Status Report

NASA SPACELINE Current Awareness List #698 13 May 2016 (Space Life Science Research Results)

By SpaceRef Editor

May 13, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Theriot CA, Westby CM, Morgan JLL, Zwart SR, Zanello SB.

High dietary iron increases oxidative stress and radiosensitivity in the rat retina and vasculature after exposure to fractionated gamma radiation.

npj Microgravity. 2016 May 5;2:16014.

http://www.nature.com/articles/npjmgrav201614

PI: S.B. Zanello

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This project was supported by funds awarded to S.B.Z. and S.R.Z. by the NASA Human Research Program’s Human Health Countermeasures Element to be conducted as a directed task.”

Jaworske DA, Myers JG.

Pharmaceuticals exposed to the space environment: Problems and prospects.

Cleveland, OH: NASA Glenn Research Center, 2016 Mar. 14 p. Report No.: NASA/TM—2016-218949.

http://ntrs.nasa.gov/search.jsp?R=20160003684

Note: This article may be obtained online without charge through the NASA Technical Reports Server (NTRS).

Funding: “The authors gratefully acknowledge the Human Research Program and the Exploration Medical Capability Element for their support of this effort.”

Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ.

Correction: Spaceflight activates lipotoxic pathways in mouse liver.

PLoS One. 2016 May 5;11(5):e0155282.

http://www.ncbi.nlm.nih.gov/pubmed/27145222

PI: M.L. Bouxsein

Note: From the authors: “The images for Figs 3 and 4 are incorrectly switched. The image that appears as Fig 3 should be Fig 4, and the image that appears as Fig 4 should be Fig 3. The figure captions appear in the correct order.” The original article is: Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, et al. (2016) Spaceflight activates lipotoxic pathways in mouse liver. PLoS ONE 11(4): e0152877. http://www.ncbi.nlm.nih.gov/pubmed/27097220. The original article appeared in Current Awareness List #696, 29 April 2016. This article may be obtained online without charge.

Journal Impact Factor: 3.234

Funding: From the original article: “This work was partially funded by the National Aeronautics and Space Administration grant NNX10AJ31G (D.S.G. and M.J.P.; www.nasa.gov) and NNX10AE39G (M.L.B.). Additional support was provided by Department of Anesthesiology at the University of Colorado Anschutz Medical Campus (K. R.J.) and the LLUMC Department of Radiation Medicine (D.S.G., M.J.P.).”

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Other papers of interest:

Ohnishi T.

Life science experiments performed in space in the ISS/Kibo facility and future research plans.

J Radiat Res. 2016 Apr 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27130692

Note: ISS results. This article may be obtained online without charge.

Johansen JP, Almklov PG, Mohammad AB.

What can possibly go wrong? Anticipatory work in space operations.

Cognition Technology & Work. 2016 May;18(2):333-50.

http://link.springer.com/article/10.1007%2Fs10111-015-0357-8

Note: ISS study.

Liu Q, Zhou RL, Zhao X, Chen XP, Chen SG.

Acclimation during space flight: Effects on human emotion.

Mil Med Res. 2016 May 3;3:15. Review.

http://www.ncbi.nlm.nih.gov/pubmed/27134755

Note: Shenzhou 9 results were compared to results from a head-down bed rest study. This article may be obtained online without charge.

Serradj N, Jamon M.

Postnatal training of 129/Sv mice confirms the long-term influence of early exercising on the motor properties of mice.

Behav Brain Res. 2016 Apr 26. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27130139

Note: Centrifugation and hindlimb unloading were used.

5-6

Avila JI, Ng BK, Kotowski L, Hinton BJ, Shepherd J.

Can racial differences in resting metabolic rate be explained by body composition?

Obesity (Silver Spring). 2016 May 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27145362

and

Spaeth AM, Dinges DF, Goel N.

Response to: “Can racial differences in resting metabolic rate be explained by body composition?”

Obesity (Silver Spring). 2016 May 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27145242

Note: These letters comment on the article: Spaeth AM, Dinges DF, Goel N. Resting metabolic rate varies by race and by sleep duration. Obesity. 2015 Dec;23(12):2349-56.

http://www.ncbi.nlm.nih.gov/pubmed/26538305, which appeared ahead of print in Current Awareness List #673, 13 Nov 2015.

Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, McDermott MG, Monteiro CD, Gundersen GW, Ma’ayan A.

Enrichr: A comprehensive gene set enrichment analysis web server 2016 update.

Nucleic Acids Res. 2016 May 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27141961

Note: This article may be obtained online without charge.

Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J.

Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice.

J Nutr Biochem. 2016 May;31:67-76. Epub 2016 Feb 8.

http://www.ncbi.nlm.nih.gov/pubmed/27133425

Note: Muscle atrophy was achieved via sciatic denervation.

Kang KS, Hong JM, Robling AG.

Postnatal beta-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.

Bone. 2016 Apr 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27143110

Metzger CE, Baek K, Swift SN, De Souza MJ, Bloomfield SA.

Exercise during energy restriction mitigates bone loss but not alterations in estrogen status or metabolic hormones.

Osteoporos Int. 2016 Apr 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27129456

Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV.

Microgravity induction of TRAIL expression in preosteoclast cells enhances osteoclast differentiation.

Sci Rep. 2016 May 4;6:25143.

http://www.ncbi.nlm.nih.gov/pubmed/27142480

Note: A rotary cell culture system was used. This article may be obtained online without charge.

Feng X, Xiang-Hong J, Qian L, Xue-Jun Y, Zhan-Chun P, Chun-Xin Y.

Comparison of organ doses in human phantoms: Variations due to body size and posture.

Radiat Prot Dosimetry. 2016 Apr 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27129689

Li Z, Chen S, Nambiar S, Sun Y, Zhang M, Zheng W, Yeow JT.

PMMA/MWCNT nanocomposite for proton radiation shielding applications.

Nanotechnology. 2016 Jun 10;27(23):234001. Epub 2016 Apr 29.

http://www.ncbi.nlm.nih.gov/pubmed/27125319

Pater P, Backstom G, Villegas F, Ahnesjo A, Enger SA, Seuntjens J, El Naqa I.

Proton and light ion RBE for the induction of direct DNA double strand breaks.

Med Phys. 2016 May;43(5):2131.

http://www.ncbi.nlm.nih.gov/pubmed/27147325

Van Ombergen A, Lubeck AJ, Van Rompaey V, Maes LK, Stins JF, Van de Heyning PH, Wuyts FL, Bos JE.

The effect of optokinetic stimulation on perceptual and postural symptoms in visual vestibular mismatch patients.

PLoS One. 2016 Apr 29;11(4):e0154528.

http://www.ncbi.nlm.nih.gov/pubmed/27128970

Note: This article may be obtained online without charge.

Carvil PA, Attias J, Evetts S, Waldie J, Green DA.

The effect of the gravity loading countermeasure skinsuit upon movement and strength.

J Strength Cond Res. 2016 Apr 21. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27135470

Note: The gravity loading countermeasure skinsuit (GLCS) for spaceflight was developed to simulate the continual axial loading experienced on Earth.

Andalib MN, Dzenis Y, Donahue HJ, Lim JY.

Biomimetic substrate control of cellular mechanotransduction.

Biomater Res. 2016 Apr 29;20:11. Review.

http://www.ncbi.nlm.nih.gov/pubmed/27134756

Note: This article may be obtained online without charge.