Status Report

NASA Spaceline Current Awareness List #705 1 July 2016 (Space Life Science Research Results)

By SpaceRef Editor

July 1, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Li S, Garrett-Bakelman FE, Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, Lewis ID, To LB, Delwel R, Löwenberg B, Döhner H, Döhner K, Guzman ML, Hassane DC, Roboz GJ, Grimwade D, Valk PJ, D’Andrea RJ, Carroll M, Park CY, Neuberg D, Levine R, Melnick AM, Mason CE.

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Nat Med. 2016 Jun 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27322744

PI: C.E. Mason

Journal Impact Factor: 30.357

Funding: “This work was supported by Starr Cancer Consortium grant I4-A442 (A.M.M., R.L., and C.E.M.), STARR Cancer Consortium grant I7-A765 and I9-A9-071 (C.E.M.), the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation and the WorldQuant Foundation, Pershing Square Sohn Cancer Research Alliance, and NASA (NNX14AH50G) (C.E.M.); LLS SCOR 7006-13 (A.M.M.); NCI K08CA169055 (F.E.G.-B.); an American Society of Hematology (ASHAMFDP-20121) award under the ASH-AMFDP partnership with the Robert Wood Johnson Foundation and ASH/EHA TRTH (F.E.G.-B.); a Doris Duke Medical Foundation, Leukemia and Lymphoma Society Translational Research Program, and Geoffrey Beene Cancer Center (C.Y.P.); a Leukaemia and Lymphoma Research award (D.G. and R. Dillon); German Research Foundation (DFG) grant SFB 1074 (project B3; K.D. and L.B.); DFG Heisenberg-Stipendium BU 1339/3-1 (L.B.); an Australian National Health and Medical Research Council and the Royal Adelaide Hospital Contributing Haematologists Fund financial support (R.J.D., A.L.B., and I.D.L.); US National Institutes of Health R01CA102031 (G.J.R. and M.L.G.) and R01NS076465 (C.E.M. and A.M.M.); and Leukemia Fighters funding (G.J.R., M.L.G., and D.C.H.).”

Miousse IR, Chalbot MC, Lumen A, Ferguson A, Kavouras IG, Koturbash I.

Response of transposable elements to environmental stressors.

Mutat Res Rev Mutat Res. 2015 Jul-Sep;765:19-39. Review. Epub 2015 May 30.

http://www.ncbi.nlm.nih.gov/pubmed/26281766

PI: M. Boerma/I. Koturbash/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 5.261

Funding: “The research in Koturbash’ Lab is supported, in part, by the NIH/UAMS Clinical and Translational Science Award [UL1TR000039 and KL2TR000063], National Space Biomedical Research Institute (RE03701) through National Aeronautics and Space Administration NCC 9-58, and the Arkansas Biosciences Institute. The research in Fergusons’ Lab is supported, in part, by EPA NE-00F65601-0 and X8-00F10401-1 grants.”

Liu X, He Y, Li F, Huang Q, Kato TA, Hall RP, Li CY.

Redefining the roles of apoptotic factors in carcinogenesis.

Mol Cell Oncol. 2016 Jun 10;3(3):e1054550.

http://www.ncbi.nlm.nih.gov/pubmed/27314073

PI: C-Y. Li

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This study was supported in part by grants CA131408, CA136748, CA155270, ES024015 from the National Institutes of Health (to C-Y Li), and grant NNX12AB88G (to C-Y Li) from NASA Space Radiation Biology Research Program; and grants 30428015, 30325043 from the National Science Foundation of China, grant 2004CB518804 from Ministry of Science of China “973 project” to Q. Huang.”

Kinsella A, Mattfeld R, Muth E, Hoover A.

Frequency, not amplitude, of latency affects subjective sickness in a head-mounted display.

Aerosp Med Hum Perform. 2016 Jul;87(7):604-9.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00004

Journal Impact Factor: 0.755

Funding: “Partial funding for this work was provided by NASA grant #NNX10AM76H “Portable Hardware for Sensorimotor Adaptation.””

Mao XW, Nishiyama NC, Pecaut MJ, Campbell-Beachler M, Gifford P, Haynes KE, Becronis C, Gridley DS.

Simulated microgravity and low-dose/low-dose-rate radiation induces oxidative damage in the mouse brain.

Radiat Res. 2016 Jun;185(6):647-57. Epub 2016 May 31.

http://www.ncbi.nlm.nih.gov/pubmed/27243749

PI: X.W. Mao

Note: Hindlimb unloading study.

Journal Impact Factor: 3.022

Funding: “This study was supported by the National Aeronautics and Space Administration (NASA grant no. NNX13AL97G) and the Department of Basic Sciences, Loma Linda University.”

Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M.

Novel double-hit model of radiation and hyperoxia-induced oxidative cell damage relevant to space travel.

Int J Mol Sci. 2016 Jun 16;17(6).

http://www.ncbi.nlm.nih.gov/pubmed/27322243

PI: M. Christofidou-Solomidou

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.257

Funding: “This work was funded in part by: the National Aeronautics and Space Administration (NASA) Human Research Program through a NASA-National Institutes of Health (NIH) Interagency Agreement for supplemental award to NIH and by NASA award #NNX12AK19G (Melpo Christofidou-Solomidou), NIH-R01 CA133470 (Melpo Christofidou-Solomidou), NIH-1R21AT008291-01 (Melpo Christofidou-Solomidou), NIH-R03 CA180548 (Melpo Christofidou-Solomidou), 1P42ES023720-01 (Melpo Christofidou-Solomidou) and by pilot project support from 1P30 ES013508-02 awarded to Melpo Christofidou-Solomidou (its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH).”

Macaulay TR, Macias BR, Lee SMC, Boda WL, Watenpaugh DE, Hargens AR.

Treadmill exercise within lower-body negative pressure attenuates simulated spaceflight-induced reductions of balance abilities in men but not women.

npj Microgravity. 2016;2:16022. Epub 2016 Jun 30.

http://www.nature.com/articles/npjmgrav201622

PIs: A.R. Hargens, B.R. Macias

Note: Bed rest study. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This study was funded by NASA grants NAG 9-1425, NCC2-1133, NNX10AM18G, and NNX13AJ12G, NIH grant to the UCSD GCRC M01 RR00827. B.R.M. was supported by the National Space Biomedical Research Institute through NCC 9-58.”

Perlis ML, Grandner MA, Brown GK, Basner M, Chakravorty S, Morales KH, Gehrman PR, Chaudhary NS, Thase ME, Dinges DF.

Nocturnal wakefulness as a previously unrecognized risk factor for suicide.

J Clin Psychiatry. 2016 Jun;77(6):e726-33.

http://www.ncbi.nlm.nih.gov/pubmed/27337421

PI:M. Basner

Journal Impact Factor: 5.408

Funding: “The study had no direct support by grant funding. Partial salary support was provided by the National Institute on Aging grant R01AG041783 (Drs Perlis and Morales); National Center for Complementary and Alternative Medicine grant R01AT003332 (Drs Perlis and Morales); National Institute of Mental Health grant R01MH077900 (Drs Perlis and Morales), R01MH086572 (Dr Brown), R21MH103963 (Dr Gehrman), and R01MH082794 (Dr Thase); National Institute of Environmental Health Services grant R21ES022931 (Dr Grandner); National Heart, Lung, and Blood Institute grant K23HL110216 (Dr Grandner); National Institute of Nursing Research grant R01NR004281 (Dr Dinges); National Space Biomedical Research Institute grant NCC 9-58 through the National Aeronautics and Space Administration (Dr Basner); and US Department of Veterans Affairs grant IK2CX000855 (Dr Chakravorty).”

Uzer G, Rubin CT, Rubin J.

Cell mechanosensitivity is enabled by the LINC nuclear complex.

Curr Mol Biol Rep. 2016 Mar;2(1):36-47. Epub 2016 Feb 1.

http://www.ncbi.nlm.nih.gov/pubmed/27326387

PI: G. Uzer, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: Not available for this journal

Funding: “This study was supported by NIH AR056655, AR066616, EB014351, and National Space Biomedical Research Institute PF04304 through NASA NCC 9–58.”

Rai A, Robinson JA, Tate-Brown J, Buckley N, Zell M, Tasaki K, Karabadzhak G, Sorokin IV, Pignataro S.

Expanded benefits for humanity from the International Space Station.

Acta Astronaut. 2016 Jun 23. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576516301989

Note: This article refers to the book listed below, International Space Station benefits for humanity, 2^nd ed. It reviews and summarizes revisions to the 2012 edition, including updated statistics on the impacts of the benefits. It also includes new benefits that have developed since the earlier edition with additional sections on economic development of space and innovative technology.

Journal Impact Factor: 1.095

Funding: No funding cited. J. Robinson is affiliated with NASA Johnson Space Center.

International Space Station benefits for humanity. 2nd ed.

Houston, TX: NASA Johnson Space Center, 2015. 154 p. NP-2015-01-001-JSC.

https://www.nasa.gov/audience/foreducators/topnav/materials/listbytype/ISS_Benefit_for_Humanity.html#.V3QIg6LyaLk

Note: The book is a collaborative work by the members of the International Space Station Program Science Forum: National Aeronautics and Space Administration, Canadian Space Agency, European Space Agency, Japan Aerospace Exploration Agency, Russian Federal Space Agency, and the Italian Space Agency. From the Executive Summary: “Since the publication of the first edition, a new constituency has developed, one that is using the ISS in a totally different fashion—to develop a commercial market in low-Earth orbit. From pharmaceutical companies conducting commercially-funded research on ISS, to private firms offering unique research capabilities and other services, to commercial cargo and crew, the ISS is proving itself to be just as adaptable to new business relationships as it has been for a broad diversity in research disciplines. This book summarizes the scientific, technological and educational accomplishments of research on the space station that have had and will continue to have an impact to life on Earth. All serve as examples of the space station’s potential as a groundbreaking research facility. Through advancing the state of scientific knowledge of our planet, looking after our health, developing advanced technologies and providing a space platform that inspires and educates the science and technology leaders of tomorrow, these benefits will drive the legacy of the space station as its research strengthens economies and enhances the quality of life here on Earth for all people.”

______________________________________________________

Other papers of interest:

Han J, Dai J.

Microgravity may help future organ/tissue manufacture.

Sci China Life Sci. 2016 Jun 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27333784

Note: SJ-10 satellite results. This article may be obtained online without charge.

Kalicinski M, Steinberg F, Dalecki M, Bock O.

Gaze behavior while operating a complex instrument control task.

Aerosp Med Human Perform. 2016 Jul;87(7):646-51.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00010

Note: Parabolic flight results.

Huang CC, Yang CM.

Visual information and support surface for postural control in visual search task.

Percept Mot Skills. 2016 Jun 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27324165

Note: This article may be obtained online without charge.

Simons R.

Use of gene expression biomarkers to predict suicidality.

Aerosp Med Hum Perform. 2016 Jul;87(7):659-60.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00013

Jang TY, Jung AY, Kim YH.

Effect of long-term antiorthostatic suspension in a murine model of acute lung injury.

Clin Exp Otorhinolaryngol. 2016 Jun 18. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27334509

Note: This article may be obtained online without charge.

Valk PJL, Simons R, Jetten AM, Valiente R, Labeaga L.

Cognitive performance effects of bilastine 20 mg during 6 hours at 8000 ft cabin altitude.

Aerosp Med Hum Perform. 2016 Jul;87(7):622-7.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00007

Alkner BA, Norrbrand L, Tesch PA.

Neuromuscular adaptations following 90 days bed rest with or without resistance exercise.

Aerosp Med Hum Perform. 2016 Jul;87(7):610-7.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00005

Note: Bed rest study.

Verdijk LB, Snijders T, Holloway TM, van Kranenburg J, van Loon LJ.

Resistance training increases skeletal muscle capillarization in healthy older men.

Med Sci Sports Exerc. 2016 Jun 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27327032

Pilmanis AA, Balldin UI, Fischer JR.

Cognition effects of low-grade hypoxia.

Aerosp Med Hum Perform. 2016 Jul;87(7):596-603.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000007/art00003

Baxendale S, Whitfield TT.

Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course.

Methods Cell Biol. 2016;134:165-209. Review. Epub 2016 Mar 9.

http://www.ncbi.nlm.nih.gov/pubmed/27312494

Crane BT.

Perception of combined translation and rotation in the horizontal plane in humans.

J Neurophysiol. 2016 Jun 22:jn.00322.2016. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27334952

Matthews G.

Multidimensional profiling of task stress states for human factors: A brief review.

Hum Factors. 2016 Jun 21. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27329044

Pernisova M, Prat T, Grones P, Harustiakova D, Matonohova M, Spichal L, Nodzynski T, Friml J, Hejatko J.

Cytokinins influence root gravitropism via differential regulation of auxin transporter expression and localization in Arabidopsis.

New Phytol. 2016 Jun 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27322763

Belaadi N, Aureille J, Guilluy C.

Under pressure: Mechanical stress management in the nucleus.

Cells. 2016 Jun 14;5(2):Review.

http://www.ncbi.nlm.nih.gov/pubmed/27314389

Note: This article may be obtained online without charge.

Greenberg MJ, Arpa? G, Tuzel E, Ostap EM.

A perspective on the role of myosins as mechanosensors.

Biophys J. 2016 Jun 21;110(12):2568-76. Review.

http://www.ncbi.nlm.nih.gov/pubmed/27332116

Yan Y, Sun H, Gong Y, Yan Z, Zhang X, Guo Y, Wang Y.

Mechanical strain promotes osteoblastic differentiation through integrin-β1-mediated beta-catenin signaling.

Int J Mol Med. 2016 Jun 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27314666

SpaceRef Editor

SpaceRef staff editor.

Follow on Twitter