Status Report

NASA Spaceline Current Awareness List #701 3 June 2016 (Space Life Science Research Results)

By SpaceRef Editor

June 3, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Stuster J.

Behavioral issues associated with long duration space expeditions: Review and analysis of Astronaut Journals Experiment 01-E104 (Journals) Phase 2 final report.

Houston, TX: NASA Johnson Space Center, 2016 Apr 1. 116 p. NASA/TM-2016-218603.

http://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TM-2016-218603

PI: J. Stuster

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not applicable

Funding: “Cooperative Agreement NNX11AG22A.”

Bogren LK, Johnston EL, Barati Z, Martin PA, Wojda SJ, Van Tets IG, LeBlanc AD, Donahue SW, Drew KL.

The effects of hibernation and forced disuse (neurectomy) on bone properties in arctic ground squirrels.

Physiol Rep. 2016 May 4;4(10).

http://www.ncbi.nlm.nih.gov/pubmed/27225624

Note: Hindlimb immobilization was accomplished via sciatic neurectomy. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported in part by Alaska Space Grant Program under NASA grant NNX10AI67H.”

Li B, Sankaran JS, Judex S.

Trabecular and cortical bone of growing C3H mice is highly responsive to the removal of weightbearing.

PLoS One. 2016 May 25;11(5):e0156222.

http://www.ncbi.nlm.nih.gov/pubmed/27223115

PI: S. Judex

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.234

Funding: “This study was funded by the National Aeronautics and Space Administration (NNX12AL25G).”

Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M.

The vitamin E analog gamma-tocotrienol (GT3) suppresses radiation-induced cytogenetic damage.

Pharm Res. 2016 May 23. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27216753

PIs: M. Boerma/I. Koturbash/M. Hauer-Jensen/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.420

Funding: “This study was supported by the National Institutes of Health (P20 GM109005 (MH-J), R37 CA71382 (MH-J), and R01 CA148679 [MB]), the US Veterans Administration (MH-J), the Arkansas Space Grant Consortium through the National Aeronautics and Space Administration (NNX15AK32A [RP]), and the National Space Biomedical Research Institute (RE03701) through NCC 9-58 (MB). This publication was made possible, in part, by the Arkansas INBRE program, supported by funding from NIH/NIGMS (P20 GM103429, formerly P20RR016460 [AB]) and the National Center for Research Resources (NCRR – P20RR016460, NIGMS – P20 GM103429) from the National Institutes of Health, (AB).”

Wang J, Zhang X, Wang P, Wang X, Farris III AB, Wang Y.

Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments.

Life Sci Space Res. 2016 May 24. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300189

PI: Y. Wang/NSCOR

Journal Impact Factor: 1.183

Funding: “This work is supported by grants from the National Aeronautics and Space Administration (NNX11AC30G to Y.W.) and the National Cancer Institute (CA186129, CA185882 to Y.W. and P30CA138292 to the Institute).”

Wilson JW, Slaba TC, Badavi FF, Reddell BD, Bahadori AA.

Solar proton exposure of an ICRU sphere within a complex structure Part I: Combinatorial geometry.

Life Sci Space Res. 2016 May 24. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300062

PI: J. Norbury

Journal Impact Factor: 1.183

Funding: “This work was supported by the Human Research Program under the Human Exploration and Operations Mission Directorate of NASA and by NASA Grant number NNX09AR20A.”

Gilroy S, Bialasek M, Suzuki N, Gorecka M, Devireddy A, Karpinski S, Mittler R.

ROS, calcium and electric signals: Key mediators of rapid systemic signaling in plants.

Plant Physiol. 2016 May 10. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27208294

PI: S. Gilroy

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.841

Funding: “This work was supported by funding from the National Science Foundation (IOS-1353886, IOS-0639964, IOS-0743954, IOS-1063287, IOS-0943128, IOS-11213800, MCB-1329723) and NASA (NNX13AM50G, NNX14AT25G), the University of North Texas, College of Arts and Sciences, Sophia University, Faculty of Science and Technology. SK, MB and MG were supported by the Opus 4 (UMO-2012/07/B/NZ3/00228),Opus 6 (UMO-2013/11/B/NZ3/00973) and Maestro 6 (UMO-2014/14/A/NZ1/00218) projects financed by the Polish National Science Centre and also co-supported by the project (PBS3/A9/37/2015) financed by the Polish National Research and Development Center.”

Translational cell and animal research in space 1965-2011. April E. Ronca, Kenneth A. Souza, Richard C. Mains, editors.

Mountain View, CA: NASA Ames Research Center, 2015. 489 p. NASA/SP-2015-625.

https://www.nasa.gov/ames/research/space-biosciences/technical-reports

Note: Research was conducted on Biosatellite, STS, Cosmos, Bion, Foton, Mir, Progress, and ISS.

Journal Impact Factor: Not applicable

Funding: No funding cited. A.E. Ronca, K.A. Souza (deceased), and R.C. Mains are affiliated with NASA Ames Research Center.

Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. Cheryl A. Nickerson, Neal R. Pellis, C. Mark Ott, editors.

New York: Springer; 2016. 310 p.

http://www.springer.com/us/book/9781493932764

Note: Sections include: The Principles and Translational Impact of Space Life Sciences Research, Human Cellular Investigations, and Microbial Investigations. Individual chapters are listed separately below.

Funding: No funding cited. C.M. Ott, as well as other chapter authors B. Crucian and D.L. Pierson, is affiliated with NASA Johnson Space Center.

Note: Listed below are chapters from Effect of spaceflight and space flight analogue culture on human and microbial cells, edited by Cheryl A. Nickerson, Neal R. Pellis, C. Mark Ott. New York: Springer, 2016. The chapters discuss results from many spaceflights, including Apollo, Skylab, Mir, STS, and ISS as well as spaceflight analogues such as the Mars 500 Project and a variety of rotating wall vessels used for both ground and space studies.

Pellis NR, Choukèr A, Yic B, Tauber S, Ullrich O, Sundaresan A.

Overview and translational impact of space cell biology research.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 3-37.

http://www.springer.com/us/book/9781493932764

Wolf DA, Kleis SJ.

Principles of analogue and true microgravity bioreactors to tissue engineering.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 39-60.

http://www.springer.com/us/book/9781493932764

Yi B, Crucian B, Tauber S, Ullrich O, Choukèr A.

Immune dysfunction in spaceflight: An integrative view.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 61-79.

http://www.springer.com/us/book/9781493932764

Nickerson CA, Ott CM.

Biomedical advances in three dimensions: An overview of human cellular studies in space and spaceflight analogues.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 83-92.

http://www.springer.com/us/book/9781493932764

Crabbé A, Barrila J, Ott CM, Nickerson CA.

Outpacing infectious disease: Mimicking the host-pathogen microenvironment in three-dimensions.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 93-119.

http://www.springer.com/us/book/9781493932764

Tauber S, Yi B, Choukèr A, Ullrich O.

Use of in vitro cell culture models to understand the cellular and molecular basis of immune dysfunction during spaceflight.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 121-9.

http://www.springer.com/us/book/9781493932764

Wang R, Chu GC-Y, Zhau HE, Chung LWK.

Using a spaceflight three-dimensional microenvironment to probe cancer–stromal interactions.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 131-50.

http://www.springer.com/us/book/9781493932764

Clarke MSF.

Skeletal muscle culture under spaceflight conditions.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 151-74.

http://www.springer.com/us/book/9781493932764

Ronaldson K, Vunjak-Novakovic G.

Microgravity and microgravity analogue studies of cartilage and cardiac tissue engineering.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 175-95.

http://www.springer.com/us/book/9781493932764

Pierson DL, Ott CM.

Microbial investigations: Overview.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 199-208.

http://www.springer.com/us/book/9781493932764

Barrila J, Wilson JW, Soni A, Yang J, Ott CM, Nickerson CA.

Using spaceflight and spaceflight analogue culture for novel mechanistic insight into Salmonella pathogenesis.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 209-35.

http://www.springer.com/us/book/9781493932764

Crabbé A, Ledesma MA, Ott CM, Nickerson CA.

Response of Pseudomonas aeruginosa to spaceflight and spaceflight analogue culture: Implications for astronaut health and the clinic.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 237-57.

http://www.springer.com/us/book/9781493932764

Singh R, Matin AC.

Cellular response of Escherichia coli to microgravity and microgravity analogue culture.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 259-82.

http://www.springer.com/us/book/9781493932764

Castro SL, Niesel DW, Barrila J, Ott CM.

Spaceflight and spaceflight analogue induced responses in gram positive bacteria.

In: Effect of spaceflight and spaceflight analogue culture on human and microbial cells: Novel insights into disease mechanisms. New York: Springer, 2016. p. 283-96.

http://www.springer.com/us/book/9781493932764

______________________________________________________

Other papers of interest:

Ritzmann R, Freyler K, Krause A, Gollhofer A.

No neuromuscular side-effects of scopolamine in sensorimotor control and force-generating capacity among parabolic fliers.

Microgravity Science and Technology. 2016 May 27:1-14. [Article in Press]

http://link.springer.com/article/10.1007%2Fs12217-016-9504-y

Note: Parabolic flight results.

Lychakov DV.

[Behavioral and functional vestibular disturbances after space flight. 2. Fishes, amphibians and birds].

Zh Evol Biokhim Fiziol. 2016 Jan-Feb;52(1):3-16. Review. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/27220235

Note: Specific space flights are not identified in the English abstract.

Ballinger MA, Hess C, Napolitano MW, Bjork JA, Andrews MT.

Seasonal changes in brown adipose tissue mitochondria in a mammalian hibernator: From gene expression to function.

Am J Physiol Regul Integr Comp Physiol. 2016 May 25. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27225952

Cooper ST, Sell SS, Fahrenkrog M, Wilkinson K, Howard DR, Bergen H, Cruz E, Cash SE, Andrews MT, Hampton M.

Effects of hibernation on bone marrow transcriptome in thirteen-lined ground squirrels.

Physiol Genomics. 2016 May 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27207617

Drakul A, Bockisch CJ, Tarnutzer AA.

Does gravity influence the visual line bisection task?

J Neurophysiol. 2016 May 25. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27226452

Balshaw TG, Massey GJ, Maden-Wilkinson TM, Tillin NA, Folland JP.

Training specific functional, neural and hypertrophic adaptations to explosive- vs. sustained-contraction strength training.

J Appl Physiol (1985). 2016 Jun 1;120(11):1364-73. Epub 2016 Apr 7.

http://www.ncbi.nlm.nih.gov/pubmed/27054989

Onda A, Kono H, Jiao Q, Akimoto T, Miyamoto T, Sawada Y, Suzuki K, Kusakari Y, Minamisawa S, Fukubayashi T.

A new mouse model of skeletal muscle atrophy using spiral wire immobilization.

Muscle Nerve. 2016 May 26. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27227343

Note: Hindlimb unloading method is described.

Duan P, Bonewald LF.

The role of the Wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth.

Int J Biochem Cell Biol. 2016 May 19. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27210503

Goggin PM, Zygalakis KC, Oreffo RO, Schneider P.

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: Insights on bone development, ageing, health and disease.

Eur Cell Mater. 2016 May 22;31:264-95.

http://www.ncbi.nlm.nih.gov/pubmed/27209400

Note: A supplementary video is available at the publisher’s website: http://www.ecmjournal.org/journal/papers/vol031/vol031a18.php. The article and video may be obtained online without charge.

Mercuri EG, Daniel AL, Hecke MB, Carvalho L.

Influence of different mechanical stimuli in a multi-scale mechanobiological isotropic model for bone remodelling.

Med Eng Phys. 2016 May 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27215171

Rivina L, Davoren MJ, Schiestl RH.

Mouse models for radiation-induced cancers.

Mutagenesis. 2016 May 21. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27209205

Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR.

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.

Nat Commun. 2016 May 24;7:11508.

http://www.ncbi.nlm.nih.gov/pubmed/27215798