Status Report

NASA SPACELINE Current Awareness List #696 6 May 2016 (Space Life Science Research Results)

By SpaceRef Editor

May 6, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Keune JA, Philbrick KA, Branscum AJ, Iwaniec UT, Turner RT.

Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation.

npj Microgravity. 2016;2:16016. Epub 2016 Apr 28.

http://www.nature.com/articles/npjmgrav201616

PI: R.T. Turner

Note: STS-62 results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by the National Science Foundation Research Traineeship Program (DGE-0956280) and a grant from the National Aeronautics and Space Administration (NNX12AL24G).”

Jeong SM, Kim SO, DeLorey DS, Babb TG, Levine BD, Zhang R.

Lack of correlation between cerebral vasomotor reactivity and dynamic cerebral autoregulation during stepwise increases in inspired CO2 concentration.

J Appl Physiol (1985). 2016 Apr 21:jap.00390.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27103653

PI: B.D. Levine

Journal Impact Factor: 3.056

Funding: “This study was supported in part by a NASA grant NNH047ZUU003N and a research fellowship award to Dr. Sung-Moon Jeong from the College of Medicine University of Ulsan, Seoul, Korea.”

Jain V, Wotring VE.

Medically induced amenorrhea in female astronauts.

npj Microgravity. 2016;2:16008. Review. Epub 2016 Apr 21.

http://www.nature.com/articles/npjmgrav20168

PI: V.E. Wotring

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “The efforts of VEW were funded by NASA’s Human Research Program.”

Hendrickson EA.

Precise genome engineering and the CRISPR revolution (Boldly going where no technology has gone before).

THREE. 2016. Epub 2016 Apr 6. Review.

https://three.jsc.nasa.gov/articles/CRISPR.pdf

Note: This article may be obtained online without charge.

Journal Impact Factor: Not applicable

Funding: “This work has been supported in part by grants CA154461, CA190492 and GM088351 from the NCI and the NIH to EAH.” THREE is a publication of the NASA Johnson Space Center Space Radiation Program Element.

Graham T, Wheeler R.

Root restriction: A tool for improving volume utilization efficiency in bioregenerative life-support systems.

Life Sci Space Res. 2016 Apr 27. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552415300134

Journal Impact Factor: 1.183

Funding: “This work was supported by Oak Ridge Associated Universities’ (ORAU) NASA Post- Doctoral Research Fellowship Program (Thomas Graham – NASA/KSC affiliation at the time the research was conducted).”

______________________________________________________

Other papers of interest:

Gomoiu I, Chatzitheodoridis E, Vadrucci S, Walther I, Cojoc R.

Fungal spores viabilityon the International Space Station.

Orig Life Evol Biosph. 2016 Apr 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27106019

Note: STS-133, STS-135 andISS results. Paper was presented at the conference: Habitability in the Universe: From the Early Earth to Exoplanets, 22–27 March 2015, Porto, Portugal.

Ichijo T, Yamaguchi N, Tanigaki F, Shirakawa M, Nasu M.

Four-year bacterial monitoring in the International Space Station—Japanese Experiment Module “Kibo” with culture-independent approach.

npj Microgravity. 2016;2:16007. Epub 2016 Apr 21.

http://www.nature.com/articles/npjmgrav20167

Note: ISS results.

Dachev TP, Tomov BT, Matviichuk YN, Dimitrov PG, Bankov NG.

High dose rates obtained outside ISS in June 2015 during SEP event.

Life Sci Space Res. 2016. 2016 Apr 27. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552415300158

Note: ISS results.

Zhong GH, Ling SK, Li YX.

[Mechanism of cardiac atrophy under weightlessness/simulated weightlessness].

Sheng Li Xue Bao. 2016 Apr 25;68(2):194-200. Chinese.

http://www.ncbi.nlm.nih.gov/pubmed/27108907

Note: Spaceflight and method of weightlessness simulation are not identified in the English abstract.

Feng L, Liu XM, Cao FR, Wang LS, Chen YX, Pan RL, Liao YH, Wang Q, Chang Q.

Anti-stress effects of ginseng total saponins on hindlimb-unloaded rats assessed by a metabolomics study.

J Ethnopharmacol. 2016 Apr 21. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27109340

Note: Hindlimb unloading study.

Brown GN, Leong PL, Guo XE.

T-type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics.

Bone. 2016 Apr 20. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27108342

Dirks ML, Backx EM, Wall BT, Verdijk LB, van Loon LJ.

May bed rest cause greater muscle loss than limb immobilization?

Acta Physiol (Oxf). 2016 Apr 28. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27124248

Note: Bed rest and full cast leg immobilization were used. This article may be obtained online without charge.

Feng BO, Wu W, Wang H, Wang J, Huang D, Cheng L.

Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy.

Biomed Rep. 2016 May;4(5):589-94. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27123252

Note: This article may be obtained online without charge.

McKendry J, Pérez-López A, McLeod M, Luo D, Dent R, Smeuninx B, Yu J, Taylor AE, Philp A, Breen L.

Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signaling in young males.

Exp Physiol. 2016 Apr 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27126459

Rullman E, Mekjavic IB, Fischer H, Eiken O.

PlanHab (Planetary Habitat Simulation): The combined and separate effects of 21 days bed rest and hypoxic confinement on human skeletal muscle miRNA expression.

Physiol Rep. 2016 Apr 4;4(8).

http://www.ncbi.nlm.nih.gov/pubmed/27117806

Note: Bed rest study. This article may be obtained online without charge.

Yoshihara T, Yamamoto Y, Shibaguchi T, Miyaji N, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T.

Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle.

J Physiol Sci. 2016 Apr 27. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27117878

Note: Hindlimb unloading study.

Cacao E, Hada M, Saganti PB, George KA, Cucinotta FA.

Relative biological effectiveness of HZE particles for chromosomal exchanges and other surrogate cancer risk endpoints.

PLoS One. 2016 Apr 25;11(4):e0153998.

http://www.ncbi.nlm.nih.gov/pubmed/27111667

Note: This article may be obtained online without charge.

Kavaz E, Peri?ano?lu U, Ekinci N, Özdemir Y.

Determination of energy absorption and exposure buildup factors by using G-P fitting approximation for radioprotective agents.

Int J Radiat Biol. 2016 Apr 28:1-8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27124103

Ashford A, Huang J, Zhang C, Wei W, Mustain W, Eby T, Zhu H, Zhou W.

The cervical vestibular-evoked myogenic potentials (cVEMPs) recorded along the sternocleidomastoid muscles during head rotation and flexion in normal human subjects.

J Assoc Res Otolaryngol. 2016 Apr 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27105980

Takimoto Y, Imai T, Okumura T, Takeda N, Inohara H.

Three-dimensional analysis of otolith-ocular reflex during eccentric rotation in humans.

Neurosci Res. 2016 Apr 23. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27114182

Landgraf D, Long JE, Proulx CD, Barandas R, Malinow R, Welsh DK.

Genetic disruption of circadian rhythms in the suprachiasmatic nucleus causes helplessness, behavioral despair, and anxiety-like behavior in mice.

Biol Psychiatry. 2016 Mar 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27113500

De Sá Teixeira NA.

The visual representations of motion and of gravity are functionally independent: Evidence of a differential effect of smooth pursuit eye movements.