Status Report

NASA Spaceline Current Awareness List #714 9 September 2016 (Space Life Science Research Results)

By SpaceRef Editor
September 9, 2016
Filed under , , ,


Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: 


Papers deriving from NASA support:



Menon AS, Jourdan D, Nusbaum DM, Garbino A, Buckland DM, Norton S, Clark JB, Antonsen EL.

Crew recovery and contingency planning for a manned stratospheric balloon flight – The StratEx Program.

Prehosp Disaster Med. 2016 Aug 30:1-8. [Epub ahead of print]

Note: Balloon flight results.

Journal Impact Factor: 1.03

Funding: No funding cited. E.L. Antonsen is affiliated with NASA Johnson Space Center.



Brisbane W, Bailey MR, Sorensen MD.

An overview of kidney stone imaging techniques.

Nat Rev Urol. 2016 Aug 31. [Epub ahead of print] Review.

PI: M.R. Bailey

Journal Impact Factor: 5.957

Funding: “Funding was provided by National Space Biomedical Research Institute through NASA NCC 9–58, grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK043881 and DK092197), the University of Washington Applied Physics Laboratory, and the University of Washington Department of Urology.”



Stulberg E, Fravel D, Proctor LM, Murray DM, LoTempio J, Chrisey L, Garland J, Goodwin K, Graber J, Harris MC, Jackson S, Mishkind M, Porterfield DM, Records A.

An assessment of US microbiome research.

Nat Microbiol. 2016 Jan 11;1:15015.

Note: To assess the status of US microbiome research, a team of government scientists conducted an analysis of federally funded microbiome research. This article may be obtained online without charge at:

Journal Impact Factor: Not available for this journal

Funding: No funding cited. D.M. Porterfield is affiliated with NASA Headquarters.



Lindenmaier LB, Philbrick KA, Branscum AJ, Kalra SP, Turner RT, Iwaniec UT.

Hypothalamic leptin gene therapy reduces bone marrow adiposity in ob/ob mice fed regular and high-fat diets.

Front Endocrinol (Lausanne). 2016 Aug 16;7:110.

PI: R.T. Turner

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This study was supported by NIH AR060913, NASA NNX12AL24G, and USDA 38420-17804.”



Datesman A.

Shot noise in radiobiological systems.

J Environ Radioact. 2016 Aug 24;164:365-8. [Epub ahead of print]

Note: From the abstract: “As a model for human tissue, this report considers the rate of free radical generation in a dilute solution of water in which a beta-emitting radionuclide is uniformly dispersed.”

Journal Impact Factor: 2.047

Funding: No funding cited. A. Datesman is affiliated with NASA Goddard Space Flight Center.



Stankovic A, Alexander DJ, Oman CM, Schneiderman J.

A review of cognitive and behavioral effects of increased carbon dioxide exposure in humans.

Houston, TX: NASA Johnson Space Center, 2016 Aug. 22 p. NASA/TM-2016-219277.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. D. Alexander is affiliated with NASA Johnson Space Center.



Britt TW, Jennings KS, Goguen C, Sytine A.

The role of meaningful work in astronaut health and performance during long-duration space exploration missions.

Houston, TX: NASA Johnson Space Center, 2016 78 p. NASA/TM-2016-219276. 

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication                 

Funding: “This report constitutes the third deliverable for NASA Contract Number NNJ15HK13P titled “Meaningful Work.””



Other papers of interest:



Zhao L, Gao Y, Mi D, Sun Y.

Mining potential biomarkers associated with space flight in Caenorhabditis elegans experienced Shenzhou-8 mission with multiple feature selection techniques.

Mutat Res. 2016 Aug 17;791-792:27-34. [Epub ahead of print]

Note: Shenzhou-8 results.



Pletser V, Migeotte PF, Legros JC, Deneyer B, Caron R.

The Suborbital Research Association: Using suborbital platforms for scientific and student experiments.

Microgravity Sci Technol. 2016 May 27:1-16. [Article in Press]

Note: From the Introduction: “A group of Scientists involved in space research have created the Suborbital Research Association (SRA) whose goals are to promote the suborbital scientific and technical research aboard suborbital platforms that will be available in the coming years; to provide the necessary assistance to the practical realization of fundamental and applied scientific research in suborbital environment; and to promote scientific research in suborbital flights to the general public, youth and students.”



Chen Z, Luo Q, Yuan L, Song G.

Microgravity directs stem cell differentiation.

Histol Histopathol. 2016 Sep 1:11810. Review. [Epub ahead of print]

Note: The discussion examines results from several unnamed spaceflights and ground-based studies that used the rotating cell culture system, 2-D clinostat, rotating wall vessels, and hindlimb unloading.



Janmaleki M, Pachenari M, Seyedpour SM, Shahghadami R, Sanati-Nezhad A.

Impact of simulated microgravity on cytoskeleton and viscoelastic properties of endothelial cell.

Sci Rep. 2016 Sep 1;6:32418.

Note: A random positioning machine was used. This article may be obtained online without charge.



Seref-Ferlengez Z, Suadicani SO, Thi MM.

A new perspective on mechanisms governing skeletal complications in type 1 diabetes.

Ann N Y Acad Sci. 2016 Aug 29. [Epub ahead of print] Review. 

Note: From the abstract: “we highlight the mechanosensitive nature of bone tissue and the importance of mechanical loading for bone health.”



Lau RY-C, Qian X, Po KT, Li LM, Guo X.

Response of rat tibia to prolonged unloading under the influence of electrical stimulation at the dorsal root ganglion.

Neuromodulation. 2016 Aug 31. [Epub ahead of print]

Note: Hindlimb unloading study.



Reilly BD, Franklin CE.

Prevention of muscle wasting and osteoporosis: The value of examining novel animal models.

J Exp Biol. 2016 Sep 1;219(Pt 17):2582-95. Review.



Kwon OS, Nelson DS, Barrows KM, O’Connell RM, Drummond MJ.

Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by toll-like receptor 4 during hindlimb unloading.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 31:ajpregu.00253.2016. [Epub ahead of print]

Note: Hindlimb unloading study.



Dobashi S, Horiuchi M, Endo J, Kiuchi M, Koyama K.

Cognitive function and cerebral oxygenation during prolonged exercise under hypoxia in healthy young males.

High Alt Med Biol. 2016 Sep 1. [Epub ahead of print]



Mizuno K, Matsumoto A, Aiba T, Abe T, Ohshima H, Takahashi M, Inoue Y.

Sleep patterns among shift-working flight controllers of the International Space Station: An observational study on the JAXA Flight Control Team.

J Physiol Anthropol. 2016 Sep 1;35(1):19.

Note: This article may be obtained online without charge.



Gensberger KD, Kaufmann AK, Dietrich H, Branoner F, Banchi R, Chagnaud BP, Straka H.

Galvanic vestibular stimulation: Cellular substrates and response patterns of neurons in the vestibulo-ocular network.

J Neurosci. 2016 Aug 31;36(35):9097-110.



Komorowski M, Fleming S, Hinkelbein J.

Anaesthesia in outer space: The ultimate ambulatory setting?

Curr Opin Anaesthesiol. 2016 Aug 31. [Epub ahead of print] Review.



Jayaprakash N, Ali R, Kashyap R, Bennett C, Kogan A, Gajic O.

The incorporation of focused history in checklist for early recognition and treatment of acute illness and injury.

BMC Emerg Med. 2016 Aug 31;16(1):35.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.



Prytz EG, Rybing J, Jonson CO.

Workload differences across command levels and emergency response organizations during a major joint training exercise.

J Emerg Manag. 2016 Jul-Aug;14(4):289-97.

Note: The NASA Task Load Index was used.



SpaceRef staff editor.