Status Report

NASA Spaceline Current Awareness List #717 30 September 2016 (Space Life Science Research Results)

By SpaceRef Editor
September 30, 2016
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Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here:

Papers deriving from NASA support:


Please note: To improve security and privacy, and by Federal government mandate, the National Center for Biotechnology Information (NCBI) is moving all of its web sites and services to HTTPS. The National Library of Medicine (NLM) PubMed database was moved to HTTPS-only on September 27, 2016. The PubMed links in Current Awareness List citations now start with https://. You should notice no difference in linking to PubMed articles. Links to PubMed URLs in earlier Current Awareness Lists should automatically convert to HTTPS when clicked.



Hosamani R, Leib R, Bhardwaj SR, Adams CM, Bhattacharya S.

Elucidating the ‘gravome’: Quantitative proteomic profiling of the response to chronic hypergravity in Drosophila.

J Proteome Res. 2016 Sep 20. [Epub ahead of print]

PIs: S. Govind; R. Bodmer; R. Hasamani, NASA Post-Doctoral Program

Note: Centrifugation was used.

Journal Impact Factor: 4.172

Funding: “This work was funded by NASA grants to SB (NNX15AB42G and NNX13AN38G). RH was supported by a NASA Post-Doctoral Program (NPP) Fellowship.”



Liu M, Lee S, Liu B, Wang H, Dong L, Wang Y.

Ku-dependent non-homologous end-joining as the major pathway contributes to sublethal damage repair in mammalian cells.

Int J Radiat Biol. 2015 Nov;91(11):867-71.


Journal Impact Factor: 1.779

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NNX11AC30G to Y.W.) and the National Cancer Institute (P30CA138292 to the Institute).”



Willey JS, Kwok AT, Moore JE, Payne V, Lindburg CA, Balk SA, Olson J, Black PJ, Walb MC, Yammani RR, Munley MT.

Spaceflight-relevant challenges of radiation and/or reduced weight bearing cause arthritic responses in knee articular cartilage.

Radiat Res. 2016 Sep 7. [Epub ahead of print]

PI: J.S. Willey, NSBRI Career Advancement Award

Note: Hindlimb unloading study.

Journal Impact Factor: 3.022

Funding: “This study was supported by National Space Biomedical Research Institute Career Advancement Award EO00008 through NASA NCC 9-58 (JSW).”



Spaeth AM, Dinges DF, Goel N.

Objective measurements of energy balance are associated with sleep architecture in healthy adults.

Sleep. 2016 Sep 9. [Epub ahead of print]

PI: N. Goel

Journal Impact Factor: 4.793

Funding: “This research was supported by NIH grants R01 NR004281 (DFD) and F31 AG044102 (AMS); the Department of the Navy, Office of Naval Research Award No. N00014-11-1-0361 (NG); National Aeronautics and Space Administration NNX14AN49G (NG) and Clinical and Translational Research Center (CTRC) grant UL1TR000003.”



McIntosh T, Mulhearn T, Gibson C, Mumford MD, Yammarino FJ, Connelly S, Day EA, Vessey WB.

Planning for long-duration space exploration: Interviews with NASA subject matter experts.

Acta Astronaut. 2016 Aug 26. [Article in Press]

Journal Impact Factor: 1.095

Funding: “Parts of this work were supported by the National Aeronautics and Space Administration, Michael Mumford, Principal Investigator (Grant number #NNJ13487783Q).”



Mulhearn T, McIntosh T, Gibson C, Mumford MD, Yammarino FJ, Connelly S, Day EA, Vessey B.

Leadership for long-duration space missions: A shift toward a collective approach.

Acta Astronaut. 2016 Sep 8. [Article in Press]

Journal Impact Factor: 1.095

Funding: “This work was supported by the National Aeronautics and Space Administration (#NNJ13487783Q).”



Other papers of interest:



Montag C, Zander T, Schneider S.

Who dares to join a parabolic flight?

Acta Astronaut. 2016 Dec;129:223-8.

Note: Parabolic flight. The study examined whether a certain personality type is associated with people willing to participate in parabolic flights (parabonauts).



Morita H, Abe C, Tanaka K.

Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex.

Sci Rep. 2016 Sep 16;6:33405.

Note: ISS results. This article may be obtained online without charge.



Otsuka K, Cornelissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C.

Correction: Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: Observational study.

npj Microgravity. 2016 Sep 29;2:16037.

Note: ISS results.From the authors: “In this Article, data within Table 1 and a sentence within the Methods inadvertently included information that breached subject confidentiality. This information has been removed from Table 1 and Methods in the online versions of the paper.” The original article is: Otsuka K, Cornelissen G, Kubo Y, Hyashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: Observational study. npj Microgravity. 2015 Nov 30;1:15018. The original article appeared in Current Awareness List #676, 4 Dec 2015.  This article may be obtained online without charge.



Gonfalone A.

Sleep on manned space flights: Zero gravity reduces sleep duration.

Pathophysiology. 2016 Aug 18. [Epub ahead of print] Review.

Note: Specific spaceflight missions are not identified. This article may be obtained online without charge.



Tymko MM, Rickards CA, Skow RJ, Ingram-Cotton NC, Howatt MK, Day TA.

The effects of superimposed tilt and lower body negative pressure on anterior and posterior cerebral circulations.

Physiol Rep. 2016 Sep;4(17).

Note: Head up and head down tilt, as well as lower body negative pressure were used. This article may be obtained online without charge.



Li J, Liu H, Zhang X, Zhao Z, Tan C, Tang Z, Ren W, Chen S, Chen X.

Effects of 45 d-6° head-down bed rest on human cardiopulmonary function and protection of Rhodiola rosea.

Space Med Med Eng. 2016;2016(3):185-8. Chinese.

Note: Bed rest study.



Louwies T, Jaki Mekjavic P, Cox B, Eiken O, Mekjavic IB, Kounalakis S, De Boever P.

Separate and combined effects of hypoxia and horizontal bed rest on retinal blood vessel diameters.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4927-32.

Note: Bed rest study. This article may be obtained online without charge.



Yu H, Jiang T, Wang C.

Effects of 30 min postural change on intraocular pressure and visual performance.

Space Med Med Eng. 2016;2016(3):195-200. Chinese.

Note: Bed rest study.



Marzuca-Nassr GN, Vitzel KF, De Sousa LG, Murata GM, Crisma AR, Rodrigues CF Jr, Abreu P, Torres RP, Mancini-Filho J, Hirabara SM, Newsholme P, Curi R.

Effects of high EPA and high DHA fish oils on changes in signaling associated with protein metabolism induced by hindlimb suspension in rats.

Physiol Rep. 2016 Sep;4(18).

Note: Hindlimb unloading study. This article may be obtained online without charge.



Ohno Y, Matsuba Y, Hashimoto N, Sugiura T, Ohira Y, Yoshioka T, Goto K.

Suppression of myostatin stimulates regenerative potential of injured antigravitational soleus muscle in mice under unloading condition.

Int J Med Sci. 2016 Aug 10;13(9):680-5.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Perry BD, Wyckelsma VL, Murphy RM, Steward CH, Anderson M, Levinger I, Petersen AC, McKenna MJ.

Dissociation between short-term unloading and resistance training effects on skeletal muscle Na+,K+-ATPase, muscle function and fatigue in humans.

J Appl Physiol (1985). 2016 Sep 15:jap.00558.2016. [Epub ahead of print]

Note: Unilateral lower limb suspension was used.



Singh AK, Shree S, Chattopadhyay S, Kumar S, Gurjar A, Kushwaha S, Kumar H, Trivedi AK, Chattopadhyay N, Maurya R, Ramachandran R, Sanyal S.

Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.

Mol Cell Endocrinol. 2016 Sep 16. [Epub ahead of print]



Chen Z, Zhao F, Qi Y, Hu L, Li D, Yin C, Su P, Zhang Y, Ma J, Qian J, Zhou H, Zou Y, Qian A.

Simulated microgravity alters the expression of cytoskeleton- and ATP-binding-related genes in MLO-Y4 osteocytes.

Acta Astronaut. 2016 Dec;129:186-92.

Note: A random positioning machine was used.



Zhang H, Ren N, Liu N, Yang Y, Li  J, Zhang R, Zhang Y, Wang Z, Mao K.

Risk of bone fracture and differences in male and female rats under simulated weightlessness.

Space Med Med Eng. 2016;2016(3):169-74. Chinese.

Note: Hindlimb unloading study.



Zhang X, Wang Q, Wan Z, Li J, Liu L, Zhang X.

CKIP-1 knockout offsets osteoporosis induced by simulated microgravity.

Prog Biophys Mol Biol. 2016 Sep 22. [Epub ahead of print]

Note: Hindlimb unloading study.



Dicarolo PR.

Galactic cosmic rays dose mitigation inside a spacecraft by a superconductor “compact” toroid: A FLUKA Monte Carlo study.

Acta Astronaut. 2016 Dec;129:154-60. Epub 2016 Sep 9.



Lorat Y, Timm S, Jakob B, Taucher-Scholz G, Rübe CE.

Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation.

Radiother Oncol. 2016 Sep 13. [Epub ahead of print]



Wu R, Wang Y.

Psychological studies based on analog spaceflight missions: Task, content and method.

Space Med Med Eng. 2016;2016(3):217-23. Chinese. Review.

Note: Analog missions include: CAPSULS, HUBES, SFINCSS-99, NEEMO, HMP-2008 and Mars-500.



Kawada T.

Applicability of the actigraphy for astronauts in spaceflight.

Sleep Sci. 2016 Apr-Jun;9(2):59. Epub 2016 Jul 15.

Note: This letter comments on: Pandi-Perumal SR, Gonfalone AA. Sleep in space as a new medical frontier: The challenge of preserving normal sleep in the abnormal environment of space missions. Sleep Sci. 2016 Jan-Mar;9(1):1-4., which appeared in Current Awareness List #701, 6 Jun 2016.  This article may be obtained online without charge.



Volante WG, Merz M, Stowers K, Hancock PA.

Sleep, workload and boredom: Subject matter expert insights.

Proc Hum Factors Ergon Soc Annu Meet. 2016 Sep 1;60(1):1833-7.

Note: Issues related to sleep and workload on long duration spaceflight are examined.



Balaban CD.

Neurotransmitters in the vestibular system.

Handb Clin Neurol. 2016;137:41-55. Review.



Bronstein AM.

Multisensory integration in balance control.

Handb Clin Neurol. 2016;137:57-66, Review.



Furman JM.

Rotational testing.

Handb Clin Neurol. 2016;137:177-86.

Note: Topics include earth-vertical axis rotation (EVAR), off-vertical axis rotation (OVAR), unilateral centrifugation/off-axis rotation, visual-vestibular interaction (VVI), head-only rotational testing (HORT), and computerized rotational head impulse testing (crHIT).



Golding JF.

Motion sickness.

Handb Clin Neurol. 2016;137:371-90.



Tang W, Chen S, Xiao Y, Jiang G, Tian Z.

Cause analysis of reciprocating operation and accidents in manipulator teleoperation under different 3D information levels.

Space Med Med Eng. 2016;2016(3):201-8. Chinese.

Note: The objective of the study is to “provide a theoretical reference for strengthening the teleoperation error probability prediction and perfecting the system design and astronaut training through the study of the causes of accidents and influencing factors in teleoperation process from cognitive layer based on the manipulator remote docking missions.”



Groemer G, Losiak A, Soucek A, Plank C, Zanardini L, Sejkora N, Sams S.

The AMADEE-15 Mars Simulation.

Acta Astronaut. 2016 Sep 19. [Article in Press] 

Note: The AMADEE-15 Mars Simulation was a 12-day Mars analog field test conducted at Austria’s Kaunertial Glacier with a mission support center at Innsbruck.



Agnisarman SO, Chalil Madathil K, Smith K, Ashok A, Welch B, McElligott JT.

Lessons learned from the usability assessment of home-based telemedicine systems.

Appl Ergon. 2017 Jan;58:424-34. Epub 2016 Aug 12.

Note: The NASA Task Load Index was used.




SpaceRef staff editor.