts returning from space flight.
JCI Insight. 2016 Aug 4;1(12):e88787. Epub 2016 Oct 5.
https://www.ncbi.nlm.nih.gov/pubmed/27699228
PIs: R.P. Stowe, A. Barrett
Note: This article may be obtained online without charge at https://insight.jci.org/articles/view/88787.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by NASA awards/grants NNJ06HB73A, NAS901006, NNJ04HD67G, NNJ06HC59G, and NNJ04HD75G.”
3
Pongkitwitoon S, Uzer G, Rubin J, Judex S.
Cytoskeletal configuration modulates mechanically induced changes in mesenchymal stem cell osteogenesis, morphology, and stiffness.
Sci Rep. 2016 Oct 06;6:34791.
https://www.ncbi.nlm.nih.gov/pubmed/27708389
PIs: S. Judex, G. Uzer
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.228
Funding: “This study was supported by Department of Defense W81XWH-14-1-0281 (SJ), the National Aeronautics and Space Administration NNX12AL25G (SJ), the National Institutes of Health EB014351 (JR), and the National Space Biomedical Research Institute PF04304 (GU) through NASA NCC 9-58.”
4
Parihar VK, Allen BD, Caressi C, Kwok S, Chu E, Tran KK, Chmielewski NN, Giedzinski E, Acharya MM, Britten RA, Baulch JE, Limoli CL.
Cosmic radiation exposure and persistent cognitive dysfunction.
Sci Rep. 2016 Oct 10;6:34774.
https://www.ncbi.nlm.nih.gov/pubmed/27721383
PIs: J.E. Baulch; R.A. Britten; C.L. Limoli; G. Nelson/C.L. Limoli/NSCOR; C.L. Limoli/R.A. Britten/NSCOR
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.228
Funding: “This work was supported by NASA Grants NNX13AK70G (JEB), NNX14AE73G (RAB), NNX13AD59G (CLL), NNX10AD59G (CLL), UARC NAS2-03144 (CLL) and NNX15AI22G (RAB, CLL).”
5
St Hilaire MA, Ruger M, Fratelli F, Hull JT, Phillips AJ, Lockley SW.
Modeling neurocognitive decline and recovery during repeated cycles of extended sleep and chronic sleep deficiency.
Sleep. 2016 Sep 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27692052
PIs: S.W. Lockley, C.M. Oman, G.C. Brainard
Journal Impact Factor: 4.793
Funding: “This work was supported by an investigator-initiated grant from Philips Lighting (Royal Philips Electronics, The Netherlands) to SWL. MR and SWL were supported in part by National Space Biomedical Research Institute grants NBPF02001 (MR; SWL), HPF00001 (SWL), and HPF01301 (SWL) through NASA NCC 9-58. JTH and MSH were supported in part by NHLBI training grant T32-HL07901. AJKP was supported by NIH R00 HL119618. The study was supported by the Harvard Clinical and Translational Science Center (1 UL1RR025758-04) from the National Center for Research Resources.”
6
Lim H, Kim J, Wang Y, Min J, Carvajal NA, Lloyd CW.
Child health promotion program in South Korea in collaboration with US National Aeronautics and Space Administration: Improvement in dietary and nutrition knowledge of young children.
Nutr Res Pract. 2016 Oct;10(5):555-62.
https://www.ncbi.nlm.nih.gov/pubmed/27698964
Note: A feasibility study was conducted in Korean kindergarten classes to assess the efficacy of NASA’s Mission X: Train Like an Astronaut program in children younger than age 8. Mission X is an international fitness and nutrition challenge for children aged 8-12. This article may be obtained online without charge.
Journal Impact Factor: 1.416
Funding: “The study was funded by the Korea Institute of Child Care and Education in the Republic of Korea. A part of Drs. Min and Wang’s effort was funded by research grants from the National Institute of Health (NIH, U54 HD070725). The U54 project (U54 HD070725) is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the Office of the Director, National Institutes of Health (OD).” C.W. Lloyd is affiliated with NASA Johnson Space Center.
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Other papers of interest:
1
Owens GE, New DM, Olvera AI, Manzella JA, Macon BL, Dunn JC, Cooper DA, Rouleau RL, Connor DS, Bjorkman PJ.
Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity.
Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):762-71.
https://www.ncbi.nlm.nih.gov/pubmed/27710941
Note: ISS results. The study was funded in part by the Center for the Advancement of Science in Space (CASIS). This article may be obtained online without charge.
2
Hauslage J, Abbrecht M, Hanke L, Hemmersbach R, Koch C, Hanke W, Kohn FPM.
Cytosolic calcium concentration changes in neuronal cells under clinorotation and in parabolic flight missions.
Microgravity Sci Technol. 2016 Oct 11. [Article in Press]
http://link.springer.com/article/10.1007/s12217-016-9520-y
Note: Parabolic flight results; clinorotation was used for ground-based studies.
3
Lee SG, Lee CG, Wu HM, Oh CS, Chung SW, Kim SG.
Corrigendum: A load of mice to hypergravity causes AMPKa repression with liver injury, which is overcome by preconditioning loads via Nrf2.
Sci Rep. 2016 Oct 5;6:34677.
https://www.ncbi.nlm.nih.gov/pubmed/27703208
Note: “This Article contains errors in Figure 5A and Figure 8. In Figure 5A, the immunoblot for ‘Akt’ is incorrect. In Figure 8, the immunoblot for Nrf2 is incorrectly duplicated as PGC-1α . The correct Figures 5A and 8 appear below as Figure 1 and Figure 2 respectively.” The original article appeared in SPACELINE Current Awareness List #672 on Nov 6, 2015, https://www.ncbi.nlm.nih.gov/pubmed/26493041. Centrifugation was used in the study. This article may be obtained online without charge.
4
Day BL, Muller T, Offord J, Di Giulio I.
Dual processing of visual rotation for bipedal stance control.
J Physiol. 2016 Oct 1;594(19):5661-71.
https://www.ncbi.nlm.nih.gov/pubmed/27686250
5
Mera P, Laue K, Wei J, Berger JM, Karsenty G.
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice.
Mol Metab. 2016 Oct;5(10):1042-7.
https://www.ncbi.nlm.nih.gov/pubmed/27689017
Note: This article may be obtained online without charge.
6
Reihmane D, Gram M, Vigelso A, Wulff Helge J, Dela F.
Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization.
Eur J Sport Sci. 2016 Nov;16(8):1039-46.
https://www.ncbi.nlm.nih.gov/pubmed/27686402
Note: Casting was used for immobilization.
7
Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini G, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T.
Control of bone anabolism in response to mechanical loading and PTH by distinct mechanisms downstream of the PTH receptor.
J Bone Miner Res. 2016 Oct 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27704638
8
Prabhala SK, Chien S, Yokota H, Anwar S.
A mechatronic loading device to stimulate bone growth via a human knee.
Sensors (Basel). 2016 Sep 29;16(10).
https://www.ncbi.nlm.nih.gov/pubmed/27690057
Note: This article may be obtained online without charge.
9
Chen C, Lu J, Hao L, Zheng Z, Zhang N, Wang Z.
Discovery and characterization of miRNAs in mouse thymus responses to ionizing radiation by deep sequencing.
Int J Radiat Biol. 2016 Aug 11:1-10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27686407
10
Shang X, Xu B, Li Q, Zhai B, Xu X, Zhang T.
Neural oscillations as a bridge between glutamatergic system and emotional behaviors in simulated microgravity-induced mice.
Behav Brain Res. 2016 Sep 28;317:286-91. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27693609
Note: Hindlimb unloading study.
11
Murray JM, Sletten TL, Magee M, Gordon C, Lovato N, Bartlett DJ, Kennaway DJ, Lack LC, Grunstein RR, Lockley SW, Rajaratnam SM.
Prevalence of circadian misalignment and its association with depressive symptoms in delayed sleep phase disorder.
Sleep. 2016 Sep 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27692050
12
Alsina B, Whitfield TT.
Sculpting the labyrinth: Morphogenesis of the developing inner ear.
Semin Cell Dev Biol. 2016 Sep 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27686400
Note: This article may be obtained online without charge.
13
Kawao N, Morita H, Obata K, Tamura Y, Okumoto K, Kaji H.
The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice.
Physiol Rep. 2016 Oct;4(19).
https://www.ncbi.nlm.nih.gov/pubmed/27697847
Note: Centrifugation was used. This article may be obtained online without charge.
14
Wagner DR, Saunders S, Robertson B, Davis JE.
Normobaric hypoxia effects on balance measured by computerized dynamic posturography.
High Alt Med Biol. 2016 Sep;17(3):222-7.
https://www.ncbi.nlm.nih.gov/pubmed/27689470
New frontiers in aerospace medicine: The Physician’s Role in Fictional Space Medicine:
15
Henderson L, Carter S.
Doctors in space (ships): Biomedical uncertainties and medical authority in imagined futures.
Med Humanit. 2016 Sep 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/27694600
Note: From the abstract: “There has been considerable interest in images of medicine in popular science fiction and in representations of doctors in television fiction. Surprisingly little attention has been paid to doctors administering space medicine in science fiction. This article redresses this gap. We analyse the evolving figure of ‘the doctor’ in different popular science fiction television series.” This article may be obtained online without charge.
