Status Report

NASA Spaceline Current Awareness List #671 30 October 2015

By SpaceRef Editor
October 30, 2015
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In case you missed it: Here is a link to a discussion about plants in space from NPR’s Science Friday broadcast on October 2, 2015 — Research on Arabidopsis by Drs. Anna-Lisa Paul and Robert Ferl is highlighted. Astronaut Don Pettit talks about his experience with growing zucchini, broccoli, and sunflowers on the International Space Station. The website contains a link to a Macroscope video about Paul and Ferl’s research into the effects of light on plants grown in space.



Papers deriving from NASA support:



Ade CJ, Broxterman RM, Craig JC, Schlup SJ, Wilcox SL, Barstow TJ.

Standardized exercise tests and simulated terrestrial mission task performance.

Aerosp Med Hum Perform. 2015 Nov;86(11):982-9.

PI: T.J. Barstow

Journal Impact Factor: 0.875

Funding: “This study was supported by the National Aeronautics and Space Administration (NASA) research grant NNX10AK60G awarded to T. J. Barstow.”



Westby CM, Martin DS, Lee SM, Stenger MB, Platts SH.

Left ventricular remodeling during and after 60 days of sedentary head-down bed rest.

J Appl Physiol (1985). 2015 Oct 22:jap.00676.2015. [Epub ahead of print]

PI: S.H. Platts

Journal Impact Factor: 3.056

Funding: “This work was funded by the National Aeronautics and Space Administration Human Research Program (NASA BRC-2003-0000-0543) and supported in part by grant 1UL1RR029876-01 from the National Center for Advancing Translational Sciences, National Institutes of Health.”



Kim SB, Bozeman RG, Kaisani A, Kim W, Zhang L, Richardson JA, Wright WE, Shay JW.

Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.

Oncogene. 2015 Oct 19. [Epub ahead of print]

PIs: J.W. Shay; A. Fornace/J.W. Shay/NSCOR; J.D. Minna/J.W. Shay/J.A. Richardson/W.E. Wright/NSCOR; A. Fornace/J.W. Shay/J.A. Richardson/W.E. Wright/NSCOR

Journal Impact Factor: 8.459

Funding: “This work was performed in laboratories constructed with support from NIH grant C06 RR30414. This work was supported by NASA Grant nos. NNX15AI21G, NNX11AC15G, NNJ05HD36G and NNX09AU95G to JWS.”



Raber J, Marzulla T, Kronenberg A, Turker MS.

16Oxygen irradiation enhances cued fear memory in B6D2F1 mice.

Life Sci Space Res. 2015 Nov;7:61-5.

PIs: J.A. Raber, A. Kronenberg, M.S. Turker

Journal Impact Factor: 1.183

Funding: “This work was supported by NASA grants NNJ05HE63G, NNJ12ZSA001N, NNX10AC12G, and NNJ12HB88I.”



Heilbronn LH, Borak TB, Townsend LW, Tsai P-E, Burnham CA, McBeth RA.

Neutron yields and effective doses produced by galactic cosmic ray interactions in shielded environments in space.

Life Sci Space Res. 2015 Oct 23. [Article in Press]

Journal Impact Factor: 1.183

Funding: “This work was supported by Grant NNX13AD19G from the National Aeronautics and Space Administration, through a subcontract with Colorado State University (Subaward G-6565-1).”



Basner M, Savitt A, Moore TM, Port AM, McGuire S, Ecker AJ, Nasrini J, Mollicone DJ, Mott CM, McCann T, Dinges DF, Gur RC.

Development and validation of the Cognition test battery for spaceflight.

Aerosp Med Hum Perform. 2015 Nov;86(11):942-52.

PubMed PMID:

PI: M. Basner

Journal Impact Factor: 0.875

Funding: “The research was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58 and by NASA through grants NNX14AM81G, NNX14AH27G, and NNX14AH98G. The sleep deprivation protocols were supported by NIH through R01NR00428 and the Office of Naval Research through N00014-11-1-0361. . . Cognition was programmed by Pulsar Informatics, Inc., with the support of the NSBRI, project NBPF02501.”



Other papers of interest:



Seo Y, Fennell C, Burns K, Pollock BS, Gunstad J, McDaniel J, Glickman E.

Exercise improves mood state in normobaric hypoxia.

Aerosp Med Hum Perform. 2015 Nov;86(11):976-81.



Wang Q, Mazur A, Guerrero F, Lambrechts K, Buzzacott P, Belhomme M, Theron M.

Antioxidants, endothelial dysfunction and DCS: In vitro and in vivo study.

J Appl Physiol (1985). 2015 Oct 15:jap.00167.2015. [Epub ahead of print]



Wada T, Yoshida K.

Effect of passengers’ active head tilt and opening/closure of eyes on motion sickness in lateral acceleration environment of cars.

Ergonomics. 2015 Oct 20:1-26. [Epub ahead of print]



Blue RS, Blacher E, Castleberry TL, Vanderploeg JM.

Centrifuge-simulated suborbital spaceflight in a subject with cardiac malformation.

Aerosp Med Hum Perform. 2015 Nov;86(11):999-1003.



Breen MS, Beliakova-Bethell N, Mujica-Parodi LR, Carlson JM, Ensign WY, Woelk CH, Rana BK.

Acute psychological stress induces short-term variable immune response.

Brain Behav Immun. 2015 Oct 14. [Epub ahead of print]



Simpson RJ, Kunz H, Agha N, Graff R.

Exercise and the regulation of immune functions.

Prog Mol Biol Transl Sci. 2015;135:355-80. Epub 2015 Sep 5.



Fregly BJ, Fregly CD, Kim BT.

Computational simulation of muscle loading during ARED squat exercise on the International Space Station.

J Biomech Eng. 2015 Oct 16. [Epub ahead of print] Review.

Note: A computational simulation model of the Advanced Resistive Exercise Device (ARED) was developed. From the Acknowledgements: “The student authors would like to thank . . . NASA Johnson Space Center for providing ARED squat motion data on Earth, and NASA Glenn Space Center for providing ARED CAD models to perform this study.”



McGlory C, Phillips SM.

Exercise and the regulation of skeletal muscle hypertrophy.

Prog Mol Biol Transl Sci. 2015;135:153-73. Review. Epub 2015 Jul 31.



Booth FW, Ruegsegger GN, Toedebusch RG, Yan Z.

Endurance exercise and the regulation of skeletal muscle metabolism.

Prog Mol Biol Transl Sci. 2015;135:129-51. Review. Epub 2015 Sep 5.



Laurent MR, Dubois V, Claessens F, Verschueren SM, Vanderschueren D, Gielen E, Jardi F.

Muscle-bone interactions: From experimental models to the clinic? A critical update.

Mol Cell Endocrinol. 2015 Oct 23. [Epub ahead of print] Review.



Kjaer M, Jorgensen NR, Heinemeier K, Magnusson SP.

Exercise and regulation of bone and collagen tissue biology.

Prog Mol Biol Transl Sci. 2015;135:259-91. Review. Epub 2015 Aug 7.



Naruse K, Uchida K, Suto M, Miyagawa K, Kawata A, Urabe K, Takaso M, Itoman M, Mikuni-Takagaki Y.

Alendronate does not prevent long bone fragility in an inactive rat model.

J Bone Miner Metab. 2015 Oct 16. [Epub ahead of print]



Petersen B, Hastings B, Gottschall JS.

Low load, high repetition resistance training increases bone mineral density in untrained adults.

J Sports Med Phys Fitness. 2015 Sep 11. [Epub ahead of print] 



Bannister LA, Serran ML, Mantha RR.

Low-dose gamma radiation does not induce an adaptive response for micronucleus induction in mouse splenocytes.

Radiat Res. 2015 Oct 23. [Epub ahead of print]



Geng C, Tang X, Gong C, Guan F, Johns J, Shu D, Chen D.

A Monte Carlo-based radiation safety assessment for astronauts in an environment with confined magnetic field shielding.

J Radiol Prot. 2015 Oct 20;35(4):777-88. [Epub ahead of print]



Hellweg CE, Dilruba S, Adrian A, Feles S, Schmitz C, Berger T, Przybyla B, Briganti L, Franz M, Segerer J, Spitta LF, Henschenmacher B, Konda B, Diegeler S, Baumstark-Khan C, Panitz C, Reitz G.

Space experiment “Cellular Responses to Radiation in Space (CellRad)”: Hardware and biological system tests.

Life Sci Space Res. 2015 Nov;7:73-89.

Note: From the abstract: “The purpose of the experiment “Cellular Responses to Radiation in Space” (CellRad, formerly CERASP) is to study the effects of combined exposure to microgravity, radiation and general space flight conditions on mammalian cells, in particular Human Embryonic Kidney (HEK) cells that are stably transfected with different plasmids allowing monitoring of proliferation and the Nuclear Factor κB (NF-κB) pathway by means of fluorescent proteins.” The investigation and hardware are being prepared for a future experiment aboard the International Space Station in the Biolab Facility.



Roche M, Neti PV, Kemp FW, Azzam EI, Ferraris RP, Howell RW.

High levels of dietary supplement vitamins A, C and E are absorbed in the small intestine and protect nutrient transport against chronic gamma irradiation.

Radiat Res. 2015 Oct 20. [Epub ahead of print]



Vasilyeva I, Bespalov V, Baranova A.

Radioprotective combination of alpha-tocopherol and ascorbic acid promotes apoptosis that is evident by release of low-molecular weight DNA fragments into circulation.

Int J Radiat Biol. 2015 Oct 16:1-6. [Epub ahead of print]



Wang J, Shao L, Hendrickson HP, Liu L, Chang J, Luo Y, Seng J, Pouliot M, Authier S, Zhou D, Allaben W, Hauer-Jensen M.

Total body irradiation in the “hematopoietic” dose range induces substantial intestinal injury in non-human primates.

Radiat Res. 2015 Oct 23. [Epub ahead of print]



Stingl JC, Welker S, Hartmann G, Damann V, Gerzer R.

Where failure is not an option – Personalized medicine in astronauts.

PLoS One. 2015 Oct 21;10(10):e0140764.

Note: From the abstract: “. . . we scrutinized the list of the 78 drugs permanently available at the ISS (year 2014) to determine the extent to which their metabolism may be affected by genetic polymorphisms, potentially requiring genotype-specific dosing or choice of an alternative drug. The purpose of this analysis was to estimate the potential benefit of pharmacogenetic diagnostics in astronauts to prevent therapy failure or side effects.” This article may be obtained online without charge.



Dyakov MY, Insarova ID, Kharabadze DE, Ptushenko VV, Shtaer OV.

Influence of extreme ambient temperatures and anaerobic conditions on Peltigera aphthosa (L.) Willd. viability.

Life Sci Space Res. 2015 Nov;7:66-72.

SpaceRef staff editor.