Status Report

NASA Spaceline Current Awareness List #703 17 June 2016 (Space Life Science Research Results)

By SpaceRef Editor

June 17, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Taguchi S, Ogoh S, Hashimoto T, Yamasaki S, Okamoto H, Yamori Y, Hatton DC, McCarron DA.

Spaceflight and biohistochemical alterations of antigravity soleus muscle in spontaneously hypertensive rats (SHR) to dietary low and high-calcium intake.

J Bioanal Biomed. 2016 Jun 7;8:041-7.

http://www.omicsonline.org/open-access/spaceflight-and-biohistochemical-alterations-of-antigravity-soleus-musclein-spontaneously-hypertensive-rats-shr-to-dietary-low-and-1948-593X-1000151.php?aid=73794

PI: D.A. McCarron

Note: STS results.This article may be obtained online without charge.

Journal Impact Factor: 1.480

Funding: “This work was supported in part by National Aeronautics and Space Administration Grant no. NCC-2-934 [Editor’s Note: grant was awarded in 1995] and the Grant-in-Aid from the Japan Society from Promotion of Science (#25560380, #25282201).”

Galazka JM, Klocko AD, Uesake M, Honda S, Selker EU, Freitag M.

Neurospora chromosomes are organized by blocs of importin alpha-dependent heterochromatin that are largely independent of H3K9me3.

Genome Res. 2016 Jun 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27260477

PI: J.M. Galazka, NASA Postdoctoral Fellowship Program

Journal Impact Factor: 11.351

Funding: “Funding was provided by grants from the NIH to MF (GM097637), EUS (GM035690 and GM093061) and AK (GM097821), and a Competitive Funds in Program to Disseminate Tenure Tracking System grant, MEXT, Japan to SH. JG was partly supported by a NASA Postdoctoral Program fellowship.”

Xie A, Wu MD, Cigarroa G, Belcik JT, Ammi A, Moccetti F, Lindner JR.

Influence of DNA-microbubble coupling on contrast ultrasound-mediated gene transfection in muscle and liver.

J Am Soc Echocardiogr. 2016 Jun 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27267307

PI: J.R. Lindner

Journal Impact Factor: 4.265

Funding: “Dr. Lindner is supported by grants R01-HL078610 and R01-HL111969 from the National Institutes of Health (NIH), grant 14NSBRI1-0025 from the National Space Biomedical Research Institute (NASA), and a research award from GE Healthcare. Dr. Wuis supported by grant T32-HL-94294-5 from the NIH. Dr. Moccetti is funded by a grant from the Swiss National Science Foundation.”

Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, Moshrefi A, Pham K, Stedman W, Liang T, Saghbini M, Dzakula Z, Hastie A, Cao H, Deikus G, Schadt E, Sebra R, Bashir A, Truty RM, Chang CC, Gulbahce N, Zhao K, Ghosh S, Hyland F, Fu Y, Chaisson M, Xiao C, Trow J, Sherry ST, Zaranek AW, Ball M, Bobe J, Estep P, Church GM, Marks P, Kyriazopoulou-Panagiotopoulou S, Zheng GX, Schnall-Levin M, Ordonez HS, Mudivarti PA, Giorda K, Sheng Y, Rypdal KB, Salit M.

Extensive sequencing of seven human genomes to characterize benchmark reference materials.

Sci Data. 2016 Jun 7;3:160025.

http://www.ncbi.nlm.nih.gov/pubmed/27271295

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “C.E.M. acknowledges funding from the Starr Cancer Consortium grant I4-A442, I7-A765, I9-A9-071), the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation and the WorldQuant Foundation (CEM), The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G), and the National Institutes of Health (R25EB020393, R01NS076465).”

Kassemi M, Thompson DA.

Prediction of renal crystalline size distributions in space using a PBE analytical model: 1. Effect of microgravity-induced biochemical alterations.

Am J Physiol Renal Physiol. 2016 Jun 8:ajprenal.00401.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27279490

PI: M. Kassemi

Note: “PBE” in the title stands for “Population Balance Equation.”

Journal Impact Factor: 3.390

Funding: “We gratefully acknowledge funding support from the Exploration Medical Capabilities Element of NASA’s Human Research.”

Kassemi M, Thompson DA.

Prediction of renal calculi size distributions in space using a PBE analytical model: 2. Effect of dietary countermeasures.

Am J Physiol Renal Physiol. 2016 Jun 8:ajprenal.00402.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27279491

PI: M. Kassemi

Note: “PBE” in the title stands for “Population Balance Equation.”

Journal Impact Factor: 3.390

Funding: “We gratefully acknowledge funding support from the Exploration Medical Capabilities Element of NASA’s Human Research.”

Chen H, Chong ZZ, De Toledo SM, Azzam EI, Elkabes S, Souayah N.

Delayed activation of human microglial cells by high dose ionizing radiation.

Brain Res. 2016 Jun 2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27265419

PI: E.I Azzam

Journal Impact Factor: 2.561

Funding: “This work was supported in part by RAM Capital II, startup fund from the Department of Neurology and Neurosciences at NJMS to NS. EIA is supported by Grant CA049062 from the National Institutes of Health and Grant NNX15AD62G from National Aeronautics and Space Administration (NASA, United States).”

Wang J, Farris AB, Xu K, Wang P, Zhang X, Duong DM, Yi H, Shu HK, Sun SY, Wang Y.

GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis.

Nat Commun. 2016 Jun 8;7:11795.

http://www.ncbi.nlm.nih.gov/pubmed/27273304

PIs: Y. Wang/S-Y. Sun/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 11.329

Funding: “This work is supported by grants from the NASA (NNX11AC30G) and NIH (CA186129, CA185882, 1S10RR-025679-01 and P30CA138292).”

Evans MJ, Choi WG, Gilroy S, Morris RJ.

A ROS-assisted calcium wave dependent on AtRBOHD and TPC1 propagates the systemic response to salt stress in Arabidopsis roots.

Plant Physiol. 2016 Jun 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27261066

PI: S. Gilroy

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.280

Funding: “The authors gratefully acknowledge funding from the Biotechnology and Biological Sciences Research Council (BBSRC) to RJM, from BBSRC’s Norwich Research Park Doctoral Training Programme to ME, and NASA and NSF to SG and WGC.”

Peleg M, Normand MD, Goulette TR.

Calculating the degradation kinetic parameters of thiamine by the isothermal version of the endpoints method.

Food Res Int. 2016 Jan;79:73-80.

http://www.sciencedirect.com/science/article/pii/S0963996915302726

PI: H. Xiao

Journal Impact Factor: 3.182

Funding: “The authors gratefully acknowledge NASA’s support of the study under project SA-14-042.”

Peleg M, Normand MD.

Simulating shelf life determination by two simultaneous criteria.

Food Res Int. 2015 Dec;78:388-95.

http://www.sciencedirect.com/science/article/pii/S0963996915301770

PI: H. Xiao

Journal Impact Factor: 3.182

Funding: “The authors gratefully acknowledge NASA’s support of the study under project SA-14-042.”

Peleg M, Normand MD.

Predicting chemical degradation during storage from two successive concentration ratios: Theoretical investigation.

Food Res Int. 2015 Sep;75:174-81.

http://www.sciencedirect.com/science/article/pii/S096399691530051X

PI: H. Xiao

Journal Impact Factor: 3.182

Funding: “NASA’s support of the work under project SA-14-042 is gratefully acknowledged.”

______________________________________________________

Other papers of interest:

Bauer J, Bussen M, Wise P, Wehland M, Schneider S, Grimm D.

Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: A case study on microgravity-caused changes in cells.

Expert Rev Proteomics. 2016 Jun 6. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27269583

Note: Results from studies using random positioning machines, rotating wall vessels, and 2D clinostats are reviewed.

Lin SC, Gou GH, Hsia CW, Ho CW, Huang KL, Wu YF, Lee SY, Chen YH.

Simulated microgravity disrupts cytoskeleton organization and increases apoptosis of rat neural crest stem cells via upregulating CXCR4 expression and RhoA-ROCK1-p38 MAPK-p53 signaling.

Stem Cells Dev. 2016 Jun 6. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27269634

Note: A rotary cell culture system was used.

Xianghan W, Jianxin D, Demei W, Fan Z, Yukui W, Fuli W, Chengcheng F, Nuomin L, Rongji D, Yulin D, Zhenzhen Q, Hong Q.

Effects ofsimulated microgravity on human brain nervous tissue.

Neurosci Lett. 2016 Jun 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27268042

Note: A clinostat was used.

Nishida Y, Maruyama S, Shouji I, Kemuriyama T, Tashiro A, Ohta H, Hagisawa K, Hiruma M, Yokoe H.

Effects and biological limitations of +Gz acceleration on the autonomic functions-related circulation in rats.

J Physiol Sci. 2016 Jun 4. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27262847

Note: Centrifugation was used. This article may be obtained online without charge.

Leach J.

Psychological factors in exceptional, extreme and torturous environments.

Extrem Physiol Med. 2016 Jun 1;5:7. Review.

http://www.ncbi.nlm.nih.gov/pubmed/27257476

Note: This article may be obtained online without charge.

Fu W, Hu H, Dang K, Chang H, Du B, Wu X, Gao Y.

Remarkable preservation of Ca(2+) homeostasis and inhibition of apoptosis contribute to anti-muscle atrophy effect in hibernating Daurian ground squirrels.

Sci Rep. 2016 Jun 3;6:27020.

http://www.ncbi.nlm.nih.gov/pubmed/27256167

Note: This article may be obtained online without charge.

Gombos GC, Bajsz V, Pék E, Schmidt B, Sió E, Molics B, Betlehem J.

Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass.

BMC Musculoskelet Disord. 2016 Jun 8;17(1):254.

http://www.ncbi.nlm.nih.gov/pubmed/27278385

Note: This article may be obtained online without charge.

Madej W, van Caam A, Davidson EB, Buma P, van der Kraan PM.

Unloading results in rapid loss of TGFβ signaling in articular cartilage: Role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?

Osteoarthritis Cartilage. 2016 Jun 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27268943

Mayer-Wagner S, Hammerschmid F, Blum H, Krebs S, Redeker JI, Holzapfel BM, Jansson V, Müller PE.

Effects of single and combined low frequency electromagnetic fields and simulated microgravity on gene expression of human mesenchymal stem cells during chondrogenesis.

Arch Med Science. 2016 May 16. [Epub ahead of print]

http://www.termedia.pl/Journal/-19/Streszczenie-27554

Note: An external motor gear simulated microgravity bioreactor was used. This article may be obtained online without charge.

Zhang D, Hu M, Chu T, Lin L, Wang J, Li X, Ke HZ, Qin YX.

Erratum to Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse [Bone 87 (2016) 161-168].

Bone. 2016 Jun 1. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27262889

Note: Figure 4 in the original was incorrect; the corrected figure is published here. The original article appeared in SPACELINE Current Awareness List #687 on 26 Feb 2016. http://www.ncbi.nlm.nih.gov/pubmed/26868528. This article may be obtained online without charge.

Brooks AL, Hoel DG, Preston RJ.

The role of dose rate in radiation cancer risk: Evaluating the effect of dose rate at the molecular, cellular and tissue levels using key events in critical pathways following exposure to low LET radiation.

Int J Radiat Biol. 2016 Jun 7:1-22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27266588

Lochard J, Bartlett DT, Ruhm W, Yasuda H, Bottollier-Depois JF.

ICRP publication 132: Radiological protection from cosmic radiation in aviation.

Ann ICRP. 2016 Jun;45(1):5-48.

http://www.ncbi.nlm.nih.gov/pubmed/27279360

Note: From the Abstract: “In this publication, the International Commission on Radiological Protection (ICRP) provides updated guidance on radiological protection from cosmic radiation in aviation, taking into account the current ICRP system of radiological protection, the latest available data on exposures in aviation, and experience gained worldwide in the management of exposures in aviation.”

Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M.

Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS – A novel mechanism of DNA radioprotection.

Biochim Biophys Acta. 2016 Sep;1860(9):1884-97. Epub 2016 May 31.

http://www.ncbi.nlm.nih.gov/pubmed/27261092

Note: This article may be obtained online without charge.

Zhao Q, Mao A, Yan J, Si J, Zhou R, Gan L, Liu Y, Zhang H.

Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis.

Life Sci. 2016 May 31. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27259810

Kim HR, Angelaki DE, DeAngelis GC.

The neural basis of depth perception from motion parallax.

Philos Trans R Soc Lond B Biol Sci. 2016 Jun 19;371(1697).

http://www.ncbi.nlm.nih.gov/pubmed/27269599

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S.

Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.

Sci Rep. 2016 Jun 8;6:27607.

http://www.ncbi.nlm.nih.gov/pubmed/27271267

Note: This article may be obtained online without charge.

Claassen J, Bardins S, Spiegel R, Strupp M, Kalla R.

Gravity matters: Motion perceptions modified by direction and body position.

Brain Cogn. 2016 Jul;106:72-7. Epub 2016 May 31.

http://www.ncbi.nlm.nih.gov/pubmed/27258411

Note: From the Abstract: “In this study we analysed the influence of the position and direction of moving objects on their perception and thereby the influence of gravity.”

Kniss JS, Jiang L, Piotrowski T.

Insights into sensory hair cell regeneration from the zebrafish lateral line.

Curr Opin Genet Dev. 2016 Jun 4;40:32-40. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27266973

Peters RM, Blouin JS, Dalton BH, Inglis JT.

Older adults demonstrate superior vestibular perception for virtual rotations.

Exp Gerontol. 2016 Jun 1;82:50-7. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27262689

Note: Rotation was used.

Rincon Gonzalez L, Selen LP, Halfwerk K, Koppen M, Corneil BD, Medendorp WP.

Decisions in motion: Vestibular contributions to saccadic target selection.

J Neurophysiol. 2016 Jun 8:jn.01071.2015. [Epub ahead of print]