Status Report

NASA SPACELINE Current Awareness List #694 15 April 2016 (Space Life Science Research Results)

By SpaceRef Editor

April 15, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Crucian B, Johnston S, Mehta S, Stowe R, Uchakin P, Quiriarte H, Pierson D, Laudenslager ML, Sams C.

A case of persistent skin rash and rhinitis with immune system dysregulation onboard the International Space Station.

J Allergy Clin Immunol Pract. 2016 Mar 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27036643

PI: C. Sams

Note: ISS results.

Journal Impact Factor: Not available for this journal

Funding: “This study was supported by a grant from the NASA Human Research Program (SDBI1900/SMO-015) to CS.”

Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J.

Genotoxicity of cytolethal distending toxin (CDT) on isogenic human colorectal cell lines: Potential promoting effects for colorectal carcinogenesis.

Front Cell Infect Microbiol. 2016 Mar 23;6:34.

http://www.ncbi.nlm.nih.gov/pubmed/27047802

PI: J.W. Shay; A.J. Fornace Jr/J.W. Shay/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.719

Funding: “This work was supported by an ANR program to GM (Grant number ANR-10-CESA-011) and by the INRA support to LH and JV (Internal program of the TOXALIM Institute termed collaborative project). NASA grants NNX15A121G and NNX16AE08G (JWS).”

Baulch JE, Acharya MM, Allen BD, Ru N, Chmielewski NN, Martirosian V, Giedzinski E, Syage A, Park AL, Benke SN, Parihar VK, Limoli CL.

Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain.

Proc Natl Acad Sci U S A. 2016 Apr 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27044087

PI: J.E. Baulch

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.674

Funding: “This work was supported by Defense Threat Reduction Agency Grant HDTRA 1-13-1-0022 (to C.L.L.), NIH National Institute of Neurological Disorders and Stroke (NINDS) Grant R01 NS074388 (to C.L.L.), American Cancer Society Grant UCI-IRG-98-279-08 (to M.M.A.), University of California, Irvine Institute for Clinical and Translational Science KL2 Award KL2TR001416 (to M.M.A.), and NASA Grant NNX13AK69G (to J.E.B.).”

Impey S, Pelz C, Tafessu A, Marzulla T, Turker MS, Raber J.

Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus.

BMC Genomics. 2016;17(1):273. Epub 2016 Mar 31.

http://www.ncbi.nlm.nih.gov/pubmed/27036964

PI: J. Raber

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.986

Funding: “This work was supported by NASA grant NNJ12ZSA001N.”

Dalal J, Lewis DR, Tietz O, Brown EM, Brown CS, Palme K, Muday GK, Sederoff HW.

ROSY1, a novel regulator of gravitropic response is a stigmasterol binding protein.

J Plant Physiol. 2016 Mar 24;196-197:28-40. Epub 2016 Mar 24.

http://www.ncbi.nlm.nih.gov/pubmed/27044028

PI: G.K. Muday

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.557

Funding: “This work was funded by NASA grant # NNX08AR20G to H.W.S. and C.S.B. and by DFG grant (SFB 746, EXC 294), BMBF (SYSTEC) and DLR (50WB1022) to K.P. and NASA Grant to G.K.M.”

Committee to Review NASA’s Evidence Reports on Human Health Risks, Board on Health Sciences Policy. Institute of Medicine,

Review of NASA’s evidence reports on human health risks: 2015 letter report.

Washington (DC): National Academies Press (US). 2016; 83p.

http://www.ncbi.nlm.nih.gov/pubmed/27054233

Note: From the Abstract: “This report builds on the 2008 IOM report Review of NASA’s Human Research Program Evidence Books: A Letter Report, which provided an initial and brief review of the evidence reports. This letter report reviews seven evidence reports and examines the quality of the evidence, analysis, and overall construction of each report; identifies existing gaps in report content; and provides suggestions for additional sources of expert input. The report analyzes each evidence report’s overall quality, which included readability; internal consistency; the source and breadth of cited evidence; identification of existing knowledge and research gaps; authorship expertise; and, if applicable, response to recommendations from the 2008 IOM letter report.” This article may be obtained online without charge.

Funding: “This project was supported by Contract NNH13CK19B, Task Order NNH13CK20D, between the National Academy of Sciences and the National Aeronautics and Space Administration.’

______________________________________________________

Other papers of interest:

Harada S, Hashizume T, Nemoto K, Shao Z, Higashitani N, Etheridge T, Szewczyk NJ, Fukui K, Higashibata A, Higashitani A.

Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling.

npj Microgravity. 2016;2:16006. Epub 2016 Apr 7

http://www.nature.com/articles/npjmgrav20166

Note: ISS results. This article may be obtained online without charge.

Shinde V, Brungs S, Henry M, Wegener L, Nemade H, Rotshteyn T, Acharya A, Baumstark-Khan C, Hellweg CE, Hescheler J, Hemmersbach R, Sachinidis A.

Simulated microgravity modulates differentiation processes of embryonic stem cells.

Cell Physiol Biochem. 2016 Apr 4;38(4):1483-99. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27035921

Note: A clinostat was used. This article may be obtained online without charge.

Gupta M, Doss B, Lim CT, Voituriez R, Ladoux B.

Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling.

Cell Adh Migr. 2016 Apr 6. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27050660

Smith JR, Broxterman RM, Ade CJ, Evans KK, Kurti SP, Hammer SM, Barstow TJ, Harms CA.

Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise.

Physiol Rep. 2016 Apr;4(7).

http://www.ncbi.nlm.nih.gov/pubmed/27044854

Note: This article may be obtained online without charge.

Fernandez J, Zhang J, Heidlauf T, Sartori M, Besier T, Röhrle O, Lloyd D.

Multiscale musculoskeletal modelling, data-model fusion and electromyography-informed modelling.

Interface Focus. 2016 Apr 6;6(2):20150084.

http://www.ncbi.nlm.nih.gov/pubmed/27051510

Shimazu J, Wei J, Karsenty G.

Smurf1 inhibits osteoblast differentiation, bone formation, and glucose homeostasis through serine 148.

Cell Rep. 2016 Apr 5;15(1):27-35. Epub 2016 Mar 24.

http://www.ncbi.nlm.nih.gov/pubmed/27052174

Note: This article may be obtained online without charge.

Aceto J, Nourizadeh-Lillabadi R, Bradamante S, Maier JA, Alestrom P, van Loon JJWA, Muller M.

Effects of microgravity simulation on zebrafish transcriptomes and bone physiology—Exposure starting at 5 days post fertilization.

npj Microgravity. 2016;2:16010. Epub 2016 Apr 17.

http://www.nature.com/articles/npjmgrav201610

Note: Clinorotation was used. This article may be obtained online without charge.

Takamatsu Y, Koike W, Takenouchi T, Sugama S, Wei J, Waragai M, Sekiyama K, Hashimoto M.

Protection against neurodegenerative disease on Earth and in space.

npj Microgravity. 2016;2:16013. Epub 2016 Apr 7.

http://www.nature.com/articles/npjmgrav201613

Note: Hindlimb suspension was used. This article may be obtained online without charge.

Hellweg CE, Spitta LF, Henschenmacher B, Diegeler S, Baumstark-Khan C.

Transcription factors in the cellular response to charged particle exposure.

Front Oncol. 2016;6:61. Epub 2016 Mar 21.

http://www.ncbi.nlm.nih.gov/pubmed/27047795

Note: This article may be obtained online without charge.

Desmaris G.

Cosmic radiation in aviation: Radiological protection of Air France aircraft crew.

Ann ICRP. 2016 Apr 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27044363

Note: Data are from France’s SIEVERT project (Système d’Information et d’Evaluation par Vol de l’Exposition au Rayonnement cosmique dans les Transports aériens), a computerized system for flight assessment of exposure to cosmic radiation in air transport.

Buratovic S, Stenerlöw B, Fredriksson A, Sundell-Bergman S, Eriksson P.

Developmental effects of fractionated low-dose exposure to gamma radiation on behaviour and susceptibility of the cholinergic system in mice.

Int J Radiat Biol. 2016 Apr 4:1-9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27043364

Okoukoni C, Lynch SK, McTyre ER, Randolph DM, Weaver AA, Blackstock AW, Lally BE, Munley MT, Willey JS.

A cortical thickness and radiation dose mapping approach identifies early thinning of ribs after stereotactic body radiation therapy.

Radiother Oncol. 2016 Apr 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27072937

Paul P, Dhandapani V, Rameneni JJ, Li X, Sivanandhan G, Choi SR, Pang W, Im S, Lim YP.

Genome-wide analysis and characterization of Aux/IAA family genes in Brassica rapa.

PLoS One. 2016;11(4):e0151522. Epub 2014 Apr 7.

http://www.ncbi.nlm.nih.gov/pubmed/27049520

Note: This article may be obtained online without charge.

Laiakis EC, Pannkuk EL, Diaz-Rubio ME, Wang YW, Mak TD, Simbulan-Rosenthal CM, Brenner DJ, Fornace AJ Jr.

Implications of genotypic differences in the generation of a urinary metabolomics radiation signature.

Mutat Res. 2016 Mar 25. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27040378

Radtke F, Nowell CS.

Linking inflammation and mechanotransduction in stem cell regulation.

Cell Cycle. 2016 Apr 6. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27050820

Note: This article may be obtained online without charge.

SpaceRef Editor

SpaceRef staff editor.

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